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Identification of m6A-Associated RNA Binding Proteins Using an Integrative Computational Framework

Yiqian Zhang, Michiaki Hamada
2021 Frontiers in Genetics  
The framework was composed of an enrichment analysis and a classification model. Utilizing RBPs' binding data, we analyzed reproducible m6A regions from independent studies using this framework.  ...  On the other hand, a Random Forest classification model was built for the reproducible m6A regions using RBPs' binding data.  ...  MoAIMS called enriched regions at 200-bp resolution as default, therefore we obtained m 6 A-enriched regions with a size of 200 bp for each MeRIP-Seq sample, and then we identified reproducible m 6 A regions  ... 
doi:10.3389/fgene.2021.625797 pmid:33732286 pmcid:PMC7957075 fatcat:jhun6heqlbbgda3lbfurmes6jq