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PHASE I CLINICAL TRIAL OF A NEW CHEMOTHERAPEUTIC AGENT, AB-206
新化学療法剤AB-206の健常人における第一相臨床研究

KEIICHI NAKAGAWA, TATSUO SUZUKI, MITSUHIRO YOKOZAWA
1978 Chemotherapy  
Fig. 1 Chemical structure of AB-206 AB-206を 動 物 に経 口投 与 し た場 合,比 較 的 高 い血 清, 胆 汁 お よび 尿 中濃 度 を示 す こ とが 知 られ て い る2)。  ...  新化 学 療 法 剤AB-206の 健 常 人 に お け る第一 相 臨 床 研 究 中 川 圭 一 ・鈴 木 達 夫 東 京共済病院 内科 横 沢 光 博 東京共済病院臨床検査科 AB-206は 住 友化 学工 業 株 式 会 社 に お い て合 成 され た 新 し い化 学療 法 剤 で あ り(Fig.1),グ ラム陰 性 菌 お よび 一 部 の グ ラ ム陽 性菌 に 対 し広範 囲  ...  Relatively high serum levels of AB-206 and the dose response of serum levels among these two doses were observed.  ... 
doi:10.11250/chemotherapy1953.26.supplement4_267 fatcat:zst4ezfthnhqxjd424lcsj3xf4

Clinical studies of spinal cord tumors
当科における脊髄腫ようの治療経験

Hideya Kawamura, Takashi Naono, Tetsurou Isayama, Masahiko Ono, Tetsuichi Abe, Hideaki Abe, Mitsuhiro Takashita
1988 Orthopedics & Traumatology  
Between the years of [1975][1976][1977][1978][1979][1980][1981][1982][1983][1984][1985][1986][1987] 20 cases of spinal cord tumor were operated at Beppu National Hospital. 8 cases were female and 12 were male. There were 7 neurinomas, 5 meningiomas, 2 extradural cysts, 2 malignant lymphomas, 2 hemangiomas, an ependymoma, and a glioblastoma. These patients had neurological deficits in varying degrees before oparation. 13 patients had severe muscle weakness, 13 had anesthetic area in limbs and 12
more » ... had bowel and bladder dysfunctions. After operation these patients were improved by 66%, according to our evaluation score, but 3 cases died and 5 cases had some neurological deficits disturbing their daily life.
doi:10.5035/nishiseisai.37.699 fatcat:s6qxrwv7rvb2pcguhigv3rcuda

A clinical study on tuberculous spondylitis
当科における脊椎カリエスの治療経験

Tetsuichi Abe, Takashi Naono, Hideya Kawamura, Tetsuro Isayama, Masahiko Ono, Hideaki Abe, Mitsuhiro Takashita
1989 Orthopedics & Traumatology  
This is a clinical study of tuberculous Spondylitiss in our department in the past ten years. 18 cases were investigated : 6 cases treated conservatively and 12 cases operatively. On the whole, we had good results both on the conservative and operative treatment, but the average period of bed rest and hospitalization was longer in the non-operative than in the operative treatment. Biopsy seemed to be most reliable method to get diagnosis of tuberculous spondylitis in early stages, although
more » ... were some cases which could not be diagnosed with biopsy only. Once diagnosis of tuberculous spondylitis is made, operative treatment should be taken in consideration.
doi:10.5035/nishiseisai.38.898 fatcat:44s47xphcfahzb3usbbny3vj4u

Multifocal osteosarcoma following therapeutic radiation a case report
多発性骨病巣を呈したpostradiation osteosarcomaの一例

Tetsurou Isayama, Takashi Naono, Masahiko Ono, Hideya Kawamura, Tetsuichi Abe, Hideaki Abe, Mitsuhiro Takashita
1989 Orthopedics & Traumatology  
doi:10.5035/nishiseisai.37.1724 fatcat:nmoco7bqvjdbbkqrwrwmtqb32y

Thermodynamic Analysis of the Fe-Al-C Ternary System by Incorporating ab initio Energetic Calculations into the CALPHAD Approach

Hiroshi Ohtani, Maki Yamano, Mitsuhiro Hasebe
2004 ISIJ International  
KEY WORDS: phase diagram; thermodynamic analysis; ab initio energetic calculations; ternary carbide. Table 1.  ...  The ab initio energetic calculations show that the stable E2 1 structure of the k phase is highly preferred compared with the metastable Fe 3 Al-L1 2 structure.  ...  approach, may be circumvented by employing a first principle energetic calculation method, such as the Full Potential Linearized Augmented Plane Wave (FLAPW) method. 2) Our group has attempted to combine ab  ... 
doi:10.2355/isijinternational.44.1738 fatcat:skkgptudmzea7dcto5evv7keju

Anterolateral Approach for Thoracic Disc Disease

Yoshinobu IWASAKI, Hiroshi ABE, Mitsuhiro TADA, Toyohiko ISU, Minoru AKINO, Kiyoshi KANEDA
1988 Neurologia medico-chirurgica  
The authors describe six cases of thoracic disc disease successfully treated by anterior spinal cord decompression via the transpleural or retroperitoneal approach. The patients included two with ossification of the posterior longitudinal ligament, one with a soft disc, and three with spondylosis (two of whom had ossification of the yellow ligament at the level of the spondylosis). The lesions were situated at the Th7 to L2 levels. In all cases the protruding disc, spur, or ossified ligament
more » ... completely removed. In five cases bone grafting was performed, and in three, anterior internal fixation was accomplished with a Kaneda device. All six patients' neurological deficits improved. Thus, when neurological deficit results from anterior pressure on the dural tube at the thoracic level, anterior decompression is an effective therapeutic procedure.
doi:10.2176/nmc.28.798 pmid:2461528 fatcat:r7sqa4tnnvdnvi6n5qcxczek44

Groups associated with some types of infinite dimensional Lie algebras

Eiichi Abe, Mitsuhiro Takeuchi
1992 Journal of Algebra  
Therefore, f,'ERB and d(u,(f))ERB@AB+AB@RB. called the Lie algebra of G and denoted by Lie G.  ... 
doi:10.1016/0021-8693(92)90073-u fatcat:yhhaaux4ovauzd3oer4jrgfgbm

BASIC AND CLINICAL EVALUATION OF SULFOBENZYLPENICILLIN
Sulfobenzylpenicillinの基礎的臨床的検討

KEIICHI NAKAGAWA, KENTARO WATANABE, KO FUKUI, JUNZABURO ABE, NORIO KIHARA, MITSUHIRO YOKOZAWA
1971 Chemotherapy  
E.coli50株 に つ い て み る とSB-PC MIC は12.5mcg/mlな い し25mcg/mlの 株 が 大 部 分 で CB-PCあ るい はAB-PCに 比 し若干 抗 菌 力 が 劣 つ て い る。StaPhylo.mreusに 対 して もE.coliと 同様SB - PCはAB-PC,CB-PCよ り も抗菌 力 が劣 つ て い る。 II.  ...  PC) was a little lower than that to ampicillin (AB-PC) and carbenicillin (CB-PC).  ... 
doi:10.11250/chemotherapy1953.19.927 fatcat:oxtodlwkdrcitjjbjbzur6oaje

Interleukin-6 and tumour necrosis factor during cardiopulmonary bypass

Kazuo Abe, Mitsuhiro Nishimura, Tetsuo Sakakibara
1994 Canadian Journal of Anesthesia  
Cold face test in the assessment of trigeminal-brainstemvagal function in humans. Ann Neurol 1980; 7: 144-9. 3 Smeland EB, Owe JO, Anderson HT. Modification of the "diving bradycardia" by hypoxia or exercise. Respir Physiol 1984; 56: 245-51. REPLY We thank you for your informative comments on the diving reflex. You noted no episodes of the diving reflex during cold ocular irrigation of the anterior chamber of the eye and we would like to respond to your comments. The generation of any reflex is
more » ... at best problematic and its occurrence is multi factorial. Although the diving reflex was not noted during cold saline anterior chamber ocular irrigation, it has never been described during anterior eye chamber irrigation. The circumstances described in your letter are different from our paper. The diving reflex classically has been described during cold ocular irrigation in the distribution of the fifth division of trigeminal nerve supplying the cornea, eyelid and the skin sensory areas surrounding the eye. t One also must question if clinical circumstances might inhibit the oculocardiac reflex. Topical ocular 0.75% bupivacaine was used, yet it is stated that the afferent impulses from the anterior chamber are unblocked. It is possible the bupivacaine has diff~ed over the time course of the surgery and partially or totally blocked the sensory input necessary to elicit the reflex. The innervation of the anterior chamber may also be different from that of the surrounding skin of the eye. 2 This skin sensory input triggered by cold solution may be needed to prompt the reflex. It is also common to use vagolytic drugs of the belladonna alkaloid family for mydriatics. Their use is not noted and would also block the reflex. We believe the diving reflex does occur under general anaesthesia. However, we feel it is not a common occurrence but that when it occurs it is problematic. The diving reflex is well known in other branches of clinical medicine, primarily cardiology where the diving reflex is used to terminate suprventricular tachycardias in both children and adults, z-s It is also known to cause bradycardia in awake humans through the parasympathetic nervous systems. 6'~ The goal of our paper was to remind clinicians that the diving reflex may occur and why it may happen.
doi:10.1007/bf03011610 pmid:7525092 fatcat:txl2zrqserhbpi5tnjvwtkvvay

A case of scarred liver with portal hypertension
門脈圧こう進症を伴ったはん痕肝と考えられる1例

Yasuo MATSUBARA, Mitsuhiro TERADA, Kenji ARII, Masahiro OHTA, Mitsuhiro SAITO, Toshiyuki BABA, Masayoshi ITO, Yukihiro SAKURAI, Sachio TAKASU, TAKASHI ABE, Fumiaki IKEGAMI, Kazuyoshi YAMAGUCHI (+1 others)
1994 Kanzo  
scarred liver with portal hypertension Yasuo MATSUBARA, Mitsuhiro TERADA, Kenji ARII, Masahiro OHTA, Mitsuhiro SAITO, Toshiyuki BABA, Masayoshi ITO, Yukihiro SAKURAI, Sachio TAKASU*, Abe TAKASHI, Fumiaki  ... 
doi:10.2957/kanzo.35.455 fatcat:3w2s22dpgnhobl3te3ir7sdevu

Venous Hemangioma of the Temporalis Muscle —Case Report—

Mitsuhiro TADA, Yutaka SAWAMURA, Hiroshi ABE, Fumio ITOH, Hisatoshi SAITO, Kazuo NAGASHIMA
1996 Neurologia medico-chirurgica  
A 14-year-old girl presented with a diffuse venous hemangioma of the right temporalis muscle. The muscle had become swollen, thinning the underlying zygomatic and temporal bones. Magnetic resonance (MR) imaging demonstrated a diffuse isointense area containing high intensity foci on the T1-weighted images, and a serpiginous high intensity pattern on the T2-weighted images. A biopsy specimen revealed irregularly dilated veins in the fibrous stroma of the muscle. Diffuse abnormal sig nals on MR
more » ... ages may be a pathognomonic feature of intramuscular venous hemangiomas.
doi:10.2176/nmc.36.23 pmid:8786831 fatcat:7vzpzble2zgnhoczog552pvxmu

Papillary Craniopharyngioma of the Third Ventricle —Case Report—

Mitsuhiro TADA, Toshimitsu AIDA, Mitsuyuki KOIWA, Yoshimi CHONO, Takeshi KASHIWABA, Hiroshi ABE
1992 Neurologia medico-chirurgica  
Cyst formation is less frequent (36%), but calcification is usually ab sent.  ...  Am J Surg Pathol 8: 57-64, 1984 15) Goldstein SJ, Wilson DD, Young AB, Guidry GJ: Craniopharyngioma intrinsic to the third ventricle.  ... 
doi:10.2176/nmc.32.972 pmid:1283625 fatcat:hi6bjuhuqjcyrnkxj6kniff5we

Basilar Invagination Associated with an Intercarotid Paraganglioma —Case Report—

Nobuaki ISHII, Yutaka SAWAMURA, Mitsuhiro TADA, Tsutomu KATO, Hiroshi ABE
1997 Neurologia medico-chirurgica  
A 24-year-
doi:10.2176/nmc.37.279 pmid:9095630 fatcat:der74u7tlza2joekqfw6c3poya

Theoretical Analysis of a Subsonic TE CO Laser

Mitsuhiro IYODA, Shunichi SATO, Katsuhiko KOMATSU, Takao ABE, Tomoo FUJIOKA
1982 The Review of Laser Engineering  
Takao ABE*, and Tomoo FUJIOKA* (Received September 16, 1982) In a transversely excited (TE) electric discharge laser (CO EDL) with subsonic flow, fundamental laser characteristics have been theoretically  ... 
doi:10.2184/lsj.10.582 fatcat:6cdvd3m4dvhzlfdycrvir6qlei

Lack of GTP-bound Rho1p in secretory vesicles ofSaccharomyces cerevisiae

Mitsuhiro Abe, Hiroshi Qadota, Aiko Hirata, Yoshikazu Ohya
2003 Journal of Cell Biology  
Abe.  ... 
doi:10.1083/jcb.200301022 pmid:12847085 pmcid:PMC2172714 fatcat:gyfjjshjj5cjbgwkknlflgrdv4
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