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Mitochondria-based Renal Cell Carcinoma Subtyping: Learning from Deep vs. Flat Feature Representations [article]

Peter J. Schüffler, Judy Sarungbam, Hassan Muhammad, Ed Reznik, Satish K. Tickoo, Thomas J. Fuchs
2016 arXiv   pre-print
We compare and evaluate models based on domain specific hand-crafted "flat"-features versus "deep" feature representations from various layers of a pre-trained convolutional neural network (CNN).  ...  Accurate subtyping of renal cell carcinoma (RCC) is of crucial importance for understanding disease progression and for making informed treatment decisions.  ...  Flat Features for Mitochondria-based Renal Cell Carcinoma Subtyping -Supplement Figure 10 shows the tissue micro array where the individual spots have been identified and numbered automatically. 96 RCC  ... 
arXiv:1608.00842v1 fatcat:qez6lqvdknfglcc4rfkrsi67qi

Genitourinary Pathology

2016 Modern Pathology  
The histological features with statistically significance are shown in the following table.  ...  In this study, we tried to determine whether any histological features are specially associated with post-appendectomy CRCs.  ...  Background: Type 10 soluble adenyl cyclase (sAC) is a ubiquitous, newly characterized enzyme that has a variety of functions based on its cellular localization which is distinct from transmembrane adenyl  ... 
doi:10.1038/modpathol.2016.10 pmid:26820333 fatcat:xgnongxywfgdff66nze3gwbv6m

USCAP 2018 Abstracts: Gastrointestinal Pathology (657–893)

2018 Laboratory Investigation  
Regression analyses revealed histopathologist predictors of diagnostic concordance at expert level and allowed us to model optimal revision strategies based on individual case and pathologists characteristics  ...  Primary cancers included melanoma (10, 40%), non small cell lung cancer (4, 16%), and renal cell carcinoma (3, 12%) etc.  ...  Location was documented from deep to superficial: muscularis mucosa, base, neck, and isthmus. The length of each tissue section was recorded.  ... 
doi:10.1038/labinvest.2018.9 pmid:29551806 fatcat:evk75ih3fvaijfyuw4cce63r24


1998 Acta Cytologica  
INTRODUCTION: Chromophobe renal cell carcinoma (ChRCC) is a distinct tumor with prognosis intermediate between renal oncocytoma (RO) and clear cell renal cell carcinoma.  ...  Oncocytoma Be Distinguished from Renal Cell Carcinoma on Fine Needle Aspiration Specimens?  ... 
doi:10.1159/000332117 fatcat:rmpmtc6nanbcxnet63pjkd4hku

Proceedings: Congresso Annaule di Anatomia Patologica SIAPEC-IAP 2019

2019 Pathologica  
The model is based on a retrospective study of tissue samples positive for ROS1, evaluated with both IHC and FISH method, from Jenuary 2017 to July 2019. Conclusions.  ...  in patients with pulmonary adenocarcinoma; however, cases with ROS1 IHC positive should be confirmed by a molecular or cytogenetic method. (3) Although until 2018 only the monoclonal antibody D4D6 (Cell-Signaling  ...  Sections from tissue blocks of each tumor and 120 control cases (50 clear cell renal cell carcinomas, 20 papillary renal cell carcinomas, 20 chromophobe renal cell carcinomas, 20 oncocytomas and 10 clear  ... 
doi:10.32074/1591-951x-25-19 pmid:31748758 fatcat:tgsswyd6pnhkpbgykby7san4zy


2014 Der Pathologe  
Chordomas arise along the spine with hot spots at the upper (skull base 20-30%) and lower (sacro-coccygeal 50-60%) end, and are therefore thought to originate from remnants of the notochord.  ...  The giant cell tumour of the bone is a locally aggressive bone tumour of intermediary character which have a benign course in 90% of the cases but 4-5% show malignancy from its onset or undergo malignant  ...  DO-077 Chimeric read-through RNAs in renal cell carcinoma Aims.  ... 
doi:10.1007/s00292-014-1944-9 fatcat:jxkoidekjjeh7gq2ivyrysuzwe

7thESACP Congress in Caen April 1–5, 2001

2001 Analytical Cellular Pathology  
MAC: 1 feature 76 94 "normal" vs. MAC: 2 features 85 100 "normal" vs. MAC: 3 features n.s. 100 "normal" vs.  ...  These control cells define a learning population.  ...  Aims: To develop a new type of didactic tool as a combination of computer based teaching and learning multimedia software with a knowledge based diagnostic system in cytopathology of effusions.  ... 
doi:10.1155/2001/414753 fatcat:7vxekd2dbjherbnpv5q7dshpsu


Gajalakshmi Dr. P.
2020 International Journal of Pharma and Bio Sciences  
Consent from the patient was taken for local examination and biopsy.  ...  Ethics Prior to the study, ethical permission was obtained from Hospital Ethics committee.  ...  MTT reduction assessing the functional metabolic activity of mitochondria based on the enzymatic reduction of a tetrazolium salt by mitochondrial dehydrogenases of viable cells, while tryphan blue is based  ... 
doi:10.22376/ijpbs/ijlpr/sp07/jan/2020.1-87 fatcat:6lb7xdovbre7zle2hi7fx2erde

Nemosis [chapter]

Antti Vaheri
2017 Encyclopedia of Cancer  
Cellular Features of Necroptosis As a subtype of necrosis, necroptosis possesses the morphological features of necrosis.  ...  the mitochondria within cells.  ...  Therefore, one dose of drug leads to cytoreduction from 10 6 cells to 10 4 cells in the same way that one dose at 10 4 cells reduces tumor volume to 10 2 cells.  ... 
doi:10.1007/978-3-662-46875-3_4002 fatcat:xt3vgg7pyjes5hmumo2qkyhlni

ECR 2012 Book of Abstracts - A - Postergraduate Educational Programme

2012 Insights into Imaging  
To learn how to differentiate ischaemia from inflammation.  ...  Learning Objectives: 1. To understand the multimodality approach to MI based on PET-CT-MRI. 2. To learn about the different radiotracers that can be used with multimodality equipment. 3.  ...  However, it can help in the differentiation of subtypes of renal cell carcinomas based on tumour vascularity since non clear-cell carcinomas, such as the papillary type, are usually more hypovascular than  ... 
doi:10.1007/s13244-012-0153-4 pmid:22696127 pmcid:PMC3481066 fatcat:te6ctbtakzh5njsw43geghw3ta

Western Medical Research Conference 2017 ( Formerly Western Regional Meeting ) Camel, California, January 26–28, 2017

2016 Journal of Investigative Medicine  
He had a depressed nasal bridge and short, flat nasal tip with a tented upper lip and mild micrognathia. He had deep palmar and IP creases and overriding second toes.  ...  High grade serous ovarian carcinoma is thought to originate from fallopian tube epithelium.  ...  Samples were grouped based on Banff scoring of biopsy: T cell-mediated rejection (TCMR; n=33), borderline rejection (BRD; n=115), and NoTCMR (n=235).  ... 
doi:10.1136/jim-2016-000365.226 fatcat:vvkrand7yzghpk3cquk3hfm654

2021 AOA Research Abstracts and Poster Competition

2021 Journal of Osteopathic Medicine  
To enhance the readability of this special feature, abstracts have been edited for basic style only.  ...  We utilized the segmentation wizard feature in Dragonfly 2020.1 (ORS) to select and train a Deep Learning Model.  ...  Multiple Deep Learning models, implemented in Dragonfly 2020.1 (ORS), were trained on one sample for image segmentation.  ... 
doi:10.1515/jom-2021-2000 fatcat:jc3gj7xpgbht3ii5gzjhevaduu

Fourth Japan-US Joint Congress of Histochemistry and Cytochemistry: Thirty-fifth Annual Meeting of the Japan Society of Histochemistry and Cytochemistry and Forty-fifth Annual Meeting of the Histochemical Society-Abstracts

1994 Acta Histochemica et Cytochemica  
The techniques of radioautography (RAG) can be classified into 3 categories from viewpoint of specimen size,i. e. whole body, light microscopic and electron microscopic, as well as into 2 from viewpoint  ...  The techniques of demonstrating radioisotope labeled compounds to localize their sites in cells and tissues by electron microscopy is designated as electron microscopic radioautography and is one of the  ...  In electron microscopy, the renal proximal tubular cells showed several autophagosomes full of degenerated mitochondria, single membrane-bound dense bodies etc.. 4) At 45 minutes after administration,  ... 
doi:10.1267/ahc.27.376 fatcat:s4wbvzdktrbljkzvg37hjkeohq

Abstracts 624-854

2009 Hepatology  
Results: LLR was performed for 15 Hepatocellular carcinomas, 8 colorectal metastases and 22 benign conditions. The following were significantly less in the LLR group (LLR vs.  ...  Disclosures: The following people have nothing to disclose: from causes other than biliary related.  ...  In these case-based learning clinics, partners rapidly gain deep domain expertise in HCV as they collaborate with university specialists in hepatology, psychiatry and sub- stance abuse in co-managing  ... 
doi:10.1002/hep.23303 fatcat:u77ngflxbjhavkka2lxiuilrky

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2009, n°1 - Full issue

2011 Atlas of Genetics and Cytogenetics in Oncology and Haematology  
Note BTK (Bruton's tyrosine kinase) is a cytoplasmic nonreceptor protein tyrosine kinase that is essential for B cell maturation in humans and mice.  ...  Weaver syndrome Piccione M, Corsello G NF1 associated with Clinical features Patients from % literature (n=48) Macrosomia 46/48 96 Macrocephaly 35/38 97 Flat occiput 14/28 50 Prominent forehead 40/42 95  ...  , large cell carcinomas).  ... 
doi:10.4267/2042/45324 fatcat:222l4mxzhndozczwoutx2ajcni
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