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Selbstkonzeptförderung im Sportunterricht

Mirko Schmidt, Achim Conzelmann
<span title="2011-08-06">2011</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/j74xq2l6a5ditimow3xhsancau" style="color: black;">Sportwissenschaft</a> </i> &nbsp;
Mirko Schmidt Institut für Sportwissenschaft (ISPW), Universität Bern Bremgartenstr. 145, 3012 Bern Schweiz mirko.schmidt@ispw.unibe.ch Interessenkonflikt.  ...  Zusammenfassung · Abstract Sportwiss 2011 · 41:190-201 DOI 10.1007/s12662-011-0195-7 © Springer-Verlag 2011 Mirko Schmidt · Achim Conzelmann Selbstkonzeptförderung im Sportunterricht.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s12662-011-0195-7">doi:10.1007/s12662-011-0195-7</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/kw5543q5wveerdhqpjicmj2c6a">fatcat:kw5543q5wveerdhqpjicmj2c6a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200215082723/https://boris.unibe.ch/40954/8/12662_2011_Article_195.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7f/7b/7f7b746619a0cc182b4a210f81b38ba3cd8aee18.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s12662-011-0195-7"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>

Tunneling Nanotubes and Tumor Microtubes in Cancer

Cora Roehlecke, Mirko H H Schmidt
<span title="2020-04-01">2020</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2zwku6u6nfdcri773tpisi6ldi" style="color: black;">Cancers</a> </i> &nbsp;
Intercellular communication among cancer cells and their microenvironment is crucial to disease progression. The mechanisms by which communication occurs between distant cells in a tumor matrix remain poorly understood. In the last two decades, experimental evidence from different groups proved the existence of thin membranous tubes that interconnect cells, named tunneling nanotubes, tumor microtubes, cytonemes or membrane bridges. These highly dynamic membrane protrusions are conduits for
more &raquo; ... t cell-to-cell communication, particularly for intercellular signaling and transport of cellular cargo over long distances. Tunneling nanotubes and tumor microtubes may play an important role in the pathogenesis of cancer. They may contribute to the resistance of tumor cells against treatments such as surgery, radio- and chemotherapy. In this review, we present the current knowledge about the structure and function of tunneling nanotubes and tumor microtubes in cancer and discuss the therapeutic potential of membrane tubes in cancer treatment.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cancers12040857">doi:10.3390/cancers12040857</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32244839">pmid:32244839</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7226329/">pmcid:PMC7226329</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/g6ttg6bwqzditlgml6ltipq3gi">fatcat:g6ttg6bwqzditlgml6ltipq3gi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200405012648/https://res.mdpi.com/d_attachment/cancers/cancers-12-00857/article_deploy/cancers-12-00857.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/8c/91/8c917caa50183909401863c60713d91d0e59eb8b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cancers12040857"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226329" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Directed biosynthesis of fluorinated polyketides [article]

Alexander Rittner, Mirko Joppe, Jennifer J. Schmidt, Lara Maria Mayer, Elia Heid, David H. Sherman, Martin Grininger
<span title="2021-07-30">2021</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Modification of polyketides with fluorine offers a promising approach to develop new pharmaceuticals. While synthetic chemical methods for site-specific incorporation of fluorine in complex molecules have improved in recent years, approaches for the direct biosynthetic fluorination of natural compounds are still rare. Herein, we present a broadly applicable approach for site-specific, biocatalytic derivatization of polyketides with fluorine. Specifically, we exchanged the native acyltransferase
more &raquo; ... domain (AT) of a polyketide synthase (PKS), which acts as the gatekeeper for selection of extender units, with an evolutionarily related but substrate tolerant domain from metazoan type I fatty acid synthase (FAS). The resulting PKS/FAS hybrid can utilize fluoromalonyl coenzyme A and fluoromethylmalonyl coenzyme A for polyketide chain extension, introducing fluorine or fluoro-methyl disubstitutions in polyketide scaffolds. Addition of a fluorine atom is often a decisive factor toward developing superior properties in next-generation antibiotics, including the macrolide solithromycin. We demonstrate the feasibility of our approach in the semisynthesis of a fluorinated derivative of the macrolide antibiotic YC-17.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2021.07.30.454469">doi:10.1101/2021.07.30.454469</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/izhbrivlajeu7k33dmalsfhi3a">fatcat:izhbrivlajeu7k33dmalsfhi3a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210807153230/https://www.biorxiv.org/content/biorxiv/early/2021/07/30/2021.07.30.454469.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7f/0c/7f0c987732379aec50dbeb52fd4a98930e1cedec.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2021.07.30.454469"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

Muster, Entwicklungstypen und Persönlichkeit

Mario Müller, Mirko Schmidt, Marc Zibung, Achim Conzelmann
<span title="">2013</span> <i title="Hogrefe Publishing Group"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/gw3dnv76mnazrlx6p65c4urucm" style="color: black;">Zeitschrift für Sportpsychologie</a> </i> &nbsp;
Sportlichen Aktivitäten wird eine besondere Bedeutung für die Persönlichkeitsentwicklung von Kindern und Jugendlichen zugeschrieben (Schmidt, 2009 ).  ...  Fontayne & Brunel, 2006) , die Leistungsentwicklung der Sportlerinnen und Sportler (Alfermann, Stiller & Würth, 2003; Marsh & Perry, 2005) oder die Inszenierung der sportlichen Aktivität (Conzelmann, Schmidt  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1026/1612-5010/a000107">doi:10.1026/1612-5010/a000107</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/6unfyzhl7za53ms2yexg6ozd54">fatcat:6unfyzhl7za53ms2yexg6ozd54</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180721042210/https://boris.unibe.ch/40955/1/M%C3%BCller%20et%20al_2013.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/70/a1/70a1a74108ab8de10f00eddd6f316d0020b7024e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1026/1612-5010/a000107"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Trends and Challenges in Tumor Anti-Angiogenic Therapies

József Jászai, Mirko H.H. Schmidt
<span title="2019-09-18">2019</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3iichab3fbz7jq46o55l6trkq" style="color: black;">Cells</a> </i> &nbsp;
Excessive abnormal angiogenesis plays a pivotal role in tumor progression and is a hallmark of solid tumors. This process is driven by an imbalance between pro- and anti-angiogenic factors dominated by the tissue hypoxia-triggered overproduction of vascular endothelial growth factor (VEGF). VEGF-mediated signaling has quickly become one of the most promising anti-angiogenic therapeutic targets in oncology. Nevertheless, the clinical efficacy of this approach is severely limited in certain tumor
more &raquo; ... types or shows only transient efficacy in patients. Acquired or intrinsic therapy resistance associated with anti-VEGF monotherapeutic approaches indicates the necessity of a paradigm change when targeting neoangiogenesis in solid tumors. In this context, the elaboration of the conceptual framework of "vessel normalization" might be a promising approach to increase the efficacy of anti-angiogenic therapies and the survival rates of patients. Indeed, the promotion of vessel maturation instead of regressing tumors by vaso-obliteration could result in reduced tumor hypoxia and improved drug delivery. The implementation of such anti-angiogenic strategies, however, faces several pitfalls due to the potential involvement of multiple pro-angiogenic factors and modulatory effects of the innate and adaptive immune system. Thus, effective treatments bypassing relapses associated with anti-VEGF monotherapies or breaking the intrinsic therapy resistance of solid tumors might use combination therapies or agents with a multimodal mode of action. This review enumerates some of the current approaches and possible future directions of treating solid tumors by targeting neovascularization.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cells8091102">doi:10.3390/cells8091102</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31540455">pmid:31540455</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6770676/">pmcid:PMC6770676</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4rjos34p5bawhmypzncmzjta2y">fatcat:4rjos34p5bawhmypzncmzjta2y</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200216135848/https://res.mdpi.com/d_attachment/cells/cells-08-01102/article_deploy/cells-08-01102-v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b4/04/b4042c0b7304af7729cf422397309fb960221f00.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cells8091102"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770676" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

SRA: Fast Removal of General Multipath for ToF Sensors [article]

Daniel Freedman, Eyal Krupka, Yoni Smolin, Ido Leichter, Mirko Schmidt
<span title="2014-03-24">2014</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
A major issue with Time of Flight sensors is the presence of multipath interference. We present Sparse Reflections Analysis (SRA), an algorithm for removing this interference which has two main advantages. First, it allows for very general forms of multipath, including interference with three or more paths, diffuse multipath resulting from Lambertian surfaces, and combinations thereof. SRA removes this general multipath with robust techniques based on L_1 optimization. Second, due to a novel
more &raquo; ... ension reduction, we are able to produce a very fast version of SRA, which is able to run at frame rate. Experimental results on both synthetic data with ground truth, as well as real images of challenging scenes, validate the approach.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1403.5919v1">arXiv:1403.5919v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mthvektj5vdldiyb2sgn7jbqwq">fatcat:mthvektj5vdldiyb2sgn7jbqwq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191014051858/https://arxiv.org/pdf/1403.5919v1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/73/67/73673206a53e9a268172ac5c78d929ea52518c55.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1403.5919v1" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

The Role of SVZ Stem Cells in Glioblastoma

Christine Altmann, Stefanie Keller, Mirko H. H. Schmidt
<span title="2019-03-29">2019</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2zwku6u6nfdcri773tpisi6ldi" style="color: black;">Cancers</a> </i> &nbsp;
Acknowledgments: We thank members of the Schmidt lab for all their support. Conflicts of Interest: The authors declare no conflict of interest.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cancers11040448">doi:10.3390/cancers11040448</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30934929">pmid:30934929</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6521108/">pmcid:PMC6521108</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/nqh2uzbhxvfqnpdew37xqmrgl4">fatcat:nqh2uzbhxvfqnpdew37xqmrgl4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190506010106/https://res.mdpi.com/cancers/cancers-11-00448/article_deploy/cancers-11-00448-v2.pdf?filename=&amp;attachment=1" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e2/ef/e2ef8d5ccaca8abf32ab1148067a0a2b5232b837.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cancers11040448"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521108" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Notching on Cancer's Door: Notch Signaling in Brain Tumors

Marcin Teodorczyk, Mirko H. H. Schmidt
<span title="2015-01-05">2015</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mefn5t5kjndavkrqau5bzfpaoe" style="color: black;">Frontiers in Oncology</a> </i> &nbsp;
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fonc.2014.00341">doi:10.3389/fonc.2014.00341</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25601901">pmid:25601901</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4283135/">pmcid:PMC4283135</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/g4sico5zxneivpjgk2gzyoiv7u">fatcat:g4sico5zxneivpjgk2gzyoiv7u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170830095225/https://fjfsdata01prod.blob.core.windows.net/articles/files/124061/pubmed-zip/.versions/2/.package-entries/fonc-04-00341-r1/fonc-04-00341.pdf?sv=2015-12-11&amp;sr=b&amp;sig=l%2BJutR12xZmWv6vuXvaPKBBeRZZQKtFxmQ%2FbBPOJXGI%3D&amp;se=2017-08-30T09%3A52%3A30Z&amp;sp=r&amp;rscd=attachment%3B%20filename%2A%3DUTF-8%27%27fonc-04-00341.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3e/27/3e278fd002d03d64715d7cc0df2943e8e4a2355a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fonc.2014.00341"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283135" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

EGFL7 meets miRNA-126: an angiogenesis alliance

Iva Nikolic, Karl-Heinz Plate, Mirko HH Schmidt
<span title="">2010</span> <i title="Publiverse Online S.R.L"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/6eiw6fkzi5ad7prynajcxrtfsa" style="color: black;">Journal of Angiogenesis Research</a> </i> &nbsp;
Nikolic Iva Plate Karl-Heinz Schmidt Mirko HH @ + @ EGFL7 structure, temporal and spatial distribution Initially, EGFL7 was described as a 30 kD protein exclusively expressed by vascular endothelial cells  ...  Interestingly, a similar pattern of differential Notch pathway modulation was reported by Schmidt et al.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/2040-2384-2-9">doi:10.1186/2040-2384-2-9</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20529320">pmid:20529320</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2901201/">pmcid:PMC2901201</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7ze7yjypqvcd7azhz2odugdxzu">fatcat:7ze7yjypqvcd7azhz2odugdxzu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190430154144/https://vascularcell.com/index.php/vc/article/download/10.1186-2040-2384-2-9/59" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d2/ed/d2ed18d6ed895bdb10ae6d0da492850bb114e01f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/2040-2384-2-9"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901201" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Double ionization by one and many photons

Reinhard Dörner, Horst Schmidt-Böcking, Thorsten Weber, Till Jahnke, Markus Schöffler, Alexandra Knapp, Mirko Hattass, Achim Czasch, Lothar Ph. H. Schmidt, Ottmar Jagutzki
<span title="">2004</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/il2ajs2avjedfck3fivbcsgroy" style="color: black;">Radiation Physics and Chemistry</a> </i> &nbsp;
The fully differential cross sections have been reviewed recently by Briggs and Schmidt (2000) .  ...  A detailed discussion goes beyond the scope of the present review, we refer the reader to (Briggs and Schmidt, 2000) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.radphyschem.2003.12.012">doi:10.1016/j.radphyschem.2003.12.012</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ksbseu2aizc2dfx2b2fjjctoa4">fatcat:ksbseu2aizc2dfx2b2fjjctoa4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20161230132849/http://amo-csd.lbl.gov/TWeber/downloads/PAPER/Doerner_2004_rad_phys_chem.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/cd/e1/cde1e1a3858ce7a20004e70b94d1abf86daf45f2.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.radphyschem.2003.12.012"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Neuron–Glia Interaction in the Developing and Adult Enteric Nervous System

Verena Pawolski, Mirko H. H. Schmidt
<span title="2020-12-31">2020</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3iichab3fbz7jq46o55l6trkq" style="color: black;">Cells</a> </i> &nbsp;
The enteric nervous system (ENS) constitutes the largest part of the peripheral nervous system. In recent years, ENS development and its neurogenetic capacity in homeostasis and allostasishave gained increasing attention. Developmentally, the neural precursors of the ENS are mainly derived from vagal and sacral neural crest cell portions. Furthermore, Schwann cell precursors, as well as endodermal pancreatic progenitors, participate in ENS formation. Neural precursorsenherite three
more &raquo; ... s: a bipotent neuron-glia, a neuronal-fated and a glial-fated subpopulation. Typically, enteric neural precursors migrate along the entire bowel to the anal end, chemoattracted by glial cell-derived neurotrophic factor (GDNF) and endothelin 3 (EDN3) molecules. During migration, a fraction undergoes differentiation into neurons and glial cells. Differentiation is regulated by bone morphogenetic proteins (BMP), Hedgehog and Notch signalling. The fully formed adult ENS may react to injury and damage with neurogenesis and gliogenesis. Nevertheless, the origin of differentiating cells is currently under debate. Putative candidates are an embryonic-like enteric neural progenitor population, Schwann cell precursors and transdifferentiating glial cells. These cells can be isolated and propagated in culture as adult ENS progenitors and may be used for cell transplantation therapies for treating enteric aganglionosis in Chagas and Hirschsprung's diseases.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cells10010047">doi:10.3390/cells10010047</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33396231">pmid:33396231</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/qglc3esgozcvlhmk6kj7y4mdom">fatcat:qglc3esgozcvlhmk6kj7y4mdom</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210101154301/https://res.mdpi.com/d_attachment/cells/cells-10-00047/article_deploy/cells-10-00047.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3e/44/3e44ffaf05b9f6f06eda0f330d16c964b5eca86c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cells10010047"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a>

Acute Physical Activity Enhances Executive Functions in Children with ADHD

Valentin Benzing, Yu-Kai Chang, Mirko Schmidt
<span title="2018-08-17">2018</span> <i title="Springer Nature America, Inc"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/tnqhc2x2aneavcd3gx5h7mswhm" style="color: black;">Scientific Reports</a> </i> &nbsp;
Acute physical activity of moderate to vigorous intensity has been shown to improve cognitive functions in children. However, the empirical evidence associated with Attention Deficit Hyperactivity Disorder (ADHD) in children is still limited, in particular regarding which specific cognitive functions benefit. This study investigated the effects of an acute bout of physical activity on multiple aspects of executive functions (inhibition, switching, and visual working memory) in children with
more &raquo; ... . Forty-six children (8-12 years old; 82.6% boys) were randomly assigned to either 15 minutes of acute exergaming (physical activity of moderate intensity) or to a control condition (sedentary). Executive function performance in inhibition, switching and visual working memory were assessed before and after each condition, using a modified version of both the Flanker and the Color Span Backwards Task. The results revealed that participants in the exergaming group performed significantly faster than those in the control group in terms of both inhibition and switching, but there was no significant difference in the accuracy of the two tasks nor in visual working memory performance. These findings suggest that acute physical activity utilizing exergaming has the potential to improve specific aspects of executive functions (reaction times in inhibition and switching) in children with ADHD. Attention Deficit Hyperactivity Disorder (ADHD) is recognized as a highly prevalent disorder (3-7%) in childhood and adolescence 1,2 . The male-to-female ratio in community-based samples is approximately 3:1 1 , whereas it ranges between 5:1 and 9:1 in clinical samples 3 . The primary symptoms of ADHD are inattention, disorganisation, and hyperactivity-impulsivity 4 . These symptoms are frequently observed at pre-school age and often persist into adulthood 5 . Children with ADHD display an increased risk of suffering from social, long-term academic, and work-related impairments 6 , creating a large social burden 7 . ADHD is linked to lower Executive Function (EF) performance and motor deficits 8-10 . EFs are defined as the higher-order cognitive functions that modulate fundamental cognitive processes and are therefore required for goal-oriented, adaptive and flexible behavior 11,12 . EFs are thought to be comprised of three core processes 13 : (1) inhibition, which includes inhibiting predominant responses and controlling attention; (2) switching, which includes switching between tasks or mental sets; and (3) working memory, which includes retaining and processing information. Deficiency of the aforementioned EFs is seen as one prevailing explanation for the development of ADHD 10 , with previous studies suggesting that pronounced ADHD symptomatology is associated with poor EF performance 14-17 . A predominant model for the underlying mechanisms of ADHD describes dysfunction of the prefrontal-striatal circuitry 18 , where abnormal prefrontal-striatal-related cortices, such as the prefrontal cortex or basal ganglia, could underpin EF impairment in ADHD 18, 19 . For example, children with ADHD display pronounced hypoactivation during cognitive task performance. This hypoactivation has been detected in systems involved in the frontoparietal and the ventral attentional network, both of which are supposed to be linked to EFs and attention 20,21 . Another proposed mechanism is associated with disrupted catecholamine neurotransmission, meaning that individuals with ADHD have decreased levels of dopamine and norepinephrine in brain networks that are connected to EFs and attention, resulting in decreased cognitive performance 22 . Although the empirical evidence in children is limited, it seems that single bouts of exercise (also known as acute exercise or acute physical activity) have a positive impact on neurotransmission and brain functioning 23,24 . Research exists showing that acute exercise seems to trigger catecholamine neurotransmission 24, 25 , which in turn
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41598-018-30067-8">doi:10.1038/s41598-018-30067-8</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30120283">pmid:30120283</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6098027/">pmcid:PMC6098027</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/qjpauaoiijbkbja5dbs5gyrmnu">fatcat:qjpauaoiijbkbja5dbs5gyrmnu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190427171816/https://boris.unibe.ch/121352/1/s41598-018-30067-8-2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/93/0a/930a4dc86053c1535748190c1d99b39c39a79614.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41598-018-30067-8"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098027" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Exergaming for Children and Adolescents: Strengths, Weaknesses, Opportunities and Threats

Valentin Benzing, Mirko Schmidt
<span title="2018-11-08">2018</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dwd4kjnpxfgfljif4cg2bgznpm" style="color: black;">Journal of Clinical Medicine</a> </i> &nbsp;
Exergaming, or active video gaming, has become an emerging trend in fitness, education and health sectors. It is defined as digital games that require bodily movements to play, stimulating an active gaming experience to function as a form of physical activity (PA). Since exergaming is becoming more popular, claims have been made on the usefulness of exergaming. It has, for example, been entitled as being "the future of fitness" by the American College of Sports Medicine, promoting PA and health
more &raquo; ... in children and adolescents. However, research also suggests that long-term engagement in exergaming is difficult to achieve, and there is a noticeable reservation towards exergaming by parents, teachers and caregivers. To provide an overview and to outline the future directions of exergaming, the aim of this review was to critically illustrate the strengths, weaknesses, opportunities and threats of exergaming to promote PA and health in children and youth. The available evidence indicates that exergaming has the potential to improve health via an increase in PA. However, it seems that this potential is frequently underexploited, and further developments such as customized exergames are needed.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/jcm7110422">doi:10.3390/jcm7110422</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30413016">pmid:30413016</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6262613/">pmcid:PMC6262613</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/fadrupz4lvbc3fbw5pwyq32iyu">fatcat:fadrupz4lvbc3fbw5pwyq32iyu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190220215355/http://pdfs.semanticscholar.org/29d9/ff0a58b260a29e960f35cfc2534ed5537cba.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/29/d9/29d9ff0a58b260a29e960f35cfc2534ed5537cba.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/jcm7110422"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262613" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Classroom-Based Physical Activity Breaks and Children's Attention: Cognitive Engagement Works!

Mirko Schmidt, Valentin Benzing, Mario Kamer
<span title="2016-10-04">2016</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5r5ojcju2repjbmmjeu5oyawti" style="color: black;">Frontiers in Psychology</a> </i> &nbsp;
., 2015) , 45 min (Schmidt et al., 2015a) or 50 min (Gallotta et al., 2012 (Gallotta et al., , 2015 .  ...  Recent studies have attempted to measure CE using either newly developed observational data (Schmidt et al., 2015b) , psychophysiological measures or subjective ratings of perceived CE (Benzing et al.  ...  Copyright © 2016 Schmidt, Benzing and Kamer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fpsyg.2016.01474">doi:10.3389/fpsyg.2016.01474</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27757088">pmid:27757088</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5047899/">pmcid:PMC5047899</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bgend6ry35gqffr6f5dzlafima">fatcat:bgend6ry35gqffr6f5dzlafima</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190323011807/https://core.ac.uk/download/pdf/79439451.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/70/c7/70c799bde91a6a92520fe247a1aca8062bd3d435.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fpsyg.2016.01474"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047899" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Targeting Immune Modulators in Glioma While Avoiding Autoimmune Conditions

Lynn Bitar, Ulrike Schumann, Renate König, Frauke Zipp, Mirko H. H. Schmidt
<span title="2021-07-14">2021</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2zwku6u6nfdcri773tpisi6ldi" style="color: black;">Cancers</a> </i> &nbsp;
Communication signals and signaling pathways are often studied in different physiological systems. However, it has become abundantly clear that the immune system is not self-regulated, but functions in close association with the nervous system. The neural–immune interface is complex; its balance determines cancer progression, as well as autoimmune disorders. Immunotherapy remains a promising approach in the context of glioblastoma multiforme (GBM). The primary obstacle to finding effective
more &raquo; ... pies is the potent immunosuppression induced by GBM. Anti-inflammatory cytokines, induction of regulatory T cells, and the expression of immune checkpoint molecules are the key mediators for immunosuppression in the tumor microenvironment. Immune checkpoint molecules are ligand–receptor pairs that exert inhibitory or stimulatory effects on immune responses. In the past decade, they have been extensively studied in preclinical and clinical trials in diseases such as cancer or autoimmune diseases in which the immune system has failed to maintain homeostasis. In this review, we will discuss promising immune-modulatory targets that are in the focus of current clinical research in glioblastoma, but are also in the precarious position of potentially becoming starting points for the development of autoimmune diseases like multiple sclerosis.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cancers13143524">doi:10.3390/cancers13143524</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/473op42dczb3xfatrbnfhjqsda">fatcat:473op42dczb3xfatrbnfhjqsda</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210716060441/https://res.mdpi.com/d_attachment/cancers/cancers-13-03524/article_deploy/cancers-13-03524.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/85/6b/856bdf46a64cfa755c9e6c57b7652f93819ab3e1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/cancers13143524"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a>
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