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Impact of common sample pre-treatments on key soil microbial properties

Julia Schroeder, Lisa Kammann, Mirjam Helfrich, Christoph C. Tebbe, Christopher Poeplau
2021 Soil Biology and Biochemistry  
Pre-treatment of soil samples prior to analysis is acknowledged to affect microbial activity and community parameters, but recommendations are diverging and there are no best-practice or standardised laboratory protocols. For the microbial carbon use efficiency (CUE) as a ratio parameter of C allocated to anabolism over total metabolised C, the effects of sample pre-treatment are unpredictable because the underlying parameters of microbial metabolism may be affected differently. In treatment or
more » ... land use comparisons, it is important to know whether soils are affected in a similar way by pre-treatment. Based on five different paired sites (each with cropland and forest), the effects of six common pre-treatments were evaluated on 18 O-CUE and associated parameters, i.e. respiration rate, soil microbial biomass C, total DNA extracted, and estimated abundances of fungi, bacteria and archaea. The six common pre-treatments were: (i) immediate analysis of field-fresh soil samples, and analysis following 14 d pre-incubation of soil samples that were (ii) field-fresh, (iii) air-dried, (iv) oven-dried (40 • C), (v) frozen at − 20 • C and (vi) frozen in-situ (dry ice and subsequently liquid N 2 ). The experiment revealed two main findings. The first was that pre-incubation of 14 d had the most pronounced effect and reduced microbial respiration rate, growth rate and microbial biomass C by between 28% and 63% on average compared with field-fresh samples, suggesting an impact of the reduction in readily available substrates on microbial activity. The second finding was that even after 14 days of pre-incubation, drying & rewetting caused an increase in the microbial respiration rate in forest soil samples of 64 ± 53% (air-drying) and 86 ± 65% (oven-drying), known as the Birch effect. However, CUE as a ratio parameter was found to be unaffected by sample pre-treatment, with only minor changes after 14 d of pre-incubation. Pre-treatment (including pre-incubation) affected cropland and forest samples similarly, with one exception: the estimated abundance of fungi increased only with drying & rewetting in forest soils. This suggests that dried cropland soils could potentially yield appropriate community data, while forest soils respond to soil drying in a more complex way. It was concluded that CUE values can be derived from soil samples regardless of whether they were dried & rewetted, frozen & thawed, or stored fresh.
doi:10.1016/j.soilbio.2021.108321 fatcat:ujrfzipti5bptdvucqyaqgpu5u

Coagulation Factor XIII in Cerebral Venous Thrombosis

Bojun Li, Mirjam R. Heldner, Marcel Arnold, Jonathan M. Coutinho, Susanna M. Zuurbier, Joost C. M. Meijers, Hans P. Kohler, Verena Schroeder
2019 TH Open  
doi:10.1055/s-0039-1693487 pmid:31338488 pmcid:PMC6645911 fatcat:3oaiwh5xavf7nn5lah56yusjiq

Fragment-based identification of multi-target ligands by self-organizing map alignment

Janosch Achenbach, Franca-Maria Klingler, Steffen Hahn, Svenja Steinbrink, Mirjam Schroeder, Frank Loehr, Volker Doetsch, Dieter Steinhilber, Ewgenij Proschak
2012 Journal of Cheminformatics  
doi:10.1186/1758-2946-4-s1-p57 pmcid:PMC3341322 fatcat:sy4w5vt3bzhdnhiv7mynsljjvm

Self-reported neck pain is associated with migraine but not with tension-type headache in adolescents

Astrid Blaschek, Siona Decke, Lucia Albers, Andreas Sebastian Schroeder, Steffi Lehmann, Andreas Straube, Mirjam N Landgraf, Florian Heinen, Rüdiger von Kries
2014 Cephalalgia  
Aim: The aim of the present analysis is to confirm or refute the association of neck pain to migraine or tension-type headache and to assess whether this association is independent of other risk factors for headache. Methods: Secondary school students were invited to complete a questionnaire on headache and lifestyle factors in a cross-sectional study. Neck pain was assessed via (a) a screening question concerning neck pain and (b) denoting affected areas in schematic drawings of the human
more » ... Results: Absolute increment in prevalence of headache with pain in the shoulder-neck region was between 7.5% and 9.6%. Gender, grade, stress and lifestyle factors were assessed as potential confounding factors. Nearly all factors were associated with shoulder-neck pain and most with headache. After adjustment for confounders, the association of neck pain with headache was almost completely confined to migraine (OR 2.39; 95% CI 1.48-3.85) and migraine þ tension-type headache (OR 2.12; 95% CI 1.50-2.99), whereas the association with isolated tension-type headache was negligible (OR 1.22, 95% CI 0.87-1.69). Conclusion: Neck pain is associated with migraine but not with tension-type headache. A possible link between migraine and neck pain may be the cervico-trigeminal convergence of neck and meningeal sensory afferents or a disturbed descending inhibition in migraine.
doi:10.1177/0333102414523338 pmid:24554618 fatcat:m236yjr5irg75dzw5btycxvkry

Childhood Stroke: Awareness, Interest, and Knowledge Among the Pediatric Community

Michaela V. Bonfert, Katharina Badura, Julia Gerstl, Ingo Borggraefe, Florian Heinen, Sebastian Schroeder, Martin Olivieri, Raphael Weinberger, Mirjam N. Landgraf, Katharina Vill, Moritz Tacke, Steffen Berweck (+4 others)
2018 Frontiers in Pediatrics  
Objective: Acute childhood stroke is an emergency requiring a high level of awareness among first-line healthcare providers. This survey serves as an indicator of the awareness of, the interest in, and knowledge of childhood stroke of German pediatricians. Methods: Thousand six hundred and ninety-seven physicians of pediatric in-and outpatient facilities in Bavaria, Germany, were invited via email to an online-survey about childhood stroke. Results: The overall participation rate was 14%.
more » ... six percent of participants considered a diagnosis of childhood stroke at least once during the past year, and 47% provide care for patients who have suffered childhood stroke. The acronym FAST (Face-Arm-Speech-Time-Test) was correctly cited in 27% of the questionnaires. Most commonly quoted symptoms of childhood stroke were hemiparesis (90%), speech disorder (58%), seizure (44%), headache (40%), and impaired consciousness (33%). Migraine (63%), seizure (39%), and infections of the brain (31%) were most frequently named as stroke mimics. Main diagnostic measures indicated were magnetic resonance imaging (MRI) (96%) and computer tomography (CT) (55%). Main therapeutic strategies were thrombolysis (80%), anticoagulation (41%), neuroprotective measures, and thrombectomies (15% each). Thirty-nine percent of participants had taken part in training sessions, 61% studied literature, 37% discussed with colleagues, and 25% performed internet research on childhood stroke. Ninety-three percent of participants approve skill enhancement, favoring training sessions (80%), publications (43%), and web based offers (35%). Consent for offering a flyer on the topic to caregivers in facilities was given in 49%. Conclusion: Childhood stroke constitutes a topic of clinical importance to pediatricians. Participants demonstrate a considerable level of comprehension concerning the subject, but room for improvement remains. A multi-modal approach encompassing an elaborate Bonfert et al. Awareness of Childhood Stroke training program, regular educational publications in professional journals, and web based offers could reach a broad range of health care providers. Paired with a public adult and childhood stroke awareness campaign, these efforts could contribute to optimize the care for children suffering from stroke.
doi:10.3389/fped.2018.00182 pmid:29988546 pmcid:PMC6026646 fatcat:uld3eupbnvcmlkw6bqdmztbjom

Prognostic value of procalcitonin in respiratory tract infections across clinical settings

Alexander Kutz, Matthias Briel, Mirjam Christ-Crain, Daiana Stolz, Lila Bouadma, Michel Wolff, Kristina B Kristoffersen, Long Wei, Olaf Burkhardt, Tobias Welte, Stefan Schroeder, Vandack Nobre (+8 others)
2015 Critical Care  
Whether the inflammatory biomarker procalcitonin provides prognostic information across clinical settings and different acute respiratory tract infections (ARIs) is poorly understood. In the present study, we investigated the prognostic value of admission procalcitonin levels to predict adverse clinical outcome in a large ARI population. Methods: We analysed data from 14 trials and 4,211 ARI patients to study associations of admission procalcitonin levels and setting specific treatment failure
more » ... nd mortality alone at 30 days. We used multivariable hierarchical logistic regression and conducted sensitivity analyses stratified by clinical settings and ARI diagnoses to assess the results' consistency. Results: Overall, 864 patients (20.5%) experienced treatment failure and 252 (6.0%) died. The ability of procalcitonin to differentiate patients with from those without treatment failure was highest in the emergency department setting (treatment failure area under the curve (AUC): 0.64 (95% confidence interval (CI): 0.61, 0.67), adjusted odds ratio (OR): 1.85 (95% CI: 1.61, 2.12), P <0.001; and mortality AUC: 0.67 (95% CI: 0.63, 0.71), adjusted OR: 1.82 (95% CI: 1.45, 2.29), P <0.001). In lower respiratory tract infections, procalcitonin was a good predictor of identifying patients at risk for mortality (AUC: 0.71 (95% CI: 0.68, 0.74), adjusted OR: 2.13 (95% CI: 1.82, 2.49), P <0.001). In primary care and intensive care unit patients, no significant association of initial procalcitonin levels and outcome was found. Conclusions: Admission procalcitonin levels are associated with setting specific treatment failure and provide the most prognostic information regarding ARI in the emergency department setting.
doi:10.1186/s13054-015-0792-1 pmid:25887979 pmcid:PMC4383063 fatcat:ykfhzirf5vedxmg67fl577caam

Dispersal of suspended sediments and nutrients in the Great Barrier Reef lagoon during river-discharge events: conclusions from satellite remote sensing and concurrent flood-plume sampling

Jon Brodie, Thomas Schroeder, Ken Rohde, John Faithful, Bronwyn Masters, Arnold Dekker, Vittorio Brando, Mirjam Maughan
2010 Marine and Freshwater Research  
Intense wet-season rainfall in January 2005 caused rivers in the Mackay-Whitsunday region of Queensland, Australia, to produce large discharges to the Great Barrier Reef (GBR) lagoon. The regional land use is dominated by sugarcane cultivation, beef grazing and urban uses. The high nutrient (nitrogen and phosphorus) fluxes from these land uses via river runoff produced a massive phytoplankton bloom in the GBR lagoon, which, after 9 days, had spread 150 km offshore. The plume and algal bloom
more » ... ounded inner-shelf reefs of the GBR such as Brampton Island Reef and its spread was tracked with a variety of satellite sensors including MODIS, SeaWiFS and Landsat over the 9-day period. The ability to be able to access imagery from a large number of satellite sensors allowed almost daily estimates of the extent of plume to be made, despite periods of cloud. Analysis of water samples from the plume revealed elevated (2-50 times higher) concentrations of Chlorophyll a (and hence phytoplankton biomass), up to 50 times higher than in non-flood conditions, nutrients (2-100 times higher) and herbicide residues (10-100 times higher) compared with GBR lagoon waters in nondischarge conditions. The concentration data from the samples and estimated exposure periods from the satellite images allowed estimates of the exposure of GBR marine ecosystems (coral reefs, the pelagic community, seagrass beds and mangrove forests) to the terrestrial contaminants to be made.
doi:10.1071/mf08030 fatcat:vemrqw2b5zd5lbm7j2v7z5473y

Quantitative magnetic resonance imaging of the upper trapezius muscles – assessment of myofascial trigger points in patients with migraine

Nico Sollmann, Nina Mathonia, Dominik Weidlich, Michaela Bonfert, Sebastian A. Schroeder, Katharina A. Badura, Tabea Renner, Florian Trepte-Freisleder, Carl Ganter, Sandro M. Krieg, Claus Zimmer, Ernst J. Rummeny (+4 others)
2019 The Journal of Headache and Pain  
Research in migraine points towards central-peripheral complexity with a widespread pattern of structures involved. Migraine-associated neck and shoulder muscle pain has clinically been conceptualized as myofascial trigger points (mTrPs). However, concepts remain controversial, and the identification of mTrPs is mostly restricted to manual palpation in clinical routine. This study investigates a more objective, quantitative assessment of mTrPs by means of magnetic resonance imaging (MRI) with
more » ... mapping. Ten subjects (nine females, 25.6 ± 5.2 years) with a diagnosis of migraine according to ICHD-3 underwent bilateral manual palpation of the upper trapezius muscles to localize mTrPs. Capsules were attached to the skin adjacent to the palpated mTrPs for marking. MRI of the neck and shoulder region was performed at 3 T, including a T2-prepared, three-dimensional (3D) turbo spin echo (TSE) sequence. The T2-prepared 3D TSE sequence was used to generate T2 maps, followed by manual placement of regions of interest (ROIs) covering the trapezius muscles of both sides and signal alterations attributable to mTrPs. The trapezius muscles showed an average T2 value of 27.7 ± 1.4 ms for the right and an average T2 value of 28.7 ± 1.0 ms for the left side (p = 0.1055). Concerning signal alterations in T2 maps attributed to mTrPs, nine values were obtained for the right (32.3 ± 2.5 ms) and left side (33.0 ± 1.5 ms), respectively (p = 0.0781). When comparing the T2 values of the trapezius muscles to the T2 values extracted from the signal alterations attributed to the mTrPs of the ipsilateral side, we observed a statistically significant difference (p = 0.0039). T2 hyperintensities according to visual image inspection were only reported in four subjects for the right and in two subjects for the left side. Our approach enables the identification of mTrPs and their quantification in terms of T2 mapping even in the absence of qualitative signal alterations. Thus, it (1) might potentially challenge the current gold-standard method of physical examination of mTrPs, (2) could allow for more targeted and objectively verifiable interventions, and (3) could add valuable models to understand better central-peripheral mechanisms in migraine.
doi:10.1186/s10194-019-0960-9 pmid:30658563 pmcid:PMC6734472 fatcat:hm5sijex5vbdtpe743b3grim54

Procalcitonin to Guide Initiation and Duration of Antibiotic Treatment in Acute Respiratory Infections: An Individual Patient Data Meta-Analysis

Philipp Schuetz, Matthias Briel, Mirjam Christ-Crain, Daiana Stolz, Lila Bouadma, Michel Wolff, Charles-Edouard Luyt, Jean Chastre, Florence Tubach, Kristina B. Kristoffersen, Long Wei, Olaf Burkhardt (+7 others)
2012 Clinical Infectious Diseases  
Long (2011) [15] No (odd and even patient ID numbers) No 156/156 (100%) Not reported Nobre (2008) [18] Yes (sequentially numbered, opaque, sealed envelopes) No 52/52 (100%) 81% adherence Schroeder  ...  Nobre (2008) [18] Switzerland ICU, single center Suspected severe sepsis or septic shock Duration; R against AB: <0.5 (<0.25) or >80% drop; R for AB: >0.5 (>1.0) 52 (79) f AB use 1 mo Schroeder  ... 
doi:10.1093/cid/cis464 pmid:22573847 pmcid:PMC3412690 fatcat:av4lhla74zfedaoxvokgxyewzy

Economic evaluation of procalcitonin-guided antibiotic therapy in acute respiratory infections: a US health system perspective

Philipp Schuetz, Robert Balk, Matthias Briel, Alexander Kutz, Mirjam Christ-Crain, Daiana Stolz, Lila Bouadma, Michel Wolff, Kristina B. Kristoffersen, Long Wei, Olaf Burkhardt, Tobias Welte (+13 others)
2015 Clinical Chemistry and Laboratory Medicine  
AbstractWhether or not antibiotic stewardship protocols based on procalcitonin levels results in cost savings remains unclear. Herein, our objective was to assess the economic impact of adopting procalcitonin testing among patients with suspected acute respiratory tract infection (ARI) from the perspective of a typical US integrated delivery network (IDN) with a 1,000,000 member catchment area or enrollment.To conduct an economic evaluation of procalcitonin testing versus usual care we built a
more » ... ost-impact model based on patient-level meta-analysis data of randomized trials. The meta-analytic data was adapted to the US setting by applying the meta-analytic results to US lengths of stay, costs, and practice patterns. We estimated the annual ARI visit rate for the one million member cohort, by setting (inpatient, ICU, outpatient) and ARI diagnosis.In the inpatient setting, the costs of procalcitonin-guided compared to usual care for the one million member cohort was $2,083,545, compared to $2,780,322, resulting in net savings of nearly $700,000 to the IDN for 2014. In the ICU and outpatient settings, savings were $73,326 and $5,329,824, respectively, summing up to overall net savings of $6,099,927 for the cohort. Results were robust for all ARI diagnoses. For the whole US insured population, procalcitonin-guided care would result in $1.6 billion in savings annually.Our results show substantial savings associated with procalcitonin protocols of ARI across common US treatment settings mainly by direct reduction in unnecessary antibiotic utilization. These results are robust to changes in key parameters, and the savings can be achieved without any negative impact on treatment outcomes.
doi:10.1515/cclm-2014-1015 pmid:25581762 fatcat:ivutlwbpbrez5eagk2rddeuwy4

Frequency of Thrombocytopenia and Platelet Factor 4/Heparin Antibodies in Patients With Cerebral Venous Sinus Thrombosis Prior to the COVID-19 Pandemic

Mayte Sánchez van Kammen, Mirjam R. Heldner, Justine Brodard, Adrian Scutelnic, Suzanne Silvis, Verena Schroeder, Johanna A. Kremer Hovinga, Saskia Middeldorp, Marcel Levi, Sini Hiltunen, Erik Lindgren, Maryam Mansour (+12 others)
2021 Journal of the American Medical Association (JAMA)  
Cases of cerebral venous sinus thrombosis in combination with thrombocytopenia have recently been reported within 4 to 28 days of vaccination with the ChAdOx1 nCov-19 (AstraZeneca/Oxford) and Ad.26.COV2.S (Janssen/Johnson & Johnson) COVID-19 vaccines. An immune-mediated response associated with platelet factor 4/heparin antibodies has been proposed as the underlying pathomechanism.
doi:10.1001/jama.2021.9889 pmid:34213527 pmcid:PMC8317004 fatcat:4nzed57hrjh3fl2o6m63dy45w4

Duration of antibiotic treatment using procalcitonin-guided treatment algorithms in older patients: a patient-level meta-analysis from randomized controlled trials

Eva Heilmann, Claudia Gregoriano, Djillali Annane, Konrad Reinhart, Lila Bouadma, Michel Wolff, Jean Chastre, Charles-Edouard Luyt, Florence Tubach, Angela R Branche, Matthias Briel, Mirjam Christ-Crain (+26 others)
2021 Age and Ageing  
Background Older patients have a less pronounced immune response to infection, which may also influence infection biomarkers. There is currently insufficient data regarding clinical effects of procalcitonin (PCT) to guide antibiotic treatment in older patients. Objective and design We performed an individual patient data meta-analysis to investigate the association of age on effects of PCT-guided antibiotic stewardship regarding antibiotic use and outcome. Subjects and methods We had access to
more » ... ,421 individual infection patients from 28 randomized controlled trials comparing PCT-guided antibiotic therapy (intervention group) or standard care. We stratified patients according to age in four groups (&lt;75 years [n = 7,079], 75–80 years [n = 1,034], 81–85 years [n = 803] and &gt;85 years [n = 505]). The primary endpoint was the duration of antibiotic treatment and the secondary endpoints were 30-day mortality and length of stay. Results Compared to control patients, mean duration of antibiotic therapy in PCT-guided patients was significantly reduced by 24, 22, 26 and 24% in the four age groups corresponding to adjusted differences in antibiotic days of −1.99 (95% confidence interval [CI] −2.36 to −1.62), −1.98 (95% CI −2.94 to −1.02), −2.20 (95% CI −3.15 to −1.25) and − 2.10 (95% CI −3.29 to −0.91) with no differences among age groups. There was no increase in the risk for mortality in any of the age groups. Effects were similar in subgroups by infection type, blood culture result and clinical setting (P interaction &gt;0.05). Conclusions This large individual patient data meta-analysis confirms that, similar to younger patients, PCT-guided antibiotic treatment in older patients is associated with significantly reduced antibiotic exposures and no increase in mortality.
doi:10.1093/ageing/afab078 pmid:33993243 pmcid:PMC8437072 fatcat:rcojjmdu2rbbzasmjuhlxuqvoa

Titelei/Inhaltsverzeichnis [chapter]

Götz Schulze
2016 Aktuelle Rechtsfragen im Profifußball  
TrunzDer Spielertransfer in der EU -20 Jahre nach dem Bosman-UrteilWerner SchroederDiskussionsbericht zum Vortrag von Werner Schroeder "Ablösesummen und Spielertransfer nach Bosman"Gabriella PirasDer  ...  von Christoph Schulte-Kaubrügger, "Insolvenz in der laufenden Saison und ihre Auswirkungen auf den Spielbetrieb" Das Erstellen und Weitergeben von Kopien dieses PDFs ist nicht zulässig.Ulrich Haas / Mirjam  ... 
doi:10.5771/9783845264257-1 fatcat:g75ktydvybgl3iuvkgzyhvf7ie

Page 5496 of Psychological Abstracts Vol. 79, Issue 12 [page]

1992 Psychological Abstracts  
, Karen A., 2857 Schroeder, Marsha L., “an * ames Schruijer, Sandra G.  ...  ., Schmader, Kenneth, 43687 Schmaltz, Stephen, 41511 Schmid, Hillel, 45068 Schmida, Mirjam, 44874 Schmidt, —* 43661 Schmidt, Frank L., 44586 Schmidt, John J., 44754 Schmidt, Kirsten W., 42873 Schmidt,  ... 

Page 517 of Psychological Abstracts Vol. 59, Issue 2 [page]

1978 Psychological Abstracts  
., 2829 Schroeder, James E., 2585, 2666 Schroeder, Mirjam, 3796 Schubert, Daniel S., 3460, 3461 Schubring, G., 3035 Schucman, Helen, 3714 Schufer de Paikin, Marta L., 2424 Schuld, Donald, 3712 Schulman  ...  ., 3139 Schroeder, D.  ... 
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