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A Tunable Microfluidic Device for Drug Delivery [chapter]

Tayloria Adams, Chungja Yang, John Gress, Nick Wimmer, Adrienne R.
2012 Advances in Microfluidics  
The microneedles are nontoxic, minimally invasive, can be mass-produced for a range of materials such as silicon dioxide and polymers, are easily disposable/interchangeable, and can be made from biodegradable  ...  advantages over other non-invasive drug delivery techniques.  ... 
doi:10.5772/37355 fatcat:l656jyakrjgunb5lrhisazcbke

Flexible Robotic Scanning Device for Intraoperative Endomicroscopy in MIS

Siyang Zuo, Michael Hughes, Guang-Zhong Yang
2017 IEEE/ASME transactions on mechatronics  
Optical biopsy methods such as probe-based confocal endomicroscopy can provide intraoperative real-time assessment of tumour margins, including during minimally invasive surgery with flexible endoscopes  ...  Mosaics can be produced by translating the probe across the target, but it remains difficult to scan over a large field-of-view with a flexible endomicroscope.  ...  INTRODUCTION ith the development of minimally invasive approaches to surgery, such as single port surgery [1] [2] and natural orifice transluminal endoscopic surgery (NOTES) [3] [4] [5] , flexible endoscopes  ... 
doi:10.1109/tmech.2017.2700008 fatcat:vpmqmwx6tzd7nbpyqh4l5n3m7y

An Integrated Field-Effect Microdevice for Monitoring Membrane Transport in Xenopus laevis Oocytes via Lateral Proton Diffusion

Daniel Felix Schaffhauser, Monica Patti, Tatsuro Goda, Yuji Miyahara, Ian Cameron Forster, Petra Stephanie Dittrich, Steven Barnes
2012 PLoS ONE  
By establishing a stable contact between the oocyte vitelline membrane and an ion-sensitive field-effect (ISFET) sensor inside a microperfusion channel, changes in surface pH that are hypothesized to result  ...  The proposed sensor mechanism was verified by heterologously expressing membrane transport proteins and recording changes in surface pH during application of the specific substrates.  ...  It integrated 6 liquid inlet channels and 1 outlet channel as well as the immobilization orifice.  ... 
doi:10.1371/journal.pone.0039238 pmid:22792166 pmcid:PMC3390327 fatcat:se2htdxkanaofbodlacq2aspvu

Soft Robot-Assisted Minimally Invasive Surgery and Interventions: Advances and Outlook

Ka-Wai Kwok, Helge Wurdemann, Alberto Arezzo, Arianna Menciassi, Kaspar Althoefer
2022 Proceedings of the IEEE  
Effective local treatment, alongside screening programs, would, therefore, significantly reduce the need for more invasive treatment, be that extensive surgical resection, or minimally invasive techniques  ...  Most importantly, by virtue of their soft nature, they are considered inherently safe for use in minimally invasive surgery (MIS).  ... 
doi:10.1109/jproc.2022.3167931 fatcat:mjxwkfoqa5g4lbwfxrpv4apwdu

Ultracompact 3D microfluidics for time-resolved structural biology

Juraj Knoška, Luigi Adriano, Salah Awel, Kenneth R. Beyerlein, Oleksandr Yefanov, Dominik Oberthuer, Gisel E. Peña Murillo, Nils Roth, Iosifina Sarrou, Pablo Villanueva-Perez, Max O. Wiedorn, Fabian Wilde (+3 others)
2020 Nature Communications  
Such devices can be printed in minutes by locally adjusting print resolution during fabrication.  ...  By integrating an additional orifice, we implement a low consumption flow-focusing nozzle, which is validated by solving a hemoglobin structure.  ...  Operating minimally invasive ultrahigh-throughput single-cell genomic, transcriptomic, and proteomic analysis and sorting workflows 67, 68 in vivo will therefore become feasible.  ... 
doi:10.1038/s41467-020-14434-6 pmid:32005876 pmcid:PMC6994545 fatcat:dkepcvl66bgwphnbct2pkctjlu

Analytical and Quantitative in Vivo Monitoring of Brain Neurochemistry by Electrochemical and Imaging Approaches

Fei Wu, Ping Yu, Lanqun Mao
2018 ACS Omega  
On one hand, in vivo electroanalysis combined with miniature electrodes has evolved into a minimally invasive method for probing transient events during neural communication and metabolism.  ...  Finally, the self-driven nature will aid GRP development in many ways. The most appealing benefit is the improved compatibility with minimally invasive and longitude brain monitoring. 2.4.  ...  To achieve this goal, minimally invasive or noninvasive methods applied to unrestricted living entities have emerged in two major intriguing trends: in vivo electroanalysis and imaging.  ... 
doi:10.1021/acsomega.8b02055 pmid:30411032 pmcid:PMC6217607 fatcat:mysbqvjssvernptihf3bc6p2fe

Microsensors for Microreaction and Lab-on-a-Chip Applications [chapter]

Pawel Knapkiewicz, Rafal Walczak
2011 Microsensors  
by the detection channel.  ...  The narrow wavelength range is ensured by one or more interference filters and a dichroic mirror.  ...  Several interesting applications area are also discusses in the book like MEMS gyroscopes for consumer and industrial applications, microsensors for non invasive imaging in experimental biology, a heat  ... 
doi:10.5772/16388 fatcat:kmdrd6avvrhtrj4hmljgug5aee

Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications

Luis Abelardo Villarruel Mendoza, Natalia Antonela Scilletta, Martin Gonzalo Bellino, Martin Federico Desimone, Paolo Nicolas Catalano
2020 Frontiers in Bioengineering and Biotechnology  
controlled release of drugs has posed numerous challenges with the aim of optimizing parameters such as the release of the suitable quantity of drugs in the right site at the right time with the least invasiveness  ...  Some of the factors that challenge conventional drug release include long-term treatments, narrow therapeutic windows, complex dosing schedules, combined therapies, individual dosing regimens, and labile  ...  The proposed device herein sought to improve these aspects by offering a promising and minimally invasive strategy for ondemand and pulsatile drug delivery, based on light activation.  ... 
doi:10.3389/fbioe.2020.00827 pmid:32850709 pmcid:PMC7405504 fatcat:pkdxck6q25e3pdeeolk37z6rpy

Advances in High-Resolution Microscale Impedance Sensors

Marco Carminati
2017 Journal of Sensors  
Today, the downscaling of the size of sensing elements to micrometric and submicrometric dimensions is enabled by the diffusion of lithographic processes and fostered by the convergence of complementary  ...  Acknowledgments The research activities, here reviewed, to which the author had the opportunity to contribute were led by M. Sampietro and G.  ...  The series of the two impedances is driven by a differential signal.  ... 
doi:10.1155/2017/7638389 fatcat:l4ltfpipljcxjlyxxseuwd3fui

Electronic MEMS for triggered delivery

A Richards Grayson
2004 Advanced Drug Delivery Reviews  
Implantable electronic devices such as pacemakers and neural implants are often used for electrical stimulation.  ...  invasiveness and tissue disruption.  ...  Drug-coated stents Stents are one method by which the size of arteries can be increased in patients with heart disease and narrowing of the arteries.  ... 
doi:10.1016/j.addr.2003.07.012 pmid:14741114 fatcat:mlexri6ufvflxmg4v2ansleyfy

Human Brain/Cloud Interface

Nuno R. B. Martins, Amara Angelica, Krishnan Chakravarthy, Yuriy Svidinenko, Frank J. Boehm, Ioan Opris, Mikhail A. Lebedev, Melanie Swan, Steven A. Garan, Jeffrey V. Rosenfeld, Tad Hogg, Robert A. Freitas
2019 Frontiers in Neuroscience  
The Internet comprises a decentralized global system that serves humanity's collective effort to generate, process, and store data, most of which is handled by the rapidly expanding cloud.  ...  Through TS, individuals might experience episodic segments of the lives of other willing participants (locally or remote) to, hopefully, encourage and inspire improved understanding and tolerance among  ...  Or in some cases, they may be minimally invasive.  ... 
doi:10.3389/fnins.2019.00112 pmid:30983948 pmcid:PMC6450227 fatcat:z3k6sqwu4vhkvkleeq5ej7zquq

Droplet-based microfluidics in drug discovery, transcriptomics and high-throughput molecular genetics

Nachiket Shembekar, Chawaree Chaipan, Ramesh Utharala, Christoph A. Merten
2016 Lab on a Chip  
Upon application of the electric field, the interphases merge and the pressurized dark liquid is injected through a narrow orifice into the incoming droplets.  ...  This process can be achieved either by active (on-demand droplet production using valves or electric fields) or by passive (continuous droplet production using pressure-driven flow and a special geometry  ... 
doi:10.1039/c6lc00249h pmid:27025767 fatcat:6n2feja5dngtjfx262ipavsliq

Progress of Microfluidic Continuous Separation Techniques for Micro-/Nanoscale Bioparticles

Se-woon Choe, Bumjoo Kim, Minseok Kim
2021 Biosensors  
However, most of the conventional particle separation techniques are based on membrane filtration techniques, whose efficiency is limited by membrane characteristics, such as pore size, porosity, surface  ...  In this paper, we present a comprehensive review of the recent advances in microfluidic separation of micro-/nano-sized bioparticles by summarizing the physical principles behind the separation system  ...  Most microfluidic separation devices using a DC electric field try to minimize mobilities by bulk flow, making summation of µ EOF and µ PDF negligible by balancing hydraulic heads and minimizing surface  ... 
doi:10.3390/bios11110464 pmid:34821680 pmcid:PMC8615634 fatcat:lgnndfcwtzcgfb5bkj6amum6su

Steam-powered sensing

Chengjie Zhang, Affan Syed, Young Cho, John Heidemann
2011 Proceedings of the 9th ACM Conference on Embedded Networked Sensor Systems - SenSys '11  
Second, we show that non-invasive sensing can reduce the cost of sensing by avoiding sensors that pierce the pipeline and have high installation cost with interruption to production.  ...  First, we eliminate the high cost of bringing power to the field by generating electricity from heat, exploiting the high temperature of the very pipelines we monitor.  ...  Each of our sensor packages is powered by a custom-built thermo-electric generator (TEG) described in §3.  ... 
doi:10.1145/2070942.2070964 dblp:conf/sensys/ZhangSCH11 fatcat:ro6eik2skbah3kjc57sdaoad5i

Tactile Sensing for Minimally Invasive Surgery: Conventional Methods and Potential Emerging Tactile Technologies

Wael Othman, Zhi-Han A. Lai, Carlos Abril, Juan S. Barajas-Gamboa, Ricard Corcelles, Matthew Kroh, Mohammad A. Qasaimeh
2022 Frontiers in Robotics and AI  
As opposed to open surgery procedures, minimally invasive surgery (MIS) utilizes small skin incisions to insert a camera and surgical instruments.  ...  Optical-based tactile sensing is another conventional approach that facilitates electrically passive force sensing compatible with magnetic resonance imaging.  ...  MINIMALLY INVASIVE SURGERY "Surgeons applaud large incisions and denigrate "keyhole surgery."  ... 
doi:10.3389/frobt.2021.705662 pmid:35071332 pmcid:PMC8777132 fatcat:ngl76gcwkzarpg2j7oawpctzti
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