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A Tunable Microfluidic Device for Drug Delivery
[chapter]
2012
Advances in Microfluidics
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The microneedles are nontoxic, minimally invasive, can be mass-produced for a range of materials such as silicon dioxide and polymers, are easily disposable/interchangeable, and can be made from biodegradable ...
advantages over other non-invasive drug delivery techniques. ...
doi:10.5772/37355
fatcat:l656jyakrjgunb5lrhisazcbke
Flexible Robotic Scanning Device for Intraoperative Endomicroscopy in MIS
2017
IEEE/ASME transactions on mechatronics
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Optical biopsy methods such as probe-based confocal endomicroscopy can provide intraoperative real-time assessment of tumour margins, including during minimally invasive surgery with flexible endoscopes ...
Mosaics can be produced by translating the probe across the target, but it remains difficult to scan over a large field-of-view with a flexible endomicroscope. ...
INTRODUCTION ith the development of minimally invasive approaches to surgery, such as single port surgery [1] [2] and natural orifice transluminal endoscopic surgery (NOTES) [3] [4] [5] , flexible endoscopes ...
doi:10.1109/tmech.2017.2700008
fatcat:vpmqmwx6tzd7nbpyqh4l5n3m7y
An Integrated Field-Effect Microdevice for Monitoring Membrane Transport in Xenopus laevis Oocytes via Lateral Proton Diffusion
2012
PLoS ONE
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By establishing a stable contact between the oocyte vitelline membrane and an ion-sensitive field-effect (ISFET) sensor inside a microperfusion channel, changes in surface pH that are hypothesized to result ...
The proposed sensor mechanism was verified by heterologously expressing membrane transport proteins and recording changes in surface pH during application of the specific substrates. ...
It integrated 6 liquid inlet channels and 1 outlet channel as well as the immobilization orifice. ...
doi:10.1371/journal.pone.0039238
pmid:22792166
pmcid:PMC3390327
fatcat:se2htdxkanaofbodlacq2aspvu
Soft Robot-Assisted Minimally Invasive Surgery and Interventions: Advances and Outlook
2022
Proceedings of the IEEE
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Effective local treatment, alongside screening programs, would, therefore, significantly reduce the need for more invasive treatment, be that extensive surgical resection, or minimally invasive techniques ...
Most importantly, by virtue of their soft nature, they are considered inherently safe for use in minimally invasive surgery (MIS). ...
doi:10.1109/jproc.2022.3167931
fatcat:mjxwkfoqa5g4lbwfxrpv4apwdu
Ultracompact 3D microfluidics for time-resolved structural biology
2020
Nature Communications
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Such devices can be printed in minutes by locally adjusting print resolution during fabrication. ...
By integrating an additional orifice, we implement a low consumption flow-focusing nozzle, which is validated by solving a hemoglobin structure. ...
Operating minimally invasive ultrahigh-throughput single-cell genomic, transcriptomic, and proteomic analysis and sorting workflows 67, 68 in vivo will therefore become feasible. ...
doi:10.1038/s41467-020-14434-6
pmid:32005876
pmcid:PMC6994545
fatcat:dkepcvl66bgwphnbct2pkctjlu
Analytical and Quantitative in Vivo Monitoring of Brain Neurochemistry by Electrochemical and Imaging Approaches
2018
ACS Omega
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On one hand, in vivo electroanalysis combined with miniature electrodes has evolved into a minimally invasive method for probing transient events during neural communication and metabolism. ...
Finally, the self-driven nature will aid GRP development in many ways. The most appealing benefit is the improved compatibility with minimally invasive and longitude brain monitoring. 2.4. ...
To achieve this goal, minimally invasive or noninvasive methods applied to unrestricted living entities have emerged in two major intriguing trends: in vivo electroanalysis and imaging. ...
doi:10.1021/acsomega.8b02055
pmid:30411032
pmcid:PMC6217607
fatcat:mysbqvjssvernptihf3bc6p2fe
Microsensors for Microreaction and Lab-on-a-Chip Applications
[chapter]
2011
Microsensors
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by the detection channel. ...
The narrow wavelength range is ensured by one or more interference filters and a dichroic mirror. ...
Several interesting applications area are also discusses in the book like MEMS gyroscopes for consumer and industrial applications, microsensors for non invasive imaging in experimental biology, a heat ...
doi:10.5772/16388
fatcat:kmdrd6avvrhtrj4hmljgug5aee
Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications
2020
Frontiers in Bioengineering and Biotechnology
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controlled release of drugs has posed numerous challenges with the aim of optimizing parameters such as the release of the suitable quantity of drugs in the right site at the right time with the least invasiveness ...
Some of the factors that challenge conventional drug release include long-term treatments, narrow therapeutic windows, complex dosing schedules, combined therapies, individual dosing regimens, and labile ...
The proposed device herein sought to improve these aspects by offering a promising and minimally invasive strategy for ondemand and pulsatile drug delivery, based on light activation. ...
doi:10.3389/fbioe.2020.00827
pmid:32850709
pmcid:PMC7405504
fatcat:pkdxck6q25e3pdeeolk37z6rpy
Advances in High-Resolution Microscale Impedance Sensors
2017
Journal of Sensors
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Today, the downscaling of the size of sensing elements to micrometric and submicrometric dimensions is enabled by the diffusion of lithographic processes and fostered by the convergence of complementary ...
Acknowledgments The research activities, here reviewed, to which the author had the opportunity to contribute were led by M. Sampietro and G. ...
The series of the two impedances is driven by a differential signal. ...
doi:10.1155/2017/7638389
fatcat:l4ltfpipljcxjlyxxseuwd3fui
Electronic MEMS for triggered delivery
2004
Advanced Drug Delivery Reviews
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Implantable electronic devices such as pacemakers and neural implants are often used for electrical stimulation. ...
invasiveness and tissue disruption. ...
Drug-coated stents Stents are one method by which the size of arteries can be increased in patients with heart disease and narrowing of the arteries. ...
doi:10.1016/j.addr.2003.07.012
pmid:14741114
fatcat:mlexri6ufvflxmg4v2ansleyfy
Human Brain/Cloud Interface
2019
Frontiers in Neuroscience
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The Internet comprises a decentralized global system that serves humanity's collective effort to generate, process, and store data, most of which is handled by the rapidly expanding cloud. ...
Through TS, individuals might experience episodic segments of the lives of other willing participants (locally or remote) to, hopefully, encourage and inspire improved understanding and tolerance among ...
Or in some cases, they may be minimally invasive. ...
doi:10.3389/fnins.2019.00112
pmid:30983948
pmcid:PMC6450227
fatcat:z3k6sqwu4vhkvkleeq5ej7zquq
Droplet-based microfluidics in drug discovery, transcriptomics and high-throughput molecular genetics
2016
Lab on a Chip
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Upon application of the electric field, the interphases merge and the pressurized dark liquid is injected through a narrow orifice into the incoming droplets. ...
This process can be achieved either by active (on-demand droplet production using valves or electric fields) or by passive (continuous droplet production using pressure-driven flow and a special geometry ...
doi:10.1039/c6lc00249h
pmid:27025767
fatcat:6n2feja5dngtjfx262ipavsliq
Progress of Microfluidic Continuous Separation Techniques for Micro-/Nanoscale Bioparticles
2021
Biosensors
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However, most of the conventional particle separation techniques are based on membrane filtration techniques, whose efficiency is limited by membrane characteristics, such as pore size, porosity, surface ...
In this paper, we present a comprehensive review of the recent advances in microfluidic separation of micro-/nano-sized bioparticles by summarizing the physical principles behind the separation system ...
Most microfluidic separation devices using a DC electric field try to minimize mobilities by bulk flow, making summation of µ EOF and µ PDF negligible by balancing hydraulic heads and minimizing surface ...
doi:10.3390/bios11110464
pmid:34821680
pmcid:PMC8615634
fatcat:lgnndfcwtzcgfb5bkj6amum6su
Steam-powered sensing
2011
Proceedings of the 9th ACM Conference on Embedded Networked Sensor Systems - SenSys '11
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Second, we show that non-invasive sensing can reduce the cost of sensing by avoiding sensors that pierce the pipeline and have high installation cost with interruption to production. ...
First, we eliminate the high cost of bringing power to the field by generating electricity from heat, exploiting the high temperature of the very pipelines we monitor. ...
Each of our sensor packages is powered by a custom-built thermo-electric generator (TEG) described in §3. ...
doi:10.1145/2070942.2070964
dblp:conf/sensys/ZhangSCH11
fatcat:ro6eik2skbah3kjc57sdaoad5i
Tactile Sensing for Minimally Invasive Surgery: Conventional Methods and Potential Emerging Tactile Technologies
2022
Frontiers in Robotics and AI
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As opposed to open surgery procedures, minimally invasive surgery (MIS) utilizes small skin incisions to insert a camera and surgical instruments. ...
Optical-based tactile sensing is another conventional approach that facilitates electrically passive force sensing compatible with magnetic resonance imaging. ...
MINIMALLY INVASIVE SURGERY "Surgeons applaud large incisions and denigrate "keyhole surgery." ...
doi:10.3389/frobt.2021.705662
pmid:35071332
pmcid:PMC8777132
fatcat:ngl76gcwkzarpg2j7oawpctzti
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