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Kouth Chen received the B.S. degree in physics from the National Tsing Hua University, Hsin-Chu, Taiwan, and the M.S. and Ph.D. degrees from Northeastern University, Boston, MA, in 1979 MA, in , 1984 ...doi:10.1109/77.947376 fatcat:vgldyjbswrcp5n33vicgmowdwu
With the popularity of Social Networking Services (SNS), more and more sensitive information are stored online and associated with SNS accounts. The obvious value of SNS accounts motivates the usage stealing problem -- unauthorized, stealthy use of SNS accounts on the devices owned/used by account owners without any technology hacks. For example, anxious parents may use their kids' SNS accounts to inspect the kids' social status; husbands/wives may use their spouses' SNS accounts to spotarXiv:1308.5168v1 fatcat:4wnzmnjblbb25mkidlri76rj5e
more »... e affairs. Usage stealing could happen anywhere in any form, and seriously invades the privacy of account owners. However, there is no any currently known defense against such usage stealing. To an SNS operator (e.g., Facebook Inc.), usage stealing is hard to detect using traditional methods because such attackers come from the same IP addresses/devices, use the same credentials, and share the same accounts as the owners do. In this paper, we propose a novel continuous authentication approach that analyzes user browsing behavior to detect SNS usage stealing incidents. We use Facebook as a case study and show that it is possible to detect such incidents by analyzing SNS browsing behavior. Our experiment results show that our proposal can achieve higher than 80% detection accuracy within 2 minutes, and higher than 90% detection accuracy after 7 minutes of observation time.
Copyright 2022, Chen and Lin). Figure 2 . 2 Figure 2. The schematic of polypropylene physical foaming process (Reprinted with permission from Ref. . Copyright 2022, Chen and Lin). ...doi:10.3390/app12105122 fatcat:azyoie6rdvflddufapvqi7sfqu
Shih-Kuo Chen for the helpful discussion in the regulation of circadian rhythm. ...doi:10.1186/s12864-016-3239-4 pmid:27846817 pmcid:PMC5111229 fatcat:i3t42jimo5ffjgvtr2hrqyeqka
The recent growth of learning technologies has catalyzed the surge in investments in e-learning systems across higher education to revolutionize pedagogical practices. Thus, the implementation of 3D virtual learning tools has become an indispensable, standard methodological tool in higher education. More recently, the enforcement of restrictions and emergency lockdowns to curb the spread of the COVID-19 pandemic compelled higher education institutions worldwide to cope with and meet thedoi:10.3390/su13158632 fatcat:2m4zb3nznfb6rglwab3zqpe7lu
more »... ents of online education while preserving the quality of the learning experience at an equal pace. To develop a 3D physics laboratory, the appropriate equipment for physical experiments was first collected; then, the design software was applied to construct the 3D model. Software was then developed to edit the 3D experimental environment. Two practical tests were performed on the completed setup to verify the disadvantages and feasibility of the experiments. The present study develops and validates the incorporation of user satisfaction approaches to examine the quality of the most influential 3D learning tools during the coronavirus outbreak. The findings of this study confirm that 3D laboratories can positively influence learning attitudes when it comes to physics and improve learners' understanding of physics concepts; they also confirm that 3D laboratories are a suitable tool for teaching physics experiments. Finally, the difficulties and solutions encountered in the development of the 3D laboratory are outlined as a reference for subsequent studies.
One of the key design issues for IP routers is the IP Lookup mechanism. IP lookup is an important action in router that is to find the next hop of each incoming packet with a longest-prefix-match address in the routing table. In this paper, we put the routing table on a longest prefix first search tree. The tree is constructed as a heap by the prefix length. That makes a router executing IP lookup have the minimal number of memory accesses as compared with Trie , Patricia  and Prefix treedoi:10.1016/j.comnet.2007.01.023 fatcat:iv73carqsbaf7ildnu3jbaqvpe
more »...  . Some nodes of our tree can contain two entries of the routing table to reduce the number of tree nodes. For example, a 138286 of a routing table can be stored in 132050 nodes of our tree. Furthermore, the proposed scheme makes the tree can be updated without being reconstructed from scratch when the routing table is changed, and it can be applied in both the IPv4 and IPv6 routers.
Chen, S. D. Young and Z. L. Hwang. ... Unfortunately, the reproducibility and uniformity of the etching rates are hard to control (Chen et al., 1992) . ... Conventional mesa type (111) direction oriented InSb photovoltaic detectors are created by wet etching of a lactic acid/nitric acid solution (Chen et al., 1992; Tu et al., 1989) . ...doi:10.1080/02533839.2007.9671226 fatcat:gt3kyphrpfaytgfp56qdufa4sa
DB-67 and its lactone homolog DB-91 are derivatives of topoisomerase I inhibitor camptothecin (CPT) with silyl moiety, which may exhibit a slower inactivation process by changed kinetics of protein binding and/or hydrolysis of its lactone ring and result in increased antitumor activity and decreased toxicity. Pharmacokinetic properties and antitumor activities of the two silatecans were studied and compared. The lactone ring of DB-91 is more stable than those of all the other CPT derivatives indoi:10.1016/j.phrs.2009.07.005 pmid:19643180 fatcat:gkq2bczzvfhvzfsqwplhzuopbi
more »... mouse plasma. Both silatecans were metabolized faster than CPT in mouse and human liver microsomes. Pharmacokinetic study revealed a plasma elimination half-life (t 1/2 ) of 33 and 94 min for DB-67 and DB-91, respectively; similar systemic exposure in plasma between DB-67 and DB-91; and similar volume of distribution at the steady state between DB-67 and DB-91, approximately 15-fold smaller than that of CPT. While DB-91 showed limited activities, DB-67 exhibited activities against the growth of in vivo-like histocultured human tumors and s.c. xenografted human tumors in nude mice. In conclusion, DB-67 is more effective, compared to DB-91, against human tumor growth in in vitro, in vivo-like and in vivo systems. Further pre-clinical and clinical investigations of DB-67 are warranted.
PP4 is a serine/threonine phosphatase required for immunoglobulin (Ig) VDJ recombination and pro-B/pre-B cell development in mice. To elucidate the role of PP4 in mature B cells, we ablated the catalytic subunit of murine PP4 in vivo utilizing the CD23 promoter and cre-loxP recombination and generated CD23 cre PP4 F/F mice. The development of follicular and marginal zone B cells was unaffected in these mutants, but the proliferation of mature PP4-deficient B cells stimulated by in vitrodoi:10.1371/journal.pone.0107505 pmid:25215539 pmcid:PMC4162579 fatcat:o4lit32lbnbfziffiyrsrhseyy
more »... t with either anti-IgM antibody (Ab) or LPS was partially impaired. Interestingly, the induction of CD80 and CD86 expression on these stimulated B cells was normal. Basal levels of serum Igs of all isotypes were strongly reduced in CD23 cre PP4 F/F mice, and their B cells showed a reduced efficiency of class switch recombination (CSR) in vitro upon stimulation by LPS or LPS plus IL-4. When CD23 cre PP4 F/F mice were challenged with either the T cell-dependent antigen TNP-KLH or the T cell-independent antigen TNP-Ficoll, or by H1N1 virus infection, the mutant animals failed to form germinal centers (GCs) in the spleen and the draining mediastinal lymph nodes, and did not efficiently mount antigenspecific humoral responses. In the resting state, PP4-deficient B cells exhibited pre-existing DNA fragmentation. Upon stimulation by DNA-damaging drug etoposide in vitro, mutant B cells showed increased cleavage of caspase 3. In addition, the mutant B cells displayed impaired CD40-mediated MAPK activation, abnormal IgM-mediated NF-kB activation, and reduced S phase entry upon IgM/CD40-stimulation. Taken together, our results establish a novel role for PP4 in CSR, and reveal crucial functions for PP4 in the maintenance of genomic stability, GC formation, and B cell-mediated immune responses.
By determining critical success factors (CSFs), this study intends to identify indicators and offer suggestions for existing owners or operators to improve their critical works in business management, as well as for newcomers interested in investing or studying the chain business. To achieve the purpose of this study, document analysis, expert interviews, and the Delphi technique were used to verify that there are five-dimension indicators to explore the CSFs for tea drink chains. The criticaldoi:10.3390/su13168953 fatcat:tiqp5tfqivab3dmmmklkafkmqi
more »... uccess items in this study are as follows: (1) Regarding "brand image management", the most critical factors unanimously agreed by the professionals are the certification of raw materials and the guarantee of food safety, which are mainly affected by the recent food safety crisis. (2) Regarding "quality and cost control", the sub-items of raw material supplier's stability and timeliness are the most important factors. (3) Regarding the "location of business", the most important factors are the sub-items of visibility, convergence of people flow, and the structural consumption characteristics of the population in the area. Although these are not considered to be the most important factors in the questionnaires by professionals, the professors considered these sub-items to be the most critical factors in the dimension and should provide valuable references for CSFs. (4) Regarding "personnel training and customer satisfaction", the sub-item of maintaining hygiene in shop fronts is the most important critical factor, followed by the attitude and affinity of the staff, as well as their clothing, appearance, and cleanliness. (5) Regarding the "marketing mode and promotion mode", the two important sub-items include new product tasting and the irregular launch of new seasonal products.
The bioflavonoid apigenin has been shown to possess cancer-preventive and anti-cancer activities. In a drug screening, we found that apigenin can inhibit Wnt/β-catenin signaling, a pathway that participates in pivotal biological functions, which dis-regulation results in various human diseases including cancers. However, the underlying mechanism of apigenin in this pathway and its link to anti-cancer activities remain largely unknown. Here we showed that apigenin reduced the amount of total,doi:10.1038/s41598-017-00409-z pmid:28337019 pmcid:PMC5428476 fatcat:gvmnvgysazeeflpygxcwnp6sr4
more »... oplasmic, and nuclear β-catenin, leading to the suppression in the β-catenin/TCF-mediated transcriptional activity, the expression of Wnt target genes, and cell proliferation of Wnt-stimulated P19 cells and Wnt-driven colorectal cancer cells. Western blotting and immunofluorescent staining analyses further revealed that apigenin could induce autophagy-mediated down-regulation of β-catenin in treated cells. Treatment with autophagy inhibitors wortmannin and chloroquine compromised this effect, substantiating the involvement of autophagy-lysosomal system on the degradation of β-catenin during Wnt signaling through inhibition of the AKT/mTOR signaling pathway. Our data not only pointed out a route for the inhibition of canonical Wnt signaling through the induction of autophagy-lysosomal degradation of key player β-catenin, but also suggested that apigenin or other treatments which can initiate this degradation event are potentially used for the therapy of Wnt-related diseases including cancers. The natural flavone apigenin (4′,5,7-trihydroxyflavone) is abundant in fruits and vegetables. It is shown to be a bioactive flavonoid that possesses anti-inflammatory, antioxidant and anti-cancer activities 1 . Plant preparation that contains apigenin as traditional medicines for centuries in Europe is routinely used for the therapy of asthma, insomnia, neuralgia, shingles, Parkinson's disease, and degeneration-related diseases 2 . Epidemiological investigation has shown that food stuff rich in flavones is related to a reduced risk of several cancers, especially cancers of skin, breast, prostate, digestive tract, and certain hematological malignancies 1 . Apigenin has been shown to interfere with the process of carcinogenesis and is regarded as a cancer-chemo-preventive agent. Besides, apigenin can inhibit tumor growth, invasion, and metastasis 3 . Wnts are a group of secreted lipoglycoproteins that function as signaling molecules to regulate embryonic development at different stages and participate in adult tissue homeostasis 4, 5 . Dis-regulation in Wnt signaling causes a wide variety of human diseases such as leukemia, tetra-amelia, schizophrenia, kidney damage, bone morbidity, pulmonary fibrosis, and different kinds of cancers 6 . In the condition of without Wnt, members of the Wnt signaling pathway such as Axin, adenomatous polyposis coli (APC), glycogen synthase kinase 3β (GSK3β), casein kinase 1α (CK1α), microtubule actin crosslinking factor 1 (MACF1) 7 and beta-catenin (CTNNB1) form a protein complex termed the "β-catenin destruction complex" or "Axin complex" in the cytoplasm. In this complex, β-catenin will be phosphorylated by GSK3β and CK1α on serines 33, 37, 45 and threonine 41 and subsequently be tagged with polyubiquitin before its destruction by the 26S proteasome degradation system. In the presence of Wnt, Wnt binds to its membranous receptor frizzled and co-receptor low-density lipoprotein receptor-related protein 5/6 (LRP5/6). Dishevelled (DVL), another member of Wnt signaling, will be phosphorylated and Published: xx xx xxxx OPEN www.nature.com/scientificreports/ 2 Scientific RepoRts | 7: 372 |
Focal adhesion kinase (FAK) mediates vital cellular pathways during development. Despite its necessity, how FAK regulates and integrates with other signals during early embryogenesis remains poorly understood. We found that the loss of Fak1a impaired epiboly, convergent extension and hypoblast cell migration in zebrafish embryos. We also observed a clear disturbance in cortical actin at the blastoderm margin and distribution of yolk syncytial nuclei. In addition, we investigated a possible linkdoi:10.1098/rsob.190273 pmid:32097584 pmcid:PMC7058935 fatcat:exo5ygaipvebtgeufebvvzimyq
more »... between Fak1a and a well-known gastrulation regulator, Wnt5b, and revealed that the overexpression of fak1a or wnt5b could cross-rescue convergence defects induced by a wnt5b or fak1a antisense morpholino (MO), respectively. Wnt5b and Fak1a were shown to converge in regulating Rac1 and Cdc42, which could synergistically rescue wnt5b and fak1a morphant phenotypes. Furthermore, we generated several alleles of fak1a mutants using CRISPR/Cas9, but those mutants only revealed mild gastrulation defects. However, injection of a subthreshold level of the wnt5b MO induced severe gastrulation defects in fak1a mutants, which suggested that the upregulated expression of wnt5b might complement the loss of Fak1a. Collectively, we demonstrated that a functional interaction between Wnt and FAK signalling mediates gastrulation cell movements via the possible regulation of Rac1 and Cdc42 and subsequent actin dynamics.
doi:10.1016/j.jfma.2015.08.006 pmid:26337233 fatcat:us3wbd4p3jbbhdzhv4giuzgc7q
IPD22: PENILE PREPUCE BEAD IMPLANTS Jesun Lin 1,2 , Herng-Jye Jiang 1 , Jian Ting Chen 1 , Bai-Fu Wang 1 , Chin-pao Chang 1 , Mon-I. ... The post-Abstracts / Urological Science 27 (2016) S24eS35 S30 PATIENTS WITH DISORDER OF SEXUAL DEVELOPMENTKuan-Ting Chen, Yi-Sheng Tai, I-Ni Chiang, Shyh-Chan Chen, Kuo-How Huang. ...doi:10.1016/j.urols.2016.05.036 fatcat:b7dwc7wv4rgcxen6yt3fa5tieq
Enterovesical fistula (EVF) is a rare complication of diverticulitis, as well as Crohn's disease, intestinal malignancy, radiotherapy and trauma. EVF formation is associated with inflammation of the involved bowel segments. The current study presents the case of a 35-year-old man with non-Hodgkin's lymphoma who developed pneumaturia, fecaluria and recurrent urinary tract infections following chemotherapy, accompanied by regressive change of the lymphoma. Abdominal computed tomography scansdoi:10.3892/ol.2016.4561 pmid:27347146 pmcid:PMC4907006 fatcat:mdujqh5bwbe6tlae6spfqnfh4a
more »... led that the terminal ileum had adhered to the bladder wall. The patient underwent exploratory laparotomy and partial resection of the terminal ileum, and EVF was confirmed. Histological examination revealed an inflammatory response but no evidence of residual lymphoma. The diagnosis of EVF is occasionally difficult and requires appropriate radiographic examination. Surgical treatment is recommended.
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