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Bactericidal effects of high intensity focused ultrasound on Bacillus Calmette–Guerin in vivo and in vitro

Shuang Xie, Hua Cao, Jianhu Li, Vishnu Prasad Adhikari, Min Yang, Yu Dong, Dairong Li, Yonghong Du
2019 Figshare  
Purpose: The objective of this study was to investigate the bactericidal effects of high intensity focused ultrasound (HIFU) on Bacillus Calmette–Guerin (BCG, a substitute for Mycobacterium tuberculosis) in vitro and in vivo, and to explore the underlying mechanisms. Materials and methods: HIFU, at a fixed frequency of 1 MHz, was applied to both BCG culture suspensions and subcutaneous BCG abscesses in rats. Results: HIFU irradiation significantly reduced the bacterial survival rate and caused
more » ... emperature elevations both in vitro and in vivo. Furthermore, BCG suspensions irradiated for 15 s at 3185 and 6369 W/cm2 had increased cell wall damage, which resulted in morphological changes compared to the untreated control group. Additionally, we observed histological changes in the rat subcutaneous abscesses after HIFU ablation at 6369 W/cm2. H&E staining of infected lesions showed coagulative necrosis with central nucleus dissolution and increased infiltration of inflammatory cells, as well as nuclear pyknosis and nuclear fragmentation in the periphery. The volumes of the subcutaneous abscesses in the HIFU-treated group were significantly lower than those in the sham-treated group. Conclusion: HIFU has the therapeutic potential to treat BCG-infected tissues in rats. We theorize that a combination of mechanical, cavitation, and thermal effects most efficiently inactivate BCG bacteria via HIFU. This study is expected to provide a bio-plausible basis for a noninvasive and effective treatment for tuberculosis.
doi:10.6084/m9.figshare.9746675.v1 fatcat:mgd7fymrkrdujpp53speisrvja

5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader

Xin Yang, Ying Yang, Bao-Fa Sun, Yu-Sheng Chen, Jia-Wei Xu, Wei-Yi Lai, Ang Li, Xing Wang, Devi Prasad Bhattarai, Wen Xiao, Hui-Ying Sun, Qin Zhu (+12 others)
2017 Cell Research  
for 60 min at 4 °C.  ...  Then the beads were digested with 200 μl pre-heated (20 min at 50 °C) Proteinase K solution (4 mg/ml) for 40 min at 50 °C with rotation at 2 000 rpm/min.  ... 
doi:10.1038/cr.2017.55 pmid:28418038 pmcid:PMC5594206 fatcat:hkxrmnas2fad5gbegzvhfhtbny

Socio-demographic and Healthcare-seeking Predictors of Undernutrition among Children Under-five Years of Age in a Western District of Nepal

Rajan Paudel, Yogendra Bahadur Gurung, Amod Kumar Poudyal, Bijay Khatri, Deepak Raj Bhatta, Dilaram Acharya, Jitendra Kumar Singh, Min Raj Adhikari, Ranjan Sapkota, Narayan Bahadur Mahotra, Dipak Prasad Upadhyaya
2020 Journal of Nepal Health Research Council  
Undernutrition is highly prevalent in Nepal, which interferes with physical and mental development among children. It is one of the severe health problems contributing to the significant portion of the disease burden. This study aimed to explore socio-demographic and healthcare-seeking related predictors of undernutrition among children under five years old in Dang, Nepal. Methods: This was a descriptive cross-sectional study. A sample of 426 children was participated through stratified
more » ... onate random sampling to identify socio-demographics and healthcare-seeking predictors of undernutrition. Multivariable regression was applied to identify the independent predictors of undernutrition. Results: This study found that children below 24 months of age were more likely to be undernourished than children aged 24-36 months. Female children (OR=2.32, 95% CI: 1.19-4.54), illiterate or non-formally educated women (OR=4.09, 95% CI: 1.84-9.08), mother's occupation other than a housewife (OR=13.05, 95% CI: 4.19-40.68), labor work of father (OR=2.40, 95% CI: 1.04-5.57) had increased risk of undernutrition among children. Similarly, food insufficiency from their land, antenatal care visit, postnatal care visit, and delivery place were significantly associated with childhood undernutrition among children. Conclusions: The study showed that undernutrition among children is associated with age and gender of children, educational attainment of the mother, food sufficiency, health-seeking practices of the mother during pregnancy, delivery, and postnatal. Socio-demographics and health-seeking practices related predictors must be explicitly considered to address undernutrition among children under the age of five years. Keywords: Children; health care seeking; Nepal; socio-demographic factors; undernutrition.
doi:10.33314/jnhrc.v18i3.2875 pmid:33210646 fatcat:h7q3dycstrbotled47y7wgm5j4

Page 159 of Current World Leaders Vol. 38, Issue 1 [page]

1995 Current World Leaders  
Prime Min. and Min. of Defense and Foreign Affairs: Madhav Kumar NEPAL Home Affairs: Khadga Prasad Sharma OLI Local Dev. and Supply: Chandra Prakash MAINALI Finance: Bharat Mohan ADHIKARY Agriculture,.  ...  .: Man Mohan ADHIKARY Dep.  ... 

Page 161 of Current World Leaders Vol. 38, Issue 5 [page]

1995 Current World Leaders  
Prime Min. and Min. of Defense and Foreign Affairs: Madhav Kumar NEPAL Home Affairs: Khadga Prasad Sharma OLI Finance and Supply: Bharat Mohan ADHIKARY Agriculture,.  ...  .: Man Mohan ADHIKARY Dep.  ... 

Page 160 of Current World Leaders Vol. 38, Issue 3 [page]

1995 Current World Leaders  
Prime Min. and Min. of Defense and Foreign Affairs: Madhav Kumar NEPAL Home Affairs: Khadga Prasad Sharma OLI 160 A, June 1995  ...  .: Man Mohan ADHIKARY Dep.  ... 

Editorial Vol.11(1)

Hemchandra Adhikari
2020 JODEM: Journal of Language and Literature  
Finally, a review of Orhan Pamuk's novel Snow written by Uday Adhikari is included.  ...  Bam Dev Adhikari's study on Laxmi Prasad Devkota's Bapu sonnets deals with how the poet idealized Gandhian myth in these creations.  ... 
doi:10.3126/jodem.v11i1.34798 fatcat:tvjhtvxgona5llfljax4ls7jqy

Crises in NCP, Nepal in crises: The Iceberg Floats on the Bottom of the Sea [article]

Sanjayprasad Paudel
Sanjay Prasad Paudel Crises in NCP, Nepal in crises: The Iceberg Floats on the Bottom of the Sea Mediakhavar 34 mins ago Introductory Back ground Unfortunately, NCP has been divided into two main streams  ...  ( Sanjay Prasad Paudel: MA, M.Phil, writes in social and political issue.)  ... 
doi:10.6084/m9.figshare.13593581.v1 fatcat:fapbzom5sjhwlbi7pa6vser7ri

Responses of Ricinus communis L. (castor bean, phytoremediation crop) seedlings to lead (Pb) toxicity in hydroponics

Boda Ravi KİRAN, Majeti Narasimha Vara PRASAD
2017 Selcuk Journal of Agricultural and Food Sciences  
(Ashraf & Tang 2017 , Kumar & Prasad 2015 , Sharma & Dubey 2005 .  ...  Deligiannis et al 2009 , Gonzalez-chavez et al 2015 , Goyal et al 2014 , Huagang et al 2011 , Jumat et al 2010 , Kiran & Prasad 2016 , 2017 , Kumar & Prasad 2015 , Ogunniyi 2006 , Pal et al 2013 , Pandey  ... 
doi:10.15316/sjafs.2017.9 fatcat:hs7uvvol6rb53cimbljt7eok7i

Perinatal Outcome in Term Pregnancy with Isolated Oligohydramnios: Retrospective Observational Study

Ayushma Adhikari, Tika Kumari Gurung, Shree Prasad Adhikari
2021 Journal of Nepalgunj Medical College  
The two groups were compared in terms of fetal outcome like: meconium passage, low birth weight, low APGAR (Appearance, Pulse, Grimace, Activity and Respiration) score at 1 and 5 min, Neonatal Intensive  ...  the two groups there was significant difference in terms of meconium passage (11% vs 48.9%), low birth weight (5.8% vs 18%), low APGAR (Appearance, Pulse, Grimace, Activity and Respiration) score at 1 min  ...  Adhikari et at.: Perinatal Outcome in Term Pregnancy with Isolated Oligohydramnios: Retrospective Observational Study  ... 
doi:10.3126/jngmc.v19i2.42989 fatcat:u5hgc2b5rrd3boeqif6te3f2qy

Microencapsulation of chia seed oil using chia seed protein isolate⿿chia seed gum complex coacervates

Yakindra Prasad Timilsena, Raju Adhikari, Colin J. Barrow, Benu Adhikari
2016 International Journal of Biological Macromolecules  
It was kept at room temperature for 30 min and absorbance of the reaction mixture was measured at 415 nm with double beam UV spectrophotometer.  ...  of 0.5 mm methanolic solution of DPPH.The mixture was shaken vigorously and incubated for 37 min in the dark at room temperature. The absorbance was measured at 517 nm using UV spectrophotometer.  ... 
doi:10.1016/j.ijbiomac.2016.05.058 pmid:27212219 fatcat:myjy6gcrwrhhnflhtufyekftue

Staphylococcal toxic shock syndrome in a lactating mother with breast abscess: A case report

Kamal Pandit, Sushil Khanal, Prabhat Adhikari, Samaj Adhikari, Subhash Prasad Acharya
2020 Annals of Medicine and Surgery  
Her initial blood pressure was 80/60 mm of Hg, heart rate was 98/min, respiratory rate was 20/min and temperature was 102.8°F.  ...  Subhash Prasad Acharya provided support and mentorship for development, writing and revision of this case report. And he was directly involved in patient's care during his stay in ICU.  ... 
doi:10.1016/j.amsu.2020.07.027 pmid:32760582 pmcid:PMC7390825 fatcat:2awwhh4v2bbolmmhxnk4wsjnzm


2021 Journal of Pediatric Endocrinology & Metabolism (JPEM)  
Prasad, Anupama Sankaran, Gnanabalan Murugesan and Shanmughasundaram Ramanathan Impact of maternal thyroid disease on neonatal thyroid status 237 Se-Jun Park, Keun-Ho Lee, Chong-Suh Lee, Ki-Tack  ...  Chiesa, Federica Ricci, Lulash Nika, Paola Sciortino and Marco Spada SLC25A19 deficiency and bilateral striatal necrosis with polyneuropathy: a new case and review of the literature 261 Doris Taha, Amita Adhikari  ... 
doi:10.1515/jpem-2021-frontmatter2 fatcat:iwfmiubq5zhjppk4io5rz7nwmq

Total salinity stress on physico-chemical characterization of lecithin isolated from soya bean oil seeds grown in the coastal region of south, India

Pragasam Antony, Preeti Tallur, Sikandar Mulla, Vinayak Naik
2016 Journal of Applied Pharmaceutical Science  
., 1969) , ricebran (Adhikari and Adhikari, 1986), palm, coriander, carrot (Goh et al., 1982) , papaya (Prasad et al., 1987) , olive, barley, cucurbit (Schneider, 1989 ), corn, karanza, castor bean  ...  (Paulose et al., 1966 , cocoa (Parsons et al., 1969) , neem (Prasad et al., 1981) , sesame, khakan (Prasad et al., 1979 ), pear, quince, tobacco (Zlatanov et al., 2000 .  ... 
doi:10.7324/japs.2016.60805 fatcat:6kq7r3yvknanxl4y6u35asaz3u

Differential response of growth, photosynthesis, antioxidant enzymes and lipid peroxidation to UV-B radiation in three cyanobacteria

M. Zeeshan, S.M. Prasad
2009 South African Journal of Botany  
Cyanobacteria exhibited varied sensitivity to UV-B radiation (280-315 nm: 0.4 W m − 2 ) as 30 min of UV-B exposure caused 32, 88 and 95% growth yield after 10th day of treatment in N. muscorum, P. boryanum  ...  Photosynthetic pigment contents, whole cell oxygen yield, 14 C-fixation and PS II activity decreased with increasing doses of UV-B exposure (15 and 60 min), however, the inhibitory effect in N. muscorum  ...  ; Prasad et al., 2005) .  ... 
doi:10.1016/j.sajb.2009.03.003 fatcat:fy7qdrveqfhdvcxij36yguhw3y
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