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Milestones in electron crystallography

Ludovic Renault, Hui -Ting Chou, Po -Lin Chiu, Rena M. Hill, Xiangyan Zeng, Bryant Gipson, Zi Yan Zhang, Anchi Cheng, Vinzenz Unger, Henning Stahlberg
2006 Journal of Computer-Aided Molecular Design  
Electron crystallography determines the structure of membrane embedded proteins in the twodimensionally crystallized state by cryo-transmission electron microscopy imaging and computer structure reconstruction  ...  The server (http://2dx.org) provides the electron crystallography community with a central information exchange platform, which is structured in blog and Wiki form, allowing visitors to add comments or  ...  Acknowledgements This work was in part supported by the NSF, grant number MCB-0447860 and by the NIH, grant number U54-GM074929. V. Unger is supported by NIH grants GM66145 and GM071590. We thank Y.  ... 
doi:10.1007/s10822-006-9075-x pmid:17103018 pmcid:PMC2194810 fatcat:wk5opidue5cepn3fetzqyjorg4

A milestone in ribosomal crystallography: the construction of preliminary electron density maps at intermediate resolution

F. Schlünzen, H. A. S. Hansen, J. Thygesen, W. S. Bennett, N. Volkmann, J. Harms, H. Bartels, S. Krumbholz, I. Levin, A. Zaytzev-Bashan, M. Geva, S. Weinstein (+12 others)
1995 Biochemistry and Cell Biology  
as with the motifs observed in thin sections of the crystals by electron microscopy.  ...  In parallel, two in situ small and stable complexes were isolated from the halophilic ribosome. Procedures for their crystal production in large quantities are currently being developed.  ...  Assignment of phases in ribosomal crystallography unpredictable, step in structure determination, even for averagesized proteins of molecular weights of 15 000 -80 000.  ... 
doi:10.1139/o95-082 pmid:8721990 fatcat:hzgwbhwbpfct3hksqa222o7duy

Accessible atomic structures from sub-micron protein crystals

Jose A. Rodriguez
2015 Acta Crystallographica Section A: Foundations and Advances  
MicroED follows in the wake of other successful innovations to crystallography.  ...  Likewise, data collection is conducted as a cryo-EM experiment on a modern electron microscope, albeit in diffraction mode, a protocol accessible to versed microscopists.  ... 
doi:10.1107/s2053273315012206 pmid:26131893 fatcat:pezacemxdza2nfv7q7efx4kru4

Expanding the structural biology toolbox with single-molecule holography

Federico Forneris, Andrea Mattevi
2017 Proceedings of the National Academy of Sciences of the United States of America  
In crystallography, the X-ray diffraction patterns generated by single crystals are used to obtain electron densities that are interpreted to locate the atomic positions in 3D space (2) (Fig. 1A ).  ...  Classically, the methodological pillars of structural biology have been crystallography, NMR, and electron microscopy.  ... 
doi:10.1073/pnas.1620897114 pmid:28154136 pmcid:PMC5320977 fatcat:smua7k5sefdpngpaqrs4ttaiae

High-pressure crystallography, weak interactions and electron density

Andrzej Katrusiak
2009 Acta Crystallographica Section A Foundations of Crystallography  
Among several milestones in the development of the high-pressure crystallography were the introduction of gaskets allowing high-pressure studies at hydrostatic conditions [3], development of pressure calibration  ...  Now the DAC is commonly used for x-ray crystallography in many laboratories all over the world [5,6].  ...  For bioglass, structure, electronic and vibrational features of the bulk will be discussed [3] .  ... 
doi:10.1107/s0108767309099954 fatcat:q2stxharire75k4cxing65ywpe

The International Year of Crystallography (2014): A Philatelic Celebration

Daniel Rabinovich
2014 Chemistry International  
Sponsored by UNESCO and the International Union of Crystallography (IUCr), a sister organization of IUPAC, the year 2014 marks, among other milestones, the centennial of the Nobel Prize in Physics awarded  ...  The International Year of Crystallography (IYCr) is a year-round celebration of the science of crystallography, its enthralling history, and its multifarious contributions to society.  ...  Sponsored by UNESCO and the International Union of Crystallography (IUCr), a sister organization of IUPAC, the year 2014 marks, among other milestones, the centennial of the Nobel Prize in Physics awarded  ... 
doi:10.1515/ci-2014-0636 fatcat:zahdc3uxa5hrfozg23jfk3yj2u

Structural biology of G protein-coupled receptors: new opportunities from XFELs and cryoEM

Andrii Ishchenko, Cornelius Gati, Vadim Cherezov
2018 Current Opinion in Structural Biology  
Recent breakthroughs in cryo-electron microscopy and X-ray free electron lasers have accelerated structural studies of difficult-to-crystallize receptors and their signaling complexes, and have opened  ...  Here, we summarize major milestones and challenges associated with the application of these techniques and outline future directions in their development with a focus on membrane protein structural biology  ...  into the electron density.  ... 
doi:10.1016/j.sbi.2018.03.009 pmid:29554543 pmcid:PMC6139287 fatcat:tfpmkuocdrdqziq6yjaopgp4f4

From electron crystallography of 2D crystals to MicroED of 3D crystals

Michael W. Martynowycz, Tamir Gonen
2018 Current Opinion in Colloid & Interface Science  
Electron crystallography in cryoEM, was developed in the mid-1970s and used to solve the structure of several membrane proteins and some soluble proteins.  ...  In 2013, a new method for cryoEM was unveiled and named Micro-crystal Electron Diffraction, or MicroED, which is essentially three-dimensional (3D) electron crystallography of microscopic crystals.  ...  Milestones in electron crystallography of 2D crystals Investigation on biological specimens by electron crystallography arguably began when Parsons and Martius used electron diffraction to investigate  ... 
doi:10.1016/j.cocis.2018.01.010 pmid:30166936 pmcid:PMC6112780 fatcat:yhvqg4gj6vcafphmiyagfb36fm

Chemical crystallography and crystal engineering

Gautam R. Desiraju
2014 IUCrJ  
The relevance of electron diffraction, powder methods and the use of synchrotrons and electron lasers will undoubtedly increase in all aspects of chemical crystallography.  ...  The second milestone, time-resolved crystallography, was facilitated by the availability of synchrotrons and meant that crystals could be studied for short exposure times -shorter than the timescales of  ... 
doi:10.1107/s2052252514021976 pmid:25485117 pmcid:PMC4224455 fatcat:7eulgsld7vg2tka3uma2qziqje

Modelling of biomaterials: molecular recognition at the surfaces of bioactive glasses

Piero Ugliengo, Marta Corno, Albert Rimola
2009 Acta Crystallographica Section A Foundations of Crystallography  
Among several milestones in the development of the high-pressure crystallography were the introduction of gaskets allowing high-pressure studies at hydrostatic conditions [3], development of pressure calibration  ...  Now the DAC is commonly used for x-ray crystallography in many laboratories all over the world [5,6].  ...  For bioglass, structure, electronic and vibrational features of the bulk will be discussed [3] .  ... 
doi:10.1107/s0108767309099942 fatcat:b2q4geys5ra5xjm6zoqohzlfpi

The XFEL Protein Crystallography: Developments and Perspectives

Haiguang Liu, Weontae Lee
2019 International Journal of Molecular Sciences  
In the past 10 years, the world has witnessed the revolutionary development of X-ray free electron lasers (XFELs) and their applications in many scientific disciplinaries [...]  ...  The commissioning of the Linac Coherent Light Source (LCLS) in 2009 marks a milestone for both laser and hard X-ray technologies [3] : the dream of X-ray lasers came true, and the constructions of several  ...  In the past 10 years, the world has witnessed the revolutionary development of X-ray free electron lasers (XFELs) and their applications in many scientific disciplinaries [1] .  ... 
doi:10.3390/ijms20143421 pmid:31336822 pmcid:PMC6678726 fatcat:o5poar335jhqbpehs6pnr32cpq

New phase transitions

Bertrand Toudic
2010 Acta Crystallographica Section A Foundations of Crystallography  
Furthermore, in covalent solids such as transition metal oxides and carbides they appear to signal electron localization phenomena which are reflected by metal-to-insulator transitions or the suppression  ...  and relevance in chemistry and physics [2].  ...  For this, it is important to establish proper structure-property relationships in terms of the electronic distribution and, in this respect, quantum mechanical theories have been useful even at some lower  ... 
doi:10.1107/s0108767310099897 fatcat:vyudetkfzrabnpagth47n5n7yy

Crystallography matters

2014 Nature Materials  
Most practicing materials scientists will agree that crystallography (and all its related techniques, which include electron microscopy) is ubiquitous in their work.  ...  To complement these activities, Nature, Nature Materials, Nature Nanotechnology and Nature Structural & Molecular Biology have joined forces to produce a supplement entitled Nature Milestones in Crystallography  ...  Crystallography matters © OMIKRON/SCIENCE PHOTO LIBRARY X-ray diffraction of chromium.  ... 
doi:10.1038/nmat4057 pmid:25191682 fatcat:sw54rwqq4ncilj36qs6aopgtlq

Accuracy in powder diffraction IIedited by E. O. Prince and J. K. Stalick

H. Steinfink
1994 Acta Crystallographica Section A Foundations of Crystallography  
In the field of X-ray crystallography we can point to many such milestones: the advent of direct methods for phase determination and the discovery of quasicrystals are just two instances.  ...  The advances in powder diffraction surely deserve to be ranked as another such milestone.  ... 
doi:10.1107/s0108767394008470 fatcat:rgnlmifqxzegdi5tkieq4ukfcu

Doug Rosenthal.pdf [article]

Doug Rosenthal
2020 Figshare  
Also, Rosenthal relies on molecular structures from electron microscopy (EM), x-ray crystallography, and nuclear magnetic resonance spectroscopy. These photos show [...]  ...  of a common goal and which is in an incipient development in the region.  ...  Also, Rosenthal relies on molecular structures from electron microscopy (EM), x-ray crystallography, and nuclear magnetic resonance spectroscopy.  ... 
doi:10.6084/m9.figshare.12179442 fatcat:4w7ivslqnvbbhnx5b7nadyusci
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