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Neuromuscular Imaging, a new handbook edited by Mike P. Wattjes and Dirk Fischer, offers an excellent overview of these new developments and of the various uses of imaging in neuromuscular disorders. ...doi:10.1007/s00234-014-1442-z fatcat:xfsgvqjqy5fslbaqpvmtl56cyu
Kornblum C, Lutterbey G, Bogdanow M, Kesper K, Schild H, Schröder R, Wattjes MP (2006) Distinct neuromuscular phenotypes in myotonic dystrophy types 1 and 2. A whole body highfield MRI study. ...doi:10.1007/s00330-010-1799-2 pmid:20422195 pmcid:PMC2940021 fatcat:fmyyp4geonbfhfhd6arrbausxi
Many technical developments keep occurring in the field of MRI that could benefit image acquisition in the field of diagnostic neuroradiology. While there is much focus on the potential advantages of 3T and higher field strengths, it is often unclear whether these are cosmetic only, or convey clinically relevant diagnostic value. The increased signal-to-noise at 3T is certainly beneficial in different ways particularly for the acquisition of isotropic 3D sequences like FLAIR. Single-slab 3Ddoi:10.1007/s00330-010-2034-x pmid:21181406 pmcid:PMC3032195 fatcat:uf7nywexdbeqfej4pbjsmurgle
more »... ences can now be obtained with multiple contrasts in clinically attainable data acquisition times and could revolutionize MRI to evolve into a fundamentally multi-planar technique, rather similar to what has happened with the introduction of multi-detector row CT. The many revolutions of MRI The invention and development of MRI as a diagnostic tool itself is considered by many one of the greatest medical achievements of the past decades . In retrospect is hard to understand the enthusiasm of the early days given the quality of the initial MR images published. Those were 9 mm slices of the brain with an in-plane resolution of 2×2 mm 2 , with 10 slices acquired at 0.15 Tesla over 10 min or more . Advantages of 3T: diagnostic relevant or cosmetic imaging? Since the FDA approval in 2000, the installed base of wholebody high-field MR systems operating at 3T for clinical purposes has increased dramatically. Driven by the increased SNR which is the most obvious advantage of higher magnetic field strengths, many studies have demonstrated the potential benefit of 3T compared to 1.5T mainly in field of Neuroradi-
Following the approval of the U.S. Food and Drug Administration (FDA), high field magnetic resonance imaging (MRI) has been increasingly incorporated into the clinical setting. Especially in the field of neuroimaging, the number of high field MRI applications has been increased dramatically. Taking advantage on increased signal-to-noise ratio (SNR) and chemical shift, higher magnetic field strengths offer new perspectives particularly in brain imaging and also challenges in terms of severaldoi:10.1007/s00234-009-0512-0 pmid:19277621 fatcat:o6pse2acjrg6de7jzpt3kjrtfe
more »... nical and physical consequences. Over the past few years, many applications of high field MRI in patients with suspected and definite multiple sclerosis (MS) have been reported including conventional and quantitative MRI methods. Conventional pulse sequences at 3 T offers higher lesion detection rates when compared to 1.5 T, particularly in anatomic regions which are important for the diagnosis of patients with MS. MR spectroscopy at 3 T is characterized by an improved spectral resolution due to increased chemical shift allowing a better quantification of metabolites. It detects significant axonal damage already in patients presenting with clinically isolated syndromes and can quantify metabolites of special interest such as glutamate which is technically difficult to quantify at lower field strengths. Furthermore, the higher susceptibility and SNR offer advantages in the field of functional MRI and diffusion tensor imaging. The recently introduced new generation of ultra-high field systems beyond 3 T allows scanning in submillimeter resolution and gives new insights into in vivo MS pathology on MRI. The objectives of this article are to review the current knowledge and level of evidence concerning the application of high field MRI in MS and to give some ideas of research perspectives in the future.
Journal of Neurology
Granule cell neuronopathy (GCN) is a rare JC virus infection of the cerebellar granule cell neurons in immunocompromised patients. On brain imaging, GCN is characterized by cerebellar atrophy which can be accompanied by infratentorial white matter lesions. The objective of this study is to investigate the prevalence of MRI findings suggestive of GCN in a large natalizumab-associated progressive multifocal leukoencephalopathy (PML) cohort. MRI scans from before, at the time of, and duringdoi:10.1007/s00415-015-8001-3 pmid:26810721 pmcid:PMC4826658 fatcat:io6bpf5t2bh4zoh5wufpzda5ym
more »... p after diagnosis of PML in 44 natalizumab-treated MS patients, and a control group of 25 natalizumab-treated non-PML MS patients were retrospectively reviewed for imaging findings suggestive of GCN. To assess and quantify the degree of cerebellar atrophy, we used a 4 grade rating scale. Three patients in the PML group showed imaging findings suggestive of GCN and none in the control group. In two of these PML patients, cerebellar atrophy progressed from grade 0 at the time of diagnosis of isolated supratentorial PML to grade 1 and 2 after 2.5 and 3 months, respectively, in the absence of infratentorial white mater lesions. The third patient had grade 1 cerebellar atrophy before diagnosis of infra-and supratentorial PML, and showed progression of cerebellar atrophy to grade 2 in the 3 months following PML diagnosis. None of the other eight patients with infratentorial PML lesions developed cerebellar atrophy suggestive of GCN. Three cases with imaging findings suggestive of GCN were detected among 44 natalizumab-associated PML patients. GCN may, therefore, be more common than previously considered in natalizumab-associated PML patients.
High field MRI operating at 3 T is increasingly being used in the field of neuroradiology on the grounds that higher magnetic field strength should theoretically lead to a higher diagnostic accuracy in the diagnosis of several disease entities. This Editorial discusses the exhaustive review by Wardlaw and colleagues of research comparing 3 T MRI with 1.5 T MRI in the field of neuroradiology. Interestingly, the authors found no convincing evidence of improved image quality, diagnostic accuracy,doi:10.1007/s00330-012-2552-9 pmid:22821393 pmcid:PMC3472049 fatcat:3wucz725ljb7bgf73tuhnarcqu
more »... r reduced total examination times using 3 T MRI instead of 1.5 T MRI. These findings are highly relevant since a new generation of high field MRI systems operating at 7 T has recently been introduced. Key Points • Higher magnetic field strengths do not necessarily lead to a better diagnostic accuracy. • Disadvantages of high field MR systems have to be considered in clinical practice. • Higher field strengths are needed for functional imaging, spectroscopy, etc. • Disappointingly there are few direct comparisons of 1.5 and 3 T MRI. • Whether the next high field MR generation (7 T) will improve diagnostic accuracy has to be investigated.
volume (1.44 L vs 1.33 L, p<0.05), normalised grey matter volume (0.77 L vs 0.69 L, p<0.01) and putamen (12.7 mL vs 10.7 mL, p<0.05). ... Results High baseline CSF NfH-SMI35 levels predicted pronounced atrophy at 15year follow up (OR 36, p<0.01), in absence of baseline brain atrophy (OR 28, p<0.05), for the averaged MRI normalised brain ... 0.05, ** = p<0.01. ...doi:10.1177/1352458516645206 pmid:27207456 fatcat:ovwq7anrijg3zcydqis5s6kvm4
, p = 0.047). ... Results: Baseline spinal cord lesions show a higher risk of 6-year EDSS progression (odds ratio (OR): 3.6, p = 0.007) and EDSS-plus progression (OR: 2.5, p = 0.028) and 11-year EDSS progression (OR: 2.8 ... Level of significance was set at p 0.05 (bold). ...doi:10.1177/1352458519864933 pmid:31373535 fatcat:uosxyfzhpjfkveu4hczcbrpmdy
Wattjes analyzed the data, contributed to MRI imaging, and revised the article for intellectual content. ...doi:10.1212/nxi.0000000000000483 pmid:30027107 pmcid:PMC6047430 fatcat:xm4zphpsknh5jdizy2va74kmny
14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 F o r P ... 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 F o r P ...doi:10.1111/jon.12422 pmid:28102639 fatcat:nx6uav4lifcehojb7m6sz25sfy
Journal of Neurology
Mike Wattjes serves as a consultant for Roche, Novartis, and Biogen. ... = 0.001 and p = 0.007, respectively). ...doi:10.1007/s00415-016-8217-x pmid:27401179 pmcid:PMC5037162 fatcat:vpw2uqrvczgifl4kbojjgvphsy
Results Decreasing CBF was related to more advanced AD stages in all supratentorial regions (p for trend < 0.05). ... Wattjes serves as a consultant for Biogen-Idec. Dr. Wattjes receives research support from Biogen Idec, Bayer Healthcare, Roche and Janssen Cilag. Dr. ... Wattjes serves as an editorial board member of European Radiology. ...doi:10.1007/s00330-015-3834-9 pmid:26040647 pmcid:PMC4712243 fatcat:knh3xyavlna5jfrtzofhqy2cgu
Results: Compared to MS subjects with normal cognition, MS subjects with cognitive impairment showed a more random network organization as indicated by lower lambda values (all p < 0.05). ... < 0.05; ++ p < 0.01; +++ p < 0.001; comparison of MS patients with healthy controls: *p < 0.05; **p < 0.01; ***p < 0.001. ... Comparison of HC with MS patients: *p < 0.05; **p < 0.001; comparison within MS patients based on cognitive status: + p < 0.05; ++ p < 0.001. ...doi:10.1177/1352458517751650 pmid:29320933 fatcat:sqzwh6gbzvfjbiietdrxrgqyiq
Conflict of Interest Mike P. Wattjes has received speaking and consultancy fees from Biogen, IXICO, Novartis, Roche, Sanofi-Genzyme, and Springer Healthcare. ... replacement (global T2) and by removing the fat during postprocessing or by using MRS (water T2). 13, 23 Other promising techniques may also play a role, for instance diffusion tensor imaging (DTI), 31 P ...doi:10.1055/s-0040-1712955 pmid:32992368 fatcat:6ioxgea4qncjdkdzemiqmhiyuu
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