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Opportunistic treatment of hepatitis C virus infection (OPPORTUNI-C): study protocol for a pragmatic stepped wedge cluster randomized trial of immediate versus outpatient treatment initiation among hospitalized people who inject drugs

H. Midgard, A. K. Finbråten, K. B. Malme, R. M. Berg-Pedersen, L. Tanum, I. C. Olsen, R. Bjørnestad, O. Dalgard
2020 Trials  
One of the critical obstacles to HCV care in this population is the lack of treatment models within specialist healthcare adapted to marginalized individuals.  ...  To mimic usual clinical practice as closely as possible, we will use a pragmatic clinical trial approach utilizing clinical infrastructure, broad eligibility criteria, flexible intervention delivery, clinically  ...  Acknowledgements We would like to acknowledge Ana Riquelme Urzua for administrative support and coordination of enrolment; Ljubica Glumac Zacariassen, David Nilssen, Hanna Eilertsen, Karoline Landrø, Kjerstin  ... 
doi:10.1186/s13063-020-04434-8 pmid:32539853 pmcid:PMC7294626 fatcat:edbzmohwjrh35n3n3utjnj3fni

Genetic susceptibility to infectious diseases: Current status and future perspectives from genome-wide approaches

Alessandra Mozzi, Chiara Pontremoli, Manuela Sironi
2017 Infection, Genetics and Evolution  
Of these, only a minority have investigated the susceptibility to infectious diseases or the response to therapies for the treatment or prevention of infections.  ...  by GWASs, especially for those conditions that have never been investigated using this approach.  ...  strongly pointed to a role for risk variants in genes of the innate immune system.  ... 
doi:10.1016/j.meegid.2017.09.028 pmid:28951201 pmcid:PMC7106304 fatcat:avbzlsi4obezpob4ekoyhihvfq

Joint meeting of the Association of British Neurologists and the Norwegian Neurological Association on the coastal steamer Hurtigruten, 6-9 May 2001

L Bindoff
2001 Journal of Neurology, Neurosurgery and Psychiatry  
Epidemiology of multiple sclerosis: an overview R Midgard Department of Neurology, Molde Hospital, Molde, Norway As a disease, multiple sclerosis (MS) is not evenly distributed with respect to either region  ...  Methods: Lift task: the subject was required to lift and keep horizontal a platform held at either end by precision grip; the platform was loaded symmetrically or asymmetrically with diVerent loads.  ... 
doi:10.1136/jnnp.71.3.419 fatcat:fbfukhe5pzdfzlyk7by7srozsa

Kristian Brink, Susan Hydén, Kristina Jennbert, Lars Larsson and Deborah Olausson, eds. Neolithic Diversities: Perspectives from a Conference in Lund, Sweden (Acta Archaeologica Lundensia 65. Lund: Department of Archaeology and Ancient History, 2015, 250pp., 45 colour and 44 b/w figs., 11 tables, hbk, ISBN 978-91-89578-60-9)

Daniela Hofmann
2016 European Journal of Archaeology  
latter implies a substantial juvenile mortality, reducing a cohort by at the age of years. e corresponding gure is for Skateholm and for Västerbjers.  ...  (AFM) was compared to a paleodemographical analysis of two Scandinavian archaeological samples, Skateholm and Västerbjers. e salient di erence between the archaeological samples and the AFM is that the  ...  Special thanks goes to Svend Illum Hansen for providing a photo of a dry stone wall.  ... 
doi:10.1080/14619571.2016.1161128 fatcat:kccjuzfwgndavl3oalrktu5jlm

Johanson_columbia_0054D_16905.pdf [article]

2021
As such, the present study does not provide support for psychological resilience as a protective factor for the motor system in MS or for resilience in predicting differential decline in motor functioning  ...  Psychological Resilience as a Protective Factor for the Motor System in Multiple Sclerosis Laura Lane Johanson Multiple Sclerosis (MS) is a lifelong progressive neurologic disease of the central nervous  ...  Moreover, attention to resilience in MS research might provide a balanced approach to offset the focus on the negative.  ... 
doi:10.7916/d8-m1z3-6t55 fatcat:rdlwj4jl5nddnfu3qvihqcmiky

An Extensible Parallel Computing Framework for Ultra-Fast X-Ray Imaging

Matthias Vogelgesang
2014
Das entwickelte System ist über Architekturgrenzen hinweg skalierbar und ermöglicht damit regelbare Experimente, die in der Form bisher nicht möglich waren.  ...  Due to the emerge of a large mobile market however, high-powered embedded system-onchip  architectures such as 's recent Mali  architecture Midgard appeared.  ...  is approach provides a flexibility that allows for rapid prototyping of experiments which is crucial in X-ray tomography setups that must adapt to the requirements of the sample environment.  ... 
doi:10.5445/ir/1000048019 fatcat:tem45nnv7rdwfcovduytqlucxa

Fifty-Fourth Critical Bibliography of the History and Philosophy of Science and of the History of Civilization (to end of April 1938--with special reference to sections 34 to 49 inclusive)

1938 Isis  
ISIS xith (2) TO xIth CENT. (2) 485 XIth century (second half) © Nunemaker, J. Horace. A comparison of the lapidary of MarBopE with a Spanish fifteenth-century adaptation. Speculum 13, 62-7, 1938.  ...  It behooves us to appreciate, therefore, that nothing less than an herculean effort, guided by common sense, will budge the load.”’ G.  ... 
doi:10.1086/347483 fatcat:27fp2amy6fbmxlyhy7hh7kbkuq

Identification of prognostic factors predicting the long-term clinical outcome in Multiple Sclerosis

Antonio Scalfari, Paolo Muraro, Italian Multiple Sclerosis Foundation (FISM)
2015
The lack of reliable predictors of the long-term evolution prevents from applying a rational and individualized therapeutic approach.  ...  In addition, RCTs methodology is still not sufficiently rigorous for protecting against the bias due to the large variability of the clinical outcome.  ...  , to some extent, by a genetic control .  ... 
doi:10.25560/26150 fatcat:mvsp7y7atfconhknctmq6qsyde

EXPERIENTIA EST OPTIMA MAGISTRA

A Kutsenko
unpublished
A special attention is given to the literary significance of translator's contribution to the communicative effect of the translations in the target language.  ...  The article is devoted to the prime ways and techniques of idiom translation in J. Barnes's "England, England".  ...  for "genetic replication."  ... 
fatcat:glfm55a5hbfezf5mgywju2insy

Determinants of Depression in Multiple Sclerosis [article]

Sandra Berzins, University Of Calgary, University Of Calgary, Scott Patten, Andrew Bulloch
2014
Participants in this prospective cohort study (n=188) were followed for six months, starting with two baseline risk factor assessments then completing a depression screening instrument, the PHQ-9, every  ...  A response feature analysis used standard deviation of total depression scores to categorize participants in an alternative way to the typical depression high/low cut-point measures.  ...  For women, the pattern of episode duration by age groups was balanced.  ... 
doi:10.11575/prism/25602 fatcat:nupxb7ei2nafxfz6t4c6nto3tm

HOMO LUDENS A STUDY OF THE PLAY-ELEMENT IN CULTURE

J Huizinga, Routledge Kegan, Paul London, Henley Boston, Routledge
unpublished
a, 7ra.l-YJlw •• lPaideia, i. p. 119. 3Cicero, De oratione, i, 229 sq.  ...  We have already touched on the possible relationship of the contest to the rise of a law-system in our description of the potlatch, which Davy approaches exclusively fr om the juristic point of view as  ...  The distribution of largesse to the urban populace was not the monopoly of the Emperor.  ... 
fatcat:xsvto5e4grbspgrq3j3fmkycyi