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Fiber bundle length and cognition: a length-based tractography MRI study

Ashley M. Behrman-Lay, Christina Usher, Thomas E. Conturo, Stephen Correia, David H. Laidlaw, Elizabeth M. Lane, Jacob Bolzenius, Jodi M. Heaps, Lauren E. Salminen, Laurie M. Baker, Ryan Cabeen, Erbil Akbudak (+3 others)
2014 Brain Imaging and Behavior  
Results revealed that parietal and occipital FBLs explained a significant portion of variance in EF. Frontal, temporal, and occipital FBLs explained a significant portion of variance in CPS.  ...  However, it remains unclear whether white matter microstructure in these regions is associated with age-related decline in EF and/or CPS.  ...  Recruitment database searches were supported in part by NIH/NCRR grant UL1 TR000448. Conflict of interest  ... 
doi:10.1007/s11682-014-9334-8 pmid:25376332 pmcid:PMC4424188 fatcat:hgjg4s36lve6tpnfywkoyblxem

Age-related decline in white matter tract integrity and cognitive performance: A DTI tractography and structural equation modeling study

Aristotle N. Voineskos, Tarek K. Rajji, Nancy J. Lobaugh, Dielle Miranda, Martha E. Shenton, James L. Kennedy, Bruce G. Pollock, Benoit H. Mulsant
2012 Neurobiology of Aging  
Whole brain tractography and a clustering segmentation in 48 healthy individuals across the adult lifespan were used to examine: interhemispheric (corpus callosum), intrahemispheric association (cingulum  ...  Our findings suggest that decline in the microstructural integrity of white matter fibers can account for cognitive decline in normal aging.  ...  of brain regions predicted executive function performance in elderly individuals (Cabeza et al., 2002) .  ... 
doi:10.1016/j.neurobiolaging.2010.02.009 pmid:20363050 pmcid:PMC2945445 fatcat:vlscoe7wwrfwdcy23olcv27r5i

Response inhibition is associated with white matter microstructure in children

Kathrine Skak Madsen, William F.C. Baaré, Martin Vestergaard, Arnold Skimminge, Lisser Rye Ejersbo, Thomas Z. Ramsøy, Christian Gerlach, Per Åkeson, Olaf B. Paulson, Terry L. Jernigan
2010 Neuropsychologia  
Observed associations may be related to variation in phase of maturation, to activity-dependent alterations in the network subserving response inhibition, or to stable individual differences in underlying  ...  Several lines of evidence suggest that response inhibition is primarily mediated by a right-lateralized network involving inferior frontal gyrus (IFG), presupplementary motor cortex (preSMA), and subthalamic  ...  Acknowledgements This work was supported by the Danish Medical Research Council, University of Copenhagen's Research Priority Area Body and Mind, and the Lundbeck Foundation.  ... 
doi:10.1016/j.neuropsychologia.2009.11.001 pmid:19909763 fatcat:g3l7aoqtpfalvnsy2c65lbt3h4

PreSMA stimulation changes task-free functional connectivity in the fronto-basal-ganglia that correlates with response inhibition efficiency

Benjamin Xu, Marco Sandrini, Wen-Tung Wang, Jason F. Smith, Joelle E. Sarlls, Oluwole Awosika, John A. Butman, Barry Horwitz, Leonardo G. Cohen
2016 Human Brain Mapping  
and functional connectivity within the network in relation to the efficiency of 7 response inhibition evaluated with a stop-signal task.  ...  in the fronto-basal-ganglia network, is critical for 2 response inhibition.  ...  The preSMA-TMS effect on network activity and 468 response inhibition may also be influenced by the individual differences in the anatomical 469 connectivity.  ... 
doi:10.1002/hbm.23236 pmid:27144466 pmcid:PMC4980157 fatcat:fpwon6ohwbekxf5ihkfyi2hs5m

Neuroimaging and electroencephalographic (EEG) methods for investigating neural circuits in mental disorders

Mario Minor Murakami Junior, Marcelo Q. Hoexter, Elizabeth Shephard
2019 Revista de Medicina  
However, to achieve this, a better understanding of the specific alterations in neural circuits involved in different mental disorders is required.  ...  It is increasingly recognised that dysfunction in neural circuits plays a key role in the neurobiological basis of mental disorders.  ...  As in anatomical models, Di Martino and colleagues performed a rs-fMRI study to map the functional connectivity of the striatum circuitry in typically developing individuals 38 .  ... 
doi:10.11606/issn.1679-9836.v98i4p259-266 fatcat:pkyxftl6obhunbtrgbs43cmgjq

Structural Organization of the Corpus Callosum Predicts Attentional Shifts after Continuous Theta Burst Stimulation

M. Chechlacz, G. W. Humphreys, S. N. Sotiropoulos, C. Kennard, D. Cazzoli
2015 Journal of Neuroscience  
However, large individual differences in behavioral responses to stimulation have been reported.  ...  In contrast, rTMS applied over the left PPC triggers a weaker or null attentional shift. However, large interindividual differences in responses to rTMS have been reported.  ...  by FA indicates the anatomical basis of individual differences in response to cTBS over the left and right IPS.  ... 
doi:10.1523/jneurosci.2610-15.2015 pmid:26586822 pmcid:PMC4649006 fatcat:hn7rvqerxrf2fkjpyguuyjbapu

What is the function of inter-hemispheric inhibition? [article]

Richard G. Carson
2020 arXiv   pre-print
The narrowing of the excitatory focus that occurs through crossed surround inhibition is a highly conserved motif of transcallosal interactions in mammalian sensory and motor cortices.  ...  Inter-hemispheric inhibition is an instance of a more general feature of mammalian neural systems, whereby inhibitory interneurons act not simply to prevent over-excitation but to sculpt the output of  ...  In this case therefore, the variations in the response profiles of the two types of pyramidal neuron are brought about by differences in the architecture of the networks in which they are imbedded, rather  ... 
arXiv:2002.05774v1 fatcat:agbw2mywknhsxcr4yeuk5sznam

A Reproducible Triple-Network Neurobiology of Depressive Rumination [article]

Derek Pisner, Jason Shumake, Christopher Beevers, David Schnyer
2018 bioRxiv   pre-print
Ultimately, thirty-one findings replicated fully or partially, lending support to the conclusion that individual differences in WM microstructure, resting-state functional connectivity of the triple-network  ...  The underlying white-matter (WM) microstructure supporting these networks and its precise role in DR remains unknown, however.  ...  in a number of ways.  ... 
doi:10.1101/365759 fatcat:yxuizrcw7nckjibw65lt4zqnna

Dentate Gyrus Volume Mediates the Effect of Fornix Microstructure on Memory Formation in Older Adults

Dayana Hayek, Friederike Thams, Agnes Flöel, Daria Antonenko
2020 Frontiers in Aging Neuroscience  
In 30 older adults, we acquired diffusion tensor and T1-weighted images for individual deterministic tractography and volume estimation.  ...  Our study offers a neurobehavioral model to explain variability in memory retrieval in older adults, an important prerequisite for the development of interventions to counteract cognitive decline.  ...  This manuscript includes content from a Ph.D. thesis that is in line with the author's university policy, and can be accessed online (Hayek, 2019) .  ... 
doi:10.3389/fnagi.2020.00079 pmid:32265687 pmcid:PMC7098987 fatcat:5eztreb4wre6xh2x2u76v2gz7e

Emotion Regulation and Trait Anxiety Are Predicted by the Microstructure of Fibers between Amygdala and Prefrontal Cortex

Annuschka Salima Eden, Jan Schreiber, Alfred Anwander, Katharina Keuper, Inga Laeger, Peter Zwanzger, Pienie Zwitserlood, Harald Kugel, Christian Dobel
2015 Journal of Neuroscience  
Whereas a specific microstructure is associated with an anxious personality, a different structure subserves emotion regulation. Both are part of a broad fiber tract network between amygdala and PFC.  ...  Trait anxiety predicted the microstructure in pathways to the ventromedial PFC and OFC, indexing weaker connections in trait-anxious persons.  ...  Our data show that different structural networks are responsible for trait anxiety and reappraisal use.  ... 
doi:10.1523/jneurosci.3659-14.2015 pmid:25878275 fatcat:dtxshse57nbzpkt6g7romaqtlq

Probabilistic atlases of default mode, executive control and salience network white matter tracts: an fMRI-guided diffusion tensor imaging and tractography study

Teresa D. Figley, Navdeep Bhullar, Susan M. Courtney, Chase R. Figley
2015 Frontiers in Human Neuroscience  
In this study, we performed fMRI-guided DTI tractography between all of the previously defined nodes within each of six common resting-state brain networks, including the: dorsal Default Mode Network (  ...  a comprehensive cohort of functionally-defined white matter regions that can be used in future brain imaging studies to: (1) ascribe DTI or other white matter changes to particular functional brain networks  ...  Based on these atlases, future studies will be able to nominally attribute localized microstructural changes (either between groups or among individual patients) to a particular functional brain network  ... 
doi:10.3389/fnhum.2015.00585 pmid:26578930 pmcid:PMC4630538 fatcat:zhk5mu5jovhhnjblxs7tuobovq

Abnormal functional connectivity during visuospatial processing is associated with disrupted organisation of white matter in autism

Jane McGrath, Katherine Johnson, Erik O'Hanlon, Hugh Garavan, Alexander Leemans, Louise Gallagher
2013 Frontiers in Human Neuroscience  
Regions for tractography were generated from the results of a previous study, in which 10 pairs of brain regions showed abnormal functional connectivity during visuospatial processing in ASD.  ...  Using a multimodal imaging approach, this study has revealed aberrant WM microstructure in tracts that directly connect brain regions that are abnormally functionally connected in ASD.  ...  ACKNOWLEDGMENTS We wish to thank all the families who participated in this study, Mr. Sean Brennan and Dr. Miriam Law-Smith for help with recruitment, and Dr. Flavio Dell'Acqua, Dr. Marco Catani, Dr.  ... 
doi:10.3389/fnhum.2013.00434 pmid:24133425 pmcid:PMC3783945 fatcat:rp4qg32jr5evhl2jz4rwshudxu

Measuring macroscopic brain connections in vivo

Saad Jbabdi, Stamatios N Sotiropoulos, Suzanne N Haber, David C Van Essen, Timothy E Behrens
2015 Nature Neuroscience  
Decades of detailed anatomical tracer studies in non-human animals point to a rich and complex organization of long-range white matter connections in the brain.  ...  State-of-the art in vivo imaging techniques are striving to achieve a similar level of detail in humans, but multiple technical factors can limit their sensitivity and fidelity.  ...  Health Blueprint for Neuroscience (1U54MH091657-01), the US National Institutes of Health (R01 MH-60974) and the National Institute of Mental Health (P50 MH106435).  ... 
doi:10.1038/nn.4134 pmid:26505566 fatcat:6tth5q3onfbjdehkmcxqbn22ku

Function and Structure of the Right Inferior Frontal Cortex Predict Individual Differences in Response Inhibition: A Model-Based Approach

B. U. Forstmann, S. Jahfari, H. S. Scholte, U. Wolfensteller, W. P. M. van den Wildenberg, K. R. Ridderinkhof
2008 Journal of Neuroscience  
Individual differences in RT distribution parameters not only can be used to probe the efficiency and temporal dynamics of selective response inhibition, but also allow a more detailed analysis of functional  ...  The aim of the present study was to specify the relationship between model parameters of response inhibition and their functional and structural underpinnings in the brain.  ...  We studied selective response inhibition in the Simon task by capitalizing on individual differences in RT distribution parameters.  ... 
doi:10.1523/jneurosci.1465-08.2008 pmid:18815263 fatcat:u3g57kfmg5c5xc5whdfu6iaic4

Connectivity-based structural and functional parcellation of the human cortex using diffusion imaging and tractography

Lauren L. Cloutman, Matthew A. Lambon Ralph
2012 Frontiers in Neuroanatomy  
Diffusion tractography remains one of the only methods capable of visualizing the structural networks of the brain in vivo.  ...  In the current review, we explore the use of in vivo diffusion imaging and white matter tractography as a non-invasive method for the structural and functional parcellation of the human cerebral cortex  ...  There is a degree of error inherent in any estimation of the diffusion tensor within a given voxel, producing a level of uncertainty in the prediction of fiber orientation.  ... 
doi:10.3389/fnana.2012.00034 pmid:22952459 pmcid:PMC3429885 fatcat:66lmud5jkngq7kzbx6ydy7yvxu
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