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Long-term Outcome of Preterm Infants and the Role of Neuroimaging

Eliza Myers, Laura R. Ment
2009 Clinics of Perinatology  
These authors tracked 129 preterms (median BW 794 gm and 27 weeks GA) for 6-10 years and found that cognitive developmental prognosis at term corrected age was only 49% correct, with almost 40% "false  ...  Hack et al. describe 330 preterms (mean BW 811 gm and 26.4 weeks CGA) in whom a subnormal Mental Developmental Index score at corrected age 20 months is poorly predictive of cognitive function at age 8  ... 
doi:10.1016/j.clp.2009.07.008 pmid:19944835 pmcid:PMC3808964 fatcat:6l62zyqcpvb7rdaarzwelvtjda

Diffusion MRI Microstructural Abnormalities at Term-Equivalent Age Are Associated with Neurodevelopmental Outcomes at 3 Years of Age in Very Preterm Infants

M N Parikh, M Chen, A Braimah, J Kline, K McNally, J W Logan, L Tamm, K O Yeates, W Yuan, L He, N A Parikh
2021 American Journal of Neuroradiology  
Our objective was to evaluate the microstructural antecedents of cognitive and motor outcomes at 3 years' corrected age in a cohort of very preterm infants.  ...  We identified widespread microstructural white matter abnormalities in very preterm infants at term that were significantly associated with cognitive and motor development at 3 years' corrected age.  ...  DISCUSSION We used TBSS, a well-established, objective, whole-brain tool, to quantify microstructural development in infants born very preterm at term-equivalent age and to identify brain regions in which  ... 
doi:10.3174/ajnr.a7135 pmid:33958330 pmcid:PMC8367615 fatcat:xmmpfdwct5hihleydomowo7ahq

Cortical folding of the preterm brain: a longitudinal analysis of extremely preterm born neonates using spectral matching

Eliza Orasanu, Andrew Melbourne, Manuel Jorge Cardoso, Herve Lomabert, Giles S. Kendall, Nicola J. Robertson, Neil Marlow, Sebastien Ourselin
2016 Brain and Behavior  
In these infants birth coincides with a period of rapid brain growth and development, when the brain is also vulnerable to a range of insults.  ...  gestational age in nine extremely preterm born infants.  ...  This work is supported by the EPSRC-funded UCL Centre for Doctoral Training in Medical Imaging (EP/L016478/1).  ... 
doi:10.1002/brb3.488 pmid:27257515 pmcid:PMC4873564 fatcat:3ifb5vubyzax5fy3ldeguezbt4

Development of Cortical Morphology Evaluated with Longitudinal MR Brain Images of Preterm Infants

Pim Moeskops, Manon J. N. L. Benders, Karina J. Kersbergen, Floris Groenendaal, Linda S. de Vries, Max A. Viergever, Ivana Išgum, Huiguang He
2015 PLoS ONE  
The aim of this study was to quantitatively describe cortical development in a cohort of 85 preterm infants with and without brain injury imaged at 30 and 40 weeks postmenstrual age (PMA).  ...  This was more pronounced at 40 weeks PMA than at 30 weeks PMA, suggesting that the period between 30 and 40 weeks PMA might provide a window of opportunity for intervention to prevent delay in cortical  ...  Acknowledgments This study included infants participating in the Neobrain study (LSHM-CT-2006-036534) and infants from a study funded by the Wilhelmina Research Fund (10-427). Author Contributions  ... 
doi:10.1371/journal.pone.0131552 pmid:26161536 pmcid:PMC4498793 fatcat:7lcglmnmhncd7ivn2ogguwoxsa

Social brain circuitry and social cognition in infants born preterm

Angela Fenoglio, Michael K. Georgieff, Jed T. Elison
2017 Journal of Neurodevelopmental Disorders  
development in infants and children born preterm.  ...  Next, findings from studies of structural and functional brain development in infants born preterm are reviewed, with an eye toward the distinctive role of the brain circuits implicated in social functioning  ...  The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Availability of data and materials Not applicable.  ... 
doi:10.1186/s11689-017-9206-9 pmid:28729888 fatcat:u4ywa5jwdrgavpjgpc3dthzzfu

Non-right-handedness in children born extremely preterm: Relation to early neuroimaging and long-term neurodevelopment

Alise A. van Heerwaarde, Laura T. van der Kamp, Niek E. van der Aa, Linda S. de Vries, Floris Groenendaal, Marian J. Jongmans, Rian J. C. Eijsermans, Corine Koopman-Esseboom, Inge-Lot C. van Haastert, Manon J. N. L. Benders, Jeroen Dudink, Emma Duerden
2020 PLoS ONE  
(<28 weeks gestation). 179 children born extremely preterm admitted to the Neonatal Intensive Care Unit of our tertiary centre from 2006-2013 were included in a prospective longitudinal cohort study.  ...  This study aimed to define the prevalence and predictors of non-right-handedness and its link to long-term neurodevelopmental outcome and early neuroimaging in a cohort of children born extremely preterm  ...  To our knowledge, this has been the only DTI study exploring handedness in children born preterm and no studies in extremely preterm (EPT; [<28 weeks gestation]) cohorts have yet been conducted.  ... 
doi:10.1371/journal.pone.0235311 pmid:32628734 fatcat:x2dkhpkzzvbhbnak7gl2kfgbi4

Slower Postnatal Growth Is Associated with Delayed Cerebral Cortical Maturation in Preterm Newborns

J. Vinall, R. E. Grunau, R. Brant, V. Chau, K. J. Poskitt, A. R. Synnes, S. P. Miller
2013 Science Translational Medicine  
Therefore, we examined the association between neonatal growth and diffusion tensor imaging measures of microstructural cortical development in infants born very preterm.  ...  Participants were 95 neonates born between 24 and 32 weeks gestational age studied twice with diffusion tensor imaging: scan 1 at a median of 32.1 weeks (interquartile range, 30.4 to 33.6) and scan 2 at  ...  Additionally, the rate of change in cortical surface area between 24 and 44 weeks postmenstrual age predicts cognitive ability at 2 and 6 years corrected age in children born very preterm (18) .  ... 
doi:10.1126/scitranslmed.3004666 pmid:23325801 fatcat:2oey25jydfdvbdkznkbz4oap54

A tract-specific approach to assessing white matter in preterm infants

Diliana Pecheva, Paul Yushkevich, Dafnis Batalle, Emer Hughes, Paul Aljabar, Julia Wurie, Joseph V. Hajnal, A. David Edwards, Daniel C. Alexander, Serena J. Counsell, Hui Zhang
2017 NeuroImage  
Maturation of thalamic radiations between 34 and 41 weeks' gestation: a combined voxel-based study and probabilistic tractography with diffusion tensor imaging. AJNR Am J Neuroradiol 30, 1780-1786.  ...  A tract-specific approach to assessing white matter in preterm infants, NeuroImage, http://dx., E., Chau, V., Poskitt, K.J., Grunau, R.E., Synnes, A., Miller, S.P., 2010.  ...  Microstructural brain development between 30 and 40 weeks corrected age in a longitudinal cohort of extremely preterm infants. R.V., 2009.  ... 
doi:10.1016/j.neuroimage.2017.04.057 pmid:28457976 pmcid:PMC5607355 fatcat:ozfftmipjne4ng7uvkdshpoxjy

Language ability in preterm children is associated with arcuate fasciculi microstructure at term

Piergiorgio Salvan, J. Donald Tournier, Dafnis Batalle, Shona Falconer, Andrew Chew, Nigel Kennea, Paul Aljabar, Ghislaine Dehaene-Lambertz, Tomoki Arichi, A. David Edwards, Serena J. Counsell
2017 Human Brain Mapping  
We imaged a cohort of 43 preterm born infants (median age at birth of 30 gestational weeks; median age at scan of 42 postmenstrual weeks) using high b value high-angular resolution diffusion-weighted neuroimaging  ...  These findings suggest that differences in arcuate fasciculi microstructure at the time of normal birth have a significant impact on language development and modulate the first stages of language learning  ...  A cohort of 43 preterm born infants [median age at birth of 30.14 gestational (GA) weeks; range 24-32; 18 females] with no evidence of focal abnormality on MRI were imaged using high-angular resolution  ... 
doi:10.1002/hbm.23632 pmid:28470961 pmcid:PMC5518442 fatcat:ohtkt3dcmfhujorld2bdd6g2yi

Magnetic Resonance Spectroscopy at Term-Equivalent Age in Extremely Preterm Infants: Association With Cognitive and Language Development

Roopali Bapat, Ponnada A. Narayana, Yuxiang Zhou, Nehal A. Parikh
2014 Pediatric Neurology  
METHODS-Single-voxel point-resolved spectroscopy sequence was performed in a prospective cohort of 43 infants.  ...  between magnetic resonance spectroscopy metabolites and cognitive and language development at 18-22 months' corrected age.  ...  Acknowledgments The funding agencies played no role in the design, conduct, or analysis of the trial. The authors take full responsibility for the integrity of the data and analyses.  ... 
doi:10.1016/j.pediatrneurol.2014.03.011 pmid:24938140 pmcid:PMC5942892 fatcat:ixanv6uavbgqdfodynokkv42vq

Analysis of Brain Injury Biomarker Neurofilament Light and Neurodevelopmental Outcomes and Retinopathy of Prematurity Among Preterm Infants

Ulrika Sjöbom, William Hellström, Chatarina Löfqvist, Anders K. Nilsson, Gerd Holmström, Ingrid Hansen Pupp, David Ley, Kaj Blennow, Henrik Zetterberg, Karin Sävman, Ann Hellström
2021 JAMA Network Open  
To examine postnatal longitudinal serum levels of NfL and GFAP in preterm infants during the first 15 weeks of life and to explore possible associations between these biomarkers, neonatal morbidities,  ...  Circulating levels of neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) are important in the course of brain injury in adults, but longitudinal postnatal circulating levels in preterm  ...  outcomes were assessed by Bayley Scales of Infant Development (BSID) at 2 years of corrected age in cohorts 2 (n = 48) and 3 (n = 72).  ... 
doi:10.1001/jamanetworkopen.2021.4138 pmid:33797551 fatcat:t7wjbzly4zai7be4jmg3xg2b5i

Brain White Matter Maturation and Early Developmental Outcomes in Preterm Infants With Retinopathy of Prematurity

Seong Joon Ahn, Joo Young Lee, Ji Young Lee, Young-Jun Lee, Jong-Min Lee, Byung Ro Lee, Jinsup Kim, Hyun Ju Lee
2021 Investigative Ophthalmology and Visual Science  
To investigate brain white matter pathways using magnetic resonance diffusion tensor imaging (DTI) and correlate the findings with developmental outcomes at 18 months of corrected age in preterm infants  ...  Developmental outcomes were assessed using the third edition of Bayley Scales of Infant and Toddler Development (BSID-III) at 18 months of corrected age.  ...  METHODS Participants A prospective observational cohort of 98 preterm infants (born at a gestational age [GA] of <37 weeks) was recruited from the neonatal intensive care unit of Hanyang University Seoul  ... 
doi:10.1167/iovs.62.2.2 pmid:33523200 pmcid:PMC7862727 fatcat:i6zzslqw4vgyrnox4zm7sjvvoe

Preterm infants with isolated cerebellar hemorrhage show bilateral cortical alterations at term equivalent age

Aicha B. C. Dijkshoorn, Elise Turk, Lisa M. Hortensius, Niek E. van der Aa, Freek E. Hoebeek, Floris Groenendaal, Manon J. N. L. Benders, Jeroen Dudink
2020 Scientific Reports  
Each CbH infant was matched with their own preterm infant cohort (range: 20-36 infants) based on sex and gestational age at birth.  ...  In this retrospective case series study, we used MRI and advanced surface-based analyses to reconstruct gray matter (GM) changes in cortical thickness and cortical surface area in extremely preterm neonates  ...  Acknowledgements We thank the families who took part in the study and our colleagues in the Neonatal Intensive Care Unit at Wilhelmina Children's hospital. In addition, we would like to thank dr.  ... 
doi:10.1038/s41598-020-62078-9 pmid:32210267 fatcat:i4x5or6iuvg6pkzsrwppbg4vt4

Diffusion magnetic resonance imaging assessment of regional white matter maturation in preterm neonates

J. A. Kimpton, D. Batalle, M. L. Barnett, E. J. Hughes, A. T. M. Chew, S. Falconer, J. D. Tournier, D. Alexander, H. Zhang, A. D. Edwards, S. J. Counsell
2020 Neuroradiology  
This study investigated microstructural maturation of WM in preterm neonates scanned between 25 and 45 weeks postmenstrual age (PMA) with normal neurodevelopmental outcomes at 2 years using DTI and NODDI  ...  Purpose Diffusion magnetic resonance imaging (dMRI) studies report altered white matter (WM) development in preterm infants.  ...  Acknowledgments We are grateful to the families, clinicians and investigators who made this study possible.  ... 
doi:10.1007/s00234-020-02584-9 pmid:33123752 pmcid:PMC7966229 fatcat:cbdpcpd7snh4vdjcw5m7zt4hpm

Neonatal Pain in Very Preterm Infants: Long-Term Effects on Brain, Neurodevelopment and Pain Reactivity

Ruth Eckstein Grunau
2013 Rambam Maimonides Medical Journal  
, programming of stress systems, and later pain sensitivity in infants born very preterm (24-32 weeks' gestational age).  ...  Emerging studies provide convincing clinical evidence for an adverse impact of neonatal pain/stress in infants at a time of physiological immaturity, rapidly developing brain microstructure and networks  ...  In a longitudinal cohort of preterm infants followed from birth to school-age, Grunau, Ribary, and colleagues examined whether neonatal pain is associated with functional brain activity later in childhood  ... 
doi:10.5041/rmmj.10132 pmid:24228168 pmcid:PMC3820298 fatcat:kmnlrii2undt3pdbjgwudwlku4
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