1,526 Hits in 1.8 sec

Remote Control of a Scanning Electron Microsocpe Using Asynchronous Transfer Mode

Nancy R. Smith, Don Pardoe, Corinne Pelote, Mark Honer, Christopher L. Morgan
1996 Microscopy Today  
California State University, Hayward has successfully demonstrated remote control of a scanning electron microscope (SEM) using Asynchronous Transfer Mode (ATM).  ...  into larger virtual instruments, rapid access to available resources, and pooling of knowledge by a larger community.The advent of high speed networks such as ATM offers the possibility of integrated  ...  Multiplexing equipment allows various combinations of digital Carbon Build-up Stopped!  ... 
doi:10.1017/s1551929500067535 fatcat:zvwa4lldp5dq7adynpxjkb5p2m

Implication of Checkpoint Kinase-dependent Up-regulation of Ribonucleotide Reductase R2 in DNA Damage Response

Yong-Wei Zhang, Tamara L. Jones, Scott E. Martin, Natasha J. Caplen, Yves Pommier
2009 Journal of Biological Chemistry  
Silencing of ATR or ATM and inhibition of ATM activity by KU-55933 blocked Chk1 activation and RRM2 up-regulation.  ...  -300 confocal microscope software as shown in the graphs; right, quantitation of the ratio of cells with nuclear RRM2 signals with or without CPT treatment.  ...  Acknowledgments-Qiagen Inc. supplied some of the RNAi reagents used in this study to the NCI as part of a Collaborative Research Agreement.  ... 
doi:10.1074/jbc.m109.003020 pmid:19416980 pmcid:PMC2709352 fatcat:tkpx7czmxnej7nsnzva3qijism

A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX phosphorylation in human peripheral blood mononuclear cells

Christopher J. Bakkenist, R. Kenneth Czambel, Pamela A. Hershberger, Hussein Tawbi, Jan H. Beumer, John C. Schmitz
2015 Oncoscience  
Here we report the pre-clinical analytical validation and fit-for-purpose biomarker method validation of a quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX phosphorylation  ...  Inhibitors of DNA repair enzymes including APE1, ATM, ATR, DNA-PK and PARP have been developed and the PARP inhibitor olaparib is the first-in-class approved in Europe and the USA for the treatment of  ...  Microscopic γH2AX foci are widely used as a PD biomarker for DNA double-strand breaks (DSBs) in cells.  ... 
doi:10.18632/oncoscience.162 pmid:26097887 pmcid:PMC4468340 fatcat:v36qtvmetjed3norgvol2w7svi

Page 660 of Mathematical Reviews Vol. , Issue 2004a [page]

2004 Mathematical Reviews  
A Markov chain model of an ATM multiplexer with Bernoulli random traffic sources is analyzed. Laurent Decreusefond (F-ENST-INR; Paris) 2004a:90015 90B20 Lee, C. C.  ...  {For the entire collection see MR 2003j:90003. } Mark Kelbert (4-WALSB; Swansea) 2004a:90014 90B20 Chiang, Shu-Yin Performance analysis of ATM multiplexer with Bernoulli traffic sources.  ... 

Targeted Mass Spectrometry Enables Quantification of Novel Pharmacodynamic Biomarkers of ATM Kinase Inhibition

Jeffrey R. Whiteaker, Tao Wang, Lei Zhao, Regine M. Schoenherr, Jacob J. Kennedy, Ulianna Voytovich, Richard G. Ivey, Dongqing Huang, Chenwei Lin, Simona Colantonio, Tessa W. Caceres, Rhonda R. Roberts (+16 others)
2021 Cancers  
The ATM serine/threonine kinase (HGNC: ATM) is involved in initiation of repair of DNA double-stranded breaks, and ATM inhibitors are currently being tested as anti-cancer agents in clinical trials, where  ...  To identify and quantify PD biomarkers of ATM inhibition, we developed and analytically validated a 51-plex assay (DDR-2) quantifying protein expression and DNA damage-responsive phosphorylation.  ...  in response to DNA damage, we used a model system (human LCL-57; ATM +/+) to profile the response to DNA damage after exposure to IR.  ... 
doi:10.3390/cancers13153843 pmid:34359745 pmcid:PMC8345163 fatcat:uzqdwdquwvb53bejv45ew3icwi


Peter M. Schlag
1999 Archives of Surgery  
Three-dimensional image reconstruction is warranted, and if such data shall be useful during surgery, different image sources must be combined into some virtual, multiparametric body model and matched  ...  T he vision of telesurgery comprises a multitude of new communicative elements influencing the way surgeons will treat their patients in the future.  ...  this model of collegial reassurance and specialist consultation will certainly grow.  ... 
doi:10.1001/archsurg.134.11.1216 pmid:10555636 fatcat:fzwsqoyigjaefl3cu62thlx5yq

Radon spectroscopy of packet delay [chapter]

Andre Broido, Ryan King, Evi Nemeth, K.C. Claffy
2003 Teletraffic science and engineering  
We demonstrate the feasibility of Internet spectroscopy techniques for analysis of rate limiting, packet interarrival delay and passive bitrate estimation of cell-or slot-based broadband connections.  ...  They also restrict the choice of multiplexing schemes and connection topology.  ...  of ATM cell delay.  ... 
doi:10.1016/s1388-3437(03)80187-7 fatcat:yqdfnkqstnd65jfueeli46pun4

An Analytical Description of the Packet Train Model for LAN traffic characterization [chapter]

Maurice Gagnaire, Daniel Kofman, Hayri Korezlioglu
1995 Performance Modelling and Evaluation of ATM Networks  
This model allows to faithfully describe the statistical behaviour of LAN traffic by means of computer simulations.  ...  We propose an approach for mapping experimental measurements to the various parameters of our model.  ...  INTRODUCTION B-ISDNs are based on the ATM technique. This technique allows a gain in the network resource utilization when statistical multiplexing is used.  ... 
doi:10.1007/978-0-387-34881-0_1 fatcat:voh4oaaop5dwbgy5i7arnbax7u

High Capacity Nanoporous Silicon Carrier for Systemic Delivery of Gene Silencing Therapeutics

Jianliang Shen, Rong Xu, Junhua Mai, Han-Cheon Kim, Xiaojing Guo, Guoting Qin, Yong Yang, Joy Wolfram, Chaofeng Mu, Xiaojun Xia, Jianhua Gu, Xuewu Liu (+3 others)
2013 ACS Nano  
Treatment of cells with a microRNA-18a mimic in PCPS (PCPS/miR-18) knocked down 90% expression of the microRNA-18a target gene ATM.  ...  Systemic delivery of PCPS/STAT3 siRNA in murine model of MDA-MB-231 breast cancer enriched particles in tumor tissues and reduced STAT3 expression in cancer cells, causing significant reduction of cancer  ...  Acknowledgments The authors acknowledge financial support from the following sources: Department of Defense grants W81XWH-09-1-0212 and W81XWH-12-1-0414, National Institute of Health grants U54CA143837  ... 
doi:10.1021/nn4035316 pmid:24131405 pmcid:PMC3868485 fatcat:sj6on6ksargkpclsxjt5kuwpqu

ATM Phosphorylation Kinetics as a Biological Reporter of Cellular Radiosensitivity

A. Lavaf, J. Kao, S. Peters
2007 International Journal of Radiation Oncology, Biology, Physics  
We hypothesize that quantitative analysis of ATM autophosphorylation may serve as a reporter of DNA damage induction and repair after IR in two ATM wild-type prostate cancer cell lines PC-3 and DU-145  ...  RESULTS: Within 10 min after IR, discrete foci of ATM autophosphorylation appeared at putative sites of DNA strand breaks.  ...  We also examined the spatial distribution of ATM autophosphorylation and H2AX foci after IR by using a multiplexed immunofluorescence assays.  ... 
doi:10.1016/j.ijrobp.2007.07.120 fatcat:peuofrruwrgcxnzufishf2pj7i

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

David Patsouris, Ping-Ping Li, Divya Thapar, Justin Chapman, Jerrold M. Olefsky, Jaap G. Neels
2008 Cell Metabolism  
in obese mouse models.  ...  Here, we used a conditional cell ablation system, based on transgenic expression of the diphtheria toxin receptor under the control of the CD11c promoter, to study the effects of depletion of CD11c + cells  ...  the study and completed the bone marrow transplantations, DT treatments, GTTs, ITTs, clamp studies, tissue harvests, immunohistological analyses, data analysis, and manuscript preparation as a member of  ... 
doi:10.1016/j.cmet.2008.08.015 pmid:18840360 pmcid:PMC2630775 fatcat:nctwaaj5qvdcxmhh3y74ytxo7u

Genetic variation and radiation quality impact cancer promoting cellular phenotypes in response to HZE exposure

Deepa M. Sridharan, Shiena Enerio, Chris Wang, Mark A. LaBarge, Martha R. Stampfer, Janice M. Pluth
2019 Life Sciences in Space Research  
repair genes; BRCA1, BRCA2 and ATM.  ...  The aberration frequency increases with dose, complexity of the lesion generated by different radiation qualities and age of the individual.  ...  Conflict of interest The authors declare no competing financial interests.  ... 
doi:10.1016/j.lssr.2018.10.002 fatcat:6bmaeu24urdsxnrj3466hbxnb4

Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress

Rebecca L Lloyd, Vaclav Urban, Francisco Muñoz-Martínez, Iñigo Ayestaran, John C Thomas, Christelle de Renty, Mark J O'Connor, Josep V Forment, Yaron Galanty, Stephen P Jackson
2021 Nucleic Acids Research  
Strikingly, two of the strongest resistance-gene hits in both ATM-proficient and ATM-deficient cells encode Cyclin C and CDK8: members of the CDK8 kinase module for the RNA polymerase II mediator complex  ...  Overall, our work identifies novel biomarkers of ATRi efficacy in ATM-proficient and ATM-deficient cells, and highlights transcription-associated replication stress as a predominant driver of ATRi-induced  ...  from the School of Biological Sciences, and the Wellcome-MRC Institute of Metabolic Science -Metabolic Research Laboratories Imaging Core (Wellcome Trust Major Award grant 208363/Z/17/Z).  ... 
doi:10.1093/nar/gkab628 pmid:34329458 pmcid:PMC8421211 fatcat:xlo3uweujzff3iu4dujctvz76e

Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species

Jane L. Roberts, Andrew Poklepovic, Laurence Booth
2017 OncoTarget  
Multiplex analyses of plasma taken after drug exposure at animal nadir indicated that the levels of M-CSF, CXCL-9, PDGF and G-CSF were significantly increased by [curcumin + sildenafil] and that expression  ...  The present studies focused on the ability of the phosphodiesterase 5 (PDE5) inhibitor sildenafil to enhance the anti-cancer properties of clinically relevant concentrations of the dietary diarylheptanoid  ...  Young and the Betts family fund for support in the purchase of the Hermes Wiscan instrument. Thanks to Dr. David. L. Boone for providing the HCT116 cell clones.  ... 
doi:10.18632/oncotarget.19807 pmid:29245915 pmcid:PMC5725106 fatcat:hdqvauotyzc5javdidfs5hntie

Genistein Sensitizes Bladder Cancer Cells to HCPT Treatment In Vitro and In Vivo via ATM/NF-κB/IKK Pathway-Induced Apoptosis

Yong Wang, He Wang, Wei Zhang, Chen Shao, Peng Xu, Chang Hong Shi, Jian Guo Shi, Yu Mei Li, Qiang Fu, Wei Xue, Yong Hua Lei, Jing Yu Gao (+6 others)
2013 PLoS ONE  
Genistein significantly attenuated the ability of HCPT to induce activation of the antiapoptotic NF-kB pathway both in vitro and in vivo in a bladder cancer xenograft model, and thus counteracted the antiapoptotic  ...  Pretreatment with genistein sensitized BDEC and bladder cancer cell lines to HCPT-induced DNA damage by the synergistic activation of ataxia telangiectasia mutated (ATM) kinase.  ...  Claudia Buehnemann (University of Oxford, UK) for her excellent technical assistance. Author Contributions  ... 
doi:10.1371/journal.pone.0050175 pmid:23365634 pmcid:PMC3554754 fatcat:dmmqosfk7bh7jif74tmdreu5pi
« Previous Showing results 1 — 15 out of 1,526 results