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Remote Control of a Scanning Electron Microsocpe Using Asynchronous Transfer Mode
1996
Microscopy Today
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California State University, Hayward has successfully demonstrated remote control of a scanning electron microscope (SEM) using Asynchronous Transfer Mode (ATM). ...
into larger virtual instruments, rapid access to available resources, and pooling of knowledge by a larger community.The advent of high speed networks such as ATM offers the possibility of integrated ...
Multiplexing equipment allows various combinations of digital Carbon Build-up Stopped! ...
doi:10.1017/s1551929500067535
fatcat:zvwa4lldp5dq7adynpxjkb5p2m
Implication of Checkpoint Kinase-dependent Up-regulation of Ribonucleotide Reductase R2 in DNA Damage Response
2009
Journal of Biological Chemistry
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Silencing of ATR or ATM and inhibition of ATM activity by KU-55933 blocked Chk1 activation and RRM2 up-regulation. ...
-300 confocal microscope software as shown in the graphs; right, quantitation of the ratio of cells with nuclear RRM2 signals with or without CPT treatment. ...
Acknowledgments-Qiagen Inc. supplied some of the RNAi reagents used in this study to the NCI as part of a Collaborative Research Agreement. ...
doi:10.1074/jbc.m109.003020
pmid:19416980
pmcid:PMC2709352
fatcat:tkpx7czmxnej7nsnzva3qijism
A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX phosphorylation in human peripheral blood mononuclear cells
2015
Oncoscience
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Here we report the pre-clinical analytical validation and fit-for-purpose biomarker method validation of a quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX phosphorylation ...
Inhibitors of DNA repair enzymes including APE1, ATM, ATR, DNA-PK and PARP have been developed and the PARP inhibitor olaparib is the first-in-class approved in Europe and the USA for the treatment of ...
Microscopic γH2AX foci are widely used as a PD biomarker for DNA double-strand breaks (DSBs) in cells. ...
doi:10.18632/oncoscience.162
pmid:26097887
pmcid:PMC4468340
fatcat:v36qtvmetjed3norgvol2w7svi
Page 660 of Mathematical Reviews Vol. , Issue 2004a
[page]
2004
Mathematical Reviews
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A Markov chain model of an ATM multiplexer with Bernoulli random traffic sources is analyzed. Laurent Decreusefond (F-ENST-INR; Paris)
2004a:90015 90B20
Lee, C. C. ...
{For the entire collection see MR 2003j:90003. } Mark Kelbert (4-WALSB; Swansea)
2004a:90014 90B20 Chiang, Shu-Yin Performance analysis of ATM multiplexer with Bernoulli traffic sources. ...
Targeted Mass Spectrometry Enables Quantification of Novel Pharmacodynamic Biomarkers of ATM Kinase Inhibition
2021
Cancers
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The ATM serine/threonine kinase (HGNC: ATM) is involved in initiation of repair of DNA double-stranded breaks, and ATM inhibitors are currently being tested as anti-cancer agents in clinical trials, where ...
To identify and quantify PD biomarkers of ATM inhibition, we developed and analytically validated a 51-plex assay (DDR-2) quantifying protein expression and DNA damage-responsive phosphorylation. ...
in response to DNA damage, we used a model system (human LCL-57; ATM +/+) to profile the response to DNA damage after exposure to IR. ...
doi:10.3390/cancers13153843
pmid:34359745
pmcid:PMC8345163
fatcat:uzqdwdquwvb53bejv45ew3icwi
Telemedicine
1999
Archives of Surgery
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Three-dimensional image reconstruction is warranted, and if such data shall be useful during surgery, different image sources must be combined into some virtual, multiparametric body model and matched ...
T he vision of telesurgery comprises a multitude of new communicative elements influencing the way surgeons will treat their patients in the future. ...
this model of collegial reassurance and specialist consultation will certainly grow. ...
doi:10.1001/archsurg.134.11.1216
pmid:10555636
fatcat:fzwsqoyigjaefl3cu62thlx5yq
Radon spectroscopy of packet delay
[chapter]
2003
Teletraffic science and engineering
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We demonstrate the feasibility of Internet spectroscopy techniques for analysis of rate limiting, packet interarrival delay and passive bitrate estimation of cell-or slot-based broadband connections. ...
They also restrict the choice of multiplexing schemes and connection topology. ...
of ATM cell delay. ...
doi:10.1016/s1388-3437(03)80187-7
fatcat:yqdfnkqstnd65jfueeli46pun4
An Analytical Description of the Packet Train Model for LAN traffic characterization
[chapter]
1995
Performance Modelling and Evaluation of ATM Networks
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This model allows to faithfully describe the statistical behaviour of LAN traffic by means of computer simulations. ...
We propose an approach for mapping experimental measurements to the various parameters of our model. ...
INTRODUCTION B-ISDNs are based on the ATM technique. This technique allows a gain in the network resource utilization when statistical multiplexing is used. ...
doi:10.1007/978-0-387-34881-0_1
fatcat:voh4oaaop5dwbgy5i7arnbax7u
High Capacity Nanoporous Silicon Carrier for Systemic Delivery of Gene Silencing Therapeutics
2013
ACS Nano
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Treatment of cells with a microRNA-18a mimic in PCPS (PCPS/miR-18) knocked down 90% expression of the microRNA-18a target gene ATM. ...
Systemic delivery of PCPS/STAT3 siRNA in murine model of MDA-MB-231 breast cancer enriched particles in tumor tissues and reduced STAT3 expression in cancer cells, causing significant reduction of cancer ...
Acknowledgments The authors acknowledge financial support from the following sources: Department of Defense grants W81XWH-09-1-0212 and W81XWH-12-1-0414, National Institute of Health grants U54CA143837 ...
doi:10.1021/nn4035316
pmid:24131405
pmcid:PMC3868485
fatcat:sj6on6ksargkpclsxjt5kuwpqu
ATM Phosphorylation Kinetics as a Biological Reporter of Cellular Radiosensitivity
2007
International Journal of Radiation Oncology, Biology, Physics
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We hypothesize that quantitative analysis of ATM autophosphorylation may serve as a reporter of DNA damage induction and repair after IR in two ATM wild-type prostate cancer cell lines PC-3 and DU-145 ...
RESULTS: Within 10 min after IR, discrete foci of ATM autophosphorylation appeared at putative sites of DNA strand breaks. ...
We also examined the spatial distribution of ATM autophosphorylation and H2AX foci after IR by using a multiplexed immunofluorescence assays. ...
doi:10.1016/j.ijrobp.2007.07.120
fatcat:peuofrruwrgcxnzufishf2pj7i
Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals
2008
Cell Metabolism
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in obese mouse models. ...
Here, we used a conditional cell ablation system, based on transgenic expression of the diphtheria toxin receptor under the control of the CD11c promoter, to study the effects of depletion of CD11c + cells ...
the study and completed the bone marrow transplantations, DT treatments, GTTs, ITTs, clamp studies, tissue harvests, immunohistological analyses, data analysis, and manuscript preparation as a member of ...
doi:10.1016/j.cmet.2008.08.015
pmid:18840360
pmcid:PMC2630775
fatcat:nctwaaj5qvdcxmhh3y74ytxo7u
Genetic variation and radiation quality impact cancer promoting cellular phenotypes in response to HZE exposure
2019
Life Sciences in Space Research
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repair genes; BRCA1, BRCA2 and ATM. ...
The aberration frequency increases with dose, complexity of the lesion generated by different radiation qualities and age of the individual. ...
Conflict of interest The authors declare no competing financial interests. ...
doi:10.1016/j.lssr.2018.10.002
fatcat:6bmaeu24urdsxnrj3466hbxnb4
Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress
2021
Nucleic Acids Research
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Strikingly, two of the strongest resistance-gene hits in both ATM-proficient and ATM-deficient cells encode Cyclin C and CDK8: members of the CDK8 kinase module for the RNA polymerase II mediator complex ...
Overall, our work identifies novel biomarkers of ATRi efficacy in ATM-proficient and ATM-deficient cells, and highlights transcription-associated replication stress as a predominant driver of ATRi-induced ...
from the School of Biological Sciences, and the Wellcome-MRC Institute of Metabolic Science -Metabolic Research Laboratories Imaging Core (Wellcome Trust Major Award grant 208363/Z/17/Z). ...
doi:10.1093/nar/gkab628
pmid:34329458
pmcid:PMC8421211
fatcat:xlo3uweujzff3iu4dujctvz76e
Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species
2017
OncoTarget
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Multiplex analyses of plasma taken after drug exposure at animal nadir indicated that the levels of M-CSF, CXCL-9, PDGF and G-CSF were significantly increased by [curcumin + sildenafil] and that expression ...
The present studies focused on the ability of the phosphodiesterase 5 (PDE5) inhibitor sildenafil to enhance the anti-cancer properties of clinically relevant concentrations of the dietary diarylheptanoid ...
Young and the Betts family fund for support in the purchase of the Hermes Wiscan instrument. Thanks to Dr. David. L. Boone for providing the HCT116 cell clones. ...
doi:10.18632/oncotarget.19807
pmid:29245915
pmcid:PMC5725106
fatcat:hdqvauotyzc5javdidfs5hntie
Genistein Sensitizes Bladder Cancer Cells to HCPT Treatment In Vitro and In Vivo via ATM/NF-κB/IKK Pathway-Induced Apoptosis
2013
PLoS ONE
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Genistein significantly attenuated the ability of HCPT to induce activation of the antiapoptotic NF-kB pathway both in vitro and in vivo in a bladder cancer xenograft model, and thus counteracted the antiapoptotic ...
Pretreatment with genistein sensitized BDEC and bladder cancer cell lines to HCPT-induced DNA damage by the synergistic activation of ataxia telangiectasia mutated (ATM) kinase. ...
Claudia Buehnemann (University of Oxford, UK) for her excellent technical assistance.
Author Contributions ...
doi:10.1371/journal.pone.0050175
pmid:23365634
pmcid:PMC3554754
fatcat:dmmqosfk7bh7jif74tmdreu5pi
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