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Dystrophy of Oligodendrocytes and Adjacent Microglia in Prefrontal Gray Matter in Schizophrenia

Natalya A. Uranova, Olga V. Vikhreva, Valentina I. Rakhmanova, Diana D. Orlovskaya
2020 Frontiers in Psychiatry  
Some evidence support the notion that microglia activation in acute state of schizophrenia might contribute to damage of oligodendrocytes and myelinated fibers.  ...  Mitochondria in microglia and oligodendrocytes may be a target for treatment strategy of schizophrenia.  ...  Our study showed different signs of microglial activation in schizophrenia: the presence of activated microglia ( Figure 1B) , contacts between microglial cytoplasm and nucleus of oligodendrocytes in  ... 
doi:10.3389/fpsyt.2020.00204 pmid:32292358 pmcid:PMC7135882 fatcat:bqngpwqfsnggrcaajvfwrangue

Redox and Microglia in the Pathophysiology of Schizophrenia

Takahiro A. Kato, Fuminori Hyodo, Mayumi Yamato, Hideo Utsumi, Shigenobu Kanba
2015 Yakugaku zasshi  
Recent postmortem and imaging studies have indicated microglial activation in the brain of schizophrenia patients.  ...  In addition, minocycline, an antibiotic and the best known inhibitor of microglial activation, has therapeutic e‹cacy in schizophrenia.  ...  Based on theseˆndings, we have suggested that microglia are crucial players in the brain in schizophrenia, and modulating microglia may be a novel therapeutic target.  ... 
doi:10.1248/yakushi.14-00235-4 pmid:25948311 fatcat:4522etx36reanptt3l2cv2sozu

Role of microglia disturbances and immune-related marker abnormalities in cortical circuitry dysfunction in schizophrenia

David W. Volk
2017 Neurobiology of Disease  
Finally, we discuss the role that activated microglia may play in connecting these observations and as potential therapeutic treatment targets in schizophrenia.  ...  Furthermore, direct evidence of cortical immune activation, including markedly elevated levels of many immune-related markers, have been reported in the prefrontal cortex in multiple cohorts of schizophrenia  ...  The Potential Role of Activated Microglia in Cortical Circuitry Dysfunction in Schizophrenia Microglia may play an important role in the cortical circuitry disturbances reported in schizophrenia, such  ... 
doi:10.1016/j.nbd.2016.12.019 pmid:28007586 pmcid:PMC5303150 fatcat:3qorafdh3jcx3ds57sndwn5lae

Microglia Activation and Schizophrenia: Lessons From the Effects of Minocycline on Postnatal Neurogenesis, Neuronal Survival and Synaptic Pruning

Dragos Inta, Undine E. Lang, Stefan Borgwardt, Andreas Meyer-Lindenberg, Peter Gass
2016 Schizophrenia Bulletin  
Further support for increased activation of microglia in schizophrenia comes from recent translocator-protein [ 11 C]PBR28 positron emission tomography (PET) brain imaging data that demonstrated elevated  ...  In this respect, the antibiotic minocycline that effectively inhibits the activation of microglia 5 represents one alternative therapeutic option.  ...  Acknowledgments The authors have declared that there are no conflicts of interest in relation to the subject of this study.  ... 
doi:10.1093/schbul/sbw088 pmid:27352782 pmcid:PMC5464012 fatcat:ixt75fzjgrcjzifi7t4hpnkw2e

Neuroinflammation in Late-Onset Schizophrenia: Viewing from the Standpoint of the Microglia Hypothesis

Akira Monji, Yoshito Mizoguchi
2021 Neuropsychobiology  
Schizophrenia develops mainly in adolescence, but late-onset schizophrenia (LOS) is not uncommon.  ...  This review outlines the abnormalities of the neuroimmune system in the pathophysiology of LOS, especially focusing on the role of microglia.  ...  In a PET study of schizophrenia using a ligand that detects TSPO (translocator protein) that is strongly expressed in activated microglia, microglial activation was significantly enhanced compared to the  ... 
doi:10.1159/000517861 pmid:34515181 fatcat:tyrrgqfzqjfrhbeb6bgz6ofvxm

Inflammation and the neural diathesis-stress hypothesis of schizophrenia: a reconceptualization

O D Howes, R McCutcheon
2017 Translational Psychiatry  
Activation of microglia perinatally may make them vulnerable to subsequent overactivation by stressors experienced in later life.  ...  In addition to immune and traumatic stimuli, microglial activation occurs in response to psychosocial stress.  ...  Stress • Microglia activation in rats ↑by wide range of stressors.• Adolescent stress exposure leads to ↑microglial activation in rats that have experienced prenatal immune activation. • Schizophrenia  ... 
doi:10.1038/tp.2016.278 pmid:28170004 pmcid:PMC5438023 fatcat:3bfuz4ivovf2toqih7dezfvoka

Microglial intracellular Ca2+ signaling as a target of antipsychotic actions for the treatment of schizophrenia

Yoshito Mizoguchi, Takahiro A. Kato, Hideki Horikawa, Akira Monji
2014 Frontiers in Cellular Neuroscience  
Microglia are resident innate immune cells which release many factors including proinflammatory cytokines, nitric oxide (NO) and neurotrophic factors when they are activated in response to immunological  ...  Recent reports show that pathophysiology of schizophrenia is related to the inflammatory responses mediated by microglia.  ...  For example, a quantitative (R)-[(11)C]PK11195 PET scan showed that activated microglia were present in the gray matter of patients suffered from schizophrenia within the first 5 years of disease onset  ... 
doi:10.3389/fncel.2014.00370 pmid:25414641 pmcid:PMC4220695 fatcat:uf6dc5vxabdofppewhz6fow2x4

New Insights Regarding Diagnosis and Medication for Schizophrenia Based on Neuronal Synapse–Microglia Interaction

Naotaka Izuo, Atsumi Nitta
2021 Journal of Personalized Medicine  
Microglia physiologically eliminate unnecessary synapses during the developmental period. The overactivation of synaptic pruning by microglia is involved in the pathology of brain disease.  ...  Recent genetic studies have focused on the association between schizophrenia and the immune system, especially microglia–synapse interactions.  ...  (b) Healthy microglia eliminate complement-tagged synapses with lower activity. In schizophrenia, hyper-ramified microglia prune healthy synapses by the excessive activation of complements.  ... 
doi:10.3390/jpm11050371 pmid:34063598 fatcat:xxrj6bem4bft5hw7xqr5gjwuay

Microglial Dysregulation in Psychiatric Disease

Luciana Romina Frick, Kyle Williams, Christopher Pittenger
2013 Clinical and Developmental Immunology  
Microglia, the brain's resident immune cells, are phagocytes of the macrophage lineage that have a key role in responding to inflammation and immune challenge in the brain.  ...  Here we summarize postmortem, animal, neuroimaging, and other evidence for microglial pathology in major depression, schizophrenia, autism, obsessive-compulsive disorder, and Tourette syndrome.  ...  One of these found differential microglial activation in different clinical subtypes of schizophrenia; HLA-DR + microglia were increased in the posterior hippocampus of individuals with paranoid schizophrenia  ... 
doi:10.1155/2013/608654 pmid:23690824 pmcid:PMC3652125 fatcat:nnhlqwktlbhttezcdalento74i

Profile of minocycline and its potential in the treatment of schizophrenia

Lulu Zhang, Jingping Zhao
2014 Neuropsychiatric Disease and Treatment  
Accumulating evidence suggests that neuroinflammation affecting microglia plays an important role in the etiology of schizophrenia, and appropriate control of microglial activation may be a promising therapeutic  ...  Minocycline, a second-generation tetracycline that inhibits microglial activation, has been shown to have a neuroprotective effect in various models of neurodegenerative disease, including anti-inflammatory  ...  Disclosure The authors report no conflicts of interest in this work.  ... 
doi:10.2147/ndt.s64236 pmid:24971013 pmcid:PMC4069141 fatcat:as5v5lim5babdduhmqehbatyuu

Neuroinflammation in Schizophrenia

Feytie Magda Mawey, Azimatul Karimah, Erlyn Limoa, Muhammad Nazmuddin
2021 Jurnal Psikiatri Surabaya  
Schizophrenia is a chronic debilitating mental illness. In many aspects, the neuropathology of schizophrenia is closely associated with neuroinflammation, especially microglial activation.  ...  role of microglial activation and proinflammatory cytokines as common of features schizophrenia.  ...  MICROGLIAL ACTIVATION AND SCHIZOPHRENIA Microglia and inflammation markers While glial involvement in schizophrenia has long been suspected, the extent to which it contributes to the disease's pathology  ... 
doi:10.20473/jps.v10i1.20871 fatcat:cflvt5atyzdydjzfiyocylfl24

Quantitative analysis of activated microglia, ramified and damage of processes in the frontal and temporal lobes of chronic schizophrenics

Teresa Wierzba-Bobrowicz, Eliza Lewandowska, Waldemar Lechowicz, Tomasz Stepień, Elzbieta Pasennik
2005 Folia Neuropathologica  
In schizophrenia, characterised by an essential role played by immunological mechanisms, quantitative analysis of activated microglia -- with well-developed ramification (RM), degenerative traits and damaged  ...  In both structures of the brain, the number of activated microglial cells was higher in schizophrenic brains than in control brains.  ...  Density of active microglia cells (N/mm 2 ) in cerebral cortex of the frontal lobe (gyrus cinguli), R RM M -ramified microglia cells, D DM M -active microglia without processes.  ... 
pmid:16012909 fatcat:4fl7gb4wqfbqxoo62qhnbav6l4

Role of Microglial M1/M2 Polarization in Relapse and Remission of Psychiatric Disorders and Diseases

Yutaka Nakagawa, Kenji Chiba
2014 Pharmaceuticals  
Psychiatric disorders such as schizophrenia and major depressive disorder were thought to be caused by neurotransmitter abnormalities.  ...  In this review, we summarize immunoregulatory functions of microglia and discuss a possible role of microglial M1/M2 polarization in relapse and remission of psychiatric disorders and diseases.  ...  Figure 2 . 2 Hypothetical model of relationship between M1/M2 microglia activities and symptom severity in schizophrenia.  ... 
doi:10.3390/ph7121028 pmid:25429645 pmcid:PMC4276905 fatcat:yfysapr7xjdk3la5eifpkwrxqa

Microglial Gene Expression Alterations in the Brains of Patients with Psychiatric Disorders

Mai Sakai, Yuta Takahashi, Zhiqian Yu, Hiroaki Tomita
2016 Advances in Neuroimmune Biology  
Microglial abnormalities have consistently been observed in psychiatric postmortem brain studies, including altered microglial activation and changes in the protein and mRNA expression levels of microglial  ...  As recent studies have shown that microglia play a key role in inflammation and immunological challenges as well as have broader roles in synaptic modulation in the brain, studies on psychiatric disorders  ...  ., activated) microglia are found in patients with lateonset schizophrenia (age older than 40 years) [20] .  ... 
doi:10.3233/nib-160110 fatcat:ufdfxer5vbgg7lfvgbhkco6tre

Microglia in the dorsal raphe nucleus plays a potential role in both suicide facilitation and prevention in affective disorders

Ralf Brisch, Johann Steiner, Christian Mawrin, Marta Krzyżanowska, Zbigniew Jankowski, Tomasz Gos
2017 European Archives of Psychiatry and Clinical Neuroscience  
from our workgroup in the same cohort 4 ) suggested a positive impact of microglia on ribosomal DNA transcription in DRN neurons in the non-suicidal depressed subgroup, but not in depressed suicidal cases  ...  Therefore, the interaction between microglia and neurons in the DRN may be potentially involved in opposite ways regarding suicide facilitation and prevention in the tested subgroups of depressed patients  ...  Moreover, microglia density correlated positively with rDNA transcriptional activity in DRN neurons in this subgroup. Similar correlation existed in the residual subgroup of our schizophrenia cohort.  ... 
doi:10.1007/s00406-017-0774-1 pmid:28229240 pmcid:PMC5509773 fatcat:wn5xvzyvhvbipbnnfm33mm2elu
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