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Cerebral small vessel disease and Alzheimer's disease

Zhiyou Cai, Chuanling Wang, Wenbo He, Hanjun Tu, Zhengang Tang, Ming Xiao, Liang-Jun. Yan
2015 Clinical Interventions in Aging  
CSVD mainly contains lacunar infarct or lacunar stroke, leukoaraiosis, Binswanger's disease, and cerebral microbleeds.  ...  It seems that the treatment and prevention for cerebrovascular diseases with statins have such a role in the same function for AD.  ...  Natural Science Foundation (15K70), and the Natural Science Foundation of Renmin Hospital, Hubei University of Medicine to Dr Zhiyou Cai.  ... 
doi:10.2147/cia.s90871 pmid:26604717 pmcid:PMC4629951 fatcat:d4oudulbyvethpillgfxahtc74

Vascular dementia: current concepts and nomenclature harmonization

Lea Tenenholz Grinberg
2012 Dementia & Neuropsychologia  
The aim of the present review was to discuss current nomenclature for cerebrovascular lesions and suggest modifications to allow better diagnostic reproducibility in this field  ...  One of the greatest barriers of conducting clinicopathological studies in vascular dementia concerns the overlapping of nomenclature for these lesions.  ...  These vessel disorders can induce various types of A A cerebral tissue lesions such as hemorrhage, infarction, hippocampal sclerosis, and white matter lesions. 9 urrently, vascular lesions are classified  ... 
doi:10.1590/s1980-57642012dn06030002 pmid:29213784 pmcid:PMC5618957 fatcat:nbssslno4jgrbicfhmgpe5wxtm

Cerebral Small Vessel Disease

Qian Li, Yang Yang, Cesar Reis, Tao Tao, Wanwei Li, Xiaogang Li, John H. Zhang
2018 Cell Transplantation  
Neuroimaging features of CSVD include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy.  ...  Cerebral small vessel disease (CSVD) is composed of several diseases affecting the small arteries, arterioles, venules, and capillaries of the brain, and refers to several pathological processes and etiologies  ...  The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.  ... 
doi:10.1177/0963689718795148 pmid:30251566 fatcat:ug24t5ld4jgb3bqxbdl55c4moq

Quantitative Electroencephalographic Changes and Retinal Alterations in Subclinical Cerebrovascular Injury: A Case Report

Brown-Martínez M
2017 Austin Journal of Cerebrovascular Disease & Stroke  
It comprises a group of lesions visible only by magnetic resonance imaging technique, which cannot be used in a comprehensive evaluation of hypertensive patient because of its cost and availability.  ...  Quantitative electroencephalographic analysis showed a significant increase in theta frequency, predominantly in left frontal, central and temporal regions.  ...  It has a subclinical course for long periods, causing lesions such as lacunar infarcts, white matter lesions, and microbleeds.  ... 
doi:10.26420/austinjcerebrovascdisstroke.2017.1065 fatcat:kx5dgehzqjfljkt55b2qd345da

Clinical vascular imaging in the brain at 7 T

Laurens JL De Cocker, Arjen Lindenholz, Jaco JM Zwanenburg, Anja G van der Kolk, Maarten Zwartbol, Peter R Luijten, Jeroen Hendrikse
2018 NeuroImage  
Even at standard-fieldstrengths (1.5 T), MRI is by far the most sensitive imaging technique to detect acute brain infarctions and to characterize incidental cerebrovascular lesions, such as white matter  ...  As a result, highresolution imaging studies of the brain and its blood supply at 7 T have generated new concepts of different cerebrovascular diseases.  ...  At 7 T, BOLD fMRI may detect differences in cerebrovascular reactivity at a millimeter scale, and may be applied to study the association of CVR with lacunes, white matter hyperintensities and microbleeds  ... 
doi:10.1016/j.neuroimage.2016.11.044 pmid:27867089 pmcid:PMC5862656 fatcat:b52vlddvojhmhajj2bbmrk6w24

Hypertension and the Brain: A Risk Factor for More Than Heart Disease

Anja Meissner
2016 Cerebrovascular Diseases  
Microbleedings, subcortical lacunar infarctions and diffuse areas of white matter lesions resulting from vascular injury are associated with reduced cognitive function mostly characterized by difficulties  ...  By pointing out knowledge gaps, it aims to spur future studies in search of specific targets helping to prevent therapy failures and decelerate the rapidly progressing neurodegeneration of patients suffering  ...  Local disturbances in CBF lead to brain lesions affecting important white-matter tracts and manifesting as complete and incomplete infarcts, microbleeds and white-matter hyperintensities.  ... 
doi:10.1159/000446082 pmid:27173592 fatcat:bzbwszrrjncuni2ylstyfmo4da

Cerebral Small Vessel Disease Associated with Subclinical Vascular Damage Indicators in Asymptomatic Hypertensive Patients

Zenaida Milagros Hernández-Díaz, Marisol Peña-Sánchez, Alina González-Quevedo Monteagudo, Sergio González-García, Paula Andrea Arias-Cadena, Marta Brown-Martínez, Mélany Betancourt-Loza, Anay Cordero-Eiriz
2019 Behavioral Sciences  
For CSVD, white matter hyperintensities (WMH), enlarged Virchow–Robin perivascular spaces (EVRPS), lacunar infarcts, and microbleeds were investigated.  ...  The IMT + plaque was significantly associated with all MRI variables; but retinopathy was correlated with EVRPS and lacunar infarcts.  ...  In fact, a study in Ecuador determined that silent lacunar and microbleed infarcts correlated with a worse cardiovascular health (determined by risk factors such as HT) [44] .  ... 
doi:10.3390/bs9090091 pmid:31443428 pmcid:PMC6769830 fatcat:twycmmvtx5gp5iq54uz3c2k5q4

Relationship of cerebral microbleeds to inflammatory marker levels

Qiao-Li Lu, Chen Li, Ying Song, Liang Wang, Zhi-Rong Jia
2017 Neuroimmunology and Neuroinflammation  
Conclusion: The age, prevalence of hypertension, silent lacunar infarction, white matter lesion, MoCA Score, the using rate of antithrombotic drugs and serum hs-CRP, IL-6, and MMP-9 levels were the independent  ...  Multivariate logistic regression analyses showed that the age, the prevalence of hypertension, silent lacunar infarction, white matter lesion, Montreal Cognitive Assessment Score, the using rate of antithrombotic  ...  Ethics approval All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964  ... 
doi:10.20517/2347-8659.2017.05 fatcat:dfebgadt7jcd7dfosvxl5q4654

Malnutrition-inflammation is a risk factor for cerebral small vessel diseases and cognitive decline in peritoneal dialysis patients: a cross-sectional observational study

Ke Zheng, Haiyun Wang, Bo Hou, Hui You, Jing Yuan, Kai Luo, Limeng Chen, Mingxi Li, Qun Xu, Yicheng Zhu, Liying Cui, Sagar Uday Nigwekar (+2 others)
2017 BMC Nephrology  
Results: In our PD patients, the brain MRI showed the prevalence different signs of CSVD were: lacunar infarcts 38. 9%, microbleeds 36.1%, abnormal brain white matter hyperintensities (WMHs) 48.6%, and  ...  intracerebral hemorrhage 4.2%. 25% and 86.8%of our patients could be diagnosed as cognitive impairment, according to the MMSE and MoCA test, respectively. nPCR was lower in patients with a lacunar infarct  ...  Acknowledgements The authors acknowledge and thank all participants for their cooperation. Funding The contributing studies were funded by the National "Twelfth  ... 
doi:10.1186/s12882-017-0777-1 pmid:29262796 pmcid:PMC5738894 fatcat:fuw3bcgskvca7e4ljkawk27hta

Lenticulostriate Arterial Lumina Are Normal in Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy: A High-Field In Vivo MRI Study

M. K. Liem, J. van der Grond, M. J. Versluis, J. Haan, A. G. Webb, M. D. Ferrari, M. A. van Buchem, S. A. J. Lesnik Oberstein
2010 Stroke  
Methods-Twenty-two NOTCH3 mutation carriers and 11 healthy control subjects were examined using high-resolution 3-dimensional time-of-flight MR angiography imaging on a 7-T MRI scanner.  ...  and Purpose-Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small vessel disease.  ...  Analysis of Lacunar Infarcts, White Matter Hyperintensities, and Microbleeds The MRI scans were first analyzed for overall lesion load on a digital workstation by 1 observer (M.K.L.) who was blinded to  ... 
doi:10.1161/strokeaha.110.586883 pmid:20966419 fatcat:iabzqarnhjd3dnuquxtvqfypya

Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging

Joanna M Wardlaw, Colin Smith, Martin Dichgans
2013 Lancet Neurology  
The term "cerebral small vessel disease" (SVD) describes a range of neuroimaging, pathological and associated clinical features.  ...  how these result in brain disease, how SVD lesions contribute to neurological or cognitive symptoms and the relationship to risk factors, have been the subject of much speculation.  ...  Miller Fisher, clinical neuroscientist extraordinaire, sadly recently deceased, for providing the original inspiration, insight and clarity of thought about lacunar disease that has informed the present  ... 
doi:10.1016/s1474-4422(13)70060-7 pmid:23602162 pmcid:PMC3836247 fatcat:lnf3xsraybhnlmdi6igs76cffa

Prevention of Stroke in Patients With Silent Cerebrovascular Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association

Eric E. Smith, Gustavo Saposnik, Geert Jan Biessels, Fergus N. Doubal, Myriam Fornage, Philip B. Gorelick, Steven M. Greenberg, Randall T. Higashida, Scott E. Kasner, Sudha Seshadri
2016 Stroke  
brain infarcts, magnetic resonance imaging white matter hyperintensities of presumed vascular origin, and cerebral microbleeds.  ...  The writing committee found strong evidence that silent cerebrovascular disease is a common problem of aging and that silent brain infarcts and white matter hyperintensities are associated with future  ...  brain infarcts, white matter lesions of presumed vascular origin, and microbleeds ( Figure 1 ).  ... 
doi:10.1161/str.0000000000000116 pmid:27980126 fatcat:llonultha5bqzonly75hyzphqi

Cerebral small vessel disease: A review

Justyna Chojdak-Łukasiewicz, Edyta Dziadkowiak, Anna Zimny, Bogusław Paradowski
2021 Advances in Clinical and Experimental Medicine  
The changes affect arterioles, capillaries and small veins supplying the white matter and deep structures of the brain.  ...  The disease is characterized by a diverse clinical and radiological picture.  ...  Fig. 1 . 1 A. Acute lacunar infarction on DWI; B. White matter hyperintensities (WMHs) on the FLAIR image; C.  ... 
doi:10.17219/acem/131216 pmid:33768739 fatcat:aew47hqiwnh2ljsodrsugxo4wi

White Matter Changes in Cerebrovascular Disease: Leukoaraiosis [chapter]

Anca Hncu, Irene Ranu, Gabriela Butoi
2012 Advances in Brain Imaging  
Virgil Ionescu and Dr. Mariana Bardaş for the images of this chapter. Advances in Brain Imaging References  ...  event, knowing the effect of these comorbidities on cerebrovascular reactivity) demonstrated impaired reactivity in patients with multiple lacunar infarctions but no association between cerebrovascular  ...  In this study extensive LA was over twice more www.intechopen.com White Matter Changes in Cerebrovascular Disease: Leukoaraiosis  ... 
doi:10.5772/30565 fatcat:dxmivcnkh5h5xg7rxlvhoppogm

Cerebral Microbleeds Predict Intracerebral Hemorrhage in Hemodialysis Patients

Toshihide Naganuma, Yoshiaki Takemoto, Tetsuo Shoji, Eiji Ishimura, Mikio Okamura, Tatsuya Nakatani
2015 Stroke  
and Purpose-In hemodialysis patients, previous reports have described a high prevalence of cerebral microbleeds (CMBs), but no longitudinal studies have been performed to determine the clinical significance  ...  During a median follow-up period of 5.0 years, stroke occurred in 24 patients, including 12 with intracerebral hemorrhage and 12 with cerebral infarctions.  ...  with cerebral infarctions (7 lacunar, 3 atherothrombotic, and 2 cardioembolic infarctions; Table 2 ).  ... 
doi:10.1161/strokeaha.115.009324 pmid:26089331 fatcat:ehmu5an33rho5erypfwzvgfmei
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