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Recent Process in Microrobots: From Propulsion to Swarming for Biomedical Applications

Ruoxuan Wu, Yi Zhu, Xihang Cai, Sichen Wu, Lei Xu, Tingting Yu
2022 Micromachines  
Inspired by the motion pattern and collective behaviors of the tiny biological motors in nature, various kinds of sophisticated and programmable microrobots are fabricated with the ability for cargo delivery  ...  In particular, the locomotion of these micro/nanorobots, as well as the requirement of biocompatibility, transportation efficiency, and controllable motion for applications in the complex human body environment  ...  Lee et al. used an electromagnetic actuation (EMA) system to develop therapeutic drug delivery microrobots for precise targeting [39] .  ... 
doi:10.3390/mi13091473 pmid:36144096 pmcid:PMC9503943 fatcat:rjpd2lhwsfdvnkjqcx2hs3isyq

Micromotors for drug delivery in vivo: The road ahead

Sarvesh Kumar Srivastava, Gael Clergeaud, Thomas L. Andresen, Anja Boisen
2018 Advanced Drug Delivery Reviews  
Ability of these wireless drug carriers towards localized targeting and controlled drug release, makes them a lucrative candidate for drug administration in complex microenvironments (like solid tumors  ...  This important medical need coupled with effective dosage requirement has created the need for site-specific drug delivery systems.  ...  Nonetheless, US could also serve as an external trigger for drug delivery systems in vivo.  ... 
doi:10.1016/j.addr.2018.09.005 pmid:30236447 fatcat:yxmwxhkvpfblljwodnz6z5v3vq

Requirement and Development of Hydrogel Micromotors towards Biomedical Applications

Xinyi Lin, Borui Xu, Hong Zhu, Jinrun Liu, Alexander Solovev, Yongfeng Mei
2020 Research  
Tetherless micromotors are autonomous microdevices capable of converting local chemical energy or the energy of external fields into motive forces for self-propelled or externally powered/controlled motion  ...  Moreover, so far studies mostly concentrate on local responses of hydrogels to chemical and/or external stimuli, which significantly limit the scope of their applications.  ...  Hydrogel microparticles have been used in a wide range of drug-delivery systems [86] .  ... 
doi:10.34133/2020/7659749 pmid:32728669 pmcid:PMC7368969 fatcat:ighw2hzf5za7bctnyjkf3pxdtq

Engineering Magnetic Micro/Nanorobots for Versatile Biomedical Applications

Longchen Wang, Zheying Meng, Yu Chen, Yuanyi Zheng
2021 Advanced Intelligent Systems  
However, the existing delivery system of nanomedicine mainly relies on systemic circulation or in situ subcutaneous injection, which is inefficient and lacks penetration.  ...  [127] A diamagnetically levitated robotic system manipulated the loading and delivery of nanoliter fluid volumes in micropipettes at micrometer-scale precision, showing prospects for cell injection  ...  His research includes the development of magnetic micro/nanorobots for drug delivery and therapy with ultrasound guidance; the design, synthesis, and biomedical applications of polymer, albumin, lipid,  ... 
doi:10.1002/aisy.202000267 fatcat:v62vjfno3fbyzkli4uh2y4ale4

Molecular Building Blocks and Their Architecture in Biologically/Environmentally Compatible Soft Matter Chemical Machinery

Taro Toyota, Taisuke Banno, Sachiko Nitta, Masahiro Takinoue, Tomonori Nomoto, Yuno Natsume, Shuichi Matsumura, Masanori Fujinami
2014 Journal of Oleo Science  
such as selfpropelled droplets, drug delivery carriers, tissue regeneration scaffolds, protocell models, cell-/tissuemarkers, and molecular computing systems.  ...  Since environmental and living systems are open systems, chemical machinery must continuously fulfill its functions not only through the influx and generation of molecules but also via the degradation  ...  Masami Hagiya The University of Tokyo for careful reading and critical reviewing the manuscript. This work was partly supported by a  ... 
doi:10.5650/jos.ess14190 pmid:25341502 fatcat:3lgtojyvhjcjxkcznkagzeza7y

A Helical Microrobot with an Optimized Propeller-Shape for Propulsion in Viscoelastic Biological Media

Dandan Li, Moonkwang Jeong, Eran Oren, Tingting Yu, Tian Qiu
2019 Robotics  
One major challenge for microrobots is to penetrate and effectively move through viscoelastic biological tissues. Most existing microrobots can only propel in viscous liquids.  ...  The twisted ribbon is made of molybdenum and a sharp tip is chemically etched to generate a higher pressure at the edge of the propeller to break the biopolymeric network of the dense tissue.  ...  The authors thank Thomas Meisner, Arnold Weible and the mechanical workshop in the Max Planck Institute for the help in the fabrication of the propeller.  ... 
doi:10.3390/robotics8040087 fatcat:2lxxrk5oaretxprnrcnl6taoqu

Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents

Francesca Garello, Yulia Svenskaya, Bogdan Parakhonskiy, Miriam Filippi
2022 Pharmaceutics  
Targeted delivery of pharmaceuticals is promising for efficient disease treatment and reduction in adverse effects.  ...  We discuss the magnetic guidance of nano/microsystems or labeled cells upon injection into the systemic circulation or in the tissue; we then highlight emergent applications in tissue engineering, and  ...  The contribution of Y.S. on the magnetic microcapsules in biomedicine and MNPs for systemic circulation was supported by the Ministry of Science and Higher Educ. of the Russian Federation (project number  ... 
doi:10.3390/pharmaceutics14061132 pmid:35745705 pmcid:PMC9230665 fatcat:2fbwulhx5bethjsgyor4p7xuz4

Physical methods for enhancing drug absorption from the gastrointestinal tract

Zhi Luo, Nevena Paunović, Jean-Christophe Leroux
2021 Advanced Drug Delivery Reviews  
Overcoming the gastrointestinal (GI) barriers is a formidable challenge in the oral delivery of active macromolecules such as peptide and protein based drugs.  ...  Although in the early stages, some of these methods have shown great potential both in terms of improved bioavailability and spatiotemporal delivery of drugs.  ...  The authors thank Yulia Yuts, Elita Montanari and Michael Burger for proofreading of the manuscript.  ... 
doi:10.1016/j.addr.2021.05.024 pmid:34052229 fatcat:6r6tawagnrfu5euc365zu2hcta

Engineering microrobots for targeted cancer therapies from a medical perspective

Christine K. Schmidt, Mariana Medina-Sánchez, Richard J. Edmondson, Oliver G. Schmidt
2020 Nature Communications  
Systemic chemotherapy remains the backbone of many cancer treatments.  ...  optimised for precision-targeting of a wide range of cancers.  ...  Local drug application, such as intratumoural injection, overcomes the requirement for long-range targeting, but is often linked to considerable discomfort, particularly when the tumour is situated deep  ... 
doi:10.1038/s41467-020-19322-7 pmid:33154372 fatcat:gulp3n76wnhndhxhlzclacxg5q

Nanoparticles and the new era in diabetes management

Minyahil Woldu, Jimma Lenjisa
2014 International Journal of Basic & Clinical Pharmacology  
Inhalable, polymeric NP-based drug delivery systems have also been tried earlier for the treatment of tuberculosis and cardiovascular disease treatment.  ...  These drug delivery technologies are in various stages of research and development.  ...  ACKNOWLEDGMENTS The authors would like to thank Ambo University, Ambo, Adama referral, and Bishoftu Hospitals for their direct and indirect support while writing this review article.  ... 
doi:10.5455/2319-2003.ijbcp20140405 fatcat:qpsrogr635agnlc44ema2pvnvi

Nanobot: Artificial Intelligence, Drug Delivery and Diagnostic Approach

Gupta Jitendra, Gupta Reena, Tankara Abhishek
2021 Journal of Pharmaceutical Research International  
identification and drug delivery.  ...  Nano bioelectronics are used as the foundation for manufacturing integrated system devices with embedded nano biosensors and actuators in the nanorobot architectural paradigm, which aids in medical target  ...  ., India, for providing facilities to complete the article.  ... 
doi:10.9734/jpri/2021/v33i59b34369 fatcat:33r2yjzjzvd5jjb3fbsigpqfhu

An Overview of Robotic Capsules for Drug Delivery to the Gastrointestinal Tract

Pablo Cortegoso Valdivia, Alexander R. Robertson, Nanne K. H. De Boer, Wojciech Marlicz, Anastasios Koulaouzidis
2021 Journal of Clinical Medicine  
This review highlights the currently available systems for drug delivery in the GI tract and discusses the needs, limitations, and future considerations of these technologies.  ...  Since then, the rapid evolution of microtechnology has allowed the development of drug delivery systems (DDS) designed to address some of the needs that are not met by standard drug delivery.  ...  as consultant and/or principal investigator for TEVA Pharma BV and Takeda.  ... 
doi:10.3390/jcm10245791 pmid:34945087 pmcid:PMC8707371 fatcat:ztdyj3tpnbedpgfmkdqrsesxly

Advancements in Protein based Nano Particulate system for treatment of Pulmonary Infections- A Review

Praveen Tahilani, D P Chatterjee
2021 Asian Pacific Journal of Nursing and Health Sciences  
Thus, an advanced carrier system consisting of a fast dissolving micro particle matrix with embedded starch nano particles will be developed and characterized.  ...  Amongst others is the pulmonary application of proteins and peptides for local delivery in the case of pulmonary diseases, such as idiopathic pulmonary fibrosis, where the alveolar epithelium is affected  ...  Local delivery allows topical treatment of inflammatory bowel disease and systemic drug delivery are mainly used for to treat the hypertension.  ... 
doi:10.46811/apjnh/4.1.4 fatcat:2ty55myn55gihc4ej4qpxawteu

A Review on Applications of Nanobots in Combating Complex Diseases

Tashnuva Rifat, Md Shahadat Hossain, Md Mahbubul Alam, Abu Shara Shamsur Rouf
2019 Bangladesh Pharmaceutical Journal  
In the current years, a lot of research works have been continued in the quest to find a desired drug delivery system within the human body.  ...  Among different drug delivery systems, nanobots have become much popular due to its capability to perform different tasks like actuating, sensing, signaling, information processing and intelligence at  ...  Nanobots for targeted delivery: Drug delivery nanobots depend on systemic circulation and the force and navigation required for localized delivery and tissue penetration.  ... 
doi:10.3329/bpj.v22i1.40081 fatcat:kqzukt5dsjgjtgpco3ysw3kh2m

Modified Transdermal Technologies: Breaking the Barriers of Drug Permeation via the Skin

R Kumar, A Philip
2007 Tropical Journal of Pharmaceutical Research  
Modulation of formulation excipients and addition of chemical enhancers can increase drug flux but that is not sufficient to ensure delivery of pharmacologically effective concentration of drug therefore  ...  , several new active rate controlled TDDS technologies (electrically-based, structure-based, velocity-based, etc.) have been developed and commercialized for the transdermal delivery of 'troublesome' drugs  ...  injectors, intraject, under development, is designed to use the nitrogen propelled device which has a blank drug capsule.  ... 
doi:10.4314/tjpr.v6i1.14641 fatcat:bcxvgkqconafnclbpkteooeoey
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