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Lymphoid Aggregates Remodel Lymphatic Collecting Vessels that Serve Mesenteric Lymph Nodes in Crohn Disease
2016
American Journal of Pathology
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Early pathological descriptions of Crohn disease (CD) argued for a potential defect in lymph transport; however, this concept has not been thoroughly investigated. In mice, poor healing in response to infection-induced tissue damage can cause hyperpermeable lymphatic collecting vessels in mesenteric adipose tissue that impair antigen and immune cell access to mesenteric lymph nodes (LNs), which normally sustain appropriate immunity. To investigate whether analogous changes might occur in human
doi:10.1016/j.ajpath.2016.07.026
pmid:27746181
pmcid:PMC5225286
fatcat:kqtjang5wbe4rlrgrauhm32fk4
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... ntestinal disease, we established a three-dimensional imaging approach to characterize the lymphatic vasculature in mesenteric tissue from controls or patients with CD. In CD specimens, B-celle rich aggregates resembling tertiary lymphoid organs (TLOs) impinged on lymphatic collecting vessels that enter and exit LNs. In areas of creeping fat, which characterizes inflammation-affected areas of the bowel in CD, we observed B cells and apparent innate lymphoid cells that had invaded the lymphatic vessel wall, suggesting these cells may be mediators of lymphatic remodeling. Although TLOs have been described in many chronic inflammatory states, their anatomical relationship to preestablished LNs has never been revealed. Our data indicate that, at least in the CD-affected mesentery, TLOs are positioned along collecting lymphatic vessels in a manner expected to affect delivery of lymph to LNs. (Am J Pathol 2016, 186: 3066e3073; http://dx.
Effect of IBD medications on COVID-19 outcomes: results from an international registry
2020
Gut
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ObjectiveWe sought to evaluate COVID-19 clinical course in patients with IBD treated with different medication classes and combinations.DesignSurveillance Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD) is a large, international registry created to monitor outcomes of IBD patients with confirmed COVID-19. We used multivariable regression with a generalised estimating equation accounting for country as a random effect to analyse the association of
doi:10.1136/gutjnl-2020-322539
pmid:33082265
fatcat:iwkmetttcre63jcc4kkagkuvei
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... different medication classes with severe COVID-19, defined as intensive care unit admission, ventilator use and/or death.Results1439 cases from 47 countries were included (mean age 44.1 years, 51.4% men) of whom 112 patients (7.8%) had severe COVID-19. Compared with tumour necrosis factor (TNF) antagonist monotherapy, thiopurine monotherapy (adjusted OR (aOR) 4.08, 95% CI 1.73 to 9.61) and combination therapy with TNF antagonist and thiopurine (aOR 4.01, 95% CI 1.65 to 9.78) were associated with an increased risk of severe COVID-19. Any mesalamine/sulfasalazine compared with no mesalamine/sulfasalazine use was associated with an increased risk (aOR 1.70, 95% CI 1.26 to 2.29). This risk estimate increased when using TNF antagonist monotherapy as a reference group (aOR 3.52, 95% CI 1.93 to 6.45). Interleukin-12/23 and integrin antagonists were not associated with significantly different risk than TNF antagonist monotherapy (aOR 0.98, 95% CI 0.12 to 8.06 and aOR 2.42, 95% CI 0.59 to 9.96, respectively).ConclusionCombination therapy and thiopurines may be associated with an increased risk of severe COVID-19. No significant differences were observed when comparing classes of biologicals. These findings warrant confirmation in large population-based cohorts.MKH should be changed to MDK for co-last author line
Cogan's Syndrome in Patients With Inflammatory Bowel Disease – A Case Series
2015
Journal of Crohn's & Colitis
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BACKGROUND: Cogan's syndrome (CSy) is a very rare autoimmune disorder, mainly affecting the inner ear and the eye, and is associated with inflammatory bowel disease (IBD). METHODS: This was a European Crohn's and Colitis Organisation (ECCO) retrospective observational study, performed as part of the CONFER project. A call to all ECCO members was made to report concomitant CSy and inflammatory bowel disease (IBD) cases. Clinical data were recorded in a standardized questionnaire. RESULTS: This
doi:10.1093/ecco-jcc/jjv128
pmid:26188351
fatcat:iqjpibvpbncblntaavaeyipxr4
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... ternational case series reports on 22 concomitant CSy-IBD cases from 14 large medical centres. Mean duration of IBD until diagnosis of CSy was 8.7 years (range 0.0-38.0) and mean age at CSy diagnosis was 44.6 years (range 9.0-67.0).
The Multiple Waves of COVID-19 in Patients With Inflammatory Bowel Disease: A Temporal Trend Analysis
2022
Inflammatory Bowel Diseases
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Background Cases of coronavirus disease 2019 (COVID-19) have emerged in discrete waves. We explored temporal trends in the reporting of COVID-19 in inflammatory bowel disease (IBD) patients. Methods The Surveillance Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD) is an international registry of IBD patients diagnosed with COVID-19. The average percent changes (APCs) were calculated in weekly reported cases of COVID-19 during the periods of March
doi:10.1093/ibd/izab339
pmid:35032167
pmcid:PMC8807298
fatcat:elpjfw3m75b6tbgh3jpgyd5nl4
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... 2 to September 12, September 13 to December 12, 2020, and December 13 to July 31, 2021. Results Across 73 countries, 6404 cases of COVID-19 were reported in IBD patients. COVID-19 reporting decreased globally by 4.2% per week (95% CI, −5.3% to −3.0%) from March 22 to September 12, 2020, then climbed by 10.2% per week (95% CI, 8.1%-12.3%) from September 13 to December 12, 2020, and then declined by 6.3% per week (95% CI, −7.8% to −4.7%). In the fall of 2020, weekly reporting climbed in North America (APC, 11.3%; 95% CI, 8.8-13.8) and Europe (APC, 17.7%; 95% CI, 12.1%-23.5%), whereas reporting was stable in Asia (APC, −8.1%; 95% CI, −15.6-0.1). From December 13, 2020, to July 31, 2021, reporting of COVID-19 in those with IBD declined in North America (APC, −8.5%; 95% CI, −10.2 to −6.7) and Europe (APC, −5.4%; 95% CI, −7.2 to −3.6) and was stable in Latin America (APC, −1.5%; 95% CI, −3.5% to 0.6%). Conclusions Temporal trends in reporting of COVID-19 in those with IBD are consistent with the epidemiological patterns COVID-19 globally.
Nutzerzentrierte Gestaltung und Entwicklung eines kontextsensitiven HMI
[chapter]
Mensch und Computer 2015 - Workshopband
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Die Nutzerzentriertheit wirkt sich darüber hinaus positiv auf die Usability aus, wodurch die Ablenkung minimiert und die Fahrsicherheit erhöht wird (Rahier et al. 2015) .Als Proof of Concept eines kontextsensitiven ...
doi:10.1515/9783110443905-067
fatcat:6jq5r3qkzbgbrpdcot7dnqf2om
Architecture for Platform-and Hardware-independent Mesh Networks How to unify the channels
unpublished
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This paper will prove that mesh networks among different platforms and hardware channels can help to channel valuable information even if public telecommunication infrastructure is not available due to arbitrary reasons. Therefore, results of a simulation for mesh networks on mass events will be provided, followed by the developed architecture and an outlook on future research. The developed architecture is currently being implemented and field tested on mass events.
fatcat:6pttbhnckzew3ffovroe2haire
Page 542 of American Anthropologist Vol. 115, Issue 3
[page]
2013
American Anthropologist
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WEISS and MICHAEL J. BOSIA
Explores homophobia as a transnationa! political phenomenon. ...
—American Ethnologist
*Hardcover $75.00; Paperback $25.00; ebook
Kings for Three Days
The Play of Race and Gender in an Afro-Ecuadorian Festival
JEAN MUTEBA RAHIER
Rahier examines representations of racial ...
Page 884 of Biological Reviews Vol. 87, Issue 4
[page]
2012
Biological Reviews
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S
& BONKOWSKI
M
Michael P. Speed and others
PouLron, J. (1990
ROTHSCHILD, M
>
Lers, R )
Cyanogenesis in plants. Plant P gy 94, 401-405 ApLin, R F
Cockrum, | EDGAR, J... ...
Jou ( Ecology 12, 1189
& SPEED, M
RAHIER
defense in RUXTON SHERRATT, | ( f it ‘ Ruxton, G. & Sprep, M ‘ 273.3 SAASTAMOINEN, M 107). De
NIEMINEN, M., O'HARA, B bivore, M. ...
Page 724 of American Anthropologist Vol. 115, Issue 4
[page]
2013
American Anthropologist
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Pollock, Susan Posecznick, Alex Postero, Nancy Price, Charles Pruetz, Jill
Pullman, Daryl Quinlan, Rob Raffles, Hugh Rahier, Jean
Raikhel, Eugene Rajak, Dinah
Ralph, Laurence Rapp, Rayna Rauchholz, Manuel ...
Palavestra, Aleksandar Palsson, Gisli Pandian, Anand Paolisso, Michael Parish, Amy Randall Park, Seo Young
5
Parker, Jason
115,No.4 e December 2013
Parker, Lynette Parkin, Robert Parla, Ayse Parmentier ...
Page 1125 of Cellular and Molecular Life Sciences Vol. 40, Issue 10
[page]
1984
Cellular and Molecular Life Sciences
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Rahier, J., Goebbels, R.M., and Henquin, J.C., Cellular composi- tion of the human diabetic pancreas. Diabetologia 24 (1983) 366— 371. ...
Michaels, R.L., and Sheridan, J.D., Islets of Langerhans: dye coupling among immunocytochemically distinct cell types. Science 214 (1981) 801-803. ...
Page 1109 of The Journal of Animal Ecology Vol. 59, Issue 3
[page]
1990
The Journal of Animal Ecology
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the laboratory with unnatural predators (e.g. see reviews in Eisner 1970; Brower 1984), and therefore may have only indirect relevance to the natural situation (Duffey 1976; Pasteels, Grégoire & Rowell-Rahier ...
Dewsbury, John Eisenberg, Louis Guillette, Frank Slansky, Diana Schulmann and Mary Taitt for helpful critiques; William Calvert, Gerarado Ceballos, Carlos Galindo and Victor Sanchez for unpublished data; Michael ...
Cogan's syndrome in patients with inflammatory bowel disease--a case series
2015
Preserved Fulltext
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BACKGROUND: Cogan's syndrome (CSy) is a very rare autoimmune disorder, mainly affecting the inner ear and the eye, and is associated with inflammatory bowel disease (IBD). METHODS: This was a European Crohn's and Colitis Organisation (ECCO) retrospective observational study, performed as part of the CONFER project. A call to all ECCO members was made to report concomitant CSy and inflammatory bowel disease (IBD) cases. Clinical data were recorded in a standardized questionnaire. RESULTS: This
doi:10.5167/uzh-119264
fatcat:v2u3354c4rgo5mrr6rlb7yio6u
more »
... ternational case series reports on 22 concomitant CSy-IBD cases from 14 large medical centres. Mean duration of IBD until diagnosis of CSy was 8.7 years (range 0.0-38.0) and mean age at CSy diagnosis was 44.6 years (range 9.0-67.0).
Spatial proximity between two host plant species influences oviposition and larval distribution in a leaf beetle
2001
Oikos
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Acknowledgements -We thank Betty Benrey, Ha ˚kan Ha ¨ggstro ¨m, Nicole Kalberer, Luca Nessi, Michael C. Singer and Ted Turlings for critical comments on different versions of the manuscript. ...
PAs appear to protect beetles more efficiently than cardenolides, at least against generalist avian predators ( Rowell-Rahier et al. 1995) . ...
We relate the results to the larval performance data found for the same leaf beetle population in a separate study (Ballabeni and Rahier 2000) . ...
doi:10.1034/j.1600-0706.2001.920204.x
fatcat:du6j35jtyjhkfersaykqjrxeju
Mate choice and toxicity in two species of leaf beetles with different types of chemical defense
2003
Journal of Chemical Ecology
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analysis; Yves Borcard, Erick Campan, Loïc Didillon, Håkan Häggström, and Christina Tamò for helping with lab work; Betty Benrey, Pierre-Yves Claudin, Karl Gotthard, Philippe Küpfer, Russell Naisbit, Michael ...
., 1991; Eggenberger and Rowell-Rahier, 1993a) . ...
In neither species are defensive compounds provided to offspring by their mother Dobler and Rowell-Rahier, 1994) . ...
pmid:12921444
fatcat:7h2slswdxnh4rbn2famenieaqq
Page 384 of The Journal of Animal Ecology Vol. 80, Issue 2
[page]
2011
The Journal of Animal Ecology
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Ruxton' and Michael P. ...
chemicals into their haemol-
Introduction
Chemical defences against predation are widespread in the animal kingdom, having been found in many terrestrial arthropods (Blum 1981; Pasteels, Grégoire & Rowell-Rahier ...
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