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Lymphoid Aggregates Remodel Lymphatic Collecting Vessels that Serve Mesenteric Lymph Nodes in Crohn Disease

Gwendalyn J. Randolph, Shashi Bala, Jean-François Rahier, Michael W. Johnson, Peter L. Wang, ILKe Nalbantoglu, Laurent Dubuquoy, Amélie Chau, Benjamin Pariente, Alex Kartheuser, Bernd H. Zinselmeyer, Jean-Frederic Colombel
2016 American Journal of Pathology  
Early pathological descriptions of Crohn disease (CD) argued for a potential defect in lymph transport; however, this concept has not been thoroughly investigated. In mice, poor healing in response to infection-induced tissue damage can cause hyperpermeable lymphatic collecting vessels in mesenteric adipose tissue that impair antigen and immune cell access to mesenteric lymph nodes (LNs), which normally sustain appropriate immunity. To investigate whether analogous changes might occur in human
more » ... ntestinal disease, we established a three-dimensional imaging approach to characterize the lymphatic vasculature in mesenteric tissue from controls or patients with CD. In CD specimens, B-celle rich aggregates resembling tertiary lymphoid organs (TLOs) impinged on lymphatic collecting vessels that enter and exit LNs. In areas of creeping fat, which characterizes inflammation-affected areas of the bowel in CD, we observed B cells and apparent innate lymphoid cells that had invaded the lymphatic vessel wall, suggesting these cells may be mediators of lymphatic remodeling. Although TLOs have been described in many chronic inflammatory states, their anatomical relationship to preestablished LNs has never been revealed. Our data indicate that, at least in the CD-affected mesentery, TLOs are positioned along collecting lymphatic vessels in a manner expected to affect delivery of lymph to LNs. (Am J Pathol 2016, 186: 3066e3073; http://dx.
doi:10.1016/j.ajpath.2016.07.026 pmid:27746181 pmcid:PMC5225286 fatcat:kqtjang5wbe4rlrgrauhm32fk4

Effect of IBD medications on COVID-19 outcomes: results from an international registry

Ryan C Ungaro, Erica J Brenner, Richard B Gearry, Gilaad G Kaplan, Michele Kissous-Hunt, James D Lewis, Siew C Ng, Jean-Francois Rahier, Walter Reinisch, Flávio Steinwurz, Fox E Underwood, Xian Zhang (+2 others)
2020 Gut  
ObjectiveWe sought to evaluate COVID-19 clinical course in patients with IBD treated with different medication classes and combinations.DesignSurveillance Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD) is a large, international registry created to monitor outcomes of IBD patients with confirmed COVID-19. We used multivariable regression with a generalised estimating equation accounting for country as a random effect to analyse the association of
more » ... different medication classes with severe COVID-19, defined as intensive care unit admission, ventilator use and/or death.Results1439 cases from 47 countries were included (mean age 44.1 years, 51.4% men) of whom 112 patients (7.8%) had severe COVID-19. Compared with tumour necrosis factor (TNF) antagonist monotherapy, thiopurine monotherapy (adjusted OR (aOR) 4.08, 95% CI 1.73 to 9.61) and combination therapy with TNF antagonist and thiopurine (aOR 4.01, 95% CI 1.65 to 9.78) were associated with an increased risk of severe COVID-19. Any mesalamine/sulfasalazine compared with no mesalamine/sulfasalazine use was associated with an increased risk (aOR 1.70, 95% CI 1.26 to 2.29). This risk estimate increased when using TNF antagonist monotherapy as a reference group (aOR 3.52, 95% CI 1.93 to 6.45). Interleukin-12/23 and integrin antagonists were not associated with significantly different risk than TNF antagonist monotherapy (aOR 0.98, 95% CI 0.12 to 8.06 and aOR 2.42, 95% CI 0.59 to 9.96, respectively).ConclusionCombination therapy and thiopurines may be associated with an increased risk of severe COVID-19. No significant differences were observed when comparing classes of biologicals. These findings warrant confirmation in large population-based cohorts.MKH should be changed to MDK for co-last author line
doi:10.1136/gutjnl-2020-322539 pmid:33082265 fatcat:iwkmetttcre63jcc4kkagkuvei

Cogan's Syndrome in Patients With Inflammatory Bowel Disease – A Case Series

Stephan R. Vavricka, Thomas Greuter, Michael Scharl, Gerassimos Mantzaris, Ariella B. Shitrit, Rafal Filip, Konstantinos Karmiris, Christoph K. Thoeringer, Hubert Boldys, Anne V. Wewer, Henit Yanai, Cristina Flores (+4 others)
2015 Journal of Crohn's & Colitis  
BACKGROUND: Cogan's syndrome (CSy) is a very rare autoimmune disorder, mainly affecting the inner ear and the eye, and is associated with inflammatory bowel disease (IBD). METHODS: This was a European Crohn's and Colitis Organisation (ECCO) retrospective observational study, performed as part of the CONFER project. A call to all ECCO members was made to report concomitant CSy and inflammatory bowel disease (IBD) cases. Clinical data were recorded in a standardized questionnaire. RESULTS: This
more » ... ternational case series reports on 22 concomitant CSy-IBD cases from 14 large medical centres. Mean duration of IBD until diagnosis of CSy was 8.7 years (range 0.0-38.0) and mean age at CSy diagnosis was 44.6 years (range 9.0-67.0).
doi:10.1093/ecco-jcc/jjv128 pmid:26188351 fatcat:iqjpibvpbncblntaavaeyipxr4

The Multiple Waves of COVID-19 in Patients With Inflammatory Bowel Disease: A Temporal Trend Analysis

Gilaad G Kaplan, Fox E Underwood, Stephanie Coward, Manasi Agrawal, Ryan C Ungaro, Erica J Brenner, Richard B, Gearry, Michele Kissous-Hunt, James D Lewis, Siew C Ng, Jean-Francois Rahier, Walter Reinisch (+4 others)
2022 Inflammatory Bowel Diseases  
Background Cases of coronavirus disease 2019 (COVID-19) have emerged in discrete waves. We explored temporal trends in the reporting of COVID-19 in inflammatory bowel disease (IBD) patients. Methods The Surveillance Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD) is an international registry of IBD patients diagnosed with COVID-19. The average percent changes (APCs) were calculated in weekly reported cases of COVID-19 during the periods of March
more » ... 2 to September 12, September 13 to December 12, 2020, and December 13 to July 31, 2021. Results Across 73 countries, 6404 cases of COVID-19 were reported in IBD patients. COVID-19 reporting decreased globally by 4.2% per week (95% CI, −5.3% to −3.0%) from March 22 to September 12, 2020, then climbed by 10.2% per week (95% CI, 8.1%-12.3%) from September 13 to December 12, 2020, and then declined by 6.3% per week (95% CI, −7.8% to −4.7%). In the fall of 2020, weekly reporting climbed in North America (APC, 11.3%; 95% CI, 8.8-13.8) and Europe (APC, 17.7%; 95% CI, 12.1%-23.5%), whereas reporting was stable in Asia (APC, −8.1%; 95% CI, −15.6-0.1). From December 13, 2020, to July 31, 2021, reporting of COVID-19 in those with IBD declined in North America (APC, −8.5%; 95% CI, −10.2 to −6.7) and Europe (APC, −5.4%; 95% CI, −7.2 to −3.6) and was stable in Latin America (APC, −1.5%; 95% CI, −3.5% to 0.6%). Conclusions Temporal trends in reporting of COVID-19 in those with IBD are consistent with the epidemiological patterns COVID-19 globally.
doi:10.1093/ibd/izab339 pmid:35032167 pmcid:PMC8807298 fatcat:elpjfw3m75b6tbgh3jpgyd5nl4

Nutzerzentrierte Gestaltung und Entwicklung eines kontextsensitiven HMI [chapter]

Michael Bischof, Ludger Ey, Alexander Kuck, Michael Rahier, Thomas Ritz
Mensch und Computer 2015 - Workshopband  
Die Nutzerzentriertheit wirkt sich darüber hinaus positiv auf die Usability aus, wodurch die Ablenkung minimiert und die Fahrsicherheit erhöht wird (Rahier et al. 2015) .Als Proof of Concept eines kontextsensitiven  ... 
doi:10.1515/9783110443905-067 fatcat:6jq5r3qkzbgbrpdcot7dnqf2om

Architecture for Platform-and Hardware-independent Mesh Networks How to unify the channels

Sebastian Damm, Michael Rahier, Thomas Ritz, Thomas Schäfer
unpublished
This paper will prove that mesh networks among different platforms and hardware channels can help to channel valuable information even if public telecommunication infrastructure is not available due to arbitrary reasons. Therefore, results of a simulation for mesh networks on mass events will be provided, followed by the developed architecture and an outlook on future research. The developed architecture is currently being implemented and field tested on mass events.
fatcat:6pttbhnckzew3ffovroe2haire

Page 542 of American Anthropologist Vol. 115, Issue 3 [page]

2013 American Anthropologist  
WEISS and MICHAEL J. BOSIA Explores homophobia as a transnationa! political phenomenon.  ...  —American Ethnologist *Hardcover $75.00; Paperback $25.00; ebook Kings for Three Days The Play of Race and Gender in an Afro-Ecuadorian Festival JEAN MUTEBA RAHIER Rahier examines representations of racial  ... 

Page 884 of Biological Reviews Vol. 87, Issue 4 [page]

2012 Biological Reviews  
S & BONKOWSKI M Michael P. Speed and others PouLron, J. (1990 ROTHSCHILD, M > Lers, R ) Cyanogenesis in plants. Plant P gy 94, 401-405 ApLin, R F Cockrum, | EDGAR, J...  ...  Jou ( Ecology 12, 1189 & SPEED, M RAHIER defense in RUXTON SHERRATT, | ( f it ‘ Ruxton, G. & Sprep, M ‘ 273.3 SAASTAMOINEN, M 107). De NIEMINEN, M., O'HARA, B bivore, M.  ... 

Page 724 of American Anthropologist Vol. 115, Issue 4 [page]

2013 American Anthropologist  
Pollock, Susan Posecznick, Alex Postero, Nancy Price, Charles Pruetz, Jill Pullman, Daryl Quinlan, Rob Raffles, Hugh Rahier, Jean Raikhel, Eugene Rajak, Dinah Ralph, Laurence Rapp, Rayna Rauchholz, Manuel  ...  Palavestra, Aleksandar Palsson, Gisli Pandian, Anand Paolisso, Michael Parish, Amy Randall Park, Seo Young 5 Parker, Jason 115,No.4 e December 2013 Parker, Lynette Parkin, Robert Parla, Ayse Parmentier  ... 

Page 1125 of Cellular and Molecular Life Sciences Vol. 40, Issue 10 [page]

1984 Cellular and Molecular Life Sciences  
Rahier, J., Goebbels, R.M., and Henquin, J.C., Cellular composi- tion of the human diabetic pancreas. Diabetologia 24 (1983) 366— 371.  ...  Michaels, R.L., and Sheridan, J.D., Islets of Langerhans: dye coupling among immunocytochemically distinct cell types. Science 214 (1981) 801-803.  ... 

Page 1109 of The Journal of Animal Ecology Vol. 59, Issue 3 [page]

1990 The Journal of Animal Ecology  
the laboratory with unnatural predators (e.g. see reviews in Eisner 1970; Brower 1984), and therefore may have only indirect relevance to the natural situation (Duffey 1976; Pasteels, Grégoire & Rowell-Rahier  ...  Dewsbury, John Eisenberg, Louis Guillette, Frank Slansky, Diana Schulmann and Mary Taitt for helpful critiques; William Calvert, Gerarado Ceballos, Carlos Galindo and Victor Sanchez for unpublished data; Michael  ... 

Cogan's syndrome in patients with inflammatory bowel disease--a case series

Stephan R Vavricka, Thomas Greuter, Michael Scharl, Gerassimos Mantzaris, Ariella B Shitrit, Rafal Filip, Konstantinos Karmiris, Christoph K Thoeringer, Hubert Boldys, Anne V Wewer, Henit Yanai, Cristina Flores (+4 others)
2015
BACKGROUND: Cogan's syndrome (CSy) is a very rare autoimmune disorder, mainly affecting the inner ear and the eye, and is associated with inflammatory bowel disease (IBD). METHODS: This was a European Crohn's and Colitis Organisation (ECCO) retrospective observational study, performed as part of the CONFER project. A call to all ECCO members was made to report concomitant CSy and inflammatory bowel disease (IBD) cases. Clinical data were recorded in a standardized questionnaire. RESULTS: This
more » ... ternational case series reports on 22 concomitant CSy-IBD cases from 14 large medical centres. Mean duration of IBD until diagnosis of CSy was 8.7 years (range 0.0-38.0) and mean age at CSy diagnosis was 44.6 years (range 9.0-67.0).
doi:10.5167/uzh-119264 fatcat:v2u3354c4rgo5mrr6rlb7yio6u

Spatial proximity between two host plant species influences oviposition and larval distribution in a leaf beetle

Pierluigi Ballabeni, Davide Conconi, Sophie Gateff, Martine Rahier
2001 Oikos  
Acknowledgements -We thank Betty Benrey, Ha ˚kan Ha ¨ggstro ¨m, Nicole Kalberer, Luca Nessi, Michael C. Singer and Ted Turlings for critical comments on different versions of the manuscript.  ...  PAs appear to protect beetles more efficiently than cardenolides, at least against generalist avian predators ( Rowell-Rahier et al. 1995) .  ...  We relate the results to the larval performance data found for the same leaf beetle population in a separate study (Ballabeni and Rahier 2000) .  ... 
doi:10.1034/j.1600-0706.2001.920204.x fatcat:du6j35jtyjhkfersaykqjrxeju

Mate choice and toxicity in two species of leaf beetles with different types of chemical defense

Estelle Labeyrie, Wolf U Blanckenhorn, Martine Rahier
2003 Journal of Chemical Ecology  
analysis; Yves Borcard, Erick Campan, Loïc Didillon, Håkan Häggström, and Christina Tamò for helping with lab work; Betty Benrey, Pierre-Yves Claudin, Karl Gotthard, Philippe Küpfer, Russell Naisbit, Michael  ...  ., 1991; Eggenberger and Rowell-Rahier, 1993a) .  ...  In neither species are defensive compounds provided to offspring by their mother Dobler and Rowell-Rahier, 1994) .  ... 
pmid:12921444 fatcat:7h2slswdxnh4rbn2famenieaqq

Page 384 of The Journal of Animal Ecology Vol. 80, Issue 2 [page]

2011 The Journal of Animal Ecology  
Ruxton' and Michael P.  ...  chemicals into their haemol- Introduction Chemical defences against predation are widespread in the animal kingdom, having been found in many terrestrial arthropods (Blum 1981; Pasteels, Grégoire & Rowell-Rahier  ... 
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