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To support strategic planning of protection, management, and restoration of peatlands, we assessed the conservation status of three peatland types within the trans-border Neman River basin. ... Spatial analyses of the Neman River basin showed the mean peatland patch size distribution varied by country and peatland type, with Belarus having the largest mean Spatial analyses of the Neman River ... Gap Analyses Overall Protection of Peatlands within the Neman River Basin at the National Level In total, 26% of the Neman River basin's peatlands are protected, with Poland having protected 90% of its ...doi:10.3390/land10020174 fatcat:v25r43j5bjbvhnkwxdrtkdjjpa
Cell-based therapies have intriguing potential for the treatment of a variety of neurological disorders. One such example is genetically engineered cytotoxic T lymphocytes (CTLs) that are being investigated in brain tumor clinical trials. The development of methods for CTL delivery is critical to their use in the laboratory and clinical setting. In our study, we determined whether CTLs can migrate through fibrin matrices and if their migration, survival, and function could be modulated bydoi:10.1371/journal.pone.0034652 pmid:22496835 pmcid:PMC3319597 fatcat:wlzp4dvna5drnmqlfcshwbula4
more »... chemokines to the matrix. Our results indicated that CTLs can freely migrate through fibrin matrices. As expected, the addition of the monocyte chemotactic protein-1 (MCP-1), also known as chemokine C-C motif ligand 2 (CCL2), to the surrounding media increased egress of the CTLs out of the fibrin clot. Interleukin (IL) -2 and/or IL-15 embedded in the matrix enhanced T cell survival and further promoted T cell migration. The interleukin-13 receptor alpha 2 specific (IL-13R alpha2) T cells that traveled out of the fibrin clot retained the capacity to kill U251 glioma cells. In summary, CTLs can survive and migrate robustly in fibrin matrices. These processes can be influenced by modification of matrix constituents. We conclude that fibrin matrices may be suitable T cell carriers and can be used to facilitate understanding of T cell interaction with the surrounding microenvironment.
In response to recent studies, we investigated an association between perioperative β-blockade and breast cancer metastases. First, a retrospective study examining perioperative β-blocker use and cancer recurrence and metastases was conducted on 1,029 patients who underwent breast cancer surgery at the City of Hope Cancer Center between 2000 and 2010. We followed the clinical study and examined proliferation, migration, and invasion in vitro of primary and brain-metastatic breast cancer cellsdoi:10.3892/or.2016.4710 pmid:27035124 pmcid:PMC4869944 fatcat:pafyodzunrce5evvwu42b7r4ly
more »... response to β2-activation and inhibition. We also investigated in vivo the metastatic potential of propranolol-treated metastatic cells. For stage II breast cancer patients, perioperative β-blockade was associated with decreased cancer recurrence using Cox regression analysis (hazard's ratio =0.51; 95% CI: 0.23-0.97; p=0.041). Triple-negative (TN) brain-metastatic cells were found to have increased β2-adrenergic receptor mRNA and protein expression relative to TN primary cells. In response to β2-adrenergic receptor activation, TN brain-metastatic cells also exhibited increased cell proliferation and migration relative to the control. These effects were abrogated by propranolol. Propranolol decreased β2-adrenergic receptor-activated invasion. In vivo, propranolol treatment of TN brain-metastatic cells decreased establishment of brain metastases. Our results suggest that stress and corresponding β2-activation may promote the establishment of brain metastases of TN breast cancer cells. In addition, our data suggest a benefit to perioperative β-blockade during surgery-induced stress with respect to breast cancer recurrence and metastases. Abbreviations: 231Br, MDA-MB-231Br; ADRB2, β2-adrenergic receptor; TN, triple-negative; BBM, breast-to-brain metastasis; 231, MDA-MB-231
Sustaining economic activities while curbing the number of new coronavirus disease 2019 (COVID-19) cases until effective vaccines or treatments become available is a major public health and policy challenge. In this paper, we use agent-based simulations of a network-based susceptible−exposed−infectious−recovered (SEIR) model to investigate two network intervention strategies for mitigating the spread of transmission while maintaining economic activities. In the simulations, we assume thatdoi:10.1073/pnas.2014297117 pmid:33177237 fatcat:mmio3pcdvrbgnbdbwbjqinejgm
more »... engage in group activities in multiple sectors (e.g., going to work, going to a local grocery store), where they interact with others in the same group and potentially become infected. In the first strategy, each group is divided into two subgroups (e.g., a group of customers can only go to the grocery store in the morning, while another separate group of customers can only go in the afternoon). In the second strategy, we balance the number of group members across different groups within the same sector (e.g., every grocery store has the same number of customers). The simulation results show that the dividing groups strategy substantially reduces transmission, and the joint implementation of the two strategies could effectively bring the spread of transmission under control (i.e., effective reproduction number ≈ 1.0).
Nanotechnology is the design and assembly of submicroscopic devices called nanoparticles, which are 1-100 nm in diameter. Nanomedicine is the application of nanotechnology for the diagnosis and treatment of human disease. Disease-specific receptors on the surface of cells provide useful targets for nanoparticles. Because nanoparticles can be engineered from components that (1) recognize disease at the cellular level, (2) are visible on imaging studies, and (3) deliver therapeutic compounds,doi:10.1016/j.neuroimage.2010.01.105 pmid:20149882 pmcid:PMC3524337 fatcat:6mibn2venjaobcbmrng7ps2jge
more »... technology is well suited for the diagnosis and treatment of a variety of diseases. Nanotechnology will enable earlier detection and treatment of diseases that are best treated in their initial stages, such as cancer. Advances in nanotechnology will also spur the discovery of new methods for delivery of therapeutic compounds, including genes and proteins, to diseased tissue. A myriad of nanostructured drugs with effective site-targeting can be developed by combining a diverse selection of targeting, diagnostic, and therapeutic components. Incorporating immune target specificity with nanostructures introduces a new type of treatment modality, nanoimmunochemotherapy, for patients with cancer. In this review, we will discuss the development and potential applications of nanoscale platforms in medical diagnosis and treatment. To impact the care of patients with neurological diseases, advances in nanotechnology will require accelerated translation to the fields of brain mapping, CNS imaging, and nanoneurosurgery. Advances in nanoplatform, nano-imaging, and nano-drug delivery will drive the future development of nanomedicine, personalized medicine, and targeted therapy. We believe that the formation of a science, technology, medicine law-healthcare policy (STML) hub/center, which encourages collaboration among universities, medical centers, US government, industry, patient advocacy groups, charitable foundations, and philanthropists, could significantly facilitate such advancements and contribute to the translation of nanotechnology across medical disciplines.
., 507 Nelson, Neman, Neman, Neman, Nemeth, Charlan, 636 Nemiah, John C., 943 Nesbit, W. ... W., 920 Nideffer, Robert M., 304 Nielzén, Séren, 830 Ni cers, Carlos J., 389 Niemela, Pirkko, 170 Nietzel, Michael T., 1036 Nigro, Georgia, 120 Nitta, Nori a, 1426 Nober, E. ...
Sayfo - An Account of the Assyrian Genocide
of Qarabash translated and annotated by Michael Abdalla and Łukasz Kiczko Tunisia's Andalusians: The Cultural Identity of a North African Minority Marta Dominguez Diaz Palestinian Citizens of Israel: ... Books in the Series (Published and Forthcoming) Ali Banuazizi Dr Aryo Makko Professor Laura Robson Professor Paul Rowe Professor Hannibal Travis Sayfo -An Account of the Assyrian Genocide Abed Mshiho Neman ... SAYFO AN ACCOUNT OF THE ASSYRIAN GENOCIDE ABED MSHIHO NEMAN OF QARABASH Translated with an Introduction and Notes by Michael Abdalla and Łukasz Kiczko Edinburgh University Press is one of the leading ...doi:10.1515/9781474447522-fm fatcat:h45b3gzgk5gbxdvvqiunuuixui
The Reliquary and Illustrated Archaeologist
1537 Muschamp, Thomas 1560 1572 Musins, John 1753 Nanfan, John 1620 Nash, Bowles 1720 1724 1721 Nash, Gawan Pe 1726 1739 Nele 1516 Nelme, Anthony | 1697 1728 Nelme, Francis 1722 1739 Nelthorpe, — 1677 Neman ... John ‘ ~ 1745 Neville, John, and Craig, Anne 1740 Newbole, George 1580 Newman, Gains 1614 Newton 1586 1596 Newton, John 1720 1726 1739 Newton, Jonathan we Tee 1711 1718 Nicholl, John 1518 1521 Nicholl, Michael ...
Missouri Supreme Court: Reports
Acts 1860, p. 8, § 2; Hey- neman v. Dannenberg, 6 Cal. 376; Castle v. Bader, 23 Cal. 76; Conroy v. Woods, 13 Cal. 626; Ib. 76; Scott v. McMillen, 1 Litt. (Ky.) 302; s. ¢.,13 Am. Dec. 239; Luthy v. ... Michael, 23 Mo. 50; Turner v. Adams, 46 Mo. 95; Pendleton v. Perkins, 49 Mo. 565; Story Eq., § 1023. After the decision of this court in Martin v. ...
The Secretary presented letters from Michael Frederick, Kenneth G. Chesley, and Sidney P. ... Neman, Secrelary 233 Broadway New York City D. P. Morcan, Treasurer COUNCILORS Past Presidents 1933 Horace G. Byers Henry ARNSTEIN M. L. CrossLey Frank G. BREYER L. V. REDMAN ALLEN ROGERS 1935 D. D. ...
S. 1085 MICHAEL, P. L. 856 MICHAUX, P. 878, 879 MIKI, M. 1080 MIKLIC, P. 588 MILLER, N. 1152 MILLS, C. B. 1001 MILNER, P. 862 MINES, A. B. 865 MINGARDI, M. 824 MINITI, A. 604 MINO, M. ... M. 594 KRMPOTIC-NEMANIC, J. 588 KRUGER, B. 619 KRUTKO, V. N. 963 KUBOVY, M. 658 KUMAZAWA, T. 977 KUMPF, W. 792 KUN, K. 795 KURILIN, I. A, 893, 1075, 1076 KUTNICK, S. L. 793 KUVSHINOV, YU. ...
Guernsey Breeders' Journal
Brenneman; 5, Mickey of Mansfield 236291, Michael Wenal. ... Post, Kenilwood, Ber- nardsville; Ruth and Carl Schmidt, Bunker Hill Stock Farm, Trenton' Michael Wenal, Inacres Farm, New Egypt. ...
Its construction was initiated and originally funded by Polish hetman, composer and poet Michael Kasimir Oginsky. ... Dnieper-Neman Canal (Oginsky Canal) This canal connected rivers Dnieper and Neman (River Dnieper ? River Pripyat ? River Yaselda ? canal ? Lake Vygonovskoe ? River Shchara ? River Neman/Nemunas ? ...doi:10.1007/s10530-007-9124-y fatcat:luysm33m2jattnof5jarsp5osi
Florida Bar Journal
Miami 33131-1803 NEMAN, Kevin Scott . 3053559900 Stroock Stroock i Lavan 200 S Biscayne Blvd Ste 3300 Miam 33131-2310 Fax: 305/789-9302 NEIMAND, Mchael J . 954/7124600 Ofc of the Ally General 110 SE 6TH ... , Adrian Dee . 305/3857050 Basic Skills Inc 13500 SW 88TH St Ste 161 Mtam 33186-1550 E-mail: BSlplay@aol.com Fax: 954/491-8570 NEMAN, Jan Stuart . 305/5359400 One Biscayne Tower 2 S Biscayne Blvd Ste 3550 ...
Florida Bar Journal
Paris FRANCE EAKER, Lawrence Neman, Jr . . .74 Paris HUSE, Joseph A . .81 Paris SANDS, Ro^S . .84 Paris TOREM. ... K . 88 Milwaukee LEVEY, Michael Alan . ...81 Milwaukee LOOS, HenryJ . ....7! ...
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