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Artemisia vulgaris L. Chemotypes

Jack D. Williams, Michael A. Campbell, Michael C. Jaskolka, Tianyue Xie
2013 American Journal of Plant Sciences  
DNA was used to confirm the identity of Artemisia vulgaris L.  ...  Artemisia vulgaris L. was collected from various regions in the USA and Montreal Canada.  ...  Examples include Origanum vulgare L. [2] ; Thymus pulegioides L. [3] ; Seriphidium kurramense [4] ; and Artemisia judaica L. [5] .  ... 
doi:10.4236/ajps.2013.46156 fatcat:tcw7ocluabdhjbuyunbjr47a5a

New Life for Ancient DNA

Kevin L. Campbell, Michael Hofreiter
2012 Scientific American  
Kevin L. Campbell et al. in Nature Genetics, Vol. 42, pages 536-540; June 2010. © 2012 Scientific American  ...  Campbell and Michael Hofreiter F or more than 150 years scientists have primarily re lied on fossilized bones and teeth to reconstruct creatures from deep time.  ... 
doi:10.1038/scientificamerican0812-46 fatcat:eszz3chz7jf7pc44uud7re66kq

Randomized control trial of topical clonidine for treatment of painful diabetic neuropathy

Claudia M. Campbell, Mark S. Kipnes, Bruce C. Stouch, Kerrie L. Brady, Margaret Kelly, William K. Schmidt, Karin L. Petersen, Michael C. Rowbotham, James N. Campbell
2012 Pain  
A length-dependent neuropathy with pain in the feet is a common complication of diabetes (painful diabetic neuropathy, PDN). It was hypothesized that pain may arise from sensitizedhyperactive cutaneous nociceptors, and that this abnormal signaling may be reduced by topical administration of the α 2 -adrenergic agonist, clonidine, to the painful area. This was a randomized, double-blind, placebo-controlled, parallel-group, multi-center trial. Nociceptor function was measured by determining the
more » ... infulness of 0.1% topical capsaicin applied to the pre-tibial area of each subject for 30 minutes during screening. Subjects were then randomized to receive 0.1% topical clonidine gel (n=89) or placebo gel (n=90) applied t.i.d. to their feet for 12 weeks. The difference in foot pain at week 12 in relation to baseline, rated on a 0-10 numerical pain rating scale (NPRS), was compared between groups. Baseline NPRS was imputed for missing data for subjects who terminated the study early. The subjects treated with clonidine showed a trend toward decreased foot pain compared to the placebo-treated group (the primary endpoint; p=0.07). In subjects who felt any level of pain to capsaicin, clonidine was superior to placebo (p<0.05). In subjects with a capsaicin pain rating ≥2 (0-10, NPRS), the mean decrease in foot pain was 2.6 for active compared to 1.4 for placebo (p=0.01). Topical clonidine gel significantly reduces the level of foot pain in PDN subjects with functional (and possibly sensitized) nociceptors in the affected skin as revealed by testing with topical capsaicin. Screening for cutaneous nociceptor function may help distinguish candidates for topical therapy for neuropathic pain.
doi:10.1016/j.pain.2012.04.014 pmid:22683276 pmcid:PMC3413770 fatcat:fitgc4so5fbrzlyx4kxnrjt6n4

Mathematical Notes

J. G. Campbell, Michael Golomb, David Ellis, L. Carlitz, S. K. Lakshmana Rao
1954 The American mathematical monthly  
CAMPBELL, Albany, Kentucky and MIcHAEL GoLoms, Purdue University 1. The problem. In this note we propose to find the polynomial solutions of (1) Ay’ = Bot Biy + Bry?  ...  We have by the convolution theorem: (1) L(fo(x) + fi(x)* +++ *fn(x)) = Lfo(x)-Lfi(x) --- Lfn(x).  ... 
doi:10.1080/00029890.1954.11988484 fatcat:acicv4u43nbktk3baemzzwjtyi

Ignition and high gain with ultrapowerful lasers*

Max Tabak, James Hammer, Michael E. Glinsky, William L. Kruer, Scott C. Wilks, John Woodworth, E. Michael Campbell, Michael D. Perry, Rodney J. Mason
1994 Physics of Plasmas  
Its recession velocity was l/4@.  ...  where the relation k=l/R between wave number and spherical harmonic index is used.  ... 
doi:10.1063/1.870664 fatcat:tsifpsrygjcsndbasw5fbyqxs4

Gene regulation and speciation in house mice

Katya L. Mack, Polly Campbell, Michael W. Nachman
2016 Genome Research  
While cis-regulatory variation is substantial in natural populations (Osada et al. 2006; Campbell et al. 2008; Genissel et al. 2008; Gruber and Long 2009; Lemmon et al. 2014) , trans-acting variation  ...  Despite this expectation, there is close agreement between our finding of X-linked overexpression and the results of Campbell et al. (2013) , who studied X-linked expression in flow-sorted germ cells  ... 
doi:10.1101/gr.195743.115 pmid:26833790 pmcid:PMC4817769 fatcat:jcllreyf7rgxhhpkqxdkcltqam

Generalisability in unbalanced, uncrossed and fully nested studies

Ajit Narayanan, Michael Greco, John L Campbell
2010 Medical Education  
When l = p and m = n, Formula 10 reduces to Formula 7 for calculating the aggregated G coefficient.  ...  G coefficients of 0.65 and G D1 ¼ a v s þa v itotal=l þ v rtotal=n ð v i =nÞþa v s þa v itotal=p þ v rtotal=m þða v s Âa v itotal=p Þþða v s  v rtotal=m Þþða v itotal=p  v rtotal=m Þþða v s Âa v itotal  ... 
doi:10.1111/j.1365-2923.2009.03606.x pmid:20444072 fatcat:jlupqsgwnrhw3kpspjlhgp45vi

Inactivation of Voltage-Gated Cardiac K + Channels

Randall L. Rasmusson, Michael J. Morales, Shimin Wang, Shuguang Liu, Donald L. Campbell, Mulugu V. Brahmajothi, Harold C. Strauss
1998 Circulation Research  
Data are shown for a step from Ϫ90 to ϩ50 mV in 2 mmol/L [K ϩ ] o . These data reproduce the findings previously reported by Rettig et al 67 (data from Rasmusson et al 75 with permission).  ...  rapidly activating delayed rectifier, I Kr , and has been linked to a form of the familial long QT syndrome. 9 The HERG channel has a rapid inactivation mechanism 51-55 that is sensitive to 100 mmol/L  ... 
doi:10.1161/01.res.82.7.739 pmid:9562433 fatcat:sjugcohpnvg2vjntel4k4ey2ti

Repertoire matching between neighbouring song sparrows

1996 Animal Behaviour  
Campbell, J. M. Burt, J. C. Nordby, C. E. Hill & M. D. Beecher, unpublished data).  ... 
doi:10.1006/anbe.1996.0095 fatcat:ph6unnlu65as7httftgs5opmcy

Leslie M. Harris, James T. Campbell, and Alfred L. Brophy, eds. Slavery and the University: Histories and Legacies. Athens: University of Georgia Press, 2019. 368 pp

Michael E. Jirik
2019 History of Education Quarterly  
Alfred L. Brophy explicates the symbiotic relationship between southern universities as engines of proslavery thought with politics and law.  ...  MICHAEL E. JIRIK University of Massachusetts Amherst doi: 10.1017/heq.2019.39 Tobias Higbie. Labor's Mind: A History of Working-Class Intellectual Life.  ... 
doi:10.1017/heq.2019.39 fatcat:6x4fzco4zjblnplgewv3a5ulka

Inclusion of Electron Interactions by Rate Equations in Chemical Models

Laurence Campbell, Dale L. Muccignat, Michael J. Brunger
2022 Atoms  
N i=l+1 k li (E i − E l − ε)/ε (23) for superelastic collisions.  ...  Thus, substituting the final density for the initial density: n i (t + ∆t) = n i (t) + G i − L i = n i (t) + G i − L i n i (t) n i (t) = n i (t) + G i − L i n i (t + ∆t) n i (t) (7) and rearranging: n  ... 
doi:10.3390/atoms10020062 fatcat:ahpreyvpmjefnkffw2f2ouciay

Evolution of UCP1 Transcriptional Regulatory Elements Across the Mammalian Phylogeny

Michael J. Gaudry, Kevin L. Campbell
2017 Frontiers in Physiology  
Among species that possess pseudogenized UCP1 genes, an intact TATA box still remains ∼290 bp upstream of the African elephant (L. africana) and manatee (T. manatus) coding sequence while the closely related  ...  Copyright © 2017 Gaudry and Campbell. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).  ... 
doi:10.3389/fphys.2017.00670 pmid:28979209 pmcid:PMC5611445 fatcat:ihtffugvy5hgri3mguf34k3vfa

Secondhand homes: Woodpecker cavity location and structure influences secondary nester′s success [article]

Faith O Hardin, Samantha Leivers, Jacquelyn K Grace, David M Cairns, Tyler Campbell, Brian L Pierce, Michael L Morrison
2020 bioRxiv   pre-print
, 156 Brown-crested Flycatcher (BCFL; Myiarchus tyrannulus), and Bewick's Wren (BEWR; 157 Thryomanes bewickii) in the southern Texas Tamaulipan Brushlands (Baumgardt, Morrison, 158 Brennan, Pierce, & Campbell  ... 
doi:10.1101/2020.09.11.293860 fatcat:3ayoa5pfsnbejkdmfomnhpmxpq

Biological response to climate change on a tropical mountain

J. Alan Pounds, Michael P. L. Fogden, John H. Campbell
1999 Nature  
Recent warming has caused changes in species distribution and abundance 1±3 , but the extent of the effects is unclear. Here we investigate whether such changes in highland forests at Monteverde, Costa Rica, are related to the increase in air temperatures that followed a step-like warming of tropical oceans in 1976 (refs 4, 5). Twenty of 50 species of anurans (frogs and toads) in a 30-km 2 study area, including the locally endemic golden toad (Bufo periglenes), disappeared following synchronous
more » ... population crashes in 1987 (refs 6±8). Our results indicate that these crashes probably belong to a constellation of demographic changes that have altered communities of birds, reptiles and amphibians in the area and are linked to recent warming. The changes are all associated with patterns of dry-season mist frequency, which is negatively correlated with sea surface temperatures in the equatorial Paci®c and has declined dramatically since the mid-1970s. The biological and climatic patterns suggest that atmospheric warming has raised the average altitude at the base of the orographic cloud bank, as predicted by the lifting-cloud-base hypothesis 9,10 . This hypothesis builds on evidence that rising sea surface temperatures (SSTs) have altered the climates of tropical mountains. Enhanced evaporation from warm ocean surfaces has generated large amounts of water vapour, and latent heat released as this moisture condenses has accelerated atmospheric warming 5 . Because vertical thermal pro®les have tended towards a moist adiabatic lapse rate, the decline in temperature with increasing elevation has diminished, amplifying the warming in the highlands relative to the lowlands 11±13 . Freezing heights have shifted upwards 11 , and glaciers on high tropical mountains are rapidly melting 14 . If temperature-dependent relative humidity surfaces, and thus cloudformation heights, have likewise shifted upwards 10 , organisms may be affected in various ways. Monteverde's stratus±stratocumulus bank, which forms as the trade winds meet the Caribbean slope of the Cordillera de Tilara Ân,¯ow upwards and cool adiabatically, in¯uences several key ecological processes. A lifting cloud base should alter regional hydrology by reducing critical dry-season inputs of mist (low-intensity windblown precipitation) and cloud water (non-precipitating droplets deposited onto vegetation) 15,16 . To examine climate trends, we have analysed patterns of precipitation, stream¯ow, air temperatures and SSTs. The rainfall and air-temperature data (collected by J.H.C.) are from leeward cloud forest (1,540 m; ,1 km west of the Monteverde Cloud Forest Preserve headquarters and ,3 km west of the continental divide). The weather station lies on the western boundary of our 30-ha study plot for anoline lizards, which overlaps a 40-ha plot for birds. Both plots lie within the 30-km 2 anuran study area. The stream-¯ow data (from the Costa Rican Electrical Institute) are for the Rõ Âo Can Äas at Lõ Âbano (300 m; ,23 km northwest of Monteverde). The SST data (from NOAA) are for the Nin Äo-3 region of the equatorial Paci®c (,850 km SW; 1508 W±908 W, 58 N±58 S). Using daily rain-gauge records from the dry season (January± April), we develop a mist-frequency index. These data underestimate windblown inputs 16 but contain signatures of mist events (as well as rare convective showers and wind-driven rains during cold fronts). Because'dry days' (ones without measurable precipitation) represent intervals with little or no mist, their pattern conveys information about the incidence and temporal distribution of mist events. The frequency of dry days is inversely related to mist frequency, so we use the former as a negative index of the latter. letters to nature NATURE | VOL 398 | 15 APRIL 1999 | 611 Figure 1 Trends and¯uctuations in dry-season precipitation and stream¯ow. a, Frequency distributions of daily rainfall by 6-yr periods. b, SSTs (mean anomalies) and dry days in runs $5. In the stepwise multiple regression, both SSTand year explained signi®cant amounts of variation in the number of dry days (t-tests for partial coef®cients, P , 0:01; for the full model, F 2:23 14:4, P , 0:001; r 2 0:56). c, The drying trend, as illustrated by the residuals from step 1 of this regression (that is, the effect of year partialled on SST). d, Recent ENSOs and total dry days. e, Annual minimum stream¯ow (minimum daily average).
doi:10.1038/19297 fatcat:6ydmhe75uzdbbloqel3y5jaqn4

An empirical foundation for product flexibility

P.K. Palani Rajan, Michael Van Wie, Matthew I. Campbell, Kristin L. Wood, Kevin N. Otto
2005 Design Studies  
Product flexibility has gained recent attention in companies, which design products for rapidly changing technologies and which are under constant pressure to frequently upgrade their products. In this paper, we develop a method to evaluate product flexibility by performing an empirical study that examines the dependency of flexibility on the number of parts, functions, interfaces, types of interfaces, modules, and the manner of module arrangement. Additionally, a set of guidelines is derived from this study to aid in designing for flexibility.
doi:10.1016/j.destud.2004.09.007 fatcat:6vimwsmfcjfobo7psx6dm6jdbu
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