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Components and Context

Michael J. Kieffer, Rose K. Vukovic
2012 Journal of Learning Disabilities  
Rose K. Vukovic, PhD, is an assistant professor in the Department of Teaching & Learning, New York University.  ...  K.  ... 
doi:10.1177/0022219411432683 pmid:22293684 fatcat:zjvmn3izifgm3o24hvne4crxzi

LIMO: Latent Inceptionism for Targeted Molecule Generation [article]

Peter Eckmann, Kunyang Sun, Bo Zhao, Mudong Feng, Michael K. Gilson, Rose Yu
2022 arXiv   pre-print
Code is available at https://github.com/Rose-STL-Lab/LIMO.  ...  To maximize properties, given a set of k property predictors (g 1 , • • • , g k ) and weights (w 1 , • • • , w k ), we minimize the following function using the Adam optimizer, initialized from z ∼ N (  ...  Lower K D is associated with better binding (i.e. higher affinity) (Santos-Martins et al., 2021) • K D (ABFE): Dissociation constant K D in nanomolar, as calculated by absolute binding free energy (ABFE  ... 
arXiv:2206.09010v1 fatcat:dcwhc35dqff77ep6govlghoonq

Virus-Like Vesicle-Based Therapeutic Vaccine Vectors for Chronic Hepatitis B Virus Infection

Tracy D. Reynolds, Linda Buonocore, Nina F. Rose, John K. Rose, Michael D. Robek, G. McFadden
2015 Journal of Virology  
31 364 HBV S 364-372 WGPSLYSIL D d 32 371 HBV S 371-378 ILSPFLPL K b 32, 33 87 HBcAg 87-95 SYVNTNMGL K d 34 93 HBcAg 93-100 MGLKFRQL K b 35 131 HBcAg 131-139 AYRPPNAPI K d  ...  TABLE 1 1 HBV surface envelope and HBcAg CD8 T cell epitopes a Epitope Protein Position Sequence MHC Reference(s) 191 HBV S 191-202 IPQSLDSWWTSL L d 30 353 HBV S 353-360 VWLSVIWM K b  ... 
doi:10.1128/jvi.01184-15 pmid:26246574 pmcid:PMC4580199 fatcat:wqpgzn5thnbvhhzijzp3zlayim

Rapid On-site Evaluation (ROSE) for Fine Needle Aspiration of Thyroid: Is It Helpful?

Ahmed K. Aly, Mahmoud A. Ali, Apoorva Sharma, Michael A. Gubbels, Xing Zhao, Ayahallah Ahmed, Sarah Aurit, Joseph Stavas
2021 SciMedicine Journal  
Specimen adequacy was compared between ROSE and non-ROSE groups. Results: 442 thyroid nodules were biopsied. ROSE was available for 65 nodules.  ...  ROSE availability improved sample adequacy of nodules less than 3 cm with statistically significant difference of 100.0% with ROSE vs. 87% without ROSE.  ...  The non-diagnostic rate was 5.3% with ROSE compared to 10.5% without ROSE in the entire group.  ... 
doi:10.28991/scimedj-2021-0301-1 fatcat:krhfnb5wkne6zfxsxxj3qcvy44

New Experiments for an Undivided Genetics: TABLE 1

Michael R. Rose, Laurence D. Mueller, Molly K. Burke
2011 Genetics  
., Rose 1991; Van Voorhies et al. 2006) .  ...  Reverse experimental evolution (see Teotonio and Rose 2000, 2001) combined with whole-genome resequencing (cf.  ... 
doi:10.1534/genetics.111.128900 pmid:21546546 pmcid:PMC3120144 fatcat:lnhejgfnqve6pazhwuqvya25zu

PHYSIOLOGICAL MECHANISMS OF EVOLVED DESICCATION RESISTANCE IN DROSOPHILA MELANOGASTER [chapter]

ALLEN G. GIBBS, ADAM K. CHIPPINDALE, MICHAEL R. ROSE
2004 Methuselah Flies  
K. Chippindale, M. R. Rose and T. J.  ...  K. Chippindale, M. R. Rose and T. J. Bradley, in preparation) .  ... 
doi:10.1142/9789812567222_0010 fatcat:eize4ogbnfdrjhw57xbx3n43cq

Evolution of ageing since Darwin

Michael R. Rose, Molly K. Burke, Parvin Shahrestani, Laurence D. Mueller
2008 Journal of Genetics  
1985) . 1980-1984: First deliberate laboratory evolution of slower ageing Working as Brian Charlesworth's graduate student at the University of Sussex in the 1970's, Michael R.  ...  in 1980 (Rose and Charlesworth 1980) .  ... 
doi:10.1007/s12041-008-0059-6 pmid:19147926 fatcat:lwjtdgly65atjczeirotk55ywy

Beyond Gender Identity Disorder Diagnoses Codes

Guneet K. Jasuja, Alexander de Groot, Emily K. Quinn, Omid Ameli, Jaclyn M.W. Hughto, Michael Dunbar, Madeline Deutsch, Carl G. Streed, Michael K. Paasche-Orlow, Hill L. Wolfe, Adam J. Rose
2020 Medical Care  
Large administrative databases often do not capture gender identity data, limiting researchers' ability to identify transgender people and complicating the study of this population. The objective of this study was to develop methods for identifying transgender people in a large, national dataset for insured adults. This was a retrospective analysis of administrative claims data. After using gender identity disorder (GID) diagnoses codes, the current method for identifying transgender people in
more » ... dministrative data, we used the following 2 strategies to improve the accuracy of identifying transgender people that involved: (1) Endocrine Disorder Not Otherwise Specified (Endo NOS) codes and a transgender-related procedure code; or (2) Receipt of sex hormones not associated with the sex recorded in the patient's chart (sex-discordant hormone therapy) and an Endo NOS code or transgender-related procedure code. Seventy-four million adults 18 years and above enrolled at some point in commercial or Medicare Advantage plans from 2006 through 2017. We identified 27,227 unique transgender people overall; 18,785 (69%) were identified using GID codes alone. Using Endo NOS with a transgender-related procedure code, and sex-discordant hormone therapy with either Endo NOS or transgender-related procedure code, we added 4391 (16%) and 4051 (15%) transgender people, respectively. Of the 27,227 transgender people in our cohort, 8694 (32%) were transmasculine, 3959 (15%) were transfeminine, and 14,574 (54%) could not be classified. In the absence of gender identity data, additional data elements beyond GID codes improves the identification of transgender people in large, administrative claims databases.
doi:10.1097/mlr.0000000000001362 pmid:32925416 fatcat:sxu4fd7aw5aknlgftwur65kv2q

Criteria for environmentally associated autoimmune diseases

Frederick W. Miller, K. Michael Pollard, Christine G. Parks, Dori R. Germolec, Patrick S.C. Leung, Carlo Selmi, Michael C. Humble, Noel R. Rose
2012 Journal of Autoimmunity  
Increasing evidence supports a role for the environment in the development of autoimmune diseases, as reviewed in the accompanying three papers from the National Institute of Environmental Health Sciences Expert Panel Workshop. An important unresolved issue, however, is the development of criteria for identifying autoimmune disease phenotypes for which the environment plays a causative role, herein referred to as environmentally associated autoimmune diseases. There are several different areas
more » ... n which such criteria need to be developed, including: 1) identifying the necessary and sufficient data to define environmental risk factors for autoimmune diseases meeting current classification criteria; 2) establishing the existence of and criteria for new environmentally associated autoimmune disorders that do not meet current disease classification criteria; and 3) identifying in clinical practice specific environmental agents that induce autoimmune disease in individual patients. Here we discuss approaches that could be useful for developing criteria in these three areas, as well as factors that should be considered in evaluating the evidence for criteria that can distinguish individuals with such disorders from individuals without such disorders with high sensitivity and specificity. Current studies suggest that multiple lines of complementary evidence will be important and that in many cases there will be clinical, serologic, genetic, epigenetic, and/or other laboratory features that could be incorporated as criteria for environmentally associated autoimmune diseases to improve diagnosis and treatment and possibly allow for preventative strategies in the future.
doi:10.1016/j.jaut.2012.05.001 pmid:22771005 pmcid:PMC3468712 fatcat:it3izyla65ag3advlqwoyzihzy

The Political Economy of European Integration

Barry Eichengreen, Jeffry Frieden, Geoffrey Garrett, Andrew K. Rose, Jürgen von Hagen, Michael Wallerstein
2000 European Union Politics  
Authors like Rose (2000) suggest that they have different economic effects as well. One response to these objections was to consider survey data on attitudes toward European integration.  ... 
doi:10.1177/1465116500001002005 fatcat:hqaztvchpzhnhmyqu532ifnr5i

Experimental evolution with Drosophila

Molly K. Burke, Michael R. Rose
2009 American Journal of Physiology. Regulatory Integrative and Comparative Physiology  
[From Figs. 1 and 2 of Rose et al. (40)].  ...  Furthermore, longer-lived lines (Rose system "O" lines) have generally been found to tolerate starvation and desiccation significantly better than lines with shorter average lifespans (Rose system "B"  ...  K. Burke and M. R. Rose.  ... 
doi:10.1152/ajpregu.90551.2008 pmid:19339679 fatcat:sv3spvjvdrf5llty2lmmwioe4q

Additional Comments on Reproductive Strategies and Population Fluctuations in Mictorine Rodents

Michael S. Gaines, William M. Schaffer, Robert K. Rose
1979 Ecology  
More recently, Rose and Gaines (1978) conducted an extensive study of Microtus ochrogaster in eastern Kansas.  ... 
doi:10.2307/1936973 fatcat:z4o4il7pljaqte4tq6gcz5e66i

Normal Replication of Vesicular Stomatitis Virus without C Proteins

EVELYNE KRETZSCHMAR, RICHARD PELUSO, MATTHIAS J. SCHNELL, MICHAEL A. WHITT, JOHN K. ROSE
1996 Virology  
E., and Rose, J. K. (1981). Localized attenuation and disconduced stop codon, we would have easily detected them tinuous synthesis during vesicular stomatitis virus transcription. Cell 23, 477-484.  ...  The first primer introduced a teins or N, P-C 0 , and L proteins were transfected into point mutation (G145 to A [in bold]) which generates a the cells using TransfectACE (Rose et al., 1991) .  ... 
doi:10.1006/viro.1996.0066 pmid:8607260 fatcat:7r52h23i4rclzc5lepchcg7a5u

Potentially hazardous Asteroid 2007 LE: Compositional link to the black chondrite Rose City and Asteroid (6) Hebe

Sherry K. Fieber-Beyer, Michael J. Gaffey, William F. Bottke, Paul S. Hardersen
2015 Icarus (New York, N.Y. 1962)  
Dynamical analysis could not directly link the fall of the Rose City meteorite to 2007 LE.  ...  Further investigation of the meteorite classes yielded a black chondrite, Rose City, which is both similar in mineralogy and spectrally to PHA 2007 LE.  ...  For our derived albedo of 8% (see below), the surface temperature of 2007 LE at a heliocentric distance of 1.058 AU would be 272 K.  ... 
doi:10.1016/j.icarus.2014.12.021 fatcat:ocof4t3q2fcpvcvqgxyemw26g4
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