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Vision-based force sensing at nanonewton scales

Michael A. Greminger, Bradley J. Nelson, Bradley J. Nelson, Jean-Marc Breguet
2001 Microrobotics and Microassembly III  
This can be done using the homogeneous transformation given by m n , ( ) E m n , ( ) E m n , ( ) I j k , ( ) T j m -k n - , ( ) - [ ] 2 k ∑ j ∑ = I j k , ( ) j k , ( ) T j k , ( ) j k E max m n , ( ) E  ...  θ sin - 0 θ sin θ cos 0 0 0 1 S 0 0 0 S 0 0 0 1 S θ cos S θ sin - T X S θ sin S θ cos Ty 0 0 1 = = S θ T X T Y x y A S θ T X T Y E S θ T X T Y , , , ( ) x Tj ' x Ij - ( ) 2 y Tj ' y Ij - ( ) 2 + [ ] j  ... 
doi:10.1117/12.444147 fatcat:oww3q3jxsngglbwmvlorl53kiq

Bootstrap confidence intervalsCommentCommentCommentCommentRejoinder

Thomas J. DiCiccio, Bradley Efron, Peter Hall, Michael A. Martin, A. J. Canty, A. C. Davison, D. V. Hinkley, Leon Jay Gleser, Stephen M. S. Lee, G. Alastair Young, Thomas J. DiCiccio, Bradley Efron
1996 Statistical Science  
Comment Peter Hall and Michael A. Martin Peter Hall is Professor and Michael A.  ...  Rejoinder Thomas J. DiCiccio and Bradley Efron If the standard intervals were invented today, they might not be publishable.  ... 
doi:10.1214/ss/1032280214 fatcat:55lvxafldzcz7lzvou6gujzo7q

Additivity ⊕ Homogeneity

Michael J. Bradley, David L. Finn
1999 The College Mathematics Journal  
A second way to generalize the example is to write it as xy 1 + j/3/x3 if x# 0 In fact, if / is not linear, then M*>JM-j cy ifx=0 is homogeneous but not additive. neous functions, as 1tr(  ... 
doi:10.2307/2687724 fatcat:25tapjniurg5fblsb3gc6rryn4

OctoMag: An Electromagnetic System for 5-DOF Wireless Micromanipulation

Michael P. Kummer, Jake J. Abbott, Bradley E. Kratochvil, Ruedi Borer, Ali Sengul, Bradley J. Nelson
2010 IEEE Transactions on robotics  
Finally, they would also like to thank J. Garweg, M.D. from the Swiss Eye Institute in Bern, Switzerland, and C.  ...  as 0 if σ j = 0, and all other entries being equal 0 [37] .  ...  The pseudoinverse is computed as A † = V Σ † U T , where Σ † is an n × 6 matrix, where the uppermost 6 × 6 elements form a diagonal matrix with the jth diagonal element defined as 1/σ j if σ j = 0 and  ... 
doi:10.1109/tro.2010.2073030 fatcat:tcj2gqqpjvbyxnzkuadxudpyh4

Hippocampal theta codes for distances in semantic and temporal spaces [article]

Ethan A Solomon, Bradley C Lega, Michael R Sperling, Michael J Kahana
2019 bioRxiv   pre-print
The medial temporal lobe (MTL) is known to support episodic memory and spatial navigation, raising the possibility that its true function is to form "cognitive maps" of any kind of information. Studies in humans and animals support the idea that the hippocampal theta rhythm (4-8 Hz) is key to this mapping function, as it has been repeatedly observed during spatial navigation tasks. If episodic memory and spatial navigation are two sides of the same coin, we hypothesized that theta oscillations
more » ... ould also reflect relations between explicitly nonspatial items, such as words. We asked 189 neurosurgical patients to perform a verbal free-recall task, of which 96 had indwelling electrodes placed in the MTL. Subjects were instructed to remember short lists of sequentially-presented nouns. We found that hippocampal theta power and connectivity during item retrieval coded for semantic distances between words, as measured using word2vec-derived subspaces. Additionally, hippocampal theta indexed temporal distances between words after filtering lists on recall performance, to ensure adequate dynamic range in time. Theta effects were only noted for semantic subspaces of 1-dimension, indicating a substantial compression of the possible semantic feature space. These results lend further support to our growing confidence that the MTL forms cognitive maps of arbitrary representational spaces, reconciling longstanding differences between the spatial and episodic memory literatures.
doi:10.1101/611681 fatcat:6ps7se2gfzazfjeo34e7xieg34

Exploration in the wild [article]

Eric Schulz, Rahul Bhui, Bradley C Love, Bastien Brier, Michael T Todd, Samuel J Gershman
2018 bioRxiv   pre-print
for each restaurant j.  ...  when it has been selected at trial t: mj,t = mj,t−1 + δj,tGj,t [yt − mj,t−1] [8] vj,t = [1 − δj,tGj,t] vj,t−1 [9] where δj,t = 1 if option j is chosen on trial t, and 0 otherwise.  ... 
doi:10.1101/492058 fatcat:gytojwqt3feqpkgmze2pu4ufdm

Genome sequencing identifies multiple deleterious variants in autism patients with more severe phenotypes

Hui Guo, Michael H. Duyzend, Bradley P. Coe, Carl Baker, Kendra Hoekzema, Jennifer Gerdts, Tychele N. Turner, Michael C. Zody, Jennifer S. Beighley, Shwetha C. Murali, Bradley J. Nelson, Michael J. Bamshad (+3 others)
2018 Genetics in Medicine  
To maximize the discovery of potentially pathogenic variants to better understand the diagnostic utility of genome sequencing (GS) and to assess how the presence of multiple risk events might affect the phenotypic severity in autism spectrum disorders (ASD).
doi:10.1038/s41436-018-0380-2 pmid:30504930 pmcid:PMC6546556 fatcat:v7swzwgi25dohjrntnbvtdy43a

PECAM-1 Polymorphism Affects Monocyte Adhesion to Endothelial Cells

Reyna S. Goodman, Christopher M. Kirton, Gertie J. Oostingh, Michael P. Schön, Michael R. Clark, J Andrew Bradley, Craig J. Taylor
2008 Transplantation  
Background. Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) plays an important role in leukocyteendothelial cell adhesion and transmigration. Single nucleotide polymorphisms of PECAM-1 encoding amino acid substitutions at positions 98 leucine/valine (L/V), 536 serine/asparagine (S/N), and 643 arginine/glycine (R/G) occur in strong genetic linkage resulting in two common haplotypes (LSR and VNG). These PECAM-1 polymorphisms are associated with graft-versus-host disease after
more » ... ietic stem cell transplantation and with cardiovascular disease, but whether they influence PECAM-1 function is unknown. Methods. We examined the effect of homozygous and heterozygous expression of the PECAM-1 LSR and VNG genotypes on the adhesive interactions of peripheral blood monocytes and activated endothelial cell monolayers under shear stress in a flow-based cell adhesion assay. Results. There was no difference in monocyte adhesion between the two homozygous genotypes of PECAM-1 but when monocytes expressed both alleles in heterozygous form, firm adhesion of monocytes to endothelial cells was markedly increased. PECAM-1 polymorphism expressed in homozygous or heterozygous form by endothelial cells did not influence monocyte adhesion. Conclusions. This is, to our knowledge, the first demonstration that PECAM-1 genotype can alter the level of monocyte binding to endothelial cells and a demonstration that heterozygous expression of a polymorphic protein may lead to altered function.
doi:10.1097/tp.0b013e3181622d65 pmid:18301339 fatcat:r64m6b3w6rbmvakh4mtbn4uawa

Turning the Bayesian Crank

Richard F. MacLehose, J. Michael Oakes, Bradley P. Carlin
2011 Epidemiology  
J. MICHAEL OAKES is an associate professor of epidemiology at the University of Minnesota engaged in social epidemiology and methods research.  ...  BRADLEY CARLIN is Mayo professor and head of biostatistics at the University of Minnesota. He is actively engaged in research in Bayesian inference and spatial statistics.  ... 
doi:10.1097/ede.0b013e318212b31a pmid:21464652 pmcid:PMC5659857 fatcat:wnhxexr42ff3jbg77rsjkzgdmi

Wireless Intraocular Microrobots: Opportunities and Challenges [chapter]

Olgaç Ergeneman, Christos Bergeles, Michael P. Kummer, Jake J. Abbott, Bradley J. Nelson
2010 Surgical Robotics  
Many current and proposed retinal procedures are at the limits of human performance and perception. Microrobots that can navigate the fluid in the interior of the eye have the potential to revolutionize the way the most difficult retinal procedures are conducted. Microrobots are typically envisioned as miniature mechatronic systems that utilize MEMS technology to incorporate sensing and actuation onboard. This chapter presents a simpler alternative approach for the development of intraocular
more » ... rorobots consisting of magnetic platforms and functional coatings. Luminescence dyes immobilized in coatings can be excited and read wirelessly to detect analytes or physical properties. Drug coatings can be used for diffusion-based delivery, and may provide more efficient therapy than microsystems containing pumps, as diffusion dominates over advection at the microscale. Oxygen sensing for diagnosis and drug therapy for retinal vein occlusions are presented as example applications. Accurate sensing and therapy requires precise control to guide the microrobot in the interior of the human eye. We require an understanding of the possibilities and limitations in wireless magnetic control. We also require the ability to visually track and localize the microrobot inside the eye, while obtaining clinically useful retinal images. Each of these topics is discussed. Magnetic microrobots contain nickel, cobalt, iron, or their alloys. These elements and their alloys are declared to be non-biocompatible. Hence, they are not used in Fig. 13.1 Relatively simple 2-D parts can be assembled into complex 3-D structures (#IEEE 2008), reprinted with permission. The parts shown have dimensions 2.0 mm 1.0 mm 42 mm and can be further miniaturized 13 Wireless Intraocular Microrobots: Opportunities and Challenges 273 276 O. Ergeneman et al.
doi:10.1007/978-1-4419-1126-1_13 fatcat:zdrdlnenp5gl3gregl43rwazb4

Self-Control and Adverse "Drinking" Consequences

Barbara J. Costello, Bradley J. Anderson, Michael D. Stein
2014 Deviant Behavior  
Clinical Trial #NCT00237003 was awarded to Michael D. Stein. Table 1. Sample Characteristics and Descriptive Statistics (n = 190). < .05, ** p < .01 Table 3.  ...  Authors Barbara J. Costello, Bradley J. Anderson, and Michael D. Stein  ... 
doi:10.1080/01639625.2014.901075 fatcat:fubhowphnbaidc2mwozos44txy

OctoMag: An electromagnetic system for 5-DOF wireless micromanipulation

Michael P Kummer, Jake J Abbott, Bradley E Kratochvil, Ruedi Borer, Ali Sengul, Bradley J Nelson
2010 2010 IEEE International Conference on Robotics and Automation  
Finally, they would also like to thank J. Garweg, M.D. from the Swiss Eye Institute in Bern, Switzerland, and C.  ...  as 0 if σ j = 0, and all other entries being equal 0 [37] .  ...  The pseudoinverse is computed as A † = V Σ † U T , where Σ † is an n × 6 matrix, where the uppermost 6 × 6 elements form a diagonal matrix with the jth diagonal element defined as 1/σ j if σ j = 0 and  ... 
doi:10.1109/robot.2010.5509241 dblp:conf/icra/KummerAKBSN10 fatcat:fppwokvrcjhuzpbyzwdz4c5w3m

Peritoneal Dissemination Complicating Morcellation of Uterine Mesenchymal Neoplasms

Michael A. Seidman, Titilope Oduyebo, Michael G. Muto, Christopher P. Crum, Marisa R. Nucci, Bradley J. Quade, David J. Sullivan
2012 PLoS ONE  
Power morcellation has become a common technique for the minimally invasive resection of uterine leiomyomas. This technique is associated with dissemination of cellular material throughout the peritoneum. When morcellated uterine tumors are unexpectedly found to be leiomyosarcomas or tumors with atypical features (atypical leiomyoma, smooth muscle tumor of uncertain malignant potential), there may be significant clinical consequences. This study was undertaken to determine the frequency and
more » ... ical consequence of intraperitoneal dissemination of these neoplasms. Methodology/Principal Findings: From 2005-2010, 1091 instances of uterine morcellation were identified at BWH. Unexpected diagnoses of leiomyoma variants or atypical and malignant smooth muscle tumors occurred in 1.2% of cases using power morcellation for uterine masses clinically presumed to be "fibroids" over this period, including one endometrial stromal sarcoma (ESS), one cellular leiomyoma (CL), six atypical leiomyomas (AL), three smooth muscle tumor of uncertain malignant potential (STUMPs), and one leiomyosarcoma (LMS). The rate of unexpected sarcoma after the laparoscopic morcellation procedure was 0.09%, 9-fold higher than the rate currently quoted to patients during pre-procedure briefing, and this rate may increase over time as diagnostically challenging or under-sampled tumors manifest their biological potential. Furthermore, when examining follow-up laparoscopies, both from in-house and consultation cases, disseminated disease occurred in 64.3% of all tumors (zero of one ESS, one of one CL, zero of one AL, four of four STUMPs, and four of seven LMS). Only disseminated leiomyosarcoma, however, was associated with mortality. Procedures are proposed for pathologic evaluation of morcellation specimens and associated follow-up specimens. Conclusions/Significance: While additional study is warranted, these data suggest uterine morcellation carries a risk of disseminating unexpected malignancy with apparent associated increase in mortality much higher than appreciated currently.
doi:10.1371/journal.pone.0050058 pmid:23189178 pmcid:PMC3506532 fatcat:7an2yxbv2jgtlbf7ww3swksiyy

Intubation Biomechanics

Bradley J. Hindman, Brandon G. Santoni, Christian M. Puttlitz, Robert P. From, Michael M. Todd
2014 Anesthesiology  
(Department of Anesthesia, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa), who developed the randomization scheme and performed outlier analysis.  ...  In our study, lateral x-rays demonstrated that anterior jaw subluxation was less with Airtraq (unpublished data: March 7, 2014, Bradley J.  ...  Intervertebral motion in the sagittal plane was measured by a single investigator (B.G.S.) in a similar manner to previous studies 7, 8, 10, 19 using publically available image analysis software (NIH Image J,  ... 
doi:10.1097/aln.0000000000000263 pmid:24739996 pmcid:PMC4110170 fatcat:2zqo6uftynhbnkhw4nk5skospa

Effects of ethanol on cocaine discrimination in rats

Michael B. Gatch, Bradley D. Youngblood, Michael J. Forster
2003 Pharmacology, Biochemistry and Behavior  
Ethanol and cocaine are frequently abused in combination, but little is known about how the subjective effects of the two drugs interact. The ability of ethanol and other GABA A -active compounds to alter the discriminative stimulus effects of cocaine was tested. Male Sprague-Dawley rats were trained to discriminate cocaine (10 mg/kg, i.p.) from saline using either singledose or cumulative dosing methods. In single-dose testing, ethanol (0.1 to 0.5 g/kg) dosedependently decreased
more » ... iate responding following the training dose of cocaine. Ethanol (0.5 g/kg) produced a rightward shift in the cocaine cumulative dose-effect curve. Ethanol (0.1 to 1.0 g/kg) failed to substitute for the discriminative stimulus effects of cocaine and the higher doses (1 to 2 g/kg) completely suppressed responding. Indirect GABA A agonists diazepam (benzodiazepine site) and pentobarbital (barbiturate site) did not block the discriminative stimulus effects of cumulative doses of cocaine. The GABA A antagonist pentylenetetrazol (10 to 40 mg/kg) did not substitute for cocaine. These findings suggest that ethanol can modulate the discriminative stimulus effects of cocaine, and that these effects may not be mediated by the actions of ethanol at the GABA A receptor.
doi:10.1016/s0091-3057(03)00158-8 pmid:12957226 pmcid:PMC3878080 fatcat:3g2fmusg5rfmfjewomzdhuy6ea
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