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Vascular resistance and the efficacy of red cell substitutes in a rat hemorrhage model

Robert M. Winslow, Armando Gonzales, Maria L. Gonzales, Michael Magde, Michael McCarthy, Ronald J. Rohlfs, Kim D. Vandegriff
1998 Journal of applied physiology  
V O 2 as a function of O 2 is shown in Fig. 11 .  ...  Figure 8 presents O 2 , the product of Q and arterial O 2 content (Ca O 2 ). O 2 falls for all three dilution groups after exchange transfusion.  ... 
doi:10.1152/jappl.1998.85.3.993 pmid:9729575 fatcat:gkv3qkjxuvhzvmiy37fe7qdm4u

Arterial Blood Pressure Responses to Cell-free Hemoglobin Solutions and the Reaction with Nitric Oxide

Ronald J. Rohlfs, Eric Bruner, Albert Chiu, Armando Gonzales, Maria L. Gonzales, Douglas Magde, Michael D. Magde, Kim D. Vandegriff, Robert M. Winslow
1998 Journal of Biological Chemistry  
Equilibrium constants (K d ) were calculated as the ratio of the dissociation rate constant to the association rate constant (K d ϭ k/kЈ).  ...  Overall equilibrium constants were calculated as the ratio of the overall dissociation rate constant to the corresponding association rate constant (K d ϭ k/kЈ).  ... 
doi:10.1074/jbc.273.20.12128 pmid:9575158 fatcat:iujvq2x2fbcx7ak4riaamuw6wy

Naturalistic Pain Synthesis for Virtual Patients [chapter]

Maryam Moosaei, Michael J. Gonzales, Laurel D. Riek
2014 Lecture Notes in Computer Science  
Within the clinical education community, there is a desire to improve learners' pain observation skills. Virtual patients can be used as a training tool for this purpose. In this paper, we present a pioneering approach for synthesizing naturalistic pain on virtual patients. Using the UNBC-McMaster pain archive and a CLM-based face tracker, we performed naturalistic pain synthesis. We conducted an experiment to validate our synthesis approach and compared it to manual methods that use
more » ... d animators. Our results suggest that our approach was effective, and yielded higher pain labeling accuracies compared to manually animated painful faces. This research offers a new tool to both the virtual patient and clinical education communities.
doi:10.1007/978-3-319-09767-1_38 fatcat:g7qgt5yk5bahbfz66opoaw6eta

Visual TASK: A Collaborative Cognitive Aid for Acute Care Resuscitation [article]

Michael J. Gonzales, Joshua M. Henry, Aaron W. Calhoun, Laurel D. Riek
2016 arXiv   pre-print
Preventable medical errors are a severe problem in healthcare, causing over 400,000 deaths per year in the US in hospitals alone. In acute care, the branch of medicine encompassing the emergency department (ED) and intensive care units (ICU), error rates may be higher to due low situational awareness among clinicians performing resuscitation on patients. To support cognition, novice team leaders may rely on reference guides to direct and anticipate future steps. However, guides often act as a
more » ... xation point, diverting the leader's attention away from the team. To address this issue, we conducted a qualitative study that evaluates a collaborative cognitive aid co-designed with clinicians called Visual TASK. Our study explored the use of Visual TASK in three simulations employing a projected shared display with two different interaction modalities: the Microsoft Kinect and a touchscreen. Our results suggest that tools like the Kinect, while useful in other areas of acute care like the OR, are unsuitable for use in high-stress situations like resuscitation. We also observed that fixation may not be constrained to reference guides alone, and may extend to other objects in the room. We present our findings, and a discussion regarding future avenues in which collaborative cognitive aids may help in improving situational awareness in resuscitation.
arXiv:1605.05224v1 fatcat:pdvrvn3xr5ezdec27qreyzal4i

Single-cell chromatin accessibility reveals principles of regulatory variation

Jason D. Buenrostro, Beijing Wu, Ulrike M. Litzenburger, Dave Ruff, Michael L. Gonzales, Michael P. Snyder, Howard Y. Chang, William J. Greenleaf
2015 Nature  
(d) The distribution of NF-κB deviation scores for single GM12878 cells. Volcano plots of (e) non-NFKB peaks and (f) NF-κB peaks in GM12878 cells, p-values were calculated using a binomial test.  ...  Characterization of high-variance trans-factors in K562 cells (a-d) Distribution of (a) GATA1, (b) GATA2, (c) actin and (d) CTCF fluorescence observed by flow cytometry.  ...  Fig. 2eand Extended DataFig. 6a-d) confirmed heterogeneous expression of GATA1 and GATA2.  ... 
doi:10.1038/nature14590 pmid:26083756 pmcid:PMC4685948 fatcat:ebcvtvqxubfoxledy4jbdg2c6a

Acute Coagulopathy of Trauma in the Rat

Daniel N. Darlington, Teresa Craig, Mary D. Gonzales, Martin G. Schwacha, Andrew P. Cap, Michael A. Dubick
2013 Shock  
Treatment with cytochalasin D (platelet function inhibitor) eliminated the increases in clotting firmness and thrombin generation seen at 2 h with rising platelet count.  ...  Acute Coagulopathy of Trauma in the rat Darlington D. N., Craig T., Gonzales M. D., Schwacha M. G., Cap A. P., Dubick M.  ...  These changes were completely eliminated after inhibition of platelet aggregation with cytochalasin D. !  ... 
doi:10.1097/shk.0b013e31829040e3 pmid:23481505 fatcat:o5fm363t7vef7in3nw526c6y2y

A sociable robotic aide for medication adherence

Michael J. Gonzales, Laurel D. Riek
2012 Proceedings of the 5th International Conference on PErvasive Technologies Related to Assistive Environments - PETRA '12  
In the United States, approximately 125,000 people die each year due to complications related to medication adherence, which costs the country approximately $100 -$300 billion dollars annually. The problem of medication adherence stems largely from people either having too many medications, causing confusion and making management harder, or taking larger dosages than prescribed. We propose a solution for improving medication adherence using a physically embodied social robot as a motivating
more » ... or. In particular, the robot's interaction will be similar to that of a digital pet game, except users will care for the pet by caring for themselves (i.e., taking their medication.) The robot will also leverage social-network support factors to promote the emotional and positive a↵ective behaviors of patients.
doi:10.1145/2413097.2413146 dblp:conf/petra/GonzalesR12 fatcat:v6or7cf67fdsva5w5a7njvs4dm

Illuminating Uveitis: Metagenomic Deep Sequencing Identifies Common and Rare Pathogens [article]

Thuy Doan, Michael R Wilson, Emily D Crawford, Eric D Chow, Lillian M Khan, Kristeene A Knopp, Dongxiang Xia, Jill K Hacker, Jay M Stewart, John A Gonzales, Nisha R Acharya, Joseph L DeRisi
2016 biorxiv/medrxiv   pre-print
BackgroundOcular infections remain a major cause of blindness and morbidity worldwide. While prognosis is dependent on the timing and accuracy of diagnosis, the etiology remains elusive in approximately 50% of presumed infectious uveitis cases.1, 2We aimed to determine if unbiased metagenomic deep sequencing (MDS) can accurately detect pathogens in intraocular fluid samples of patients with uveitis.MethodsThis is a proof-of-concept study, in which intraocular fluid samples were obtained from 5
more » ... ubjects with known diagnoses, and one subject with bilateral chronic uveitis without a known etiology. Samples were subjected to MDS, and results were compared with conventional diagnostic tests. Pathogens were identified using a rapid computational pipeline to analyze the non-host sequences obtained from MDS.FindingsUnbiased MDS of intraocular fluid produced results concordant with known diagnoses in subjects with (n=4) and without (n=1) uveitis. Rubella virus (RV) was identified in one case of chronic bilateral idiopathic uveitis. The subject's strain was most closely related to a German RV strain isolated in 1992, one year before he developed a fever and rash while living in Germany.InterpretationMDS can identify fungi, parasites, and DNA and RNA viruses in minute volumes of intraocular fluid samples. The identification of chronic intraocular RV infection highlights the eye's role as a long-term pathogen reservoir, which has implications for virus eradication and emerging global epidemics.
doi:10.1101/054148 fatcat:n5sl7cif7bbmbncy6tqqtivm7m

Pediatricians' perspectives on the impact of MRSA in primary care: a qualitative study

Adam L Hersh, Michael D Cabana, Ralph Gonzales, Budd N Shenkin, Christine S Cho
2009 BMC Pediatrics  
Recent treatment recommendations emphasize CA-MRSA as the primary cause, performing incision and drainage (I&D) as the primary therapy, and not prescribing antibiotics for uncomplicated cases.  ...  "It (I&D) puts you behind." Several participants mentioned a lack of training and limited expertise in performing I&D as an important internal barrier.  ...  There was variation in the perception of the importance of I&D.  ... 
doi:10.1186/1471-2431-9-27 pmid:19366461 pmcid:PMC2671509 fatcat:huiaepigufh73gwnmnbkt5iy44

Illuminating uveitis: metagenomic deep sequencing identifies common and rare pathogens

Thuy Doan, Michael R. Wilson, Emily D. Crawford, Eric D. Chow, Lillian M. Khan, Kristeene A. Knopp, Brian D. O'Donovan, Dongxiang Xia, Jill K. Hacker, Jay M. Stewart, John A. Gonzales, Nisha R. Acharya (+1 others)
2016 Genome Medicine  
Ocular infections remain a major cause of blindness and morbidity worldwide. While prognosis is dependent on the timing and accuracy of diagnosis, the etiology remains elusive in~50 % of presumed infectious uveitis cases. The objective of this study is to determine if unbiased metagenomic deep sequencing (MDS) can accurately detect pathogens in intraocular fluid samples of patients with uveitis. Methods: This is a proof-of-concept study, in which intraocular fluid samples were obtained from
more » ... subjects with known diagnoses, and one subject with bilateral chronic uveitis without a known etiology. Samples were subjected to MDS, and results were compared with those from conventional diagnostic tests. Pathogens were identified using a rapid computational pipeline to analyze the non-host sequences obtained from MDS. Results: Unbiased MDS of intraocular fluid produced results concordant with known diagnoses in subjects with (n = 4) and without (n = 1) uveitis. Samples positive for Cryptococcus neoformans, Toxoplasma gondii, and herpes simplex virus 1 as tested by a Clinical Laboratory Improvement Amendments-certified laboratory were correctly identified with MDS. Rubella virus was identified in one case of chronic bilateral idiopathic uveitis. The subject's strain was most closely related to a German rubella virus strain isolated in 1992, one year before he developed a fever and rash while living in Germany. The pattern and the number of viral identified mutations present in the patient's strain were consistent with long-term viral replication in the eye. Conclusions: MDS can identify fungi, parasites, and DNA and RNA viruses in minute volumes of intraocular fluid samples. The identification of chronic intraocular rubella virus infection highlights the eye's role as a long-term pathogen reservoir, which has implications for virus eradication and emerging global epidemics.
doi:10.1186/s13073-016-0344-6 pmid:27562436 pmcid:PMC4997733 fatcat:c5zhtj4grbhhfjlv4odlnnrpy4

NASA's Solar Dynamics Observatory (SDO): A systems approach to a complex mission

J. A. Ruffa, Michael Bay, David K. Ward, P. J. Gonzales, L. M. Bartusek, W. D. Pesnell
2012 2012 IEEE Aerospace Conference  
301) 286-8247 john.a.ruffa@nasa.gov Michael Bay Bay Engineering Innovations 8800 Greenbelt Rd Greenbelt, MD 20771 (301) 286-9759 Abstract-The Solar Dynamics Observatory (SDO) includes three advanced instruments  ... 
doi:10.1109/aero.2012.6187017 fatcat:qt74xjpmhvdwfpxz2owwhgv2ui

Application of a bioinformatic pipeline to RNA-seq data identifies novel virus-like sequence in human blood [article]

Marko Melnick, Mercedes Prudencio, Patrick Gonzales, Thomas J Larocca, Robin D Dowell, Yuping Song, Joanne Wuu, Michael Benatar, Bjorn Oskarsson, Leonard Petrucelli, Chris D. Link
2021 bioRxiv   pre-print
Numerous reports have suggested that infectious agents could play a role in neurodegenerative diseases, but specific etiological agents have not been convincingly demonstrated. To search for candidate agents in an unbiased fashion, we have developed a bioinformatic pipeline that identifies microbial sequences in mammalian RNA-seq data, including sequences with no significant nucleotide similarity hits in GenBank. Effectiveness of the pipeline was tested using publicly available RNA-seq data. We
more » ... then applied this pipeline to a novel RNA-seq dataset generated from a cohort of 120 samples from amyotrophic lateral sclerosis (ALS) patients and controls, and identified sequences corresponding to known bacteria and viruses, as well as novel virus-like sequences. The presence of these novel virus-like sequences, which were identified in subsets of both patients and controls, were confirmed by quantitative RT-PCR. We believe this pipeline will be a useful tool for the identification of potential etiological agents in the many RNA-seq data sets currently being generated.
doi:10.1101/2021.01.27.428546 fatcat:cjobz35wabdfvjjhkwafxfz2h4

High-order finite element methods for cardiac monodomain simulations

Kevin P. Vincent, Matthew J. Gonzales, Andrew K. Gillette, Christopher T. Villongco, Simone Pezzuto, Jeffrey H. Omens, Michael J. Holst, Andrew D. McCulloch
2015 Frontiers in Physiology  
Diffusivity is represent by symbol shape: D = 0.0126 mm 2 /ms (boxes), D = 0.0953 mm 2 /ms (circles), D = 0.953 mm 2 /ms (triangles).  ...  Diffusivity is represent by symbol shape: D = 0.0126 mm 2 /ms (boxes), D = 0.0953 mm 2 /ms (circles), D = 0.953 mm 2 /ms (triangles).  ... 
doi:10.3389/fphys.2015.00217 pmid:26300783 pmcid:PMC4525671 fatcat:yuq5uvnbfvf77il5efpln4e2x4

Erratum to: Illuminating uveitis: metagenomic deep sequencing identifies common and rare pathogens

Thuy Doan, Michael R. Wilson, Emily D. Crawford, Eric D. Chow, Lillian M. Khan, Kristeene A. Knopp, Brian D. O'Donovan, Dongxiang Xia, Jill K. Hacker, Jay M. Stewart, John A. Gonzales, Nisha R. Acharya (+1 others)
2016 Genome Medicine  
doi:10.1186/s13073-016-0377-x pmid:27876088 pmcid:PMC5118887 fatcat:a6mumhagmbenvh4yraootstfea

Joint action perception to enable fluent human-robot teamwork

Tariq Iqbal, Michael J. Gonzales, Laurel D. Riek
2015 2015 24th IEEE International Symposium on Robot and Human Interactive Communication (RO-MAN)  
To be effective team members, it is important for robots to understand the high-level behaviors of collocated humans. This is a challenging perceptual task when both the robots and people are in motion. In this paper, we describe an event-based model for multiple robots to automatically measure synchronous joint action of a group while both the robots and co-present humans are moving. We validated our model through an experiment where two people marched both synchronously and asynchronously,
more » ... le being followed by two mobile robots. Our results suggest that our model accurately identifies synchronous motion, which can enable more adept human-robot collaboration.
doi:10.1109/roman.2015.7333671 dblp:conf/ro-man/IqbalGR15 fatcat:ng4rexnjdbdq3gv6ynhweln2v4
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