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Inter-rater reliability of manual and automated region-of-interest delineation for PiB PET

Bedda L. Rosario, Lisa A. Weissfeld, Charles M. Laymon, Chester A. Mathis, William E. Klunk, Michael D. Berginc, Jeffrey A. James, Jessica A. Hoge, Julie C. Price
2011 NeuroImage  
A major challenge in positron emission tomography (PET) amyloid imaging studies of Alzheimer's disease (AD) is the reliable detection of early amyloid deposition in human brain. Manual region-of-interest (ROI) delineation on structural magnetic resonance (MR) images is generally the reference standard for the extraction of count-rate data from PET images, as compared to automated MR-template(s) methods that utilize spatial normalization and a single set of ROIs. The goal of this work was to
more » ... ss the inter-rater reliability of manual ROI delineation for PiB PET amyloid retention measures and the impact of CSF dilution correction (CSF) on this reliability for data acquired in elderly control (n=5) and AD (n=5) subjects. The intraclass correlation coefficient (ICC) was used to measure reliability. As a secondary goal, ICC scores were also computed for PiB outcome measures obtained by an automated MR-template ROI method and one manual rater; to assess the level of reliability that could be achieved using different processing methods. Fourteen ROIs were evaluated that included anterior cingulate (ACG), precuneus (PRC) and cerebellum (CER). The PiB outcome measures were the volume of distribution (V(T)), summed tissue uptake (SUV), and corresponding ratios that were computed using CER as reference (DVR and SUVR). Substantial reliability (ICC≥0.932) was obtained across 3 manual raters for V(T) and SUV measures when CSF correction was applied across all outcomes and regions and was similar in the absence of CSF correction. The secondary analysis revealed substantial reliability in primary cortical areas between the automated and manual SUV [ICC≥0.979 (ACG/PRC)] and SUVR [ICC≥0.977/0.952 (ACG/PRC)] outcomes. The current study indicates the following rank order among the various reliability results in primary cortical areas and cerebellum (high to low): 1) V(T) or SUV manual delineation, with or without CSF correction; 2) DVR or SUVR manual delineation, with or without CSF correction; 3) SUV automated delineation, with CSF correction; and 4) SUVR automated delineation, with or without CSF correction. The high inter-rater reliability of PiB outcome measures in primary cortical areas (ACG/PRC) is important as reliable methodology is needed for the detection of low levels of amyloid deposition on a cross-sectional basis and small changes in amyloid deposition on a longitudinal basis.
doi:10.1016/j.neuroimage.2010.12.070 pmid:21195782 pmcid:PMC3057323 fatcat:stnsbpf7yrg25gacn55eggmihy

Nanostructured Materials for Clean Energy and Environmental Challenges

Hui Xia, Michael Z. Hu, Ying Shirley Meng, Jianping Xie, Xiangyu Zhao
2014 Journal of Nanomaterials  
A plasmonic effect of Ag nanoparticles in the dye-sensitized solar cells has been confirmed in the paper "Solution processed silver nanoparticles in dye-sensitized solar cells" by Berginc et al.  ...  In this special issue, 14 original research papers are presented, bringing over recent advances and R&D activities in developing nanostructured materials for groundbreaking applications in energy and environment  ...  Hui Xia Michael Z. Hu Ying Shirley Meng Jianping Xie Xiangyu Zhao  ... 
doi:10.1155/2014/675859 fatcat:5xseedfc6jaffklzhb5ylmfu4q

Page 8438 of Mathematical Reviews Vol. , Issue 2004j [page]

2004 Mathematical Reviews  
Bennett, Michael A. .................  ...  D. 49063,78004 . 91116 See Berrade Ursta, M. D. Berrade Urstia, M.D. ............... 62205 Berresford, Geoffrey C.  ... 

Page 2690 of Mathematical Reviews Vol. , Issue Index [page]

Mathematical Reviews  
78A45 (Barrick, D. E.) see Green, J. J., (2004k:86001 ) Bass, Fridrikh G. (with Resnick, L.)  ...  S., 2004a:78016 Jory, Michael J. (with Perkins, Elaine A.; Sambles, J. Roy) Light emission from whispering-gallery modes in microscopic spheres.  ... 

Page 269 of Mathematical Reviews Vol. , Issue Index [page]

Mathematical Reviews  
(Summary) 2004g:47014 47A20 (15A45, 47A63) Bourke, Paul D. (with Wright, James Joseph; Rennie, C. J.; Lees, G. J.; Robinson, Peter A.; Chapman, C. L.; Gordon, Evian; Rowe, D. L.)  ...  (English summary) Waves Random Media 14 (2004), no. 3, 229-252. 78A45 — (with Berginc, G.)  ... 

Recommendations for enterovirus diagnostics and characterisation within and beyond Europe

Heli Harvala, Eeva Broberg, Kimberley Benschop, Natasa Berginc, Shamez Ladhani, Petri Susi, Claus Christiansen, James McKenna, David Allen, Phoebe Makiello, Georgina McAllister, Mirabelli Carmen (+54 others)
2018 Journal of Clinical Virology  
EVs infecting humans are classified into four species (A-D) and HRVs into three species (A-C) on the basis of genetic divergence [1] .  ...  For these reasons, type identification should be based on VP1 (or potentially VP2 or VP3) sequences EV species A-C (and recommended for EV-D and HRVs).  ... 
doi:10.1016/j.jcv.2018.01.008 pmid:29414181 fatcat:uv5c7lioxjf2ha3k3e66saxypm

Ultrafast Time-Resolved Studies on Fluorescein for Recognition Strands Architecture in Amyloid Fibrils

Piotr Hanczyc, Alexander Mikhailovsky, David R. Boyer, Michael R. Sawaya, Alan Heeger, David Eisenberg
2017 Zenodo  
Biotechnol. 2003, 21, 86− 89. (8) Berginc, K.; Zǎkelj, S.; Levstik, L.; Ursǐc, D.; Kristl, A.  ...  Acta Diabetol. 1972, 9, 290−298. (12) Korb, D. R.; Greiner, J. V.; Herman, J.  ... 
doi:10.5281/zenodo.3834323 fatcat:44kl35zbejhafazxbgtyjkv6xm

Preview: 1995 MRS Fall Meeting

1995 MRS bulletin  
All a AAA D C D F a I D L D O D R D U D Y D BB D EE • A G D D G D J D M D P D S D V D Z D C C D F F • B • E D H D K D N Q Q D T D W D No.  ...  #W68 508 Thomson Park Drive Cranberry Twp., PA 16066-6425 Contact: Alan Berginc Telephone: (412) 772-0220 Fax: (412) 772-0219 Cressington designs and manu- factures a wide range of thin film vacuum  ... 
doi:10.1557/s0883769400045395 fatcat:5tyozwjgkrd3rm5gu4bfonwkf4

The contrasting phylodynamics of human influenza B viruses

Dhanasekaran Vijaykrishna, Edward C Holmes, Udayan Joseph, Mathieu Fourment, Yvonne CF Su, Rebecca Halpin, Raphael TC Lee, Yi-Mo Deng, Vithiagaran Gunalan, Xudong Lin, Timothy B Stockwell, Nadia B Fedorova (+16 others)
2015 eLife  
N /d S site d N /d S Segment a (95% HPD) Global d N /d S Internal External Internal/External No.  ...  the Victoria lineage viruses having 194 accumulated more nonsynonymous substitutions (d N /d S = 0.19) than the Yamagata lin-195 eage (d N /d S = 0.13) (p-value, <0.05).  ... 
doi:10.7554/elife.05055 pmid:25594904 pmcid:PMC4383373 fatcat:watuzkbyqngy7cvily5w5r3pjy

Open-ended category learning for language acquisition

Luís Seabra Lopes, Aneesh Chauhan
2008 Connection science  
Cowley, Michael Anderson and the three anonymous reviewers for many helpful comments. Note 1. In the implementation, a window of W = 50 iterations and the corresponding weight w = 0.98 were used.  ...  For two objectsx andȳ, with distance D = x −ȳ , inverse Euclidean distance is given by 1/D.  ...  i N k=1 (1/D k ) , where N is the number of categories, i, k = 1, . . . , N, and D i and D k are the average Euclidean distances of the target object to the known instances of categories C i and C k ,  ... 
doi:10.1080/09540090802413228 fatcat:qma3patfpbfpvoueltrmxfhenm

Preview: 1996 MRS Spring Meeting

Thomas F. Kuech, Clifford L. Renschler, Chuang Chuang Tsai
1996 MRS bulletin  
Cressington Scientific Instruments, Inc. #520 508 Thomson Park Drive Cranberry Twp., PA 16066-6425 Contact: Alan Berginc Telephone: (412) 772-0220 Fax: (412) 772-0219 Cressington designs and manu  ...  Inc. #301 11 Dearborn Road Peabody, MA 01960 Contact: Michael Kersker (TEM) or Charlier Nielsen (SEM) Telephone: (508) 535-5900 Fax: (508) 536-2205 E-mail: kersker@jeol.com or nielsen@jeol.com  ... 
doi:10.1557/s0883769400046303 fatcat:ed5qfkbb5ncb5eadbhldspiosi

Comparison of Phase-less Direction of Arrival Estimation Methods for Switched Beam Antennas

A. Cidronali, G. Collodi, M. Lucarelli, S. Maddio, M. Passafiume, G. Pelosi, S. Selleri
2019 2019 PhotonIcs & Electromagnetics Research Symposium - Spring (PIERS-Spring)  
D.  ...  Wolf (Sandia National Laboratories); Michael Scalora (Charles M. Bowden Research Center, AMRDEC, RDECOM); Michael B. Sinclair (Sandia National Laboratories); M.  ... 
doi:10.1109/piers-spring46901.2019.9017336 fatcat:adobca2sg5ga5ccjpuepkrpbsa

A review of the bioelectrochemical system as an emerging versatile technology for reduction of antibiotic resistance genes

Ping Chen, Xiaoyan Guo, Shengnan Li, Fengxiang Li
2021 Environment International  
Acknowledgments This study was supported by the National Key R&D Program of China (2019YFC1804102) and the National Natural Science Foundation of China (31570504).  ...  Hence, specific conjugation inhibitors (COINs) are effective in hindering the dissemination of ARGs and have been widely studied (Michael et al., 2016) .  ...  Among them, transparent solar panels have received more attention because their low open-circuit voltages are conducive to enhancing power (Berginc et al., 2013) .  ... 
doi:10.1016/j.envint.2021.106689 pmid:34175779 fatcat:ricqjp5kgjgs3e7ab37zaupzr4

Applications of Radiotracer Imaging Poster Abstracts

2012 Journal of Cerebral Blood Flow and Metabolism  
Louis, Missouri, USA Background: Imaging of D 2 versus D 3 and of D 3 versus D 2 receptors in living brain has been hampered by the lack of selective D 2 or D 3 ligands.  ...  Berginc 1 and Julie Price 1 University of Pittsburgh, Pennsylvania, USA, Departments of: 1 Radiology; 2 Biostatistics; 3 PsychiatryBackground: The objective was to apply a nonparametric multimodal correlation  ... 
doi:10.1038/jcbfm.2012.78 fatcat:2uvqdqlwsfgexhr5qno2gjfmqe

Recommendations for enterovirus diagnostics and characterisation within and beyond Europe

Heli Harvala, Eeva Broberg, Kimberley Benschop, Natasa Berginc, Shamez Ladhani, Petri Susi, Claus Christiansen, James McKenna, David Allen, Phoebe Makiello, Georgina McAllister, Mirabelli Carmen (+56 others)
2019
EVs infecting humans are classified into four species (A-D) and HRVs into three species (A-C) on the basis of genetic divergence [1] .  ...  For these reasons, type identification should be based on VP1 (or potentially VP2 or VP3) sequences EV species A-C (and recommended for EV-D and HRVs).  ... 
doi:10.25646/6051 fatcat:kxogmnoefjgrznvy7cdea42qly
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