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C) FLI3 belongs to the P12b haplotype. D) The FLI1 showed a S2a haplotype. ... The beads, and the bead binding buffers were heated to 57°C for 30 min before being used. Further cleaning steps were also performed at the same hybridisation temperature. ...doi:10.1101/2020.06.11.145482 fatcat:4ujjioucevbybbvymd5kgxzbey
Thus, DC-PrP Sc prions interact with PrP C molecules through a novel interaction mechanism, yielding an expanded substrate range and highly efficient PrP Sc propagation. ... Previous studies identified two mammalian prion protein (PrP) polybasic domains that bind the disease-associated conformer PrP Sc , suggesting that these domains of cellular prion protein (PrP C ) serve ... Legend: Sc = PrP Sc ; C = PrP C ; WT = wild-type. ...doi:10.1371/journal.ppat.1002128 pmid:21779169 pmcid:PMC3136465 fatcat:utucsnl3zngdlhhu32dcjzyh3m
Joint surfaces of limb bones are loaded in compression by reaction forces generated from body weight and musculotendon complexes bridging them. In general, joints of eutherian mammals have regions of high radiodensity subchondral bone that are better at resisting compressive forces than low radiodensity subchondral bone. Identifying similar form-function relationships between subchondral radiodensity distribution and joint load distribution within the marsupial postcranium, in addition todoi:10.1371/journal.pone.0058811 pmid:23554931 pmcid:PMC3595237 fatcat:to5j5ruptrhfxim5mjngcxqw64
more »... ing a richer understanding of marsupial functional morphology, can serve as a phylogenetic control in evaluating analogous relationships within eutherian mammals. Where commonalities are established across phylogenetic borders, unifying principles in mammalian physiology, morphology, and behavior can be identified. Here, we assess subchondral radiodensity patterns in distal tibiae of several marsupial taxa characterized by different habitual activities (e.g., locomotion). Computed tomography scanning, maximum intensity projection maps, and pixel counting were used to quantify radiodensity in 41 distal tibiae of bipedal (5 species), arboreal quadrupedal (4 species), and terrestrial quadrupedal (5 species) marsupials. Bipeds (Macropus and Wallabia) exhibit more expansive areas of high radiodensity in the distal tibia than arboreal (Dendrolagus, Phascolarctos, and Trichosurus) or terrestrial quadrupeds (Sarcophilus, Thylacinus, Lasiorhinus, and Vombatus), which may reflect the former carrying body weight only through the hind limbs. Arboreal quadrupeds exhibit smallest areas of high radiodensity, though they differ non-significantly from terrestrial quadrupeds. This could indicate slightly more compliant gaits by arboreal quadrupeds compared to terrestrial quadrupeds. The observed radiodensity patterns in marsupial tibiae, though their statistical differences disappear when controlling for phylogeny, corroborate previously documented patterns in primates and xenarthrans, potentially reflecting inferred limb use during habitual activities such as locomotion. Despite the complex nature of factors contributing to joint loads, broad observance of these patterns across joints and across a variety of taxa suggests that subchondral radiodensity can be used as a unifying form-function principle within Mammalia.
(C) FLI3 belongs to the P12b haplotype. (D) The FLI1 showed a S2a haplotype. ... (C) A set of remains found inside a rock-shelter (FLI2), located close to the beach on the east coast of Flinders Island. ...doi:10.3389/fevo.2020.00217 fatcat:jtp7m5b2prgutmdmht2vn2ijby
of 2 | www.pnas.org/cgi/doi/10.1073/pnas.1418997112 Westaway et al. ...doi:10.1073/pnas.1418997112 pmid:25659745 pmcid:PMC4343145 fatcat:gfzubdg7kzaurpsq4j7txcj6wa
The Willandra Fossil Trackway: Assessment of ground penetrating radar survey results and additional OSL dating at a unique Australian site Michael C. Westaway 1,2 , Matthew L. ... Bowler et al. 2003; b c d e Table 1 1 Summary luminescence age data. Table 2 2 Sequence of superimposed tracks. ...doi:10.1080/03122417.2013.11681969 fatcat:bykbieebsvgz5nvoozpdn6iiz4
Insofar as previous work has established a requirement for WT PrP C in the A␤-dependent modulation of excitability in cholinergic basal forebrain neurons, our findings implicate PrP C regulation of Kv4.2 ... Widely expressed in the adult central nervous system, the cellular prion protein (PrP C ) is implicated in a variety of processes, including neuronal excitability. ... of WT PrP C . ...doi:10.1074/jbc.m113.488650 pmid:24225951 pmcid:PMC3873577 fatcat:kndrklnq7rdrrfwwbrepcgtu4m
We found that, by modifying the hybridization temperature to 57°C, the genome coverage obtained was significantly enhanced. ... Briefly, per-individual diploid genotypes were called using SAMtools mpileup (-C50 option) and bcftools call with the consensus caller (-c option). ...doi:10.1126/sciadv.aau5064 pmid:30585290 pmcid:PMC6300400 fatcat:5v7p2bmjn5djvom6i4ghlrjuwm
Michael C. Westaway et al. 1048 Figure 3. ... Westaway). ...doi:10.15184/aqy.2021.31 fatcat:b7pv463m3be25potarqer5akqe
Michael C. Westaway is an Associate Professor in the School of Social Sciences at the University of Queensland in Brisbane, Australia. ... We have produced four such articles, one to accompany each of the major studies we have published to date ; Adams, Westaway, and Martin 2018b; Wright, Lambert, and Wasef 2018a; Adams and Westaway 2019) ...doi:10.1080/00438243.2019.1686418 fatcat:7w3txztbvvbchivo3dzun75itu
PrP C 's C-terminal region folds into a globular three-helix bundle with a small two-stranded β sheet  . ... Positions of helices and beta strands are shaded in grey (see also panel C). C) Main chain flexibility profiles in the PrP systems. ...doi:10.1371/journal.ppat.1006826 pmid:29338055 pmcid:PMC5786331 fatcat:xv6qw77qafasbkzeegiithvxyu
Ecology and Archaeobiology, Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC 20013; b External Faculty, Santa Fe Institute, Santa Fe, NM 87501; c ... In a curious comment on our PNAS Perspective (1), Westaway and Lyman (2) offer two Australian zooarchaeological case studies-one involving eggshells and the other dingoes-that they argue undercut one of ...doi:10.1073/pnas.1610697113 pmid:27462113 pmcid:PMC4995951 fatcat:4f6ag4xovnaybdlo5pj5xtibpu
WESTAWAY. New Edition. Demy 8vo. Price 10s. 6d. net. *“ Mr. ... C. M‘Lean, F. W. Oliver, H. M. Vernon, Henry Kenwood. Price 5s. net. “One of the most interesting books of the year.”’ ...
C. M‘Lean, F. W. Oliver, H. M. Vernon, Henry Kenwood. Price 5s. net. “One of the most interesting books of the vear.” ... Westaway is an able and lucid writer.”"—New Statesman. “|. . ...
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