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Methylphenidate enhances brain activation and deactivation responses to visual attention and working memory tasks in healthy controls

D. Tomasi, N.D. Volkow, G.J. Wang, R. Wang, F. Telang, E.C. Caparelli, C. Wong, M. Jayne, J.S. Fowler
2011 NeuroImage  
Here, functional magnetic resonance imaging (fMRI) was used together with working memory (WM) and visual attention (VA) tasks to test the hypothesis that 20 mg oral MPH would increase activation in the  ...  Methylphenidate (MPH) is a stimulant drug that amplifies dopamineric and noradrenergic signaling in the brain, which is believed to underlie its cognition enhancing effects.  ...  Acknowledgments The National Institute on Alcohol Abuse and Alcoholism (2RO1AA09481) and the National Center for Research Resources (GCRC 5-MO1-RR-10710) supported this work.  ... 
doi:10.1016/j.neuroimage.2010.10.060 pmid:21029780 pmcid:PMC3020254 fatcat:xwsczu4mefc7jph455ltfudkka

Pharmaco fMRI: Determining the functional anatomy of the effects of medication

Britta Wandschneider, Matthias J Koepp
2016 NeuroImage: Clinical  
in affective disorders and emotional processing circuits; antiepileptic drugs in epilepsy and cognitive networks; and stimulants in attention-deficit/hyperactivity disorder and networks of attention control  ...  and can help to determine early treatment response, mechanisms of drug efficacy and side effects, and potentially advance CNS drug development.  ...  deficits in task inhibition, attention, working memory and timing.  ... 
doi:10.1016/j.nicl.2016.10.002 pmid:27766202 pmcid:PMC5067101 fatcat:d3vn6chg4jeurhbvcaitjo3uu4

Drug-specific laterality effects on frontal lobe activation of atomoxetine and methylphenidate in attention deficit hyperactivity disorder boys during working memory

A. Cubillo, A. B. Smith, N. Barrett, V. Giampietro, M. Brammer, A. Simmons, K. Rubia
2013 Psychological Medicine  
Both drugs enhanced fronto-temporo-striatal activation in ADHD relative to control boys and deactivated the default-mode network, which were negatively associated with the reduced DLPFC activation and  ...  Both drugs enhanced frontotemporo-striatal activation in ADHD relative to control boys and deactivated the default-mode network, which were negatively associated with the reduced DLPFC activation and performance  ...  NHS Foundation Trust and Institute of Psychiatry, King's College London and Lilly Pharmaceuticals.  ... 
doi:10.1017/s0033291713000676 pmid:23597077 fatcat:tvepa43jrre33ln245q4conqcu

A neurochemical yin and yang: does serotonin activate and norepinephrine deactivate the prefrontal cortex?

Paul J. Fitzgerald
2010 Psychopharmacology  
To assess this hypothesis, three primary lines of evidence are examined comprising the effects of 5-HT and NE on impulsivity, cognitive flexibility, and working memory.  ...  Results Here I examine the hypothesis that serotonin (5-HT) plays a general role in activating the PFC, whereas norepinephrine (NE) plays a general role in deactivating this brain region.  ...  In the monkey, systemically administered clonidine (and clonidine iontophoretically applied to the PFC) enhanced spatial working memory-related neural activity in the PFC, and iontophoretically applied  ... 
doi:10.1007/s00213-010-1856-1 pmid:20386882 fatcat:pgkuecpixfa2lks5yipyy4jgky

Methylphenidate modulates sustained attention and cortical activation in survivors of traumatic brain injury: a perfusion fMRI study

Junghoon Kim, John Whyte, Sunil Patel, Eduardo Europa, Jiongjiong Wang, H. Branch Coslett, John A. Detre
2011 Psychopharmacology  
Results-Behaviorally, MPH significantly improved both accuracy and reaction time (RT) in the sustained attention task, but only RT in the working memory task.  ...  Perfusion fMRI scanning was carried out at rest and while participants performed cognitive tasks requiring sustained attention and working memory.  ...  This study was supported by grant R24HD39621 (to J.W.), R24HD050836 (to J.W.; www.ncrrn.org), and P30NS045839 (to J.A.D.) from the NIH. Dr.  ... 
doi:10.1007/s00213-011-2622-8 pmid:22203319 pmcid:PMC3369011 fatcat:qjvoru42nnhatpnb5bhitp5g6e

Pattern Classification of Working Memory Networks Reveals Differential Effects of Methylphenidate, Atomoxetine and Placebo in Healthy Volunteers

Andre F Marquand, Sara De Simoni, Owen G O'Daly, Steven CR Williams, Janaina Mourão-Miranda, Mitul A Mehta
2011 Neuropsychopharmacology  
We combined event-related fMRI with multivariate pattern recognition to characterize the effects of MPH and ATX in healthy volunteers performing a rewarded working memory (WM) task.  ...  During rewarded trials both drugs produced the opposite effect to reward, that is, attenuating WM networks and enhancing task-related deactivations (TRDs) in regions consistent with the default mode network  ...  ACKNOWLEDGEMENTS We wish to acknowledge the support of the King's College London Centre of Excellence in Medical Engineering, funded by the Wellcome Trust and EPSRC under grant no.  ... 
doi:10.1038/npp.2011.9 pmid:21346736 pmcid:PMC3079849 fatcat:afu7ip2vw5godabbgpyjabk3g4

Dopamine Transporters in Striatum Correlate with Deactivation in the Default Mode Network during Visuospatial Attention

Dardo Tomasi, Nora D. Volkow, Ruiliang Wang, Frank Telang, Gene-Jack Wang, Linda Chang, Thomas Ernst, Joanna S. Fowler, Aldo Rustichini
2009 PLoS ONE  
and deactivation during a parametric visual attention task (measured with blood oxygenation level dependent functional magnetic resonance imaging) in healthy controls.  ...  Thus, higher striatal DAT levels, which would result in an enhanced clearance of dopamine and hence weaker dopamine signals, would be associated to lower deactivation in the DMN during an attention task  ...  To test this hypothesis we used PET and [ 11 C]cocaine to measure DAT, and BOLD-fMRI to measure brain activation during a parametric visual attention (VA) task [18] in healthy controls.  ... 
doi:10.1371/journal.pone.0006102 pmid:19564918 pmcid:PMC2699543 fatcat:m2cf2fz3k5bi7h66e6iggte7im

Methylphenidate Treatment of Cognitive Dysfunction in Adults After Mild to Moderate Traumatic Brain Injury: Rationale, Efficacy, and Neural Mechanisms

Harvey Levin, Maya Troyanskaya, JoAnn Petrie, Elisabeth A. Wilde, Jill V. Hunter, Tracy J. Abildskov, Randall S. Scheibel
2019 Frontiers in Neurology  
Positive effects of methylphenidate (MPH) on attention and cognitive processing speed have been reported in studies of patients with moderate to severe traumatic brain injury (TBI).  ...  Studies which have acquired functional brain imaging before and while using MPH have also found alteration of brain activation while performing a cognitive task; in some studies, this alteration of activation  ...  (34) found that 0.3 mg/kg of MPH taken over 7 weeks enhanced the effects of memory and attention training in a controlled study.  ... 
doi:10.3389/fneur.2019.00925 pmid:31572283 pmcid:PMC6751302 fatcat:zomzuy27mfehlhnjwhzemtfxt4

Use of Virtual Reality Working Memory Task and Functional Near-Infrared Spectroscopy to Assess Brain Hemodynamic Responses to Methylphenidate in ADHD Children

Sooah Jang, JongKwan Choi, Jooyoung Oh, Jungyeon Yeom, Narae Hong, Narae Lee, Joon Hee Kwon, Jieun Hong, Jae-jin Kim, Eunjoo Kim
2021 Frontiers in Psychiatry  
The present study aimed to explore the acute effects of methylphenidate (MPH) on behavioral performance and brain activity during a VR-based working memory task simulating real-life classroom settings  ...  Altogether, 12 healthy control (HC) subjects participated in the same task but did not receive MPH treatment.  ...  JO and J-jK contributed to interpreting the results and worked on the manuscript. All authors discussed the results and commented on the manuscript. EK supervised the project.  ... 
doi:10.3389/fpsyt.2020.564618 pmid:33551860 pmcid:PMC7859615 fatcat:a4zcplsbz5dsxnbpozhu4h5bvu

Anything goes? Regulation of the neural processes underlying response inhibition in TBI patients

Laura Moreno-López, Anne E. Manktelow, Barbara J. Sahakian, David K. Menon, Emmanuel A. Stamatakis
2017 European Neuropsychopharmacology  
Activation in the right inferior frontal gyrus (RIFG), an area associated with response inhibition, was significantly lower in patients compared to healthy controls.  ...  Despite evidence for beneficial use of methylphenidate in response inhibition, no studies so far have investigated the effects of this drug in the neurobiology of inhibitory control in traumatic brain  ...  Healthy controls (HC) underwent the same protocol without methylphenidate.  ... 
doi:10.1016/j.euroneuro.2016.12.002 pmid:28012706 fatcat:526ltbkgqff5tdwaqxbcysfs2i

Non-pharmacological cognitive enhancement

Martin Dresler, Anders Sandberg, Kathrin Ohla, Christoph Bublitz, Carlos Trenado, Aleksandra Mroczko-Wąsowicz, Simone Kühn, Dimitris Repantis
2013 Neuropharmacology  
While many ethical arguments of the cognitive enhancement debate apply to both pharmacological and non-pharmacological enhancers, some of them appear in new light when considered on the background of nonpharmacological  ...  Here we summarize empirical data on approaches using nutrition, physical exercise, sleep, meditation, mnemonic strategies, computer training, and brain stimulation for enhancing cognitive capabilities.  ...  of neural responses in widespread brain regions that are linked to conceptual processing, which suggests enhanced neural efficiency, probably via improved sustained attention and impulse control (Pagnoni  ... 
doi:10.1016/j.neuropharm.2012.07.002 pmid:22828638 fatcat:hslrjrb4nndq7loihqlaymxzxy

Methylphenidate Has Differential Effects on Blood Oxygenation Level-Dependent Signal Related to Cognitive Subprocesses of Reversal Learning

C. M. Dodds, U. Muller, L. Clark, A. van Loon, R. Cools, T. W. Robbins
2008 Journal of Neuroscience  
In a whole-brain analysis, methylphenidate attenuated BOLD signal in the ventral striatum during response switching after negative feedback but modulated activity in the prefrontal cortex when subjects  ...  level-dependent (BOLD) signal in a group of 20 healthy participants during probabilistic reversal learning, in a placebo-controlled design.  ...  Methylphenidate has been shown to modulate neural activity in the striatum during response inhibition (Vaidya et al., 1998) and divided attention (Shafritz et al., 2004) but parietofrontal regions  ... 
doi:10.1523/jneurosci.1153-08.2008 pmid:18524902 pmcid:PMC6670335 fatcat:cq3l5epy7ree7faudrl2lbotru

Methylene blue modulates functional connectivity in the human brain

Pavel Rodriguez, Amar P. Singh, Kristen E. Malloy, Wei Zhou, Douglas W. Barrett, Crystal G. Franklin, Wilson B. Altmeyer, Juan E. Gutierrez, Jinqi Li, Betty L. Heyl, Jack L. Lancaster, F. Gonzalez-Lima (+1 others)
2016 Brain Imaging and Behavior  
Low dose MB also has memory enhancing effect in rodents and humans. However, the neural correlates of the effects of MB in the human brain are unknown.  ...  Task-based and task-free fMRI were performed before and one hour after MB or placebo administration utilizing a randomized, double-blinded, placebo-controlled design.  ...  The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.  ... 
doi:10.1007/s11682-016-9541-6 pmid:26961091 pmcid:PMC5018244 fatcat:srxvv6f3dnb5xid6n6vbrdgyfq

Applications of pharmacogenetics in children with attention-deficit/hyperactivity disorder

Florence Levy
2014 Pharmacogenomics and Personalized Medicine  
This review examines molecular genetic studies shown to be of importance in the etiology of attention-deficit/hyperactivity disorder (ADHD) and contrasts prefrontal versus sub-cortical mechanisms.  ...  Further understandings of molecular mechanisms involved in etiology versus treatment and adverse effects should help personalize the treatment of ADHD.  ...  The investigators hypothesized that higher DAT levels would result in a lower concentration of extracellular dopamine, reducing the availability to deactivate the DMN during the visual attention task.  ... 
doi:10.2147/pgpm.s52844 pmid:25404861 pmcid:PMC4230702 fatcat:dqvwiu5ojzbapaooti3zo4dnom

Psychostimulants and Cognition: A Continuum of Behavioral and Cognitive Activation

S. Wood, J. R. Sage, T. Shuman, S. G. Anagnostaras
2013 Pharmacological Reviews  
Authorship Contributions Wrote or contributed to the writing of the transcript: Wood, Sage, Shuman, Anagnostaras.  ...  A lower dose of oral methylphenidate (20 mg) in a group of healthy males showed a distinct pattern of activation and deactivation in different brain regions during a working memory task and a visual attention  ...  In all, these studies indicate that methylphenidate may exert its cognitive-enhancing effects by a complicated interplay of activation and deactivation in different regions throughout the brain. D.  ... 
doi:10.1124/pr.112.007054 pmid:24344115 pmcid:PMC3880463 fatcat:npdhidfcyfahpirl3g7yqcy7qa
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