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A role for bioenergetic abnormalities in the pathophysiology of schizophrenia

Dost Öngür
2013 Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology  
There is extensive evidence for abnormalities in brain bioenergetics in SZ, including PET studies of cerebral glucose utilization (20), 31P MRS studies of high energy phosphate (HEP) molecules (21-22),  ...  Therefore, abnormalities in underlying energy metabolism could play a major role in the abnormalities seen in glutamate signaling in SZ.  ...  Metabolic mapping using 2D 31P-MR spectroscopy reveals frontal and thalamic metabolic abnormalities in schizophrenia. Neuroimage 2007;35(2):729- 37. Epub 2006 Dec 29. 23. Ben-Shachar D, Karry R.  ... 
doi:10.5455/bcp.20131218011431 fatcat:i5e4fourbjhphhhvestvyhiofi

Poster Session I

2010 Neuropsychopharmacology  
Results: We show that oxidative phosphorylation and mitochondrial function are the only significant pathways commonly affected in the frontal cortex of SMIT1 and IMPA1 knockout mice and Li-treated mice  ...  Previous studies have shown alteration in gene expression following mood stabilizing drug treatment in a variety of genes, including genes involved in inositol metabolism.  ...  Methods: In the present study, we used adeno-associated viral (AAV) and promoter-driven cre-recombinase expression to selectively excise floxed p38alpha MAPK in specific cell types and brain regions to  ... 
doi:10.1038/npp.2010.216 fatcat:v3q2xjxc45b2hckv33pzz7mtee

ACNP 55th Annual Meeting: Panels, Mini-Panels and Study Groups

2016 Neuropsychopharmacology  
imaging at a 3 T and 31P MRS measurements on a 4 T MR scanner.  ...  vivo resonances obtained from 31P MRS experiments.  ...  The major metabolites were synthesized and studied in animal models and in cell-based studies. Metabolic studies were conducted using characterized human liver microsomes.  ... 
doi:10.1038/npp.2016.239 fatcat:wg7pyurlzvhp7bvlmlbxtkunl4

Poster Session III

2006 Neuropsychopharmacology  
Discussion: Cocaine dependence has been previously revealed to lead to reduced orbitofrontal metabolism, impaired cognitive functions and reductions in presumptive gray matter size as revealed by VBM.  ...  This technique has been used recently both in healthy individuals and in various disease states including the assessment of Alzheimer's disease, schizophrenia, epilepsy and depression.  ...  Methods: Eight healthy adult control subjects (6 males, 2 females) were studied using 31P spectroscopy at 4T (Varian, Palo-Alto, CA).  ... 
doi:10.1038/sj.npp.1301268 fatcat:rl22v3qzwfh4hcr2c4z3b2daoi


2010 Epilepsia  
Purpose: To explore the causative role of PCDH19 gene, located at Xq22, in females with epilepsy.  ...  Using electronic documentation with Epivista Ò follow up is ongoing in all patients. Acknowledgments: supported by: Italian Ministry of Health, Fondazi-  ...  The most frequent AEDs used before LTG were valproate (n = 7), levetiracetame (n = 7), sulthiame (n = 6), and topiramate (n = 4).  ... 
doi:10.1111/j.1528-1167.2010.02658.x pmid:20590792 fatcat:ylmo7rjtqncydkxeudaib77noy