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Size and Charge Dual-Transformable Mesoporous Nanoassemblies for Enhanced Tumor Delivery and Penetration
2020
Chemical Science
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deep tumor penetration. 27 In another work, they reported light-triggered decomposable micelles that can release chlorin e6/cypate conjugated dendrimer for tumor penetration and phototherapy. 28 Zhao ...
doi:10.1039/c9sc06260b
pmid:34084342
pmcid:PMC8157500
fatcat:7z6oma3sp5hepmd7ljmmpuf5jq
Transdifferentiation of Fibroblasts by Defined Factors
2015
Cellular Reprogramming
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ZHAO ET AL. ...
doi:10.1089/cell.2014.0089
pmid:26053515
pmcid:PMC4487681
fatcat:zoigs65yzngnve2z5ydruy2zgy
Antibacterial Mechanism of Silkworm Seroins
2020
Polymers
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Seroin 1 and seroin 2 are abundant in silkworm cocoon silk and show strong antibacterial activities, and thus are thought to protect cocoon silk from damage by bacteria. In this study, we characterized the expression pattern of silkworm seroin 3, and found that seroin 3 is synthesized in the female ovary and secreted into egg to play its roles. After being infected, seroin 1, 2, and 3 were significantly up-regulated in the silkworm. We synthesized the full-length protein of seroin 1, 2, and 3
doi:10.3390/polym12122985
pmid:33327635
pmcid:PMC7765120
fatcat:7rc3wccm6bdz7fjbyxpwxgphwu
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... d their N/C-terminal domain (seroin-N/C), and compared the antimicrobial activities in vitro. All three seroins showed higher antibacterial activity against Gram-positive bacteria than against Gram-negative bacteria. Seroin 2 showed better antibacterial effect than seroin 1 and 3, whereas seroin 1/2/3-N was better than seroin 1/2/3-C. We found that seroin 2-C has stronger peptidoglycan binding ability than seroin 2-N per the ELISA test. The binding sites of seroin 2 with bacteria were blocked by peptidoglycan, which resulted in the loss of the antibacterial activity of seroin 2. Collectively, these findings suggest that seroin 1 and 2 play antibacterial roles in cocoon silk, whereas seroin 3 functions in the eggs. The three silkworm seroins have the same antibacterial mechanism, that is, binding to bacterial peptidoglycan by the C-terminal domain and inhibiting bacterial growth by the N-terminal domain.
An RGD-Containing Peptide Derived from Wild Silkworm Silk Fibroin Promotes Cell Adhesion and Spreading
2018
Polymers
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Arginine-Glycine-Aspartate (RGD) tripeptide can promote cell adhesion when present in the amino acid of proteins such as fibronectin. In order to demonstrate the bioactivity of an RGD-containing silk protein, a gene encoding the RGD motif-containing peptide GSGAGGRGDGGYGSGSS (–RGD–) derived from nonmulberry silk was designed and cloned, then multimerised and inserted into a commercial pGEX expression vector for recombinant expression of (–RGD–)n peptides. Herein, we focus on two
doi:10.3390/polym10111193
pmid:30961118
pmcid:PMC6290608
fatcat:qpyafza4cjez7hsdwbmasfbvxa
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... ansferase (GST)-tagged fusion proteins, GST–(–RGD–)4 and GST–(–RGD–)8, which were expressed in Escherichia coli BL21, purified by GST affinity chromatography, and analyzed with sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and mass spectrometry (MS). Target peptides (–RGD–)4 and (–RGD–)8 (6.03 and 11.5 kDa) were cleaved from the GST-tag by thrombin digestion, as verified with MS and SDS-PAGE. Isoelectric point analysis confirmed that target peptides were expressed and released in accordance with the original design. Target peptides self-assembled into a mainly α-helical structure, as determined by circular dichroism spectroscopy. Furthermore, (–RGD–)4 and (–RGD–)8 modified mulberry silk fibroin films were more effective for rapid cell adhesion, spreading and proliferative activity of L929 cells than some chemically synthesized RGD peptides modified and mulberry silk lacking the RGD motif.
Microbiome Crosstalk in Immunotherapy and Antiangiogenesis Therapy
2021
Frontiers in Immunology
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The human body and its microbiome constitute a highly delicate system. The gut microbiome participates in the absorption of the host's nutrients and metabolism, maintains the microcirculation, and modulates the immune response. Increasing evidence shows that gut microbiome dysbiosis in the body not only affects the occurrence and development of tumors but also tumor prognosis and treatment. Microbiome have been implicated in tumor control in patients undergoing anti- angiogenesis therapy and
doi:10.3389/fimmu.2021.747914
pmid:34745119
pmcid:PMC8566949
fatcat:fggtnmh6yzhd7bg4mpeab37wky
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... unotherapy. In cases with unsatisfactory responses to chemotherapy, radiotherapy, and targeted therapy, appropriate adjustment of microbes abundance is considered to enhance the treatment response. Here, we review the current research progress in cancer immunotherapy and anti- angiogenesis therapy, as well as the unlimited potential of their combination, especially focusing on how the interaction between intestinal microbiota and the immune system affects cancer pathogenesis and treatment. In addition, we discuss the effects of microbiota on anti-cancer immune response and anti- angiogenesis therapy, and the potential value of these interactions in promoting further research in this field.
Effect of hirudin on arterialized venous flap survival in rabbits
2021
Biomedicine and Pharmacotherapy
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Zhao: Formal analysis, Software, Validation. ...
: Validation, Data curation, Project administration Xiaobin Luo & Jiafeng Li: Resources, Visualization, Investigation; Yutong Xie & Baolong Li: Software, Investigation, Supervision; Hongyu Chen & Mengyao ...
doi:10.1016/j.biopha.2021.111981
pmid:34364044
fatcat:m73reyqpqbdjtimpl7sevkduru
Study of carbon brush and slip-ring system abrasion from electric contact friction under special environments
2021
IEEE Access
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MENGYAO JIANG was born in Jiangsu, China, in 1996. She received the B.S. degree from Nantong University, Nantong, China, in 2017. ...
XUEHUA ZHAO received the Ph.D. degree in electrical engineering from the China University of Mining and Technology, China, in 2016. ...
doi:10.1109/access.2021.3050098
fatcat:kjpjasxsvzb2tdzrag6lqqqdfm
Chitopentaose inhibits hepatocellular carcinoma by inducing mitochondrial mediated apoptosis and suppressing protective autophagy
2021
Bioresources and Bioprocessing
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Previous studies had revealed that COS could inhibit the progression of several cancers including colon carcinoma, cervical cancer and gastric cancer (Luo et al. 2014; Zhao et al. 2019; Yuan et al. 2018 ...
doi:10.1186/s40643-020-00358-y
fatcat:a2nlrakjkvcslg2rb5qa32nayy
Automatically query active features based on pixel-level for facial expression recognition
2019
IEEE Access
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MENGYAO ZHAO received the B.S. degree in electronic information engineering from Yanshan University, Qinhuangdao, China, in 2017, where she is currently pursuing the master's degree in electronics science ...
doi:10.1109/access.2019.2929753
fatcat:ogskzqdahbebhhszug5uzqc4ae
Neural Network Evolving Algorithm Based on the Triplet Codon Encoding Method
2018
Genes
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Artificial intelligence research received more and more attention nowadays. Neural Evolution (NE) is one very important branch of AI, which waves the power of evolutionary algorithms to generate Artificial Neural Networks (ANNs). How to use the evolutionary advantages of network topology and weights to solve the application of Artificial Neural Networks is the main problem in the field of NE. In this paper, a novel DNA encoding method based on the triple codon is proposed. Additionally, a NE
doi:10.3390/genes9120626
fatcat:njtkkj7arfh57ihnhf5jbeewx4
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... orithm Triplet Codon Encoding Neural Network Evolving Algorithm (TCENNE) based on this encoding method is presented to verify the rationality and validity of the coding design. The results show that TCENNE is very effective and more robust than NE algorithms, due to the coding design. Also, it is shown that it can realize the co-evolution of network topology and weights and outperform other neural evolution systems in challenging reinforcement learning tasks.
Engineering Rhodosporidium toruloides for limonene production
2021
Biotechnology for Biofuels
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However, the highest
Open Access Biotechnology for Biofuels *Correspondence: yangxb@nwafu.edu.cn † Sasa Liu and Mengyao Zhang contributed equally to this work 1 College of Enology, Northwest A&F University ...
doi:10.1186/s13068-021-02094-7
pmid:34937561
pmcid:PMC8697501
fatcat:2kjg3rc3abflxbuswdwlkvc2a4
Seek it or let it come
2013
CHI '13 Extended Abstracts on Human Factors in Computing Systems on - CHI EA '13
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Achieving design inspirations can be defined as the process that how designers are ignited with design ideas. It is crucial for designers since this ability partly determines the power of their design. The awareness of what its own design practice is in HCI community calls for more studies on the nature of interaction design, design practices and designers. In this paper, I present my study on designers' design processes and design philosophy, based on empirical work with ten designers from
doi:10.1145/2468356.2479509
dblp:conf/chi/Zhao13
fatcat:3zjrz5ecbzbtlftpxtx3l75ny4
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... ed design fields about how they achieve inspirations. The study has provided a practical method for designers about how they can be more inspired, which can help interaction design practitioners to build a healthier way of design thinking.
Fixed Points and Stability for Integral-Type Multivalued Contractive Mappings
2021
Journal of Function Spaces
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The existence and iterative approximations of fixed points concerning two classes of integral-type multivalued contractive mappings in complete metric spaces are proved, and the stability of fixed point sets relative to these multivalued contractive mappings is established. The results obtained in this article generalize and improve some known results in the literature. An illustrative example is given.
doi:10.1155/2021/5542414
fatcat:3aliwrf3rzckfl3rnoyfpzy5me
BS-virus-finder: virus integration calling using bisulfite sequencing data
2017
GigaScience
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Reviewer #1: Major Concerns 1. Why did the authors choose whole-genome bisulfite sequencing (WGBS) data for identification of the virus integration loci? There are many established tools or pipelines for detection of viral integration loci based on whole-genome sequencing (WGS) and/or RNA-seq. What is the rationale for developing a method using WGBS instead of improving upon the methods for WGS or RNA-seq for virus integration detection? Authors provide a reference, saying, "A recent clinical
doi:10.1093/gigascience/gix123
pmid:29267855
pmcid:PMC5788064
fatcat:ikgmu6ijibgnldzkvwacoj447y
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... udy showed that DNA methylation is associated with viral integration", but the work of Larsson GL et al, 2014 was not performed on whole-genome methylation data and hardly could be used as a rationale for using WGBS for the virus detection. Thank you for your comments. There is no existing method for analysis of virus integration by using WGBS data unless additional relative WGS and RNA-seq data is available, thus requiring more human and financial resources. Regarding this, our software tool solved this problem by finding virus integration directly from WGBS data, therefore enabling efficiently and deeply mining data. We cite the work of Larsson GL to show that there is a relationship between virus integration and DNA methylation, and not as a rationale for using WGBS.
Facile Synthesis of Uniform Virus-like Mesoporous Silica Nanoparticles for Enhanced Cellular Internalization
2017
ACS Central Science
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ORCID Fan Zhang: 0000-0001-7886-6144 Dongyuan Zhao: 0000-0001-8440-6902 Notes The authors declare no competing financial interest. ■ ACKNOWLEDGMENTS The work was supported by China National Key Basic Research ...
doi:10.1021/acscentsci.7b00257
pmid:28852697
pmcid:PMC5571464
fatcat:c46h5piybzgkpfgiuqhtmxgnoa
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