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Age- and gender-related differences in brain tissue microstructure revealed by multi-component T2 relaxometry

Erick Jorge Canales-Rodríguez, Silvia Alonso-Lana, Norma Verdolini, Salvador Sarró, Isabel Feria, Irene Montoro, Beatriz Garcia-Ruiz, Esther Jimenez, Cristina Varo, Auria Albacete, Isabel Argila-Plaza, Anna Lluch (+5 others)
2021 Neurobiology of Aging  
Such results point to a sexual dimorphism in brain tissue microstructure and suggest a lesser vulnerability to age-related changes in women.  ...  In spite of extensive work, inconsistent findings and lack of specificity in most neuroimaging techniques used to examine age- and gender-related patterns in brain tissue microstructure indicate the need  ...  Our results revealed a sexual dimorphism in the brain tissue microstructure, with WM areas showing increased MWF and GM areas showing increased FQFWF and decreased 2 IE T in men, respectively.  ... 
doi:10.1016/j.neurobiolaging.2021.06.002 pmid:34252873 fatcat:7owxvatsfbb3jkgw6mlkr5tmey

Sexually dimorphic structural abnormalities in major connections of the medial forebrain bundle in alcoholism

Ana María Rivas-Grajales, Kayle S. Sawyer, Sarina Karmacharya, George Papadimitriou, Joan A. Camprodon, Gordon J. Harris, Marek Kubicki, Marlene Oscar-Berman, Nikos Makris
2018 NeuroImage: Clinical  
The results expand upon other findings of differences in brain reward circuitry of alcoholic men and women.  ...  Given sex differences in clinical consequences of alcohol consumption, we hypothesized that alcoholic men and women would differ in structural abnormalities of the MFB.  ...  ) , the cerebellum , and the corpus callosum (Ruiz et al., 2012) .  ... 
doi:10.1016/j.nicl.2018.03.025 pmid:30035007 pmcid:PMC6051309 fatcat:jvu6hljwezestn7edvyifhkfxa

Diffusion tensor imaging of hemispheric asymmetries in the developing brain

Elisabeth A. Wilde, Stephen R. McCauley, Zili Chu, Jill V. Hunter, Erin D. Bigler, Ragini Yallampalli, Zhiyue J. Wang, Gerri Hanten, Xiaoqi Li, Marco A. Ramos, Sharjeel H. Sabir, Ana C. Vasquez (+2 others)
2009 Journal of Clinical and Experimental Neuropsychology  
Diffusion tensor imaging (DTI) was performed in 39 right-handed children to examine structural hemispheric differences and the impact of age, socioeconomic status and sex on these differences.  ...  were larger in the left as compared to right internal capsule, thalamus, and cingulate.  ...  Levin, Ph.D. by the National Institutes of Health. We gratefully acknowledge the assistance of Summer Lane and Lori Cook for their assistance in patient recruitment and Stacey K.  ... 
doi:10.1080/13803390802098118 pmid:19052951 pmcid:PMC2630367 fatcat:eqa5mtd4bjgnhbmeclzwwuqxii

Cerebral white matter sex dimorphism in alcoholism: a diffusion tensor imaging study

Kayle S. Sawyer, Nasim Maleki, George Papadimitriou, Nikos Makris, Marlene Oscar-Berman, Gordon J. Harris
2018 Neuropsychopharmacology  
Results: Sex-related differences in white matter connectivity were observed in association with alcoholism: Compared to nonalcoholic men, alcoholic men had diminished FA in portions of the corpus callosum  ...  In contrast, alcoholic women had higher FA in these regions. Sex differences also were observed for correlations between corpus callosum FA and length of sobriety.  ...  with recruitment, assessment, or neuroimaging of the research participants.  ... 
doi:10.1038/s41386-018-0089-6 pmid:29795404 fatcat:k4rvvxvc4jao7jmgpkuqyl46xq

Vascular burden and APOE ε4 are associated with white matter microstructural decline in cognitively normal older adults

Owen A. Williams, Yang An, Lori Beason-Held, Yuankai Huo, Luigi Ferrucci, Bennett A. Landman, Susan M. Resnick
2019 NeuroImage  
White matter microstructure can be measured with diffusion tensor imaging (DTI).  ...  Women showed greater decreases over time in FA in the gyrus part of the cingulum, compared to men.  ...  We thank the staff of the BLSA and the NIA MRI facility for their assistance and the BLSA participants for their dedication to this study.  ... 
doi:10.1016/j.neuroimage.2018.12.009 pmid:30557663 pmcid:PMC6601608 fatcat:sqo4wyqz3rhtdmn3fy653dyrlm

The Impact of Sex, Puberty, and Hormones on White Matter Microstructure in Adolescents

Megan M. Herting, Emily C. Maxwell, Christy Irvine, Bonnie J. Nagel
2011 Cerebral Cortex  
Methods: White matter microstructure was examined in 77 adolescents (ages 10--16) using diffusion tensor imaging.  ...  Follow-up analyses determined if sex steroids predicted microstructural characteristics in sexually dimorphic and pubertal-related white matter regions, as well as in whole brain.  ...  Jeri Janowsky for her helpful analytic suggestions and editorial comments on the manuscript. All work was performed at Oregon Health & Science University. Conflict of Interest : None declared.  ... 
doi:10.1093/cercor/bhr246 pmid:22002939 pmcid:PMC3412439 fatcat:jq3me3ixg5gkfdmdoxxdiiizz4

Cerebral White Matter Sex Dimorphism in Alcoholism: A Diffusion Tensor Imaging Study [article]

Kayle S Sawyer, Nasim Maleki, George M Papadimitriou, Nikos Makris, Marlene Oscar-Berman, Gordon J Harris
2017 bioRxiv   pre-print
Results: Sex-related differences in white matter connectivity were observed in association with alcoholism: Compared to nonalcoholic men, alcoholic men had diminished FA in portions of the corpus callosum  ...  In contrast, alcoholic women had higher FA in these regions. Sex differences also were observed for correlations between corpus callosum FA and length of sobriety.  ...  with recruitment, assessment, or neuroimaging of the research participants.  ... 
doi:10.1101/229609 fatcat:636nbnwxlveunaqoawukacuvze

Brain-based sex differences in autism spectrum disorder across the lifespan: A systematic review of structural MRI, fMRI, and DTI findings

Melissa J.M. Walsh, Gregory L. Wallace, Stephen M. Gallegos, B. Blair Braden
2021 NeuroImage: Clinical  
This systematic review on MRI-based sex differences in ASD was conducted to elucidate variations across the lifespan and inform biomarker discovery of ASD in females We identified articles through two  ...  When synthesized with the broader literature, brain-based sex differences in ASD may come from various sources, including genetic and endocrine processes involved in brain "masculinization" and "feminization  ...  Acknowledgements: We thank our participants and the Submitters to the National Institute of Mental Health (NIMH) Data Archive (NDA) who made the analysis of sex differences in symptom severity age patterns  ... 
doi:10.1016/j.nicl.2021.102719 pmid:34153690 fatcat:4qs5mz6wtbdaxah2dvfx32fcqy

Contributions of neuroimaging to understanding sex differences in cocaine abuse

Monica L. Andersen, Eileen K. Sawyer, Leonard L. Howell
2012 Experimental and clinical psychopharmacology  
SPECT and PET studies have demonstrated changes in the dopamine transporter but are less clear on other components of the dopaminergic system.  ...  In order to understand the neurobiology underlying cocaine abuse and effective treatments, it is important to consider the role of sex differences.  ...  The funding sources had no other role beyond financial support. The authors express their gratitude to Lisa Neidert, Juliet Brown, and Sergio Tufik for their assistance and support.  ... 
doi:10.1037/a0025219 pmid:21875225 pmcid:PMC3269558 fatcat:wptgdgeo5ngi5adjks2r3wyp7y

Emotion Regulation and Trait Anxiety Are Predicted by the Microstructure of Fibers between Amygdala and Prefrontal Cortex

Annuschka Salima Eden, Jan Schreiber, Alfred Anwander, Katharina Keuper, Inga Laeger, Peter Zwanzger, Pienie Zwitserlood, Harald Kugel, Christian Dobel
2015 Journal of Neuroscience  
Diffusion tensor imaging revealed that trait anxiety predicts the microstructural properties of a prespecified fiber tract between the amygdala and the perigenual anterior cingulate cortex.  ...  Diffusion-weighted images, measures of trait anxiety and of reappraisal use (an effective emotion-regulation style), were collected in 48 females.  ...  Studies revealed the sexually dimorphic nature of the cortex, limbic structures, and connecting fibers and how such sex differences might impact the development of affective disorders (for review, see  ... 
doi:10.1523/jneurosci.3659-14.2015 pmid:25878275 fatcat:dtxshse57nbzpkt6g7romaqtlq

Creative females have larger white matter structures: Evidence from a large sample study

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi (+8 others)
2016 Human Brain Mapping  
ACKNOWLEDGMENTS We thank Yuki Yamada for operating the MRI scanner, Haruka Nouchi for conducting the psychological tests, all other assistants for helping with the experiments and the study, and the study  ...  participants, and all our other colleagues at IDAC, Tohoku University for their support.  ...  These associations with CMDT were not observed in analyses of fractional anisotropy using diffusion tensor imaging.  ... 
doi:10.1002/hbm.23369 pmid:27647672 fatcat:vcoty2js7nckrb3clzgp24ews4

Statistical significance in DTI group analyses: How the choice of the estimator can inflate effect sizes [article]

Szabolcs David, Hamed Y. Mesri, Max A. Viergever, Alexander Leemans
2019 bioRxiv   pre-print
Diffusion magnetic resonance imaging (dMRI) is one of the most prevalent methods to investigate the micro- and macrostructure of the human brain in vivo.  ...  More specifically, we performed a dMRI group analysis on gender using HCP data sets and compared the results obtained with two diffusion tensor imaging estimation methods: the widely used ordinary linear  ...  Men and women are different: Diffusion tensor imaging 569 reveals sexual dimorphism in the microstructure of the thalamus, corpus callosum and cingulum. 570 Neuroimage 54, 2557-2562. https://doi.org/10.1016  ... 
doi:10.1101/755140 fatcat:dc577chrkvaznmvn67z6l5r6ma

Magnetic resonance elastography for examining developmental changes in the mechanical properties of the brain

Curtis L. Johnson, Eva H. Telzer
2017 Developmental Cognitive Neuroscience  
The measured mechanical properties reflect the microstructural composition and organization of neural tissue, and have shown significant effects in many neurological conditions and normal, healthy aging  ...  The sensitivity of MRE to brain structure, function, and health make it an ideal technique for studying the developing brain; however, brain MRE studies on children and adolescents have only just begun  ...  ) from the National Institutes of Health and the State of Delaware, and from Delaware CTR ACCEL Program with a grant from the National Institutes of General Medical Sciences (U54-GM104941) from the National  ... 
doi:10.1016/j.dcn.2017.08.010 pmid:29239832 pmcid:PMC5832528 fatcat:thhwsdko5zekdjlmupkatak45a

A Review of the Status of Brain Structure Research in Transsexualism

Antonio Guillamon, Carme Junque, Esther Gómez-Gil
2016 Archives of Sexual Behavior  
Cortical thickness and diffusion tensor imaging studies suggest that the brain of MtFs presents complex mixtures of masculine, feminine, and demasculinized regions, while FtMs show feminine, masculine,  ...  Falling within the aegis of the neurohormonal theory of sex differences, we hypothesize that cortical differences between homosexual MtFs and FtMs and male and female controls are due to differently timed  ...  , and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.  ... 
doi:10.1007/s10508-016-0768-5 pmid:27255307 pmcid:PMC4987404 fatcat:4pzkbdf7anf2ffkogua6hef6la

Sex is a defining feature of neuroimaging phenotypes in major brain disorders

Lauren E Salminen, Meral A Tubi, Joanna Bright, Sophia I Thomopoulos, Alyssa Wieand, Paul M Thompson
2021 Human Brain Mapping  
Still, sex differences in MRI outcomes are understudied, particularly in clinical samples with known sex differences in disease risk, prevalence, and expression of clinical symptoms.  ...  Neuroimaging studies of population-based samples have identified normative differences in brain structure between males and females, many of which are exacerbated in psychiatric and neurological conditions  ...  surface area) and diffusion MRI (e.g., diffusion tensor imaging [DTI] scalar metrics) outcomes when available.  ... 
doi:10.1002/hbm.25438 pmid:33949018 pmcid:PMC8805690 fatcat:4y3ufbxppjg3bobnvysm7cwd7q
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