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West Nile virus (WNV) is a widespread global pathogen that results in significant morbidity and mortality. Data from animal models provide evidence of persistent renal and neurological infection from WNV; however, the possibility of persistent infection in humans and long-term neurological and renal outcomes related to viral persistence remain largely unknown. In this paper, we provide a review of the literature related to persistent infection in parallel with the findings from cohorts ofdoi:10.1016/j.micinf.2014.12.003 pmid:25499188 fatcat:xe6jg77tbzebhlamxyep6rxik4
more »... ts with a history of WNV infection. The next steps for enhancing our understanding of WNV as a persistent pathogen are discussed.
Genetic studies are transforming the way we diagnose, evaluate and treat patients. The era of genome-wide association studies promised to discover common risk variants in heterogeneous disorders where previous small-scale association studies had on the whole failed. However, as we enter the post-association era a degree of disappoint is felt regarding the lack of risk factors with large effect for a number of disorders including vascular disease. Vascular disorders are sporadic by nature,pmid:25705074 pmcid:PMC4332411 fatcat:xjtszipfmbddhnruairm7bvfqa
more »... a familial component has been observed. This review will focus on vascular dementia, the genetic risk factors for vascular disorders and highlight how new technologies may overcome the limitations of genome-wide association and nominate those genes that influence disease risk.
Although there is no Murray Page 3 Clin Obstet Gynecol. Author manuscript; available in PMC 2017 December 01. ...doi:10.1097/grf.0000000000000234 pmid:27681693 pmcid:PMC5079293 fatcat:kmqk5buidjfufaiw7cgto622ou
Melissa Murray, Afterword to HERMA HILL KAY, PAVING THE WAY: THE FIRST AMERICAN WOMEN LAW PROFESSORS 295, 298 (2021). 11. ... For more on race and Justice Thomas's jurisprudence and worldview, see Melissa Murray, Race-ing Roe: Reproductive Justice, Racial Justice, and the Battle for Roe v. Wade, 134 HARV. L. ...doi:10.36641/mjgl.28.1.podcast fatcat:ivwsmgexevgtffc74sdhu7mcoi
Murray at the 2006 National West Nile Virus Conference in San Francisco, California. Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 13, No. 3, March 2007 ...doi:10.3201/eid1303.060602 pmid:17552106 pmcid:PMC2725905 fatcat:7ycyoawnsfbdtmdgqlxywkngri
E-mail should be sent to melissa(a)psy.uwa. edu.au. Someren, 1994) . ...doi:10.3758/bf03204776 fatcat:77wsx5viqbar7cfdot6iydalm4
Murray,, M.S. Nolan); Texas Children's Hospital, Houston (K.O. Murray, M.S. Nolan); and Texas Department of State Health Services, Austin, Texas, USA (D. Ruktanonchai, D. Hesalroad, E. ...doi:10.3201/eid1911.130768 pmid:24210089 pmcid:PMC3837649 fatcat:ysowk2ai4ffarlos2fw3ufwzqa
We Please address correspondence to: Murray Grossman, Department of Neurology -2 Gibson, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia PA 19104-4283 This work was supported ...doi:10.1016/j.neuropsychologia.2006.09.022 pmid:17126368 pmcid:PMC1876770 fatcat:3k2dqfe6inhzhnbtzpwcyb7vvm
The underlying mechanisms for impaired output on letter (F, A, and S) and category (e.g., animal) word list generation (WLG) tasks in subcortical ischemic vascular dementia (1VD) were investigated. Normal control (NC) and Alzheimer's disease (AD) participants were also studied. IVD and NC participants performed better on category than letter WLG tasks, whereas the opposite was observed among AD participants. IVD participants produced fewer responses than AD participants on letter WLG tasks, butdoi:10.1037//0894-4220.127.116.110 pmid:9223144 fatcat:rnqqply7abcp7gljwvxjgtjnbe
more »... there was no difference between AD and IVD participants on the "animal" WLG task. AD participants scored lower than 1VD and NC participants on animal WLG indexes measuring semantic knowledge. There were few differences between IVD and NC participants. The reduced output on the animal WLG task for IVD participants is consistent with search-retrieval deficits. The reduced output of AD participants may be caused by degraded semantic knowledge. Tests of letter and category word list generation (WLG) have been extensively used to study various aspects of cognitive functioning in both normal aging and a wide range of dementing illnesses. In an attempt to investigate the underlying mechanisms for successful performance on category WLG tasks, Gruenewald and Lockhead (1980) administered the animal WLG task to normal control (NC) participants. Two findings emerged from this study. First, the authors observed that clusters of semantically related responses (i.e., responses that shared many attributes) were produced relatively quickly. Second, Gruenewald and Lockhead (1980) observed that participants" shifted" or switched into other semantic clusters only after a comparatively long response latency. They proposed a two-component model to describe the performance of normal participants on category WLG tasks and concluded that the ability to generate successive clusters of semantically meaningful responses is independent from the ability to search and shift from one cluster to another. Category WLG tasks have been used to investigate the semantic knowledge deficits associated with Alzheimer's disease (AD). For example, it has been shown that output on semantically related WLG tasks declines as the illness
Towards Practical Brain-Computer Interfaces
The scope of this chapter is limited to applications where a Brain-Computer Interface (BCI) is used as an explicit interaction technique. In other words, we refer here to BCI as input which is voluntarily controlled by the user, rather than as an implicit interaction as in for mental or cognitive state monitoring. Designing applications using BCI as an explicit input technique for users with severe disability depends on understanding the control signals and how users can interact with systemsdoi:10.1007/978-3-642-29746-5_9 fatcat:evkbnyvacjcbda2fqg3x263mme
more »... ing these controls. Although designing for able-bodied users has a different set of challenges, the BCI has to "add value" in both cases. Over the past 20 years of BCI research and design, the basic control functions have been realized by the collaboration of engineers, psychologists, machine learners and end users. These basic functions provide us with the freedom to design future BCI applications which are reliable in long-term use, easy to learn and set up, aesthetically pleasing, and have the potential to improve the lives of their users. BCI can be thought of as an input technology which takes properties of other emerging input technologies to the extreme. The term "extreme" is used because the BCI interaction is much slower, noisier and more error-prone compared to other input devices, and lacks proprioceptive feedback. Because of these unusual characteristics, a theoretical framework which successfully analyses current BCI systems provides a springboard for developing and refining theories and practices within Human Computer Interaction (HCI). Although still important, research in
Participants were 47 heterosexual women (mean age = 20.5 years) recruited as part of a longitudinal study investigating the effects of new social bonds on transcriptional profiles (Murray, Haselton, Fales ...doi:10.1037/hea0000705 pmid:30652915 pmcid:PMC6592277 fatcat:yxadmdjnsjfm5agff45vlvsu5i
AbstractSchizophrenia (SZ) and bipolar disorder (BD) share numerous clinical and biological features as well as environmental risk factors that may be associated with altered DNA methylation. In this study we sought to construct a Poly-Methylomic Profile Score (PMPS) for SZ, representing the degree of epigenome-wide methylation according to previously published findings; we then examined its association with SZ and BD in an independent sample. DNA methylation for 57 SZ, 59 BD cases and 55doi:10.1101/607309 fatcat:ll775o54ozdbfoxpvcr7qiscte
more »... y controls (HCs) was quantified using the Illumina 450K methylation beadchip. We constructed five PMPSs for different p-value thresholds using summary statistics reported in a large epigenome-wide schizophrenia case-control association study, weighted by individual CpG effect sizes. All SZ PMPSs were significantly elevated in SZ cases relative to HCs, with the score calculated at the most stringent threshold accounting for the greatest amount of variance in SZ (compared to other PMPSs derived at more inclusive p-value thresholds). However, none of the PMPSs were associated with BD, or a combined cohort of BD and SZ cases relative to HCs. Results demonstrating elevated PMPSs in SZ relative to BD did not survive correction for multiple testing. PMPSs were also not associated with positive or negative symptom severity. That this SZ-derived PMPSs was elevated among SZ, but not BD participants, suggests that epigenome-wide methylation patterns associated with schizophrenia may represent distinct pathophysiology that is yet to be elucidated. Whether this PMPS may be associated with neuroanatomical or other biological endophenotypes relevant to SZ and/or BD remains to be determined.
Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease
Skaradek W, Murray N, Alvarez M. 2007. Equipment settings for cleaning seeds of smooth cordgrass (Spar//na a/tern/flora Loisel. ...doi:10.2979/npj.2007.8.1.69 fatcat:vrz5ceetgvetjdy3mqrwtouggq
An 83-year-old male with a history of diabetes but with an otherwise intact immune system presented with melena. Upper endoscopy showed gastric and duodenal ulcers. Colonoscopy showed colonic ulcers. Biopsies revealed cytomegalovirus (CMV). Therapy with an antiviral such as ganciclovir should be considered even in an immunocompetent patient if male and over the age of 55, or if they have chronic diseases such as diabetes or chronic kidney disease.pmid:24905377 fatcat:yn4ztevwvjcdvpyoje3dy3xkoa
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