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Emerging Role of Circular RNAs in Cancer

Jing Liu, Xin Zhang, Meinan Yan, Hui Li
2020 Frontiers in Oncology  
Zhang et al. (76) revealed that circNRIP1 can sponge miR-149-5p and thus affect the AKT1/mammalian target of rapamycin (mTOR) axis, acting as a tumor promoter in gastric cancer (GC).  ...  Copyright © 2020 Liu, Zhang, Yan and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).  ... 
doi:10.3389/fonc.2020.00663 pmid:32670861 pmcid:PMC7326090 fatcat:avpzgk4lrfgeledphooy64gcye

Fabrication of Nb2O5 Nanosheets for High-rate Lithium Ion Storage Applications

Meinan Liu, Cheng Yan, Yuegang Zhang
2015 Scientific Reports  
Nb 2 O 5 nanosheets are successfully synthesized through a facile hydrothermal reaction and followed heating treatment in air. The structural characterization reveals that the thickness of these sheets is around 50 nm and the length of sheets is 500 , 800 nm. Such a unique two dimensional structure enables the nanosheet electrode with superior performance during the charge-discharge process, such as high specific capacity (,184 mAh?g 21 ) and rate capability. Even at a current density of 1 A?g
more » ... 1 , the nanosheet electrode still exhibits a specific capacity of ,90 mAh?g 21 . These results suggest the Nb 2 O 5 nanosheet is a promising candidate for high-rate lithium ion storage applications. L ithium ion batteries are commonly used for consumer electronics, portable electric devices, electric vehicles and other applications 1-5 . However, for high power density applications such as in electric vehicles, it is hindered by the achievement of high-rate capability of electrode materials. Recently, transition metal oxides have been extensively explored as anode replacing graphite due to their higher theoretical capacity and high packing densities, which lead to high volumetric energy densities in devices 6-10 . Among the different transition metal oxide as anode materials, lithium titanate (Li 4 Ti 5 O 12 ) and niobium oxide (Nb 2 O 5 ) have received the most study because of the considerable safety advantage that their redox potentials match to the LUMO of the organic liquid-carbonate electrolyte 11-13 . Compared with Li 4 Ti 5 O 12 with a specific capacity of 140 mAh?g 21 , Nb 2 O 5 exhibits a higher capacity (,200 mAh?g 21 ) 11,12 . Furthermore, Augustyn and Dunn et al found that the crystal structure of orthorhombic Nb 2 O 5 permits exceptionally rapid ionic transport since the mostly empty octahedral sites between (001) planes provide natural tunnels for lithium ion transport throughout the a-b plane 14,15 , which makes Nb 2 O 5 a promising anode material. However, its intrinsic poor electric conductivity (s , 3 3 10 26 S?cm 21 ) and the capacity decay resulted from pulverization during charge-discharge process limit its practical application in lithium ion batteries, and thus it is still challenging to develop efficient but simple ways to enhance the utilization of electroactive Nb 2 O 5 15-19 . Building nanostructures with desirable morphology and size is of great importance for addressing this issue 15-31 . For instance, Dunn et al developed Nb 2 O 5 mesoporous films through a simple solution process, which exhibited high-rate lithium insertion capability 16 . Wang and Lu et al reported high performance supercapacitors based on nanocomposites of Nb 2 O 5 nanocrystals and carbon nanotubes 17 . Nb 2 O 5 -carbon core-shell nanocomposites were fabricated by Li and Ma et al, which exhibited high specific capacity and rate capability 18 . Nb 2 O 5 nanobelts and hollow nanospheres were also been developed with large capacity and high rate capability 19,20 . Among these nanostructures, two dimensional structures with nano size in thickness and micro size in length have been considered to be the appropriate morphology for energy storage 22-25 . Generally, a nano-sized thickness has short ion diffusion path and large surface area; the micro-sized length can lower the internal resistance and facilitate the electron transfer rate as compared with the noncontinuous oxide framework composed of nanoparticles 22-25 . These merits encourage us to investigate Nb 2 O 5 electrode materials with two dimensional structures. In this work, Nb 2 O 5 nanosheets were developed by a two-step hydrothermal reaction and subsequent calcination process. The two dimensional sheet-like structure was composed of thin thickness (,50 nm) and long length (,800 nm), fitting the desirable structure principles as mentioned above. As expected, the nanosheet electrodes exhibited superior capacity (,184 mAh?g 21 ), much higher than commercial Nb 2 O 5 particles (,135 mAh?g 21 ). Additionally, the samples performed well at high current density (,130 mAh?g 21 at 0.4 A?g 21 and OPEN SUBJECT AREAS: BATTERIES MATERIALS CHEMISTRY
doi:10.1038/srep08326 pmid:25659574 pmcid:PMC4321166 fatcat:7f45fotec5da5muurp77a2nznu

Fructo-Oligosaccharide Alleviates Soybean-Induced Anaphylaxis in Piglets by Modulating Gut Microbes

Meinan Chang, Yuan Zhao, Guixin Qin, Xiaodong Zhang
2018 Frontiers in Microbiology  
Soybean-induced anaphylaxis poses a severe threat to the health of humans and animals. Some commensal bacteria, such as Lactobacillus and Bifidobacteria, can prevent and treat allergic diseases. Prebiotic oligosaccharides, a food/diet additive, can enhance health and performance via modulating gut microbes and immune responses. The purpose of this study was to examine whether fructo-oligosaccharides (FOS) could alleviate soybean-induced anaphylaxis by modulating gut microbes. Piglets (21 days
more » ... age) were sensitized with a diet containing 5% soybean and 30% peeled soybean meal. The treatment with 0.6% FOS started 1 day prior to sensitization and continued everyday thereafter. Blood was collected for measurements of immune indices. The DNA samples isolated from fresh intestinal contents of the middle jejunum (M-jejunum), posterior jejunum (P-jejunum), ileum, and cecum were used for gene sequencing based on 16S rRNA. Our results showed that there was an increase of glycinin-specific IgG, β-conglycinin-specific IgG, total serum IgG and IgE, and occurrence of diarrhea in piglets sensitized with soybean antigen. There was a decrease in interleukin 4 (IL-4) and IL-10 and an increase of interferon-γ (IFN-γ) in piglets with FOS treatment, compared with the piglets without FOS treatment. Improvement of intestinal microbes was indicated mostly by the increase of Lactobacillus and Bifidobacteria in M-jejunum and the decrease of Proteobacteria in P-jejunum and ileum. The correlation analysis indicated that FOS treatment decreased those closely related to the key species of gut microbes. These results suggest that FOS can alleviate soybean antigen-induced anaphylaxis, which is associated with increased Lactobacillus and Bifidobacteria in M-jejunum and declined Proteobacteria in P-jejunum and ileum of piglets.
doi:10.3389/fmicb.2018.02769 pmid:30524396 pmcid:PMC6256172 fatcat:gjzimho24jbwxfwede2xt6y3cy

Scenario-Based Configuration Refinement for High-Load Cellular Networks: An Operator View

Ruoyu Su, Meinan Zhang, Fei Ding, Guilong Hu, Qi Qi
2022 Applied Sciences  
With the rapid growth of users and sustained network demands powered by different industries, the quality of service (QoS) of the cellular network is affected by network traffic and computing loads. The current solutions of QoS improvement in academia focus on the fundamental algorithms within the physical and medium access control (MAC) layer. However, traffic features of various scenarios extracted from field data are rarely addressed for practical network configuration refinement. In this
more » ... er, we identify significant indicators of high traffic load cells according to the field data provided by telecommunication operators. Then, we propose the analysis flow of high traffic load cells with basic principles of network configuration refinement for QoS improvement. To demonstrate the proposed analysis flow and the refinement principles, we consider three typical scenarios of high traffic load cells, including high population density, emergency, and high-speed mobility. For each scenario, we discuss traffic features with field data. The corresponding performance evaluation demonstrates that the proposed principle can significantly enhance the network performance and user experience in terms of access success rate, downlink data rate, and number of high traffic load cells.
doi:10.3390/app12031483 fatcat:lxdo3w3lxbby5ijrkznuvuc2du

Mapping Soil Organic Matter and Analyzing the Prediction Accuracy of Typical Cropland Soil Types on the Northern Songnen Plain

Meiwei Zhang, Huanjun Liu, Meinan Zhang, Haoxuan Yang, Yuanliang Jin, Yu Han, Haitao Tang, Xiaohan Zhang, Xinle Zhang
2021 Remote Sensing  
[30] and Zhang et al.  ...  [30] and Zhang et al.  ... 
doi:10.3390/rs13245162 fatcat:6nzf2l6jxnbdpa2o2ghawhuvx4

Mapping Regional Soil Organic Matter Based on Sentinel-2A and MODIS Imagery Using Machine Learning Algorithms and Google Earth Engine

Meiwei Zhang, Meinan Zhang, Haoxuan Yang, Yuanliang Jin, Xinle Zhang, Huanjun Liu
2021 Remote Sensing  
Many studies have attempted to predict soil organic matter (SOM), whereas mapping high-precision and high-resolution SOM maps remains a challenge due to the difficulty of selecting appropriate satellite data sources and prediction algorithms. This study aimed to investigate the influence of different remotely sensed images and machine learning algorithms on SOM prediction. We constructed two comparative experiments, i.e., full-band and common-band variable datasets of Sentinel-2A and MODIS
more » ... s using Google Earth Engine (GEE). The predictive performances of random forest (RF), artificial neural network (ANN), and support vector regression (SVR) algorithms were evaluated, and the SOM map was generated for the Songnen Plain. Results showed that the model based on the full-band Sentinel-2A dataset achieved the best performance. The application of Sentinel-2A data resulted in mean relative improvements (RIs) of 7.67% and 5.87%, respectively. The RF achieved a lower root mean squared error (RMSE = 0.68%) and a higher coefficient of determination (R2 = 0.67) in all of the predicted scenarios than ANN and SVR. The resultant SOM map accurately characterized the SOM spatial distribution. Therefore, the Sentinel-2A data have obvious advantages over MODIS due to their higher spectral and spatial resolutions, and the combination of the RF algorithm and GEE is an effective approach to SOM mapping.
doi:10.3390/rs13152934 fatcat:oy3r7tnolzbgtamqyhjnkn25ka

Berichtigung: Solvation Rule for Solid‐Electrolyte Interphase Enabler in Lithium‐Metal Batteries

Chi‐Cheung Su, Meinan He, Jiayan Shi, Rachid Amine, Jian Zhang, Khalil Amine
2021 Angewandte Chemie  
The authors noticed that the values of exchange current density in Figures 1 c, 3 b, S6 and S16 were calculated incorrectly due to the reverse of x and y axes during the linear fitting. The corrected values were calculated by the equation log i = (hÀa)/b, and presented in the revised Figures S6 and S16 (see the Supporting Information published online along with this Corrigendum). Revised versions for Figures 1 c and 3 b are shown below. Instead of having a negative correlation with the FEC
more » ... nt, the exchange current density actually increased with the FEC content until the critical FEC ratio. Thus, the formation of a lithium fluoride richer SEI actually enhances the charge transfer process. Still, the exchange current density stabilized at the reported critical FEC ratios for both FEC/EMC and FEC/EA systems. The results still clearly indicate the existence of critical FEC ratios for both FEC/EMC and FEC/EA systems and the critical FEC ratios are still highly consistent with the findings of the solvation, Coulombic efficiency, Li/Li cells and galvanostatic cycling studies. Therefore, this correction does not affect the conclusion of this paper, which stated that there existed a critical FEC ratio, at which the solvation number of FEC ! 1, for the FEC-based electrolyte systems. The authors apologize for this inadvertent error. Figure 1. [...] c) Exchange current density versus the ratio of FEC/EMC for Li deposition/ stripping in Li/Cu cells using 1.1 m LiPF 6 -FEC/EMC electrolytes. Figure 3. [...] b) Exchange current density against the ratio of FEC/EA for Li deposition/stripping in Li/Cu cells using 1.1 m LiPF 6 -FEC/EA electrolytes.
doi:10.1002/ange.202105308 fatcat:2vajkoydxvfgrcl2rc5qn7dhke

A mutagenesis-derived broad-spectrum disease resistance locus in wheat

Jackie Campbell, Hongtao Zhang, Michael J. Giroux, Leila Feiz, Yue Jin, Meinan Wang, Xianming Chen, Li Huang
2012 Theoretical and Applied Genetics  
Zhang contributed equally to this work.  ...  Several resistance gainof-function mutations have been reported including the semidominant mutation ssi4 (Shirano et al. 2002) and the dominant mutation snc1 in Arabidopsis (Zhang et al. 2003) .  ... 
doi:10.1007/s00122-012-1841-7 pmid:22446929 pmcid:PMC3374107 fatcat:svnvzprdejbodjyr2i57g6ztyu

Effectiveness and Safety of Botulinum Toxin Type A in the Treatment of Androgenetic Alopecia

Yaguang Zhou, Shui Yu, Jimin Zhao, Xinyue Feng, Meinan Zhang, Zigang Zhao
2020 BioMed Research International  
Background. Androgenetic alopecia (AGA) represents the most frequent clinical complaint encountered by dermatologists and is characterized by a progressive miniaturization of the hair follicle. However, the efficacy and safety of current medical treatment remain limited, and more personalized therapeutic approaches for AGA are needed. Therefore, the present study is aimed at investigating the efficacy and safety of botulinum toxin type A (BTA) in patients with AGA. Methods. 63 patients with AGA
more » ... meeting the inclusion criteria were included in this study and treated with BTA injection or BTA injection combined with oral finasteride (FNS). In the scalp, 30 sites were injected with 100 U of BTA in each site and patients received BTA after every 3 months for a total of 4 times. Hair counts, head photographs, evaluation scores, and self-assessment were assessed in patients with AGA. Results. Hair counts in both groups at all time points were significantly higher as compared with those before treatment. After 4 times of treatment, hair counts in the BTA+FNS group were higher than those in the BTA group. Hair growth and density were significantly augmented, and the area of hair loss was attenuated after each treatment as revealed by head photographs. The effective rates of BTA and BTA+FNS groups were 73.3% and 84.8%, respectively, following 4 times treatment. Conclusion. BTA is a safe and effective therapeutic strategy for the treatment of AGA without adverse effects, and BTA combined with FNS exhibited a superior therapeutic effect than BTA alone.
doi:10.1155/2020/1501893 pmid:32802833 pmcid:PMC7424364 fatcat:lvkpskwzvjdivp2lqjfeimmequ

Optimization of Cockpit Ventilation for Polar Cruise Ships in Combination with Windscreen Defogging and Cabin Comfort Considerations

Hong Shi, Qianwei Zhang, Wenbing Xu, Meinan Liu, Jiashuang Pan, Jie Yuan, Kaijie Yang
2022 Entropy  
Zhang et al. [14] carried out numerical simulations of the internal environment of a car model.  ...  Zhang [8] proposed the "rain falling" air-conditioning system, and pointed out that the cabin airconditioning system and glass-defogging system should be a combined design. You et al.  ... 
doi:10.3390/e24081061 pmid:36010725 pmcid:PMC9407560 fatcat:x3i4r6sohfb7dablkcs6js3w4i

Corrigendum: Solvation Rule for Solid‐Electrolyte Interphase Enabler in Lithium‐Metal Batteries

Chi‐Cheung Su, Meinan He, Jiayan Shi, Rachid Amine, Jian Zhang, Khalil Amine
2021 Angewandte Chemie International Edition  
doi:10.1002/anie.202105308 pmid:34062046 fatcat:2r7kaipverdclbvbsenjnhqm6y

High-performance Oxygen Evolution Catalyst Enabled by Interfacial Effect between CeO2 and FeNi Metal-organic Framework

Mimi Dai, Jian Wang, Linge Li, Qi Wang, Meinan Liu, Yuegang Zhang
2020 Huaxue xuebao  
Oxygen evolution reaction (OER) is a crucial half reaction of electrochemical water splitting and metal-air batteries. But its sluggish four-electron reaction leads to a high overpotential. Current commercial OER catalysts are mainly noble metal-based materials, but their high cost restricts their broad application. Therefore, extensive efforts have been devoted to exploring low-cost and efficient OER catalysts. Nonprecious metal-based materials have been regarded as promising OER catalyst
more » ... dates, due to their abundancy on the earth, controllable morphologies and tunable chemical states. Among various nonprecious metal-based materials, metal-organic frameworks (MOFs) have attracted much attention, because of their large specific surface area and rich metal centers. However, their poor electrochemical activities, stabilities and conductivities severely affect their application in OER catalysis. To improve the activities of MOFs, several methods have been adopted, such as synthesizing ultrathin nanosheets, growing MOFs on nickel foam or carbon cloth, doping heteroatoms, and introducing synergistic interactions between two materials. In 1970, Wagner proposed a space-charge theory, which indicates that the carrier property can be tuned through adjusting interface. Inspired by this theory, constructing metal oxide-catalyst interface seems to be a promising strategy to improve activities of catalysts. CeO 2 is a well-known cocatalyst due to its re-
doi:10.6023/a20010017 fatcat:shw5ypgrfzazzlhahcfropcsmu

Revealing Electrochemical Sodiation Mechanism of Orthogonal-Nb2O5 Nanosheets by In Situ Transmission Electron Microscopy

Guoguang Xu, Qi Wang, Yi Su, Meinan Liu, Qingwen Li, Yuegang Zhang
2020 Wuli huaxue xuebao  
With the development of clean energy sources such as solar and wind power, large-scale energy storage technologies will play a significant role in the rational utilization of clean energy. Sodium ion batteries have garnered considerable attention for largescale energy storage owing to their low cost and the presence of abundant sodium resources. It is particularly crucial to develop electrode materials for sodium battery with good rate capability and long cycle life. Orthogonal-phase niobium
more » ... de (T-Nb2O5) exhibits good potential to be used as anode material for sodium-ion batteries owing to its high theoretical specific capacity (200 mAh·g −1 ) and high ionic diffusion coefficient. Furthermore, it demonstrates a better performance than that of graphite and exhibits a higher specific capacity than that of Li4TiO4 when used in sodium-ion batteries. However, its poor electrical conductivity has hindered its practical application. Recently, effective strategies such as coating with carbon materials or metal conductive particles have been developed to overcome this issue. Although the electrochemical performance of T-Nb2O5 has been improved, the sodiation mechanism of T-Nb2O5 is still unclear. It is considered to be similar to the lithium mechanism wherein lithium ions diffuse rapidly on the (001) planes, but exhibit difficulty in diffusing across the (001) planes. In this study, the electrochemical sodiation behaviors along the (001) lattice planes and the [001] direction of the T-Nb2O5 nanosheet are studied by in situ transmission electron microscopy (TEM). The results indicate that there are a large number of dislocations and domain boundaries in nanocrystals. Furthermore, it was observed that, sodium ions can diffuse across the (001) lattice planes through these defects, and then diffuse rapidly on the (001) planes. Meanwhile, we found a modulation structure in the [001] direction of the original nanosheet, in which alternating compressive and tensile strains were observed. These strain distributions can be regulated by the insertion of sodium ions, while the modulation structure is maintained. Moreover, the in situ TEM method used in this work can be applied to various energy materials.
doi:10.3866/pku.whxb202009073 fatcat:7ouc6pup2jbltoz4hs3skizw6q

Kuntai capsules improve glucolipid metabolism in patients with polycystic ovary syndrome

Ruining Liang, Zhen Liu, Peishuang Li, Pei Fan, Ling Xu, Xueyan Sun, Jiahua Peng, Xuemei Peng, Meinan Zhang
2019 Medicine  
The aim of this study was to observe the effect and safety of Heyan Kuntai Capsule (HYKT) on glucose and lipid metabolism in patients with polycystic ovary syndrome (PCOS). Hundred patients with PCOS were randomly divided into HYKT group (n = 50) and placebo groups (n = 50) in which the individuals were treated with HYKT and its placebo continuously for 6 months. Meanwhile, all participants received health education (such as exercise and diet). The primary outcomes were serum sex hormone
more » ... a series of blood lipid, fasting and postprandial 2 hours blood glucose. Body mass index (BMI), waist-hip ratio (WHR), insulin, homeostatic model assessment of insulin resistance (HOMA-IR), and insulin-sensitive index (ISI) were also observed. In addition, adverse events were recorded to evaluate the drug safety. After treatment, the BMI and WHR of all the patients were decreased. The fasting and postprandial 2 hours blood glucose levels were significantly declined when treated with HYKT, which were not observed in the placebo group. Similarly, serum sex hormones including luteinizing hormone (LH), LH/follicle-stimulating hormone (FSH), and testosterone were lowered after treated with HYKT instead of the placebo. Besides, blood lipids outcomes such as total cholesterol, triglyceride, and low-density lipoprotein cholesterol, as well as insulin and HOMA-IR were decreased with significance in HYKT group when compared with those in the placebo group, whereas high-density lipoprotein cholesterol and ISI increased obviously. HYKT showed the effect on ameliorating the glucose and lipid metabolism disorder and improving insulin resistance and increase insulin sensitivity of PCOS patients, which is similar to insulin sensitizing agent.
doi:10.1097/md.0000000000016788 pmid:31574794 pmcid:PMC6775382 fatcat:cgitdvc3lfgmza5ybxs6qtu3va

Bamboo Forest Mapping in China Using the Dense Landsat 8 Image Archive and Google Earth Engine

Shuhua Qi, Bin Song, Chong Liu, Peng Gong, Jin Luo, Meinan Zhang, Tianwei Xiong
2022 Remote Sensing  
It is of great significance to understand the extent and distribution of bamboo for its valuable ecological services and economic benefits. However, it is challenging to map bamboo using remote sensing images over a large area because of the similarity between bamboo and other vegetation types, the availability of clear optical images, huge workload of image processing, and sample collection. In this study, we use the Landsat 8 times series images archive to map bamboo forests in China via the
more » ... oogle Earth engine. Several spectral indices were calculated and used as classification features, including the normalized difference vegetation index (NDVI), the normalized difference moisture index (NDMI) and textural features of the gray-level co-occurrence matrix (GLCM). We found that the bamboo forest covered an area of 709.92 × 104 hectares, with the provinces of Fujian, Jiangxi, and Zhejiang containing the largest area concentrations. The bamboo forest map was accurate and reliable with an average producer's accuracy of 89.97%, user's accuracy of 78.45% and kappa coefficient of 0.7789. In addition, bamboo was mainly distributed in forests with an elevation of 300–1200 m above sea level, average annual precipitation of 1200–1500 mm and average day land surface temperature of 19–25 °C. The NDMI is particularly useful in differentiating bamboo from other vegetation because of the clear difference in canopy moisture content, whilst NDVI and elevation are also helpful to improve the bamboo classification accuracy. The bamboo forest map will be helpful for bamboo forest industry planning and could be used for evaluating the ecological service of the bamboo forest.
doi:10.3390/rs14030762 fatcat:ytiwmyztsrfudmtwmgyducx5mu
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