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Flavoenzyme‐mediated regioselective aromatic hydroxylation with coenzyme biomimetics

Alice Guarneri, Adrie H. Westphal, Jos Leertouwer, Joy Lunsonga, Maurice C.R. Franssen, Diederik J. Opperman, Frank Hollmann, Willem J.H. van Berkel, Caroline Emilie Paul
2019 ChemCatChem  
Regioselective aromatic hydroxylation is desirable for the production of valuable compounds. External flavin-containing monooxygenases activate and selectively incorporate an oxygen atom in phenolic compounds through flavin reduction by the nicotinamide adenine dinucleotide coenzyme, and subsequent reaction with molecular oxygen. This study provides the proof of principle of flavoenzyme-catalyzed selective aromatic hydroxylation with coenzyme biomimetics. The carbamoylmethyl-substituted
more » ... ic in particular affords full conversion in less than two hours for the selective hydroxylation of 5 mM 3and 4-hydroxybenzoates, displaying similar rates as with NADH, achieving a 10 mM/h enzymatic conversion of the medicinal product gentisate. This biomimetic appears to generate less uncoupling of hydroxylation that typically leads to undesired hydrogen peroxide. Therefore, we show these flavoenzymes have the potential to be applied in combination with biomimetics.
doi:10.1002/cctc.201902044 fatcat:killlck54nhhbchl5jtg4iqcju

Intermittent compared to continuous real-time fMRI neurofeedback boosts control over amygdala activation

Lydia Hellrung, Anja Dietrich, Maurice Hollmann, Burkhard Pleger, Christian Kalberlah, Elisabeth Roggenhofer, Arno Villringer, Annette Horstmann
2018 NeuroImage  
Online data analysis (ROI) For the online data analysis, we used the in-house software packages rtExplorer (Hollmann et al., 2011 (Hollmann et al., , 2008 for real-time data analysis and the preprocessing  ... 
doi:10.1016/j.neuroimage.2017.10.031 pmid:29100939 fatcat:64km4iltufechnf5jj7gb7v7ei

Predicting Decisions in Human Social Interactions Using Real-Time fMRI and Pattern Classification

Maurice Hollmann, Jochem W. Rieger, Sebastian Baecke, Ralf Lützkendorf, Charles Müller, Daniela Adolf, Johannes Bernarding, Pablo Villoslada
2011 PLoS ONE  
Negotiation and trade typically require a mutual interaction while simultaneously resting in uncertainty which decision the partner ultimately will make at the end of the process. Assessing already during the negotiation in which direction one's counterpart tends would provide a tremendous advantage. Recently, neuroimaging techniques combined with multivariate pattern classification of the acquired data have made it possible to discriminate subjective states of mind on the basis of their
more » ... l activation signature. However, to enable an online-assessment of the participant's mind state both approaches need to be extended to a real-time technique. By combining real-time functional magnetic resonance imaging (fMRI) and online pattern classification techniques, we show that it is possible to predict human behavior during social interaction before the interacting partner communicates a specific decision. Average accuracy reached approximately 70% when we predicted online the decisions of volunteers playing the ultimatum game, a well-known paradigm in economic game theory. Our results demonstrate the successful online analysis of complex emotional and cognitive states using realtime fMRI, which will enable a major breakthrough for social fMRI by providing information about mental states of partners already during the mutual interaction. Interestingly, an additional whole brain classification across subjects confirmed the online results: anterior insula, ventral striatum, and lateral orbitofrontal cortex, known to act in emotional self-regulation and reward processing for adjustment of behavior, appeared to be strong determinants of later overt behavior in the ultimatum game. Using whole brain classification we were also able to discriminate between brain processes related to subjective emotional and motivational states and brain processes related to the evaluation of objective financial incentives.
doi:10.1371/journal.pone.0025304 pmid:22003388 pmcid:PMC3189203 fatcat:ox45vunbsjhbtcy2z2ik7cqufe

Asymmetric azidohydroxylation of styrene derivatives mediated by a biomimetic styrene monooxygenase enzymatic cascade

Lía Martínez-Montero, Dirk Tischler, Philipp Süss, Anett Schallmey, Maurice Charles René Franssen, Frank Hollmann, Caroline Emilie Paul
2021 Catalysis science & technology  
Enantioenriched azido alcohols are precursors for valuable chiral aziridines and 1,2-amino alcohols, however their chiral substituted analogues are difficult to access. We established a cascade for the asymmetric azidohydroxylation of...
doi:10.1039/d1cy00855b fatcat:wdkwoensf5ep7d5naangai3iaq

Flexible Adaptive Paradigms for fMRI Using a Novel Software Package 'Brain Analysis in Real-Time' (BART)

Lydia Hellrung, Maurice Hollmann, Oliver Zscheyge, Torsten Schlumm, Christian Kalberlah, Elisabeth Roggenhofer, Hadas Okon-Singer, Arno Villringer, Annette Horstmann, Natasha M. Maurits
2015 PLoS ONE  
For this purpose, BART's configuration is based on the Experiment Description Language (EDL) developed by Hollmann et al. [15] .  ... 
doi:10.1371/journal.pone.0118890 pmid:25837719 pmcid:PMC4383593 fatcat:msfqyh6izfhaloripbohpxpf5a

Wissensrepräsentation zur integrierten Steuerung von Experimenten in der Echtzeit-fMRT - neuroökonomische Untersuchung sozialer Interaktion [article]

Maurice Hollmann, Universitäts- Und Landesbibliothek Sachsen-Anhalt, Martin-Luther Universität
2018
Magdeburg, 17.08.2009 Maurice Hollmann Danksagung An dieser Stelle möchte ich mich ganz herzlich bei all jenen Menschen bedanken, die es mir mit ihrer Hilfe ermöglicht haben diese Arbeit zu verfassen.  ...  Nähere Informationen finden sich in Hollmann et al. [2008b].  ...  Hollmann et al. [2009] ; LaConte et al. [2007] und Kapitel 7 dieser Arbeit).  ... 
doi:10.25673/5003 fatcat:t5szuvzncrfgbgxqkfxorq2wbu

Erratum to: The metabolic fate of2H-labelled propafenone in man

H. G. Hege, M. Hollmann, S. Kaumeier, H. Lietz
1984 European journal of drug metabolism and pharmacokinetics  
HOLLMANN**, S. KAUMEIER**, H. LIETZ* Biochemical * and Human Pharmacology Department **.Knoll AG.  ...  propafenone in man Urinary excretion kinetics of intact quinidine and 3-0H-quinidine after oral administration of a single oral dose of quinidine gluconate in the fasting and non-fasting state JEAN-MAURICE  ... 
doi:10.1007/bf03189625 fatcat:i3pizirpqrbpvlxxskllc7nxmu

An Unified Approach for fMRI-Measurements Used by a New Real-Time fMRI Analysis System [chapter]

Maurice Hollmann, Tobias Moench, Claus Tempelmann, Johannes Bernarding
Bildverarbeitung für die Medizin 2007  
Real-time functional MRI (rfMRI) offers new experimental paradigms, such as biofeedback and interactive experiments. Usually, several separated software systems are used to control the MRI measuring sequence, the stimulus presentation, and the statistical analysis, which leads to problems concerning the user communication and synchronisation and interaction of the different software systems. Here, an approach is developed which helps to overcome those difficulties by utilising a uniform
more » ... r management using a flexible parameter description that can be used simultaneously by different separated software systems. This approach is used to control two modules: a realtime fMRI application which extracts the current activation, and an analysis-system which evaluates the current brain activation to influence the stimulus presentation and provide feedback to the volunteer.
doi:10.1007/978-3-540-71091-2_12 dblp:conf/bildmed/HollmannMTB07 fatcat:lz4kweh4vbgm5dqbf65gscvjre

Erratum to: Urinary excretion kinetics of intact qyinidine and 3-OH-quinidine after oral administration of a single oral dose of quinidine gluconate in the fasting and non-fasting state

Jean-Maurice St-Onge, Gérard Sirois, Marc-André Gagnon
1984 European journal of drug metabolism and pharmacokinetics  
HOLLMANN**, S. KAUMEIER**, H. LIETZ* Biochemical * and Human Pharmacology Department **.Knoll AG.  ...  propafenone in man Urinary excretion kinetics of intact quinidine and 3-0H-quinidine after oral administration of a single oral dose of quinidine gluconate in the fasting and non-fasting state JEAN-MAURICE  ... 
doi:10.1007/bf03189624 fatcat:mn6f7chwgjffrlg5kymoqzr4bu

Page 428 of National Union Catalog Vol. 20, Issue [page]

1958 National Union Catalog  
DNLM NNC-M NBSU-M CtY-M IaU MnU CaBVaU Hollis, Maurice Christopher see Hollis, Christopher, 1902- Hollis, Michael, Bp. Paternalism and the church; a study of south Indian church history.  ...  Hollmann, Clide Anne. Partners on the Santa Fe Trail. Philadelphia, Westmin- ster Press ,1962, 1600p. 21cm. 1 Title.  ... 

Page 117 of Radiology Vol. 25, Issue 1 [page]

1935 Radiology  
HOLLMANN, WERNER. Aneurysm of the Ab- dominal Aorta HuGueEs, A. F., with WiLson, C.  ...  MAURICE, with FRIEDENWALD, JULIUS, FESZE NKO, FOME NKO, M.  ... 

Page 130 of PMLA. Publications of the Modern Language Association of America Vol. 66, Issue 3 [page]

1951 PMLA. Publications of the Modern Language Association of America  
E., 101 (3) Kelley, Maurice, 64 (3)  ...  ., 109 (2) Hollmann, Werner, 116, 118 Holman, C. H., 49, 85 Holmes, U. T., Jr., 41, 91, 92 Holzknecht, K. J., 58 Hook, Lucyle, 62 Hooker, E. N., 65 Hoopes, Robert, 65 Hopkins, A. B., 73 Hopwood, V.  ... 

Page 1066 of AJR, American Journal of Roentgenology Vol. 41, Issue 6 [page]

1939 AJR, American Journal of Roentgenology  
Huet and Maurice Peri, 864 Affections non ulcéreuses du duodénum. By I.  ...  Hollmann, B. Rajewsky, H. Schaefer and E. Schliephake, 467 Synopsis of Digestive Diseases. By John L. Kantor, 659 L’exploration radiologique post-opératoire de la voie biliaire principale. By B.  ... 

Page 1066 of AJR, American Journal of Roentgenology Vol. 41, Issue 6 [page]

1939 AJR, American Journal of Roentgenology  
Huet and Maurice Peri, 864 Affections non ulcéreuses du duodénum. By I.  ...  Hollmann, B. Rajewsky, H. Schaefer and E. Schliephake, 467 Synopsis of Digestive Diseases. By John L. Kantor, 659 L’exploration radiologique post-opératoire de la voie biliaire principale. By B.  ... 
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