Filters








67,578 Hits in 3.1 sec

Donald R. Songer, Susan W. Johnson, C.L. Ostberg, and Matthew E. Wetstein, Law, Ideology, and Collegiality: Judicial Behaviour in the Supreme Court of Canada

Reza Barmaki
2012 Canadian journal of sociology  
Law, Ideology, and Collegiality: Judicial Behaviour in the Supreme Court of Canada. McGill-Queen's University Press, 2012, 223 pp. $29.95 paperback (978-0-7735-3929-7) is a very interesting and important book for readers of a variety of academic interests and backgrounds. Particularly, however, undergraduate and graduate students of sociology of law, law and society, and political sociology can immensely benefit from it.
doi:10.29173/cjs18510 fatcat:njgdcrselfbiteudn43jwelaiy

Ramelteon

Matthew W. Johnson, Patricia E. Suess, Roland R. Griffiths
2006 Archives of General Psychiatry  
Context: Ramelteon is a novel MT 1 and MT 2 melatonin receptor selective agonist recently approved for insomnia treatment. Most approved insomnia medications have potential for abuse and cause motor and cognitive impairment. Objective: To evaluate the potential for abuse, subjective effects, and motor and cognitive-impairing effects of ramelteon compared with triazolam, a classic benzodiazepine sedative-hypnotic drug. Design: In this double-blind crossover study, each participant received oral
more » ... oses of ramelteon (16, 80, or 160 mg), triazolam (0.25, 0.5, or 0.75 mg), and placebo during approximately 18 days. All participants received each treatment on different days. Most outcome measures were assessed at 0.5 hours before drug administration and repeatedly up to 24 hours after drug administration.
doi:10.1001/archpsyc.63.10.1149 pmid:17015817 fatcat:hf35ceffwzgcdcp6hyakw5wlei

Potential Therapeutic Effects of Psilocybin

Matthew W. Johnson, Roland R. Griffiths
2017 Neurotherapeutics  
Psilocybin and other 5-hydroxytryptamine 2A agonist classic psychedelics have been used for centuries as sacraments within indigenous cultures. In the mid-twentieth century they were a focus within psychiatry as both probes of brain function and experimental therapeutics. By the late 1960s and early 1970s these scientific inquires fell out of favor because classic psychedelics were being used outside of medical research and in association with the emerging counter culture. However, in the
more » ... -first century, scientific interest in classic psychedelics has returned and grown as a result of several promising studies, validating earlier research. Here, we review therapeutic research on psilocybin, the classic psychedelic that has been the focus of most recent research. For mood and anxiety disorders, three controlled trials have suggested that psilocybin may decrease symptoms of depression and anxiety in the context of cancer-related psychiatric distress for at least 6 months following a single acute administration. A small, open-label study in patients with treatmentresistant depression showed reductions in depression and anxiety symptoms 3 months after two acute doses. For addiction, small, open-label pilot studies have shown promising success rates for both tobacco and alcohol addiction. Safety data from these various trials, which involve careful screening, preparation, monitoring, and follow-up, indicate the absence of severe drug-related adverse reactions. Modest drug-related adverse effects at the time of medication administration are readily managed. US federal funding has yet to support therapeutic psilocybin research, although such support will be important to thoroughly investigate efficacy, safety, and therapeutic mechanisms.
doi:10.1007/s13311-017-0542-y pmid:28585222 pmcid:PMC5509636 fatcat:ko4hhrisdrgezhqqigsdxtl43u

A Nonparametric Bayesian Approach to Uncovering Rat Hippocampal Population Codes During Spatial Navigation [article]

Scott W. Linderman, Matthew J. Johnson, Matthew A. Wilson, Zhe Chen
2014 arXiv   pre-print
., 2012a; Johnson and Willsky, 2014) and use a variational Bayes (VB) method for approximate Bayesian inference.  ...  Following Johnson and Willsky (2014) , we use a "direct assignment" truncation for the HDP (Bryant and Sudderth, 2012; Liang et al., 2007) .  ... 
arXiv:1411.7706v1 fatcat:6sm4225smfajtofntnf566bgue

Temporal preference in individuals reporting chronic pain

D. Andrew Tompkins, Patrick S. Johnson, Michael T. Smith, Eric C. Strain, Robert R. Edwards, Matthew W. Johnson
2016 Pain  
Opioid therapy for pain is associated with an increased risk for substance use disorders (SUD). This study's purpose was to determine the association between opioid misuse propensity (Screener and Opioid Assessment for Patients in Pain-Revised; SOAPP-R) and delay discounting, a behavioral process linked to SUD which quantifies the extent to which outcomes are devalued due to their delay. Participants reporting chronic pain (PRCP N=249) answered pain and opioid use questions, and then completed
more » ... our delay discounting tasks. Each of these tasks assessed either money or pain consequences, framed as either rewards or punishments. Each task involved hypothetical choices between immediate smaller vs. delayed larger consequences. The extant Monetary Choice Questionnaire (MCQ) assessed delay discounting of money rewards, and a modified version assessed discounting of money losses (immediate smaller loss vs. larger delayed loss). Based on the MCQ, the novel Pain Relief Choice Questionnaire (PRCQ) assessed choices between an immediate short duration of pain relief vs. a longer duration of pain relief. Similarly, the novel Additional Pain Choice Questionnaire (APCQ) assessed choices between an immediate short duration of additional pain vs. a longer duration of additional pain. Discounting of both additional pain and money losses were significantly associated with high SOAPP-R scoresindicating participants at greatest risk for opioid misuse discount future punishments rather than future rewards compared to those at low risk. Measures of delay discounting may have promise in more accurately identifying individuals at highest risk for opioid misuse during chronic opioid therapy.
doi:10.1097/j.pain.0000000000000576 pmid:27075431 pmcid:PMC4949122 fatcat:qkhtp6hjyfhojiw53tkox4nbgq

Flash Mob Research

Matthew W. Semler, Daniel G. Stover, Andrew P. Copland, Gina Hong, Michael J. Johnson, Michael S. Kriss, Hannah Otepka, Li Wang, Brian W. Christman, Todd W. Rice
2013 Chest  
Dr Johnson: contributed to the data acquisition and critical revision of the manuscript for important intellectual content.  ... 
doi:10.1378/chest.12-1837 pmid:23197319 pmcid:PMC3747725 fatcat:3lgj664bvjhyledsr65pdfjvkq

SavvyCNV: genome-wide CNV calling from off-target reads [article]

Thomas W Laver, Elisa De Franco, Matthew B Johnson, Kashyap Patel, Sian Ellard, Michael N Weedon, Sarah E Flanagan, Matthew N Wakeling
2019 bioRxiv   pre-print
AbstractCurrent exome and targeted sequencing approaches cannot detect clinically and biologically-relevant copy number variants (CNVs) outside their target area. We present SavvyCNV, a tool which uses off-target read data to call CNVs genome-wide. Up to 70% of sequencing reads from exome and targeted sequencing fall outside the targeted regions - SavvyCNV exploits this 'free data'. Using truth sets generated from genome sequencing data and MLPA, SavvyCNV outperformed four state-of-the-art CNV
more » ... allers at calling CNVs using off-target reads. We then identified clinically relevant CNVs from a targeted panel using SavvyCNV.SavvyCNV is freely available from https://github.com/rdemolgen/SavvySuite.
doi:10.1101/617605 fatcat:2yp67tfydje5rnpyd46xsdtxvq

Recurrent switching linear dynamical systems [article]

Scott W. Linderman, Andrew C. Miller, Ryan P. Adams, David M. Blei, Liam Paninski, Matthew J. Johnson
2016 arXiv   pre-print
Finally, at each time t a linear Gaussian observation y t ∈ R N is generated from the corresponding latent continuous state, y t = C zt x t + d zt + w t , w t iid ∼ N (0, S zt ), (3) for C k ∈ R N ×M ,  ...  However, Linderman, Johnson, and Adams [2015] show how to introduce Pólyagamma auxiliary variables ω = {ω k } K k=1 so that the conditional density p(x | z, ω) becomes Gaussian.  ... 
arXiv:1610.08466v1 fatcat:zdocsqlc2naapja65lutk7w4s4

Nicotine reinforcement in never-smokers

Angela N. Duke, Matthew W. Johnson, Chad J. Reissig, Roland R. Griffiths
2015 Psychopharmacology  
Rationale-Global tobacco-related mortality dwarfs that of all other drugs. Nicotine is believed to be the primary agent responsible for tobacco use and addiction. However, nicotine is a relatively weak and inconsistent reinforcer in nonhumans and nicotine reinforcement has not been demonstrated in never-smokers. Objectives-This study investigated the discriminative, subjective, and reinforcing effects of nicotine in never-smokers. Methods-Eighteen never-smokers (<50 lifetime nicotine exposures)
more » ... participated in a doubleblind study. During a drug discrimination phase, volunteers ingested oral nicotine and placebo capsules (quasi-random order) at least 2 hours apart and rated subjective effects repeatedly for 2 hours after ingestion in daily sessions. Blocks of 10 sessions were continued until significant discrimination was achieved (p≤.05, binomial test; ≥8 of 10). Following discrimination, nicotine choice was tested by having volunteers choose which capsule set to ingest on each daily session. Successive blocks of 10 sessions were conducted until choice for nicotine or placebo met significance within each volunteer (≥8 of 10 sessions). Results-All 18 volunteers significantly discriminated nicotine from placebo; the lowest dose discriminated ranged from 1.0-4.0 mg/70kg. Nine volunteers significantly chose nicotine (choosers) and nine significantly chose placebo (nicotine avoiders). The choosers reported predominately positive nicotine subjective effects (e.g., alert/attentive, good effects, liking), while avoiders tended to report negative effects (e.g., dizzy, upset stomach, disliking). Both choosers and avoiders attributed their choice to the qualitative nature of drug effects. Conclusions-These results provide the first evidence that nicotine can function as a reinforcer in some never-smokers.
doi:10.1007/s00213-015-4053-4 pmid:26345343 pmcid:PMC5366981 fatcat:5sgtn2pf4bfbnd2t77yzhutiei

Psilocybin, psychological distress, and suicidality

Peter S Hendricks, Matthew W Johnson, Roland R Griffiths
2015 Journal of Psychopharmacology  
., 2011; Johnson et al., 2014 ; see also Nutt et al., 2013) , an analysis of the specific relationships of psilocybin use with psychological distress and suicidality may help inform decisions by the United  ...  For other indications for which psilocybin is currently being studied (cancer-related anxiety/depression and addictions; Bogenschutz et al., 2015; Grob et al., 2011; Johnson et al., 2014) , the present  ... 
doi:10.1177/0269881115598338 pmid:26395582 pmcid:PMC4721603 fatcat:ptfpinuz2rgybobkjfkhn4orga

Psychedelic medicine: a re-emerging therapeutic paradigm

Kenneth W. Tupper, Evan Wood, Richard Yensen, Matthew W. Johnson
2015 CMAJ - Canadian Medical Association Journal  
doi:10.1503/cmaj.141124 pmid:26350908 pmcid:PMC4592297 fatcat:hz7cvhidnrc37jdpaakbquchei

Demand curves for hypothetical cocaine in cocaine-dependent individuals

Natalie R. Bruner, Matthew W. Johnson
2013 Psychopharmacology  
and Bickel 2003; Johnson et al. 2004; Johnson and Bickel 2006) , and a wide variety of drugs assessed in nonhuman animals (e.g., Mattox et al. 1997; Williams and Woods 2000; Ko et al. 2002) .  ...  ., Hursh 1995; Jacobs and Bickel 1999; Giordano et al. 2001; Shahan et al. 2001; Johnson et al. 2004; Rodefer and Carroll, 1996; Wade-Galuska et al. 2007 ).  ... 
doi:10.1007/s00213-013-3312-5 pmid:24217899 pmcid:PMC3945407 fatcat:ttsuad3o4nc2rd6rdqvjovoytu

Cystamine Inhibits Caspase Activity

Mathieu Lesort, Matthew Lee, Janusz Tucholski, Gail V. W. Johnson
2002 Journal of Biological Chemistry  
Measurement of Glutathione Levels-Cells (60-mm plate, ϳ0.2-0.4 mg of protein) were washed twice with ice-cold phosphate buffered saline and deproteinized with 200 l of ice-cold 5% (w/v) 5-sulfosalicylic  ... 
doi:10.1074/jbc.m205812200 pmid:12458211 fatcat:sau6abnu5reftaar5nu4xhexfe

An online survey of tobacco smoking cessation associated with naturalistic psychedelic use

Matthew W Johnson, Albert Garcia-Romeu, Patrick S Johnson, Roland R Griffiths
2017 Journal of Psychopharmacology  
Support for Dr Garcia-Romeu and Dr Patrick Johnson was provided by National Institute on Drug Abuse Grant, T32DA07209. Support for Dr Griffiths was provided in part by NIDA Grant, R01DA003889.  ...  ., 2016; Johnson et al., 2014; Ross, 2012; Sessa and Johnson, 2015) .  ...  well-tolerated and promising adjunct to cognitive-behavioral smoking cessation treatment, with 80% of participants (N = 15) demonstrating biologically verified smoking abstinence at 6-month follow up (Johnson  ... 
doi:10.1177/0269881116684335 pmid:28095732 fatcat:t4juqmvw3rdk3fbz5ln7ubgzn4

Further Information on the Avifauna of St. Matthew and Hall Islands, Bering Sea, Alaska

Bryce W. Robinson, Jack J. Withrow, Rachel M. Richardson, Steven M. Matsuoka, Robert E. Gill, Andrew S. Johnson, Irby J. Lovette, James A. Johnson, Anthony R. DeGange, Marc D. Romano
2020 Western Birds  
Matthew, Hall, and Pinnacle islands, is located in the central Bering Sea (60° 24ʹ N, 172° 42ʹ W; Figure 1 ), and is part of the Alaska Maritime National Wildlife Refuge (see Winker et al. 2002 for physical  ...  Matthew Island group, including St.  ...  Matthew Island on 19 June, 1, 4, and 6 July (at 60° 29ʹ N, 173° 3ʹ W; Robinson et al. 2019) .  ... 
doi:10.21199/wb51.2.1 fatcat:rmilaz5jdjcavgoxeshqxxyauq
« Previous Showing results 1 — 15 out of 67,578 results