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PDBe: bringing structure to biology and beyond

Matthew J. Conroy, Sameer Velankar
<span title="2017-12-01">2017</span> <i title="International Union of Crystallography (IUCr)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/rd3cuh2n4rfezc6sy4igtb5jci" style="color: black;">Acta Crystallographica Section A: Foundations and Advances</a> </i> &nbsp;
Protein Data Bank in Europe (PDBe) [1] a founder member of the wwPDB, has a mission to bring structure to biology. Data in the PDB archive is utilised by a diverse range of users including biochemists, geneticists, medicinal chemists, physicians, and even artists and school children. The complex nature of 3D structural data means that those with a limited background or training in structural biology do not always find it easy to exploit the rich information content of the structural archives to
more &raquo; ... help them answer their research questions. It is for archive keepers such as PDBe to address this challenge and develop new ways of making structural information more easily accessible, relevant, and up-to-date. Recently, PDBe implemented several new features to facilitate easy access to macromolecular structure data. These are inherently visual and, in collaboration with CEITEC in the Czech Republic, we have incorporated an easy to use, in-browser 3D visualizer on all structure webpages. With minimal data transfer needed, this works on all devices, including smartphones. In addition to models, electron density (for crystal structures) and electric potential maps (for cryoEM models) can be viewed where possible. 3D visualisation is interactively linked to sequence and topology views, a helpful teaching tool to link sequence and structure. All views can be overlaid with annotations of domain architecture and validation. Structure data is rendered a much richer and powerful pedagogical aid if linked to accurate up-to-date annotations. The SIFTS resource (pdbe.org/sifts) [2] provides updated residue-level mappings to UniProt and annotations from a variety of other databases on a weekly basis. In conjunction with Europe PMC [3], PDBe is able to display figures and legends from open-access publications describing PDB entries and datamine literature for instances of PDB codes. PDBe pages show the availability of, and indicate the results from, other resources useful to understanding macromolecular structure using a collection of PDB components. These include data from the PDB redo team at NKI, Amsterdam; Rajini from Dr. Madan Babu's lab at LMB, Cambridge; and a component providing biological relevance of assembly annotation in the PDB from Dr. Emanuel Levy's lab. Via a RESTful API, data can be served programmatically and this is used in educational services such as Proteopedia, where a 'preferred' assembly of a structure is selected, and JalView where structure selection is used to select an appropriate structure and annotation is displayed on sequence data. Resources are being developed to support the school science curriculum in collaboration with Newcastle University. We are also introducing structures to school students studying art, and this venture bringing together art and science, has already produced some stunning artworks. We hope that this collaboration will inspire the next generation of scientists and molecular graphic artists, and also enable the current generation of scientists to view their data through fresh eyes.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1107/s2053273317089963">doi:10.1107/s2053273317089963</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/q2gizjtqcvbilftnqj7ikiozcq">fatcat:q2gizjtqcvbilftnqj7ikiozcq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180719113318/http://journals.iucr.org/a/issues/2017/a2/00/a55674/a55674.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/64/54/6454eb748bae0562ecb99dfdd7683528f101d5e4.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1107/s2053273317089963"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Early internal fixation and soft tissue cover of severe open tibial pilon fractures

J. Conroy, M. Agarwal, P. V. Giannoudis, S. J. E. Matthews
<span title="2003-12-01">2003</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dewud3lb4fcdrcolgw7kqofi6a" style="color: black;">International Orthopaedics</a> </i> &nbsp;
We studied 32 consecutive patients with open distal tibial pilon fractures. All patients had radical debridement with immediate skeletal stabilisation and early soft-tissue cover with a vascularized muscle flap. The minimum follow-up was 1 (range 1-8) year. There were four superficial infections, two deep infections and two amputations. There were no long-term problems with union and no patient required an ankle fusion. Patients were assessed using the SF-36 questionnaire. There were
more &raquo; ... differences from the US norm in physical function score (p<0.01), role physical score (p<0.05) and physical component score (p<0.01). Physical component score of 38.5 was significantly better (p<0.01) when compared with amputees from severe lower-extremity trauma. Our protocol for management resulted in a good functional outcome with low infection and amputation rates. Résumé Nous avons étudié 32 malades consécutifs avec une fracture ouverte du pilon tibial. Tous les malades avaient un débridement radical avec stabilisation squelettique immédiate et couverture tissulaire précoce avec un lambeau musculaire vascularisé. Le minimum de suivi était une année (1à 8 années). Il y avait 4 infections superficielles, 2 infections profondes et 2 amputations. Il n'y avait pas de problèmes de consolidation à long terme et aucune arthrodèse de cheville ne fut nécessaire. Les malades ont été étudiés à partir du questionnaire SF-36. Il y avait des différences significatives selon la norme américaine du score de la fonction physique (p<0.01), le rôle du score physique (p<0.05) et le score de la composante physique (p<0.01). Le score composant physique de 38.5 était considérablement meilleur (p<0.01) comparé aux amputés pour traumatisme distal sévére. Notre protocole de gestion de ces fractures a conduit à un bon résultat fonctionnel avec un taux d'infection et d'amputation très bas.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00264-003-0486-1">doi:10.1007/s00264-003-0486-1</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/12851785">pmid:12851785</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3461889/">pmcid:PMC3461889</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/d4swjvpibvewljt6yevbmxa63i">fatcat:d4swjvpibvewljt6yevbmxa63i</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200208154842/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3461889&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/fd/19/fd190febf0da2d1958742465946ecd0943489567.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00264-003-0486-1"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461889" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Powderday: Dust Radiative Transfer for Galaxy Simulations [article]

Desika Narayanan, Matthew J. Turk, Thomas Robitaille, Ashley J. Kelly, B. Connor McClellan, Ray S. Sharma, Prerak Garg, Matthew Abruzzo, Ena Choi, Charlie Conroy, Benjamin D. Johnson, Benjamin Kimock (+9 others)
<span title="2020-06-18">2020</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
The dust emissivities are computed for bins of power of radiation field absorbed by the grains per unit mass: A = 4πJ isrf κ ν dν (9) where J isrf is the mean intensity of the radiation field at the location  ...  Maraston et al. 2006; Walcher et al. 2011; Michałowski et al. 2009; Conroy et al. 2009; Conroy 2013; Dunlop 2011; Leja et al. 2017; Zhang et al. 2017; Leja et al. 2019; Lower et al. 2020) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2006.10757v1">arXiv:2006.10757v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mdw5bztycnc3rmonaadsmtjnh4">fatcat:mdw5bztycnc3rmonaadsmtjnh4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200623001524/https://arxiv.org/pdf/2006.10757v1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2006.10757v1" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Electron and atomic force microscopy of the trimeric ammonium transporter AmtB

Matthew J Conroy, Stuart J Jamieson, Daniel Blakey, Thomas Kaufmann, Andreas Engel, Dimitrios Fotiadis, Mike Merrick, Per A Bullough
<span title="">2004</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ad4yn77omvbz5mxraouyuuhroq" style="color: black;">EMBO Reports</a> </i> &nbsp;
Wang for excellent microscopy support, Mr J. Thornton for preparation of the AmtB antibody, Dr A.  ...  Conroy et al azide in a home-built dialysis machine ( Jap et al, 1992) at 20 1C for 10 days. Electron microscopy. Crystals were embedded in 1% (w/v) glucose.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/sj.embor.7400296">doi:10.1038/sj.embor.7400296</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/15568015">pmid:15568015</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC1299191/">pmcid:PMC1299191</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5li2aulqibe73h27dom5jyni7q">fatcat:5li2aulqibe73h27dom5jyni7q</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170808175454/https://www.jic.ac.uk/staff/mike-merrick/pdfs/2004/Conroy_etal_EMBORep_2004.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/16/81/1681a5336c44b564b17f305f1482f04429fcb1d5.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/sj.embor.7400296"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1299191" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Modelling the human rhesus proteins: implications for structure and function

Matthew J. Conroy, Per A. Bullough, Mike Merrick, Neil D. Avent
<span title="">2005</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/t2s5n4hupzbx5iqhhtket3b7da" style="color: black;">British Journal of Haematology</a> </i> &nbsp;
Finally, as AmtB is a trimer (Blakey et al, 2002; Conroy et al, 2004; Khademi et al, 2004; Zheng et al, 2004) , this brings into question the oligomeric state of the Rh complex.  ...  Recent structural data on the E.coli ammonia channel AmtB (Conroy et al, 2004; Khademi et al, 2004; Zheng et al, 2004) provide an opportunity to generate models of the Rh proteins using AmtB as a template  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/j.1365-2141.2005.05786.x">doi:10.1111/j.1365-2141.2005.05786.x</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/16281947">pmid:16281947</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/w4cv4w36cjfopis4dthojlsysu">fatcat:w4cv4w36cjfopis4dthojlsysu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170705100350/https://www.jic.ac.uk/STAFF/mike-merrick/pdfs/2005/Conroy_etal_BJH2005.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a9/fb/a9fba9f8a5d10cc3ac2505c3b02f1c4f08125709.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/j.1365-2141.2005.05786.x"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

ReducingLegionellaColonization of Water Systems with Monochloramine

Brendan Flannery, Lisa B. Gelling, Duc J. Vugia, June M. Weintraub, James J. Salerno, Michael J. Conroy, Valerie A. Stevens, Charles E. Rose, Matthew R. Moore, Barry S. Fields, Richard E. Besser
<span title="">2006</span> <i title="Centers for Disease Control and Prevention (CDC)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/xfv7rdysezhxpa4oce7jejarnq" style="color: black;">Emerging Infectious Diseases</a> </i> &nbsp;
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3201/eid1204.051101">doi:10.3201/eid1204.051101</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/16704806">pmid:16704806</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3294698/">pmcid:PMC3294698</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/k7aoy2nnsrfevizsd56lqarvkm">fatcat:k7aoy2nnsrfevizsd56lqarvkm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180722085353/https://wwwnc.cdc.gov/eid/article/12/4/pdfs/05-1101.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ca/93/ca93b6bd2820879ffac0eab429a4f9d28c07d89e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3201/eid1204.051101"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294698" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

RNA footprinting analysis using ion pair reverse phase liquid chromatography

MARK J. DICKMAN, MATTHEW J. CONROY, JANE A. GRASBY, DAVID P. HORNBY
<span title="">2002</span> <i title="Cold Spring Harbor Laboratory"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5r3smv4gwnggfemxt2y4fgjxqa" style="color: black;">RNA: A publication of the RNA Society</a> </i> &nbsp;
Hydroxyl radical footprinting is a powerful technique often employed in characterization of the tertiary interactions between proteins and nucleic acids. Following the generation of a nucleic acid "ladder" either by chemical or enzymatic reactions, the radiolabeled products are traditionally separated by denaturing gel electrophoresis and further quantified by phosphorimaging techniques. Here we report the use of ion pair reverse phase liquid chromatography to analyze the products of an RNA
more &raquo; ... printing reaction using fluorescently labeled RNA molecules. This technique offers several advantages over existing procedures, including rapid analysis, automation, and direct quantification of the cleavage products without the need to employ radiolabeling. To illustrate the resolving power of this technique, we have analyzed the products of base hydrolysis, generated from a fluorescently labeled RNA molecule and have subsequently used this method to define the solvent accessibility of the substrate strand as it docks with the hairpin ribozyme.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1017/s1355838202012888">doi:10.1017/s1355838202012888</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/11911369">pmid:11911369</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC1370246/">pmcid:PMC1370246</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/apcsyiorybebfhd622vxexuope">fatcat:apcsyiorybebfhd622vxexuope</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191029024648/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC1370246&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c7/fb/c7fbdfd6395f92b4cdfd41a8d1c2114b1ad487ec.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1017/s1355838202012888"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370246" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Management of the Deficient Patella in Revision Total Knee Arthroplasty

Ryan M. Garcia, Matthew J. Kraay, Patricia A. Conroy-Smith, Victor M. Goldberg
<span title="2008-08-20">2008</span> <i title="Ovid Technologies (Wolters Kluwer Health)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/lzfv534ahfcedh4w6sklgjsxvm" style="color: black;">Clinical Orthopaedics and Related Research</a> </i> &nbsp;
There are a number of options available to manage the patella when revising a failed total knee arthroplasty. If the previous patellar component is wellfixed, undamaged, not worn, and compatible with the femoral revision component, then it can be retained. When a patellar component necessitates revision and is removed with adequate remaining patellar bone stock, an onlay-type all-polyethylene cemented implant can be used. Management of the patella with severe bony deficiency remains
more &raquo; ... l. Treatment options for the severely deficient patella include the use of a cemented all-polyethylene biconvex patellar prosthesis, patellar bone grafting and augmentation, patellar resection arthroplasty (patelloplasty), performing a gull-wing osteotomy, patellectomy, or the use of newer technology such as a tantalum (trabecular metal) patellar prosthesis. Severe patellar bone deficiency is a challenging situation because restoration of the extensor mechanism, proper patellar tracking, and satisfactory anatomic relationships with the femoral and tibial components are critical for an optimal clinical outcome.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11999-008-0433-y">doi:10.1007/s11999-008-0433-y</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18712583">pmid:18712583</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2565018/">pmcid:PMC2565018</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/35mmupdpybahtkmvju3gxt4x5y">fatcat:35mmupdpybahtkmvju3gxt4x5y</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191014122946/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2565018&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/22/fc/22fc9aa3d501a1585bbf5231b4653c4937dee0a4.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s11999-008-0433-y"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565018" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Foetal brain development in offspring of women with psychosis

Mary C. Clarke, Mary Cannon, Matthew Hogg, Maureen N. Marks, Sue Conroy, Susan J. Pawlby, Anne Greenough, Kypros Nicolaides
<span title="">2007</span> <i title="Royal College of Psychiatrists"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/r2ls53ulyfeynk6h7jbxyybana" style="color: black;">British Journal of Psychiatry</a> </i> &nbsp;
MARKS, SUE CONROY, SUSAN J. PAWLBY, MAUREEN N. MARKS, SUE CONROY, SUSAN J. PAWLBY, ANNE GREENOUGH and KYPROS NICOLAIDES ANNE GREENOUGH and KYPROS NICOLAIDES et al, 2001). The finding of , 2001).  ...  J. & Nicolaides, K. H. (1994) Snijders, R. J. & Nicolaides, K. H. (1994) Fetal Fetal biometry at 14^40 weeks' gestation. biometry at 14^40 weeks' gestation.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1192/bjp.bp.106.023747">doi:10.1192/bjp.bp.106.023747</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17470961">pmid:17470961</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/flsnmnnwyfhv7nmdxtlpsj2vnm">fatcat:flsnmnnwyfhv7nmdxtlpsj2vnm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190505062344/https://www.cambridge.org/core/services/aop-cambridge-core/content/view/60644A15D46D17A72C21DB73863FD7F0/S0007125000172198a.pdf/div-class-title-foetal-brain-development-in-offspring-of-women-with-psychosis-div.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ad/ad/adadc874b936374996cdb25f15184c10110e5e6a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1192/bjp.bp.106.023747"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Nonstomatal limitations are responsible for drought-induced photosynthetic inhibition in four C4 grasses

Oula Ghannoum, Jann P. Conroy, Simon P. Driscoll, Matthew J. Paul, Christine H. Foyer, David W. Lawlor
<span title="2003-07-24">2003</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/vlsktox4cfdrtktgckwlr2q66e" style="color: black;">New Phytologist</a> </i> &nbsp;
., 1997; Ghannoum & Conroy, 1998) .  ...  P ([CO 2 ]) J O 2 J O 2 J O 2 J O 2 only on the balance between photosynthesis and respiration (Farquhar et al., 1980) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1046/j.1469-8137.2003.00835.x">doi:10.1046/j.1469-8137.2003.00835.x</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33873592">pmid:33873592</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/iotv3lsyzzac7ch6fwivmjfi2a">fatcat:iotv3lsyzzac7ch6fwivmjfi2a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20091009133348/http://www.southwestnrm.org.au/information/downloads/Ghannoum-O-etal-2003_Non-stomatal-limitations-are-responsibl.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7d/74/7d748d00034fdecca0c1dd3b838ccf32bae595b6.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1046/j.1469-8137.2003.00835.x"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Feasibility and impact of a 1-minute daily functional exercise regimen prescribed to older adults by their primary care physician

Christopher N. Sciamanna, Matthew A. Ladwig, David E. Conroy, Kathryn H. Schmitz, Matthew L. Silvis, Noel H. Ballentine, Brandon J. Auer, Margaret K. Danilovich
<span title="2021-01-04">2021</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/fdniiv75cnbf5amxdqxattjwru" style="color: black;">Preventive medicine reports</a> </i> &nbsp;
Moreover, reducing the period of recall to less than 24 h has been shown to improve the accuracy of self-report (Matthews et al., 2019) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.pmedr.2020.101307">doi:10.1016/j.pmedr.2020.101307</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33520612">pmid:33520612</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7820134/">pmcid:PMC7820134</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/y2mjpccmk5azraflnd245cilxy">fatcat:y2mjpccmk5azraflnd245cilxy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210526225606/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7820134&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/97/e9/97e9838bd5d50c657db89c7ccec9600c3b343196.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.pmedr.2020.101307"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820134" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Generation and Characterization of Human Smooth Muscle Cell Lines Derived From Atherosclerotic Plaque

L. R. Bonin, K. Madden, K. Shera, J. Ihle, C. Matthews, S. Aziz, N. Perez-Reyes, J. K. McDougall, S. C. Conroy
<span title="1999-03-01">1999</span> <i title="Ovid Technologies (Wolters Kluwer Health)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ocv5b4js4vdl7ps6ugk4rl6gja" style="color: black;">Arteriosclerosis, Thrombosis and Vascular Biology</a> </i> &nbsp;
The study of atherogenesis in humans has been restricted by the limited availability and brief in vitro life span of plaque smooth muscle cells (SMCs). We describe plaque SMC lines with extended life spans generated by the expression of the human papillomavirus (HPV)-16 E6 and E7 genes, which has been shown to extend the life span of normal adult human aortic SMCs. Resulting cell lines (pdSMC1A and 2) demonstrated at least 10-fold increases in life span; pdSMC1A became immortal. The SMC
more &raquo; ... of both pdSMC lines was confirmed by SM22 mRNA expression. pdSMC2 were generally diploid but with various structural and numerical alterations; pdSMC1A demonstrated several chromosomal abnormalities, most commonly ϪY, ϩ7, Ϫ13, anomalies previously reported in both primary pdSMCs and atherosclerotic tissue. Confluent pdSMC2 appeared grossly similar to HPV-16 E6/E7-expressing normal adult aortic SMCs (AASMCs), exhibiting typical SMC morphology/growth patterns; pdSMC1A displayed irregular cell shape/ organization with numerous mitotic figures. Dedifferentiation to a synthetic/proliferative phenotype has been hypothesized as a critical step in atherogenesis, because rat neonatal SMCs and adult intimal SMCs exhibit similar gene expression patterns. To confirm that our pdSMC lines likewise express this apparent plaque phenotype, osteopontin, platelet-derived growth factor B, and elastin mRNA levels were determined in pdSMC1A, pdSMC2, and AASMCs. However, no significant increases in osteopontin or platelet-derived growth factor B expression levels were observed in either pdSMC compared with AASMCs. pdSMC2 alone expressed high levels of elastin mRNA. Lower levels of SM22 mRNA in pdSMC1A suggested greater dedifferentiation and/or additional population doublings in pdSMC1A relative to pdSMC2. Both pdSMC lines (particularly 1A) demonstrated high message levels for matrix Gla protein, previously reported to be highly expressed by human neointimal SMCs in vitro. These results describe 2 novel plaque cell lines exhibiting various features of plaque SMC biology; pdSMC2 may represent an earlier plaque SMC phenotype, whereas pdSMC1A may be representative of cells comprising an advanced atherosclerotic lesion. (Arterioscler Thromb Vasc Biol. 1999;19:575-587.)
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1161/01.atv.19.3.575">doi:10.1161/01.atv.19.3.575</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/10073960">pmid:10073960</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5fmj5h2z2jeudfotrfdt2lw4ta">fatcat:5fmj5h2z2jeudfotrfdt2lw4ta</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180722084845/http://atvb.ahajournals.org/content/atvbaha/19/3/575.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ab/5e/ab5ee67a93b1553c7e4cbd587663a7fa77dac305.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1161/01.atv.19.3.575"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

A cohort examination to establish reporting of the remit and function of Trial Steering Committees in randomised controlled trials

Elizabeth J. Conroy, Barbara Arch, Nicola L. Harman, J. Athene Lane, Steff C. Lewis, John Norrie, Matthew R. Sydes, Carrol Gamble
<span title="">2017</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/elawdhnd7neuxgmzbrr6efzkgu" style="color: black;">Trials</a> </i> &nbsp;
The DAMOCLES project established a widely used Data Monitoring Committee (DMC) Charter for randomised controlled trials (RCTs). Typically, within the UK, the DMC is advisory and recommends to another executive body; the Trial Steering Committee (TSC). Despite the executive role of the TSC, the CONSORT Statement does not explicitly require reporting of TSC activity, although is included as an example of good reporting. A lack of guidance on TSC reporting can impact transparency of trial
more &raquo; ... , ultimately leading to a misunderstanding regarding role and, subsequently, further variation in practice. This review aimed to establish reporting practice of TSC involvement in RCTs, and thus make recommendations for reporting. Methods: A cohort examination identifying reporting practice was undertaken. The cohort comprised RCTs published in three leading medical journals (the British Medical Journal, The Lancet and the New England Journal of Medicine) within 6 months in 2012 and the full NIHR HTA Monograph series. Details of TSC constitution and impact were extracted from main publications and published supplements. Results: Of 415 publications, 264 were eligible. These were typical in terms of trial design. Variations in reporting between journals and monographs was notable. TSC presence was identified in approximately half of trials (n = 144), of which 109 worked alongside a DMC. No publications justified not convening a TSC. When reported, the role of the committee and examples of impact in design, conduct and analysis were summarised. Conclusions: We present the first review of reporting TSC activity in the published academic literature. An absence of reporting standards with regards to TSC constitution, activity and impact on trial conduct was identified which can influence transparency of reporting trial oversight. Consistent reporting is vital for the benefits and impact of the TSC role to be understood to support adoption of this oversight structure and reduce global variations in practice.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13063-017-2300-1">doi:10.1186/s13063-017-2300-1</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29221458">pmid:29221458</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5723080/">pmcid:PMC5723080</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ib4dqz2mfbee7b5fst6hfgqi4u">fatcat:ib4dqz2mfbee7b5fst6hfgqi4u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190430120942/https://research-information.bristol.ac.uk/ws/files/141316206/s13063_017_2300_1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/35/90/3590dfb5a8d66e8fc403dcc543f133bd1443dfa1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13063-017-2300-1"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723080" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Colicin N Binds to the Periphery of Its Receptor and Translocator, Outer Membrane Protein F

Thomas G. Baboolal, Matthew J. Conroy, Katrina Gill, Helen Ridley, Virak Visudtiphole, Per A. Bullough, Jeremy H. Lakey
<span title="">2008</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/y4oayrlrkfebxgzkm3rrzcps2m" style="color: black;">Structure</a> </i> &nbsp;
Colicins kill Escherichia coli after translocation across the outer membrane. Colicin N displays an unusually simple translocation pathway, using the outer membrane protein F (OmpF) as both receptor and translocator. Studies of this binary complex may therefore reveal a significant component of the translocation pathway. Here we show that, in 2D crystals, colicin is found outside the porin trimer, suggesting that translocation may occur at the protein-lipid interface. The major lipid of the
more &raquo; ... r leaflet interface is lipopolysaccharide (LPS). It is further shown that colicin N binding displaces OmpF-bound LPS. The N-terminal helix of the pore-forming domain, which is not required for pore formation, rearranges and binds to OmpF. Colicin N also binds artificial OmpF dimers, indicating that trimeric symmetry plays no part in the interaction. The data indicate that colicin is closely associated with the OmpF-lipid interface, providing evidence that this peripheral pathway may play a role in colicin transmembrane transport.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.str.2007.12.023">doi:10.1016/j.str.2007.12.023</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18334212">pmid:18334212</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2581486/">pmcid:PMC2581486</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/dpxy6fkktfh2zhb74dqujzqbye">fatcat:dpxy6fkktfh2zhb74dqujzqbye</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170808125322/http://www.faculty.jacobs-university.de/mwinterhalter/antibiotics/Marseille%20meeting/Abstract_Lakey.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/01/66/0166614c0157642e888647935fd2acaf45278a6a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.str.2007.12.023"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581486" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Genetic modification of photosynthesis with E. coli genes for trehalose synthesis

Till K. Pellny, Oula Ghannoum, Jann P. Conroy, Henriette Schluepmann, Sjef Smeekens, John Andralojc, Klaus Peter Krause, Oscar Goddijn, Matthew J. Paul
<span title="">2004</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/kwwnfmfjqnha3am4ayrbh27a4a" style="color: black;">Plant Biotechnology Journal</a> </i> &nbsp;
Improvement in photosynthesis per unit leaf area has been difficult to alter by breeding or genetic modification. We report large changes in photosynthesis in Nicotiana tabacum transformed with E. coli genes for the trehalose pathway. Significantly, photosynthetic capacity (CO 2 assimilation at varying light and CO 2 , and quantum yield of PSII electron transport) per unit leaf area and per leaf dry weight were increased in lines of N. tabacum transformed with the E. coli gene otsA , which
more &raquo; ... es trehalose phosphate synthase. In contrast, transformation with otsB , which encodes trehalose phosphate phosphatase or Trec , encoding trehalose phosphate hydrolase, produced the opposite effect. Changes in CO 2 assimilation per unit leaf area were closely related to the amount and activity of Rubisco, but not to the maximum activities of other Calvin cycle enzymes. Alterations in photosynthesis were associated with trehalose 6-phosphate content rather than trehalose. When growth parameters were determined, a greater photosynthetic capacity did not translate into greater relative growth rate or biomass. This was because photosynthetic capacity was negatively related to leaf area and leaf area ratio. In contrast, relative growth rate and biomass were positively related to leaf area. These results demonstrate a novel means of modifying Rubisco content and photosynthesis, and the complexities of regulation of photosynthesis at the whole plant level, with potential benefits to biomass production through improved leaf area.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/j.1467-7652.2004.00053.x">doi:10.1111/j.1467-7652.2004.00053.x</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17166144">pmid:17166144</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/cf7ojqsu45glddaxje5qxugx4u">fatcat:cf7ojqsu45glddaxje5qxugx4u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200313001256/https://dspace.library.uu.nl/bitstream/handle/1874/11458/PellnyPlBiotechJ2004.pdf;jsessionid=3DD7964F29C960E1561916BEF0587AA3?sequence=2" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/80/b1/80b1a7feb30acdf305b3ce9c6e4314e3ea6aa51d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/j.1467-7652.2004.00053.x"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>
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