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An ESRP-regulated splicing programme is abrogated during the epithelial–mesenchymal transition

Claude C Warzecha, Peng Jiang, Karine Amirikian, Kimberly A Dittmar, Hezhe Lu, Shihao Shen, Wei Guo, Yi Xing, Russ P Carstens
<span title="2010-08-13">2010</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/xcjlfiweh5bfpiome6ieuwel2a" style="color: black;">EMBO Journal</a> </i> &nbsp;
Epithelial splicing regulatory proteins 1 and 2 (ESRP1 and ESRP2) are cell-type-specific regulators of transcripts that switch splicing during the epithelial-mesenchymal transition (EMT).  ...  Alternative splicing achieves coordinated changes in posttranscriptional gene expression programmes through the activities of diverse RNA-binding proteins.  ...  Acknowledgements We thank Don Baldwin, Yi Li, and John Hogenesch for technical support and discussion; Kristen Lynch for review of the manuscript; and the University of Iowa ICTS for computer support.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/emboj.2010.195">doi:10.1038/emboj.2010.195</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20711167">pmid:20711167</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2957203/">pmcid:PMC2957203</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/46azijbjgzamzkelsuskalfg6q">fatcat:46azijbjgzamzkelsuskalfg6q</a> </span>
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An EMT–Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype

Irina M. Shapiro, Albert W. Cheng, Nicholas C. Flytzanis, Michele Balsamo, John S. Condeelis, Maja H. Oktay, Christopher B. Burge, Frank B. Gertler, Nancy B. Spinner
<span title="2011-08-18">2011</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/j6fzfstrmzcj3aeps7bx6tpoy4" style="color: black;">PLoS Genetics</a> </i> &nbsp;
Epithelial-mesenchymal transition (EMT), a mechanism important for embryonic development, plays a critical role during malignant transformation.  ...  The functional significance of EMT-associated alternative splicing was tested by expression of the epithelial-specific splicing factor ESRP1 or by depletion of RBFOX2 in mesenchymal cells, both of which  ...  We thank Russ Carstens for sharing the ESRP data before publication [28] . We thank Peter Stoilov and Doug Black for the RBFOX2 shRNA. We thank Eric Wang for the scrambled shRNA.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pgen.1002218">doi:10.1371/journal.pgen.1002218</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/21876675">pmid:21876675</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3158048/">pmcid:PMC3158048</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ansnhkrzsfgolbuyj4eew7inna">fatcat:ansnhkrzsfgolbuyj4eew7inna</a> </span>
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An Alternative Splicing Program for Mouse Craniofacial Development

Joan E. Hooper, Kenneth L. Jones, Francis J. Smith, Trevor Williams, Hong Li
<span title="2020-09-04">2020</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/evju7ot335gbrctgmomg4gg6je" style="color: black;">Frontiers in Physiology</a> </i> &nbsp;
We next examined how the variation in splicing correlated with the expression of RNA binding proteins across the various datasets.  ...  Recent studies have highlighted that mutation of splicing factors, resulting in the disruption of alternative splicing, can have profound consequences for mammalian craniofacial development.  ...  of RNA binding proteins.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fphys.2020.01099">doi:10.3389/fphys.2020.01099</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33013468">pmid:33013468</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7498679/">pmcid:PMC7498679</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/st3vhfx4a5b45n2vc47vbjwc2i">fatcat:st3vhfx4a5b45n2vc47vbjwc2i</a> </span>
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Genome-Wide Determination of a Broad ESRP-Regulated Posttranscriptional Network by High-Throughput Sequencing

K. A. Dittmar, P. Jiang, J. W. Park, K. Amirikian, J. Wan, S. Shen, Y. Xing, R. P. Carstens
<span title="2012-02-21">2012</span> <i title="American Society for Microbiology"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ki5pr2lmenbmbijbb4tkftguwe" style="color: black;">Molecular and Cellular Biology</a> </i> &nbsp;
We used high-throughput sequencing (RNA-Seq) to investigate the complete spectrum of alternative splicing events that are regulated by the epithelium-specific splicing regulatory proteins ESRP1 and ESRP2  ...  Tissue-specific alternative splicing is achieved through the coordinated assembly of RNA binding proteins at specific sites to enhance or silence splicing at nearby splice sites.  ...  ACKNOWLEDGMENTS We thank Jonathan Schug and members of the Functional Genomics Core Facility for assistance with the RNA-Seq analysis and design of the SELEX-Seq experiments.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1128/mcb.06536-11">doi:10.1128/mcb.06536-11</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22354987">pmid:22354987</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3318588/">pmcid:PMC3318588</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vl6ivenbzjdmvdyvaomin5hb2m">fatcat:vl6ivenbzjdmvdyvaomin5hb2m</a> </span>
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Alternative Splicing and Tumor Progression

Claudia Ghigna, Cristina Valacca, Giuseppe Biamonti
<span title="2008-12-01">2008</span> <i title="Bentham Science Publishers Ltd."> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mqegkl27nzckpogkyj47kjwblu" style="color: black;">Current Genomics</a> </i> &nbsp;
Cancer-associated alternative splicing variants may be new tools for the diagnosis and classification of cancers and could be the targets for innovative therapeutical interventions based on highly selective  ...  Both mutations in cis-acting splicing elements and alterations in the expression and/or activity of splicing regulatory factors drastically affect the splicing profile of many cancer-associated genes.  ...  ACKNOWLEDGEMENTS This work was supported by grants from the Associazione Italiana per la Ricerca sul Cancro (AIRC), from the European Union (EURASNET) Network of Excellence on Alternative Splicing (EURASNET  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2174/138920208786847971">doi:10.2174/138920208786847971</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19516963">pmid:19516963</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2694562/">pmcid:PMC2694562</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/6gmozrnyyvhcxaamwc42eql6uy">fatcat:6gmozrnyyvhcxaamwc42eql6uy</a> </span>
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Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state [article]

Yarden Katz, Feifei Li, Nicole Lambert, Ethan M Sokol, Wai-Leong Tam, Albert W Cheng, Edoardo M Airoldi, Christopher J Lengner, Piyush B Gupta, Zhengquan Yu, Rudolf Jaenisch, Christopher B Burge
<span title="2014-06-12">2014</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
and epithelial-to-mesenchymal transition (EMT) and promote an epithelial splicing pattern.  ...  The conserved Musashi (Msi) family of RNA binding proteins are expressed in stem/progenitor and cancer cells, but mostly absent from differentiated cells, consistent with a role in cell state regulation  ...  (B) Number of differential events (MISO Bayes factor ≥ 10, ΔΨ ≥ 0.12) in each alternative RNA processing category (SE -skipped exons, A5SS -alternativesplice site, A3SS -alternativesplice site,  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/006270">doi:10.1101/006270</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vhjgby6hyrh53pcwgemo25u5ze">fatcat:vhjgby6hyrh53pcwgemo25u5ze</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180724185918/https://www.biorxiv.org/content/biorxiv/early/2014/06/12/006270.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c5/ec/c5ec02f640412d6ac4014c5f803cbf77f974b7b2.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/006270"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

The Merit of Alternative Messenger RNA Splicing as a New Mine for the Next Generation Ovarian Cancer Biomarkers [chapter]

Jean-Philippe Brosseau, Sherif Abou-Elel
<span title="2013-02-27">2013</span> <i title="InTech"> Ovarian Cancer - A Clinical and Translational Update </i> &nbsp;
However, the nature of the platform used to carry the experiments and the analysis methods and sample sets makes inter-laboratory comparison very difficult and finding reliable mark-  ...  Genome-wide mRNA profiling presents an opportunity to rapidly identify RNA markers.  ...  The relatively high number of ASEs markers found coupled to the fact that several were related to the epithelial-mesenchymal transition raised the possibility that a large fraction of the discovered events  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5772/53976">doi:10.5772/53976</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/li27h5mz5nayhnqkrd5mlf4nwi">fatcat:li27h5mz5nayhnqkrd5mlf4nwi</a> </span>
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2b or Not 2b: How Opposing FGF Receptor Splice Variants Are Blocking Progress in Precision Oncology

Richard J. Epstein, Li Jun Tian, Yan Fei Gu, Chandra Singh
<span title="2021-04-30">2021</span> <i title="Hindawi Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/wewutbvhmjgxpaawukserpbooe" style="color: black;">Journal of Oncology</a> </i> &nbsp;
Strategizing how best to use FGFR-targeted drugs is complicated by multiple variables, including RNA splicing events that alter the affinity of ligands for FGFRs and hence change the outcomes of stromal-epithelial  ...  triggering epithelial-mesenchymal transition.  ...  . ese differences underlie a growing need for today's oncologists and trialists to understand the biological spectrum of FGFRs and hence to factor in more sophisticated predictive data for stratifying  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2021/9955456">doi:10.1155/2021/9955456</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34007277">pmid:34007277</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8110382/">pmcid:PMC8110382</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3axvhrea4zaw7memrpjeebxflu">fatcat:3axvhrea4zaw7memrpjeebxflu</a> </span>
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Alternative RNA Splicing—The Trojan Horse of Cancer Cells in Chemotherapy

Nikolay Mehterov, Maria Kazakova, Yordan Sbirkov, Boyan Vladimirov, Nikolay Belev, Galina Yaneva, Krassimira Todorova, Soren Hayrabedyan, Victoria Sarafian
<span title="2021-07-18">2021</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/githwx23ynaxdoftesby3jya3y" style="color: black;">Genes</a> </i> &nbsp;
Almost all transcribed human genes undergo alternative RNA splicing, which increases the diversity of the coding and non-coding cellular landscape.  ...  Taken together, these findings offer novel opportunities for future studies and the development of targeted therapy for cancer-specific splicing variants.  ...  Acknowledgments: The authors thank Kristin Ozanian for the art work. Conflicts of Interest: The authors declare no conflict of interest.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/genes12071085">doi:10.3390/genes12071085</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34356101">pmid:34356101</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8306420/">pmcid:PMC8306420</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wsgts3vmwjhjpkgfbnydy33bj4">fatcat:wsgts3vmwjhjpkgfbnydy33bj4</a> </span>
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Functional significance of U2AF1 S34F mutations in lung adenocarcinomas

Mohammad S. Esfahani, Luke J. Lee, Young-Jun Jeon, Ryan A. Flynn, Henning Stehr, Angela B. Hui, Noriko Ishisoko, Eric Kildebeck, Aaron M. Newman, Scott V. Bratman, Matthew H. Porteus, Howard Y. Chang (+2 others)
<span title="2019-12-13">2019</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/a4wan6l5o5dfzn767kyz7jqevi" style="color: black;">Nature Communications</a> </i> &nbsp;
U2AF1 S34F induced expression of genes involved in the epithelial-mesenchymal transition (EMT) and increased tumor cell invasion.  ...  To characterize this interaction, we profiled effects of S34F on the transcriptome-wide distribution of RNA binding and alternative splicing in cells harboring the ROS1 translocation.  ...  The most enriched gene set is the hallmark epithelial mesenchymal transition. b Relative protein expression of E-cadherin and fibronectin 1 (FN1) in HCC78 cells.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41467-019-13392-y">doi:10.1038/s41467-019-13392-y</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31836708">pmid:31836708</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6911043/">pmcid:PMC6911043</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ujjuf35ts5eifandtjtv63yixm">fatcat:ujjuf35ts5eifandtjtv63yixm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191217060048/https://www.nature.com/articles/s41467-019-13392-y.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f9/49/f949db878ba01e65c04fffc1016f29a166cabc25.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41467-019-13392-y"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> nature.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911043" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Circular RNAs in the cardiovascular system

Clarissa P.C. Gomes, Antonio Salgado-Somoza, Esther E. Creemers, Christoph Dieterich, Mitja Lustrek, Yvan Devaux
<span title="">2018</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/hey5e3gpqjfr3epjtitxf5sl2y" style="color: black;">Non-coding RNA Research</a> </i> &nbsp;
They are ubiquitously expressed and represent a novel branch of the family of non-coding RNAs.  ...  Finally, the potential of circRNAs as biomarkers of cardiovascular disease will be addressed and directions for future research will be proposed.  ...  During epithelial-mesenchymal transition (EMT) it was shown that about one-third of the circRNAs were regulated by QKI [20] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.ncrna.2018.02.002">doi:10.1016/j.ncrna.2018.02.002</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30159434">pmid:30159434</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6084836/">pmcid:PMC6084836</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xn6k2kdyxbdnfl3nz3fsfl6g5a">fatcat:xn6k2kdyxbdnfl3nz3fsfl6g5a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200211225737/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6084836&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/96/17/9617bcfcc6e6b790f306bf5291b39cad88377327.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.ncrna.2018.02.002"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084836" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

p53 is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state

S. Senturk, Z. Yao, M. Camiolo, B. Stiles, T. Rathod, A. M. Walsh, A. Nemajerova, M. J. Lazzara, N. K. Altorki, A. Krainer, U. M. Moll, S. W. Lowe (+2 others)
<span title="2014-07-29">2014</span> <i title="Proceedings of the National Academy of Sciences"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/nvtuoas5pbdsllkntnhizy4f4q" style="color: black;">Proceedings of the National Academy of Sciences of the United States of America</a> </i> &nbsp;
However, expression of the p53Ψ isoform attenuated the expression of E-cadherin, induced expression of markers associated with epithelial-mesenchymal transition (EMT), and enhanced the motility and invasive  ...  However, like certain p53 gain-offunction mutants, p53Ψ attenuates the expression of E-cadherin, induces expression of markers of the epithelial-mesenchymal transition, and enhances the motility and invasive  ...  required for the p53Ψ-induced epithelial to mesenchymal transition.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1073/pnas.1321640111">doi:10.1073/pnas.1321640111</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25074920">pmid:25074920</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4136628/">pmcid:PMC4136628</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/yvzpyhpgzbfvxiajbnq2zjx5ua">fatcat:yvzpyhpgzbfvxiajbnq2zjx5ua</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190302233729/http://pdfs.semanticscholar.org/aba2/9db7ee96b3eb79cb61ce8b3bc8fd1b71e195.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ab/a2/aba29db7ee96b3eb79cb61ce8b3bc8fd1b71e195.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1073/pnas.1321640111"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136628" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Genome-wide profiling of prognosis-related alternative splicing signatures in sarcoma

Weifeng Hong, Weicong Zhang, Renguo Guan, Yuying Liang, Shixiong Hu, Yayun Ji, Mouyuan Liu, Hai Lu, Min Yu, Liheng Ma
<span title="">2019</span> <i title="AME Publishing Company"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/u5ioqxxruvelzolwnumjlphsfe" style="color: black;">Annals of Translational Medicine</a> </i> &nbsp;
RNA-Seq data of the SARC cohort were downloaded from The Cancer Genome Atlas (TCGA) database. Survival-related AS events were selected by univariate and multivariate Cox regression analyses.  ...  Also, driver gene mutations were significantly associated with AS in SARC patients. Survival-related AS events may become ideal indictors for the prognosis prediction of SARCs.  ...  epithelial to mesenchymal transition (53) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.21037/atm.2019.09.65">doi:10.21037/atm.2019.09.65</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31807538">pmid:31807538</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6861818/">pmcid:PMC6861818</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tb64qmantjgjzmuo6wzv2yaxiy">fatcat:tb64qmantjgjzmuo6wzv2yaxiy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200911050507/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6861818&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.21037/atm.2019.09.65"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861818" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Unresolved Complexity in the Gene Regulatory Network Underlying EMT

Deborah P. Lavin, Vijay K. Tiwari
<span title="2020-05-12">2020</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mefn5t5kjndavkrqau5bzfpaoe" style="color: black;">Frontiers in Oncology</a> </i> &nbsp;
Epithelial to mesenchymal transition (EMT) is the process whereby a polarized epithelial cell ceases to maintain cell-cell contacts, loses expression of characteristic epithelial cell markers, and acquires  ...  A complex process that occurs during development and many disease states, EMT involves a plethora of transcription factors (TFs) and signaling pathways.  ...  The reverse process (MET; mesenchymal-epithelial transition) is vital for secondary tumor formation and also occurs during embryogenesis with multiple rounds of EMT and MET required for correct formation  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fonc.2020.00554">doi:10.3389/fonc.2020.00554</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32477926">pmid:32477926</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7235173/">pmcid:PMC7235173</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/et7rztxak5fmncvhbtfpwjjuxu">fatcat:et7rztxak5fmncvhbtfpwjjuxu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210427181502/https://pureadmin.qub.ac.uk/ws/files/219268882/Complexity.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4d/52/4d52949735208043eec47bdcf0057c34d0af3d71.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fonc.2020.00554"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235173" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

RNA splicing factors as oncoproteins and tumour suppressors

Heidi Dvinge, Eunhee Kim, Omar Abdel-Wahab, Robert K. Bradley
<span title="2016-06-10">2016</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/xoznyohbsrdunjqidaim5dfxee" style="color: black;">Nature Reviews. Cancer</a> </i> &nbsp;
Many other RNA-binding proteins regulate splicing in addition to the SR proteins and hnRNPs. These include the CUG-BP-and ETR-3-like (CELF) proteins (reviewed in 34 ), Dvinge et al.  ...  The epithelial to mesenchymal transition (EMT) is regulated by splicing factors including epithelial splicing regulatory protein 1 (ESRP1; also known as RBM35A) and ESRP2 (also known as RBM35B), which  ...  BCLAF1, Bcl-2-associated transcription factor 1; EMT, epithelial to mesenchymal transition; ESRP, epithelial splicing regulatory protein; hnRNP, heterogeneous nuclear ribonucleoprotein; NMD, nonsense-mediated  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/nrc.2016.51">doi:10.1038/nrc.2016.51</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27282250">pmid:27282250</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5094465/">pmcid:PMC5094465</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/f5rnou6kiredxpm5g66g6hbp2e">fatcat:f5rnou6kiredxpm5g66g6hbp2e</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200209090845/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5094465&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d7/a9/d7a96df35b4b37270a999617d7610fda4ae9cb5d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/nrc.2016.51"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> nature.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094465" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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