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Rationale: Personalizing transcranial stimulations promises to enhance beneficial effects for individual patients. Objective: To stimulate specific cortical regions by developing a procedure to bend and position custom shaped electrodes; to probe the effects on cortical excitability produced when the properly customized electrode is targeting different cortical areas. Method: An ad hoc neuronavigation procedure was developed to accurately shape and place the personalized electrodes on the basisdoi:10.3389/fnhum.2013.00131 pmid:23626529 pmcid:PMC3631708 fatcat:zbmwe7n2fvd6rdztki6gthavdq
more »... of individual brain magnetic resonance images (MRI) on bilateral primary motor (M1) and somatosensory (S1) cortices. The transcranial alternating current stimulation (tACS) protocol published by Feurra et al. (2011b) was used to test the effects on cortical excitability of the personalized electrode when targeting S1 or M1. Results: Neuronal excitability as evaluated by tACS was different when targeting M1 or S1, with the General Estimating Equation model indicating a clear tCS Effect (p < 0.001), and post hoc comparisons showing solely M1 20 Hz tACS to reduce M1 excitability with respect to baseline and other tACS conditions. Conclusions: The present work indicates that specific cortical regions can be targeted by tCS properly shaping and positioning the stimulating electrode. Significance:Through multimodal brain investigations continuous efforts in understanding the neuronal changes related to specific neurological or psychiatric diseases become more relevant as our ability to build the compensating interventions improves. An important step forward on this path is the ability to target the specific cortical area of interest, as shown in the present pilot work.
Ercolani acquired the data, which Zappasodi analyzed. Salustri wrote the article, and Tecchio, Zappasodi, Bevacqua, Fontana, Ercolani, Milazzo, Squitti and Rossini revised it. ...pmid:17653294 pmcid:PMC1911195 fatcat:grkluwtlqnhxriwdrw2xawsdte
Objective: Impaired cerebral vasomotor reactivity (VMR) and flow-mediated dilation (FMD) were found in selected subgroups of type 2 diabetes mellitus (T2DM) patients with long-term disease. Our study aimed to evaluate cerebral hemodynamics, systemic endothelial function and sympatho-vagal balance in a selected population of well-controlled T2DM patients with short-term disease and without cardiac autonomic neuropathy (CAN). Research Design and Methods: Twenty-six T2DM patients with short-termdoi:10.1371/journal.pone.0083287 pmid:24391751 pmcid:PMC3877017 fatcat:sxbqlnfx6ffmndfs3nsi35vtdu
more »... .4064.80 years) and well-controlled (HbA1C = 6.7161.29%) disease, without any complications, treated with diet and/or metformin, were consecutively recruited. Eighteen controls, comparable by sex and age, were enrolled also. Results: FMD and shear rate FMD were found to be reduced in T2DM subjects with short-term disease (8.5% SD 3.5 and 2.5 SD 1.3, respectively) compared to controls (15.4% SD 4.1 and 3.5 SD 1.4; p,.001 and p,.05). T2DM patients also displayed reduced VMR values than controls (39.4% SD 12.4 vs 51.7%, SD 15.5; p,.05). Sympatho-vagal balance was not different in T2DM patients compared to healthy subjects. FMD and shear rate FMD did not correlate with VMR in T2DM patients or in controls (p..05). Conclusions: In well-controlled T2DM patients with short-term disease cerebral hemodynamics and systemic endothelial function are altered while autonomic balance appeared to be preserved.
Electroencephalographic (EEG) data were recorded in 69 normal elderly (Nold), 88 mild cognitive impairment (MCI), and 109 mild Alzheimer's disease (AD) subjects at rest condition, to test whether the fronto-parietal coupling of EEG rhythms is in line with the hypothesis that MCI can be considered as a pre-clinical stage of the disease at group level. Functional coupling was estimated by synchronization likelihood of Laplaciantransformed EEG data at electrode pairs, which accounts for linear anddoi:10.1016/j.brainresbull.2005.10.013 pmid:16464686 fatcat:vu5stpfyezgs7pprqgttrmxk7a
more »... non-linear components of that coupling. Cortical rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), beta 2 (20-30 Hz), and gamma (30-40 Hz). Compared to the Nold subjects, the AD patients presented a marked reduction of the synchronization likelihood (delta to gamma) at both fronto-parietal and inter-hemispherical (delta to beta 2) electrodes. As a main result, alpha 1 synchronization likelihood progressively decreased across Nold, MCI, and mild AD subjects at midline (Fz-Pz) and right (F4-P4) fronto-parietal electrodes. The same was true for the delta synchronization likelihood at right fronto-parietal electrodes (F4-P4). For these EEG bands, the synchronization likelihood correlated with global cognitive status as measured by the Mini Mental State Evaluation. The present results suggest that at group level, fronto-parietal coupling of the delta and alpha rhythms progressively becomes abnormal though MCI and mild AD. Future longitudinal research should evaluate whether the present EEG approach is able to predict the cognitive decline in individual MCI subjects. (C. Babiloni). URL: http://hreeg.ifu.uniroma1.it/. when the cognitive deficits are barely detectable [15, 95, 102] . Accordingly, mild cognitive impairment (MCI) is characterized by selective memory impairment insufficient to meet criteria for a diagnosis of dementia [34, 81, 82] . This condition is considered as a prodromic stage of AD [2, 11, 41, 42, 81, 97] . Annual conversion rate from normality to AD is estimated at about 0.2-4% [36, 81] , whereas that from MCI to AD is about 6-25% [81, 83] . These data suggest that, in several (yet not all) cases, MCI is a transition state on a linear progression towards AD. 0361-9230/$ -see front matter
Université de Poitiers, Francia ángela maría endlich (Doctora en Geografía de la Universidade Estadual Paulista "Júlio de Mesquita Filho", Brasil) Universidade Estadual de Maringá, Brasil patricia s. ercolani ... Montaigne, Francia) Universidad Nacional de Colombia, Bogotá judith ley garcía (Doctora en Geografía de la Universidad Nacional Autónoma de México, México) Universidad Autónoma de Baja California, México matilde ...doi:10.15446/rcdg.v25n2.58801 fatcat:vrkfwaxverbgxljpi5uegjbk7m
National Union Catalog
Salimei, Matilde, ed, III. Title. ... Premio nazionale di pittura “Enrico Toti”; cmostra, Catalogo , a cura di Gino Ercolani, Palazzo delle esposi- a, 4-30 maggio 1957. ...
: Il terzo peccato, seconda edizione; Matilde Serao: // cuore infermo; Angelo Brofferio: Canzoni Piemonest, ediz. accresciuta; Emilio Pinchia: Ricordi di Tunisia. — Il sig. ... Giuseppe Lomonaco, nato nel 1803, morto nel 1880, pubblicata in Melfi, pe’ tipi Ercolani, — S'annunzia che dentro l’anno sarà, pubblicata a Milano in sei volumi la raccolta compiuta delle opere di Felice ...
Matilde Ercolani (MEG recordings) and Mr. Benito Vecchiarelli (SEP recordings) for their excellent technical assistance. ...doi:10.1016/s1388-2457(01)00725-8 pmid:11801420 fatcat:sy7gjxv2zbh2jjy6cddk324bbu
Ercolani and Lucia Fraioli for excellent technical support; neuroradiologists Chiara Gaudino and Domenico Lupoi for lesion evaluation; and engineer Alessandro Giordani for database management. ... neurologists Paolo Profice, Giacomo Della Marca, Giuseppe Granata, Nadia Mariagrazia Giannantoni e Francesco Passarelli, and Francesco Tibuzzi for scientific collaboration and patient recruitment; TNFP Matilde ...doi:10.1155/2019/1971875 pmid:31611914 pmcid:PMC6755296 fatcat:zuecap53tbfv5jatxqea6qxybq
Acknowledgments The authors would like to thank TNFP Matilde Ercolani for excellent technical support and Peter Angelo Taliaferro for language editing. ...doi:10.1371/journal.pone.0141995 pmid:26536036 pmcid:PMC4633126 fatcat:u72mfaipvjdg7duiircy4jp7om
Ercolani and Lucia Fraioli for excellent technical support; neuroradiologists Chiara Gaudino and Domenico Lupoi for lesion site and dimension evaluation. ... Acknowledgments The authors would like to thank neurologists Salvatore Assenza, Francesco Passarelli and Francesco Tibuzzi for scientific collaboration, patients recruitment and neurological examination, TNFP Matilde ...doi:10.1371/journal.pone.0100199 pmid:24967904 pmcid:PMC4072666 fatcat:v3l3xw6ptff4dhmrs7iqiaes3e
Human Brain Mapping
Matilde Ercolani, Ms. Rita Fini, Dr. Massimo Gennarelli, Dr. Nicola Girtler, and Dr. Katiuscia Sosta for help in the development of the present study. We also thank Prof. ...doi:10.1002/hbm.20175 pmid:16108018 fatcat:gqwme5se25emho5md62f5jycmq
Kathya Torquati and Dr Francesco Tibuzzi for continuous collaboration, Dr Patrizio Pasqualetti for statistical consultation, Mrs Matilde Ercolani for excellent technical support and Dr Gloria Dal Forno ...doi:10.1093/brain/awh012 pmid:14570819 fatcat:jstgj7kklrcprgpk5ndvxcx3ye
Furthermore, the authors thank Emanuele Cassetta for AD patients evaluation and Matilde Ercolani for technical assistance. Author Contributions ...doi:10.1371/journal.pone.0149587 pmid:26872349 pmcid:PMC4752290 fatcat:f7u3vdf72zb3dhuklfffxuvw44
Matilde Ercolani, Ms. Rita Fini, Dr. Giovanni Frisoni, Dr. Massimo Gennarelli, Dr. Nicola Girtler, Dr. Simone Pocaterra, and Dr. ...doi:10.1016/j.neuroimage.2006.02.015 pmid:16600641 fatcat:nhr4o7yngzc6ddrnhfuccudwjm
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