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A Bacterial Cell-Cycle Regulatory Network Operating in Time and Space

H. H. McAdams
2003 Science  
This discontinuous progression of the cell through the cell cycle is not well suited to modeling with differential equation-based cellcycle models with their implicit assumptions of continuity.  ...  Caulobacter crescentus is a productive model system for the study of bacterial cell-cycle regulation and the mechanisms of asymmetric cell division.  ... 
doi:10.1126/science.1087694 pmid:14512618 fatcat:wfiea6mvmrclhiqro7mxyow6xq

Coordination between E. coli Cell Size and Cell Cycle Mediated by DnaA [article]

Qing Zhang, Zhichao Zhang, Hualin Shi
2020 bioRxiv   pre-print
Sixty years ago, bacterial cell size was found as an exponential function of growth rate.  ...  We simulated DnaA kinetics and obtained a self-consistent cell size and a regular DnaA oscillation coordinated with the cell cycle at steady state.  ...  INTRODUCTION In the bacterial cell cycle, DNA replication, cell division, and cell growth are coordinated with each other [1] . Cell cycle events have featured timings.  ... 
doi:10.1101/2020.02.14.949446 fatcat:spqdawobjnfnng5amwnzu2icpm

Distinguishing between linear and exponential cell growth during the division cycle: single-cell studies, cell-culture studies, and the object of cell-cycle research

Stephen Cooper
2006 Theoretical Biology and Medical Modelling  
Two approaches to understanding growth during the cell cycle are single-cell studies, where growth during the cell cycle of a single cell is measured, and cell-culture studies, where growth during the  ...  These ideas are applied to the controversy between proponents of linear growth as a possible growth pattern during the cell cycle and the proponents of exponential growth during the cell cycle.  ...  Rothman of the University of Michigan Center for Statistical Consultation and Research gave invaluable help on the regression analysis presented in this paper.  ... 
doi:10.1186/1742-4682-3-10 pmid:16504098 pmcid:PMC1402260 fatcat:njir73djrjdivdoruu2ihhoddm

Nitrogen Cycle [chapter]

2008 Encyclopedia of Genetics, Genomics, Proteomics and Informatics  
the bacterial cell.  ...  deal with the social problems of his country.  ...  In the centromeric region of Drosophila interphase chromosomes the nucleosomes are tetrameric in vivo, with one copy of CenH3 (the centromere-specific H3 histone variant), H2A, H2B, and H4 each, wrapped  ... 
doi:10.1007/978-1-4020-6754-9_11438 fatcat:l3g7v7z6zbeqbcnxd5bpkr5myy

Control of growth and of the nuclear division cycle in Neurospora crassa

L Alberghina, E Sturani
1981 Microbiological reviews  
The editing and preparation of the manuscript by Betty Johnston is gratefully acknowledged. This review was partially supported by a grant from the Consiglio Nazionale delle Ricerche to L.A.  ...  The coordination of growth and the nuclear division cycle in Neurospora appears to be mediated by the achievement of a critical cell mass required for the initiation of deoxyribonucleic acid (DNA) replication  ...  there is an analogy between the C and D periods of the bacterial cell cycle and the S and G2 phases of the eucaryotic cell cycle.  ... 
doi:10.1128/mr.45.1.99-122.1981 fatcat:tirlchzb6ffhhpjlprdyw3bpwq

Control of growth and of the nuclear division cycle in Neurospora crassa

L Alberghina, E Sturani
1981 Microbiological reviews  
The editing and preparation of the manuscript by Betty Johnston is gratefully acknowledged. This review was partially supported by a grant from the Consiglio Nazionale delle Ricerche to L.A.  ...  The coordination of growth and the nuclear division cycle in Neurospora appears to be mediated by the achievement of a critical cell mass required for the initiation of deoxyribonucleic acid (DNA) replication  ...  there is an analogy between the C and D periods of the bacterial cell cycle and the S and G2 phases of the eucaryotic cell cycle.  ... 
pmid:6452573 pmcid:PMC281500 fatcat:xpjwn2blbzbuxeu6rqeblo6tc4

Transcriptional Waves in the Yeast Cell Cycle

2005 PLoS Biology  
aspects of the cell cycle.  ...  The stately march of the cell cycle-from the fi rst growth phase, through DNA synthesis, to the second growth phase, and on to mitosis and cell division-also demands increased activity, but of hundreds  ... 
doi:10.1371/journal.pbio.0030243 fatcat:pa4gsd4kkjhfbaoo7nrqq3gl7a

Complex molecular mixtures under cycling gradients as basis for lifes origins [article]

Bert Poolman, Jan Spitzer
2016 bioRxiv   pre-print
The above physicochemical principles of lifes emergence are consistent with the second law of thermodynamics, and with the current facts of molecular microbiology and planetary sciences.  ...  First, Earths prebiotic chemical evolution is historically continuous with Darwinian evolution; second, cycling energies of solar radiation are primary drivers of chemical evolution; third, environmental  ...  cell envelopes arranged in proto-biofilms, 618 with growth (metabolism) powered largely by cycling gradients, and with poorly developed heredity 619 (DNA replication and cell division) -not yet life as  ... 
doi:10.1101/050740 fatcat:kxexoq6or5agne3leya65dqqvy

Mitochondria, the Cell Cycle, and the Origin of Sex via a Syncytial Eukaryote Common Ancestor

Sriram G. Garg, William F. Martin
2016 Genome Biology and Evolution  
Here, we present an evolutionary inference for the origin of sex starting with a bacterial ancestor of mitochondria in the cytosol of its archaeal host.  ...  the simpler haploid and diploid mitotic cell cycles arose.  ...  Separate sexes and the mitochondrial theory of ageing.  ... 
doi:10.1093/gbe/evw136 pmid:27345956 pmcid:PMC5390555 fatcat:kci4m5ng3ngvnm5v4bgfr5pu44

Random versus Cell Cycle-Regulated Replication Initiation in Bacteria: Insights from Studying Vibrio cholerae Chromosome 2

Revathy Ramachandran, Jyoti Jha, Johan Paulsson, Dhruba Chattoraj
2016 Microbiology and Molecular Biology Reviews  
In bacteria with divided genomes, the replication system of one of the chromosomes typically resembles that of bacteria with undivided genomes, whereas the remaining chromosomes have plasmid-like replication  ...  SUMMARY Bacterial chromosomes initiate replication at a fixed time in the cell cycle, whereas there is generally no particular time for plasmid replication initiation or chromosomal replication initiation  ...  This research was supported (in part) by the Intramural Research Program of the Center for Cancer Research, National Cancer Institute, National Institutes of Health, and a National Institutes of Health  ... 
doi:10.1128/mmbr.00033-16 pmid:27903655 pmcid:PMC5312244 fatcat:ud7rj5xzgnhidj5qtpfw23esgu

Details Matter: Noise and Model Structure Set the Relationship between Cell Size and Cell Cycle Timing

Felix Barber, Po-Yi Ho, Andrew W. Murray, Ariel Amir
2017 Frontiers in Cell and Developmental Biology  
division cycle, confine new growth to that bud, and divide at the connection between that bud and the mother cell, like the budding yeast Saccharomyces cerevisiae.  ...  We find that in bacteria an inhibitor dilution model produces adder correlations that are not robust to noise in the timing of DNA replication initiation or in the timing from initiation of DNA replication  ...  FB wishes to thank the staff of MCB graphics for assistance with the cell illustrations in Figure 1 .  ... 
doi:10.3389/fcell.2017.00092 pmid:29164112 pmcid:PMC5675860 fatcat:xcaxc3hykvbkvnojx56firkje4

Temporal Controls of the Asymmetric Cell Division Cycle in Caulobacter crescentus

Shenghua Li, Paul Brazhnik, Bruno Sobral, John J. Tyson, Jason A. Papin
2009 PLoS Computational Biology  
Different controls for both swarmer and stalked cell cycles are represented in the mathematical scheme.  ...  Because the cell cycle control proteins of Caulobacter are conserved across many species of alphaproteobacteria, the model we are proposing here may be applicable to other genera of importance to agriculture  ...  Acknowledgments The authors thank our many colleagues in the Tyson and Sobral research groups for valuable discussions of the model. We especially thank Dr.  ... 
doi:10.1371/journal.pcbi.1000463 pmid:19680425 pmcid:PMC2714070 fatcat:igeondrq4vazjixnvk3vwqnpmq

Spirochetal motility and chemotaxis in the natural enzootic cycle and development of Lyme disease

MD A. Motaleb, Jun Liu, R Mark Wooten
2015 Current Opinion in Microbiology  
Two-thirds of all bacterial genomes sequenced to-date possess an organelle for locomotion, referred to as flagella, periplasmic flagella or type IV pili.  ...  These genomes may also contain a chemotaxis-signaling system which governs flagellar rotation, thus leading a coordinated function for motility.  ...  Caimano for providing some of the diagrams in this article.  ... 
doi:10.1016/j.mib.2015.09.006 pmid:26519910 pmcid:PMC4688064 fatcat:djipgr2kxngznfg6jjfcg5wb6q

Switching Logistic Maps to Design Cycling Approaches Against Antimicrobial Resistance [article]

Esteban A. Hernandez-Vargas, Cesar Parra-Rojas, Sorin Olaru
2020 bioRxiv   pre-print
Simulations results show the applicability of Parrondo's Paradox to design cycling therapies against drug resistance.  ...  In this paper, we introduce a logistic switching model in order to abstract mutation networks of collateral resistance.  ...  For instance, the logistic model has served as a key mathematical tool in to represent the growth of tumors [1] and microbes [24] .  ... 
doi:10.1101/2020.03.17.995928 fatcat:sdbzrjzsufaxlkefpaxmvuhc74

A Quantitative Study of the Division Cycle of Caulobacter crescentus Stalked Cells

Shenghua Li, Paul Brazhnik, Bruno Sobral, John J Tyson
2005 PLoS Computational Biology  
Progression of a cell through the division cycle is tightly controlled at different steps to ensure the integrity of genome replication and partitioning to daughter cells.  ...  The model accounts for important details of the physiology, biochemistry, and genetics of cell cycle control in stalked C. crescentus cell.  ...  Acknowledgments The authors thank our many colleagues in the Tyson and Sobral research groups for valuable discussions of the model, and especially Harley McAdams of Stanford University for bringing this  ... 
doi:10.1371/journal.pcbi.0040009.eor fatcat:v2ythyhszjhvzpmqaqatbpqh5q
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