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Mathematical investigation of IP3-dependent calcium dynamics in astrocytes

Gregory Handy, Marsa Taheri, John A. White, Alla Borisyuk
<span title="2017-03-28">2017</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2awqvcobm5bw3bostcqrykczhe" style="color: black;">Journal of Computational Neuroscience</a> </i> &nbsp;
We study evoked calcium dynamics in astrocytes, a major cell type in the mammalian brain.  ...  Here we present a qualitative analysis of a recent mathematical model of astrocyte calcium responses.  ...  Handy) and the National Institutes of Health (R01 NS078331, to J.A. White and K.S. Wilcox).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s10827-017-0640-1">doi:10.1007/s10827-017-0640-1</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28353176">pmid:28353176</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5756620/">pmcid:PMC5756620</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mbueudtjkbcylobjqn622pzm5i">fatcat:mbueudtjkbcylobjqn622pzm5i</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200209001045/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5756620&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b5/5d/b55d5045f4072b14db56561ce1c0f78cef7b89a4.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s10827-017-0640-1"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756620" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

From in silico astrocyte cell models to neuron-astrocyte network models: A review

Franziska Oschmann, Hugues Berry, Klaus Obermayer, Kerstin Lenk
<span title="">2018</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/rsleb57uhfea3pj4cykcgtttyi" style="color: black;">Brain Research Bulletin</a> </i> &nbsp;
In this review, we give an overview over the published computational models of astrocytic functions, from single-cell dynamics to the tripartite synapse level and network models of astrocytes and neurons  ...  Concurrent with the first experimental reports of the astrocytic impact on neural network dynamics, computational models describing astrocytic functions have been developed.  ...  Yet, IP3 dynamics, too, are crucial in astrocytes since IP3 formation and consumption is Ca-dependent and IP3 exchange between two coupled astrocytes supports a large part of astrocyte communication.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.brainresbull.2017.01.027">doi:10.1016/j.brainresbull.2017.01.027</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28189516">pmid:28189516</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/lh4fpxym3nel3kmkyv4nu52qbm">fatcat:lh4fpxym3nel3kmkyv4nu52qbm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180725123114/https://hal.archives-ouvertes.fr/hal-01461928/document" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/56/44/5644d5f3b6449a190f5423e4c311ac297d5b2efe.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.brainresbull.2017.01.027"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

A neuron–astrocyte transistor-like model for neuromorphic dressed neurons

G. Valenza, G. Pioggia, A. Armato, M. Ferro, E.P. Scilingo, D. De Rossi
<span title="">2011</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/oml24fsyizfuhn3rn5np75ubdi" style="color: black;">Neural Networks</a> </i> &nbsp;
Experimental evidences on the role of the synaptic glia as an active partner together with the bold synapse in neuronal signaling and dynamics of neural tissue strongly suggest to investigate on a more  ...  Among the glial cells, the astrocytes play a crucial role in the tripartite synapsis, i.e. the dressed neuron.  ...  Production of IP3, [IP3], in the intracellular space of astrocytes triggers the calcium dynamics.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neunet.2011.03.013">doi:10.1016/j.neunet.2011.03.013</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/21441011">pmid:21441011</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/btp34wvqyvgyhoyagtwuksbi6u">fatcat:btp34wvqyvgyhoyagtwuksbi6u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171117190923/http://www.ilc.cnr.it:80/~ferro/publications/A_neuron_astrocyte_transistor_like_model_for_neuromorphic_dressed_neurons.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/43/fb/43fbd1db2c1dd9181ce927c1be20064ec289dbc7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neunet.2011.03.013"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

A Proposed Mathematical Model for Tripartite Synapse to Enhance Artificial Model for Artificial Neuron-Astrocyte Networks

<span title="2020-10-15">2020</span> <i title="The World Academy of Research in Science and Engineering"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/naqzxq5hurh2bp2pnvwitnnx44" style="color: black;">International Journal of Advanced Trends in Computer Science and Engineering</a> </i> &nbsp;
Therefore, we propose mathematical models based on kinetic model for tripartite synapse to advance a new artificial model for artificial neuron-astrocyte networks.  ...  The proposed model in this work concerns the appropriate astrocyte abstractions that capture essential computational principles to advance a biologically inspired model.  ...  In turn, this stimulates the release of second messenger inositol 1,4,5-trisphospate (IP3) into the astrocytic cytoplasm, then IP3 opens channels to trigger calcium (ca +2 ).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.30534/ijatcse/2020/206952020">doi:10.30534/ijatcse/2020/206952020</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/lh7h2pebvjbv5idxypv62b7gdq">fatcat:lh7h2pebvjbv5idxypv62b7gdq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201026094740/http://www.warse.org/IJATCSE/static/pdf/file/ijatcse206952020.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/45/73/457320758cf8d3989102867a2ef7d20374968497.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.30534/ijatcse/2020/206952020"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Single Hemichannels Recorded in Lipid Bilayers and Artificial Gap Junction Formation with Cells

Mohamed Kreir, Christoph Methfessel, Christian Carnarius, Claudia Steinem, Niels Fertig
<span title="">2011</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dez2wau7t5aqvklzwrcsreuwq4" style="color: black;">Biophysical Journal</a> </i> &nbsp;
We show that this effect is a direct consequence of the major slowdown of calcium dynamics.  ...  by the cytosolic calcium buffering capacity using a combination of mathematical modeling and patch clamp recording in acute slice.  ...  Board B162 Origin and Dynamics of Calcium Waves in the Islet of Langerhans Richard K.P.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.bpj.2010.12.3266">doi:10.1016/j.bpj.2010.12.3266</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bxx6uujopjb4pn4s52kguzioje">fatcat:bxx6uujopjb4pn4s52kguzioje</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190301231230/https://core.ac.uk/download/pdf/81966673.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/21/31/213119742ebd267eb46981426e2c524b24270568.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.bpj.2010.12.3266"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

A Neuromorphic Digital Circuit for Neuronal Information Encoding Using Astrocytic Calcium Oscillations

Farnaz Faramarzi, Fatemeh Azad, Mahmood Amiri, Bernabé Linares-Barranco
<span title="2019-10-09">2019</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/wrk3kouosrhcxiprcbguskdipu" style="color: black;">Frontiers in Neuroscience</a> </i> &nbsp;
In this paper, astrocytic calcium oscillations and neuronal firing dynamics are presented by De Pittà and IF (Integrated & Fire) models, respectively.  ...  dynamic of the original models.  ...  Indeed, the role of calcium oscillations in neural information encoding is still under investigation.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnins.2019.00998">doi:10.3389/fnins.2019.00998</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31649494">pmid:31649494</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6794439/">pmcid:PMC6794439</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/lbrbukbna5bhdkr7tbeltwemaq">fatcat:lbrbukbna5bhdkr7tbeltwemaq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200211013339/https://fjfsdata01prod.blob.core.windows.net/articles/files/453882/pubmed-zip/.versions/1/.package-entries/fnins-13-00998/fnins-13-00998.pdf?sv=2015-12-11&amp;sr=b&amp;sig=K9iN5Pggw3ZjYG6kT9wzBrC7dATjpN9kENjJ82EhmEs%3D&amp;se=2020-02-11T01%3A34%3A09Z&amp;sp=r&amp;rscd=attachment%3B%20filename%2A%3DUTF-8%27%27fnins-13-00998.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f8/fa/f8faf7253eb7b65bf7de1121d1e18b246cbbe2c0.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fnins.2019.00998"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794439" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Controlling Effects of Astrocyte on Neuron Behavior in Tripartite Synapse Using VHDL–AMS

Osman Taylan, Mona Abusurrah, Ehsan Eftekhari-Zadeh, Ehsan Nazemi, Farheen Bano, Ali Roshani
<span title="2021-10-25">2021</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ye33srllvnanjouxn4tmrfgjsq" style="color: black;">Mathematics</a> </i> &nbsp;
In this model, the astrocyte acts as a controller module for neurons and can regulates the spiking activity of them.  ...  Astrocyte cells form the largest cell population in the brain and can influence neuron behavior.  ...  Moreover, calcium dynamics in the astrocyte is represented by c.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/math9212700">doi:10.3390/math9212700</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/j5xicwxpijf7rpkhkc4xbx6vv4">fatcat:j5xicwxpijf7rpkhkc4xbx6vv4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220504003548/https://mdpi-res.com/d_attachment/mathematics/mathematics-09-02700/article_deploy/mathematics-09-02700-v2.pdf?version=1638362709" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f1/f1/f1f1407369eb28d6346fd9a8a26703fb5ddb26c1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/math9212700"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a>

Bistability and Chaos Emergence in Spontaneous Dynamics of Astrocytic Calcium Concentration

Evgeniya V. Pankratova, Maria S. Sinitsina, Susanna Gordleeva, Victor B. Kazantsev
<span title="2022-04-18">2022</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ye33srllvnanjouxn4tmrfgjsq" style="color: black;">Mathematics</a> </i> &nbsp;
In this work, we consider a mathematical model describing spontaneous calcium signaling in astrocytes.  ...  Based on biologically relevant principles, this model simulates experimentally observed calcium oscillations and can predict the emergence of complicated dynamics.  ...  Acknowledgments: We are grateful to the reviewers for their constructive comments and valuable suggestions that have helped to improve the quality of the paper.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/math10081337">doi:10.3390/math10081337</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/potmuv3je5bkbcogjthfc5omhu">fatcat:potmuv3je5bkbcogjthfc5omhu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220607165230/https://mdpi-res.com/d_attachment/mathematics/mathematics-10-01337/article_deploy/mathematics-10-01337.pdf?version=1650270043" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/86/30/8630a6fe95febee177953f90b64ceb5065c0e431.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/math10081337"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a>

Estimating integrated information in bidirectional neuron-astrocyte communication

Luis Abrego, Susanna Gordleeva, Oleg Kanakov, Mikhail Krivonosov, Alexey Zaikin
<span title="2021-02-19">2021</span> <i title="American Physical Society (APS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5pgnwkvlevhybgsbuc3q7fchx4" style="color: black;">Physical review. E</a> </i> &nbsp;
Our model highlights the role of astrocytes in information processing through dynamical coordination.  ...  In this paper, we investigate how the astrocytes participate in the information integrated by individual neurons in an ensemble through the measurement of "integrated information."  ...  The effect of calcium events variation upon integrated information requires further investigation.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1103/physreve.103.022410">doi:10.1103/physreve.103.022410</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33736090">pmid:33736090</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5ue3z7xf2zb53ntiut6l7ht3na">fatcat:5ue3z7xf2zb53ntiut6l7ht3na</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210716203304/https://discovery.ucl.ac.uk/id/eprint/10125184/1/PhysRevE.103.022410.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c7/f8/c7f89cf7e63c8e6b4eb6ef0230cca7c4c39a77fb.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1103/physreve.103.022410"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> aps.org </button> </a>

Giant Glial Cell: New Insight Through Mechanism-Based Modeling

D. E. Postnov, L. S. Ryazanova, N. A. Brazhe, A. R. Brazhe, G. V. Maximov, E. Mosekilde, O. V. Sosnovtseva
<span title="2008-05-20">2008</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5u2clxgkenbypdoqy37h23rjq4" style="color: black;">Journal of biological physics (Print)</a> </i> &nbsp;
The paper describes a detailed mechanism-based model of a tripartite synapse consisting of P-and R-neurons together with a giant glial cell in the ganglia of the medical leech (Hirudo medicinalis), which  ...  is a useful object for experimental studies in situ.  ...  Acknowledgements This work was partly supported by the European Union through the Network of Excellence BioSim (contract no. LSHB-CT-2004-005137). N. B. and A.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s10867-008-9070-7">doi:10.1007/s10867-008-9070-7</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19669488">pmid:19669488</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2585624/">pmcid:PMC2585624</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/b6fvqcwpxzfybareh4rtrtevky">fatcat:b6fvqcwpxzfybareh4rtrtevky</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200210191509/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2585624&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ab/e8/abe8412633a59ed7e94cc178f2c5de98a0266c1b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s10867-008-9070-7"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585624" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Stability Analysis of Regular and Chaotic Ca2+ Oscillations in Astrocytes

Min Ye, Hongkun Zuo
<span title="2020-09-23">2020</span> <i title="Hindawi Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3s4wom7forhp3klujcroiocrpi" style="color: black;">Discrete Dynamics in Nature and Society</a> </i> &nbsp;
In more details, we theoretically analyze the stability of the equilibrium points and illustrate the regular and chaotic spontaneous calcium firing activities in the astrocytes model, which are qualitatively  ...  The main purpose of this article was to investigate dynamical behaviors and bifurcation mechanisms associated with astrocytic Ca2+ oscillations, including stability of equilibrium and classification of  ...  In the last decades, based on biological background of calcium oscillation in the neuron and astrocyte, a wide variety of mathematical models are constructed to investigate in detail the stability and  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2020/9279315">doi:10.1155/2020/9279315</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/nhpexyu2zjavnontl3hl6tsfpm">fatcat:nhpexyu2zjavnontl3hl6tsfpm</a> </span>
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Computational modeling of opioid-induced synaptic plasticity in hippocampus

Mehdi Borjkhani, Fariba Bahrami, Mahyar Janahmadi, Michel Baudry
<span title="2018-03-07">2018</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3gm7274mfe6fcs7e3jterqlri" style="color: black;">PLoS ONE</a> </i> &nbsp;
Gliotransmitters activate mGlurs and contribute to slow calcium oscillations by IP3 production. Calcium enhancement results in glutamate release.  ...  Consequently, level of presynaptic calcium is elevated through two fast and slow mechanisms. Fast calcium oscillations are due to APs, and slow ones are because of IP3 production.  ...  Acknowledgments The authors would like to thank Hadi Borjkhani Ph.D. student at the University of Tehran for his assistance and comments that greatly improved the manuscript.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0193410">doi:10.1371/journal.pone.0193410</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29513763">pmid:29513763</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5841814/">pmcid:PMC5841814</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/baxoyxknjfezpecskloqyjbiyq">fatcat:baxoyxknjfezpecskloqyjbiyq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180723015623/http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0193410&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/50/f6/50f6d0090c7b6b4ef08a850c91a1f649420189a8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0193410"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841814" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Simulation of calcium signaling in fine astrocytic processes: Effect of spatial properties on spontaneous activity

Audrey DENIZOT, Misa ARIZONO, U. Valentin NÄGERL, Hédi SOULA, Hugues BERRY, Renaud Blaise Jolivet
<span title="2019-08-19">2019</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ch57atmlprauhhbqdf7x4ytejm" style="color: black;">PLoS Computational Biology</a> </i> &nbsp;
To our knowledge, this model is the first model suited to investigate calcium dynamics in fine astrocytic processes and to propose plausible mechanisms responsible for their variability.  ...  local variations of calcium indicators might contribute to the diversity of calcium signals observed in astrocytes.  ...  Acknowledgments We thank Erik De Schutter, Iain Hepburn, Weiliang Chen and Andrew Gallimore of the Computational Neuroscience Unit, OIST, Okinawa, Japan for discussion about 3d meshes and STEPS.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pcbi.1006795">doi:10.1371/journal.pcbi.1006795</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31425510">pmid:31425510</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6726244/">pmcid:PMC6726244</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/46xo6bwzmnbjbn3ukbefrjp4ie">fatcat:46xo6bwzmnbjbn3ukbefrjp4ie</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200319234320/https://hal.inria.fr/hal-02184344/document" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c9/fb/c9fbffbd19b25a781fab6094d51e939bcec2a7ba.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pcbi.1006795"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726244" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Dynamics of a minimal neural model consisting of an astrocyte, a neuron, and an interneuron

Angelo Di Garbo
<span title="2009-05-07">2009</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5u2clxgkenbypdoqy37h23rjq4" style="color: black;">Journal of biological physics (Print)</a> </i> &nbsp;
In this paper, a biophysical neural network model consisting of a pyramidal neuron, an interneuron, and the astrocyte is studied.  ...  The corresponding dynamical properties are mainly investigated by using numerical simulations.  ...  Results Dynamical properties of the new model describing calcium dynamics in the astrocyte Let us consider the model describing calcium dynamics in the astrocyte defined in Section 2.3.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s10867-009-9143-2">doi:10.1007/s10867-009-9143-2</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19669428">pmid:19669428</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2750740/">pmcid:PMC2750740</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xsts65ugk5ftbgeydhqdfbrg44">fatcat:xsts65ugk5ftbgeydhqdfbrg44</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200210125245/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2750740&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/29/61/29614d2d5fde62000896ee21377ad16e8264c388.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s10867-009-9143-2"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750740" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Inositol 1,4,5 Triphosphate (IP3) Receptors Activate Type 1 ryanodine Receptors to Mediate Ca2+ Sparks Signaling in Adult Mammalian Skeletal Muscle

Andoria Tjondrokoesoemo, Na Li, Noah Weisleder, Jianjie Ma
<span title="">2011</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dez2wau7t5aqvklzwrcsreuwq4" style="color: black;">Biophysical Journal</a> </i> &nbsp;
phosphorylation of RyR2s. 3045-Pos Board B150 Voltage-dependent anion channels (VDACs) are pore forming proteins predominantly found in the outer mitochondrial membrane and is thought to transport calcium  ...  In this study, we have investigated the possible role of type 2 VDAC (VDAC2) in cardiac Ca 2þ signaling and Ca 2þ sparks using a lentiviral knock-down (KD) technique and two-dimensional confocal Ca 2þ  ...  We have investigated the detailed regulation of neuronal firing threshold by the cytosolic calcium buffering capacity using a combination of mathematical modeling and patch clamp recording in acute slice  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.bpj.2010.12.3261">doi:10.1016/j.bpj.2010.12.3261</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bmlj4axv4jcqxkeso5ydrkadle">fatcat:bmlj4axv4jcqxkeso5ydrkadle</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190311101458/https://core.ac.uk/download/pdf/82767903.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3c/c5/3cc5cb67ba8748f038fa00e13c1d599904511de6.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.bpj.2010.12.3261"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>
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