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Management of rehabilitation for resumption of post-stroke taxi driving
脳卒中罹患後のタクシー運転再開と望ましいリハビリテーションについての検討

Hideki OOBA, Takuya INOUE, Masahito HIRANO, Itaru TAKEHARA, Shu WATANABE, Masahito HITOSUGI
2017 Journal of the Japanese Council of Traffic Science  
doi:10.24597/jcts.16.2_46 fatcat:5ipsd6s4qvc6zmqhdrwrm4dv64

Oral Health of Iranian Workers in Japan
在日イラン人出稼ぎ労働者の口腔健康調査

Toshihiro ANSAI, Shuji AWANO, Masahito KAWASAKI, Yoshihiro SHIMAZAKI, Inho SOH, Hideo MIYAZAKI, Tadamichi TAKEHARA
1992 JOURNAL OF DENTAL HEALTH  
The purpose of this study was to evaluate the oral health of Iranian workers in Japan and their general life conditions, 125 Iranian subjects aged 20-43 yr congregating in Yoyogi and Ueno Parks in Tokyo were examined. The mean decayed, missing, and filled teeth (DMFT=7.8) and filled teeth (FT=2.3) scores were lower than the Japanese national average. The mean decayed teeth (DT=3.4) and missing teeth (MT=2.2) scores were higher than the Japanese national average. Calculus was the predominant
more » ... odontal problem, and shallow pockets prevailed in persons aged 30-34 yr. 39.7 % of the subjects had complaints about their oral health, but only 16.8% desired dental treatment in Japan. Most of the subjects could not undergo dental treatment because of the high cost. Analysis of the results showed poor dental health in this survey group and emphasizes the necessity of improving the (dental) health service programs for foreigners.
doi:10.5834/jdh.42.632 fatcat:so37wmy6ejhyxmoj4mfu4zvvpe

Characteristics of Brain Injury Patients Supported in Resumption of Driving
自動車運転再開支援を行った脳損傷者の特徴と事故について

Itaru TAKEHARA, Masahito HITOSUGI, Shu WATANABE, Yasufumi HAYASHI, Kyozo YONEMOTO, Masahiro ABO
2014 The Japanese Journal of Rehabilitation Medicine  
Objective : We conducted a fact-finding survey for the consecutive past 3 years to establish whether inpatients with brain injury who had wished to resume driving after discharge from our hospital had in fact resumed driving after discharge. The survey included both driving status and information about collisions. Methods : Patients who had been evaluated for resumption of driving and were discharged more than 1 year ago were sent a fact-finding survey questionnaire aimed at establishing
more » ... they were currently driving. The patients who had resumed driving resumers were compared with those who had not resumed driving nonresumers . From the questionnaire results we investigated driving status and whether collisions had occurred. Results : We obtained effective responses from 40 of the 54 people 48 males, 6 females who were sent the questionnaire ; the collection rate was 74.1 . Of these, twenty-nine people had resumed driving, all were male. There were no significant differences between the resumers and non-resumers in higher brain function tests. In regard to driving ability, hemiparesis impairments were significantly milder in the resumers than in the non-resumers. Two respondents had hit posts or walls within the year. All these collisions occurred when parking. One respondent had a collision while driving along a road. Conclusion : We hope to provide patients with useful and appropriate information on resuming driving so that we can support them in a safe return to the driving environment. Jpn J Rehabil Med .
doi:10.2490/jjrmc.51.138 fatcat:duk6sjzxcne57owxe3lwukc4nu

Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology

Satoshi Abe, Kaoru Kobayashi, Asami Oji, Tetsushi Sakuma, Kanako Kazuki, Shoko Takehara, Kazuomi Nakamura, Azusa Okada, Yasuko Tsukazaki, Naoto Senda, Kazuhisa Honma, Takashi Yamamoto (+4 others)
2017 Scientific Reports  
Cytochrome P450, family 3, subfamily A (CYP3A) enzymes metabolize approximately 50% of commercially available drugs. Recently, we developed fully humanized transchromosomic (Tc) CYP3A mice with the CYP3A cluster including CYP3A4, CYP3A5, CYP3A7, and CYP3A43. Our humanized CYP3A mice have the CYP3A5*3 (g.6986G) allele, resulting in the almost absence of CYP3A5 protein expression in the liver and intestine. To produce model mice for predicting CYP3A5′s contribution to pharmacokinetics, we
more » ... d a single-nucleotide polymorphism (SNP) modification of CYP3A5 (g.6986G to A, *3 to *1) on the CYP3A cluster using genome editing in both mouse ES cells and fertilized eggs, and produced humanized CYP3A5*1 mice recapitulating the CYP3A5*1 carrier phenotype in humans. The humanized CYP3A mouse with CYP3A5*1 is the first Tc mouse for predicting the SNP effect on pharmacokinetics in humans. The combination of Tc technology and genome editing enables the production of useful humanized models that reflect humans with different SNPs. Cytochrome P450, family 3, subfamily A (CYP3A) is a group of drug-metabolizing enzymes that metabolize approximately 50% of commercially available drugs. Therefore, in the field of drug development, the contribution of CYP3A in pharmacokinetics of new chemical entities has to be evaluated. In conventionally used experimental animals, such as mice and rats, the conditions do not completely reflect the human pharmacokinetics of drugs metabolized by CYP3A. It is well known that substantial species differences exist in CYP3A enzymes 1 . Therefore, we developed a humanized transchromosomic (Tc) CYP3A mouse models based on human artificial chromosome (HAC) and mouse artificial chromosome (MAC) vectors using chromosome engineering technology. CYP3A genes are clustered together on human chromosome 7 and include CYP3A4, CYP3A5, CYP3A7, and CYP3A43. We cloned 700 kilobases, including the CYP3A cluster on human chromosome 7, into the HAC vector (CYP3A-HAC) and transferred the CYP3A-HAC into mouse embryonic stem (ES) cells via microcell-mediated chromosome transfer (MMCT). We produced humanized mice carrying the CYP3A-HAC with a mouse-Cyp3a-knockout (KO) background. Our models recapitulated the gender-, tissue-, and developmental-stage-specific CYP3A expression and the CYP3A-related drug metabolism in humans [2] [3] [4] . Recently, we generated novel fully humanized CYP3A (CYP3A-MAC) mice with almost same characteristics
doi:10.1038/s41598-017-15033-0 pmid:29123154 pmcid:PMC5680201 fatcat:a7bknaaexjeltfgoocqjdgyolq

Examination of the usefulness of predictive training during driving in stroke
脳損傷者に対する「実写版危険予知トレーニング」の有用性についての検討

Shihomi WATANABE, Mine YAMAZAKI, Naoki SAKA, Hiroki HIROSAWA, Itaru TAKEHARA, Masahito HITOSUGI
2021 Journal of the Japanese Council of Traffic Science  
Safe driving requires the ability to correctly recognize dangerous situations encountered while driving and to react appropriately to them. We conducted hazard prediction training in a group of individuals with brain injuries to determine whether this could be a method to assess and support safe driving ability in those suffering from brain injuries. The subjects were 20 brain-injured patients (19 males and 1 female, mean age 49.7 ± 9.6 years) and 23 healthy individuals (13 males and 10
more » ... mean age 48.1 ± 16.6 years) admitted to or visiting our hospital
doi:10.24597/jcts.20.2_30 fatcat:lquzplvdlrf4dmdmyujplfvkwa

Evidence-based clinical practice guidelines for Liver Cirrhosis 2020

Hitoshi Yoshiji, Sumiko Nagoshi, Takemi Akahane, Yoshinari Asaoka, Yoshiyuki Ueno, Koji Ogawa, Takumi Kawaguchi, Masayuki Kurosaki, Isao Sakaida, Masahito Shimizu, Makiko Taniai, Shuji Terai (+9 others)
2021 Journal of gastroenterology  
Creation Committee Evaluation Committee Chair: Tetsuo Takehara (Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine).  ...  The Japanese Society of Gastroenterology The Japan Society of Hepatology President: Tetsuo Takehara (Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine).  ... 
doi:10.1007/s00535-021-01788-x pmid:34231046 pmcid:PMC8280040 fatcat:ayfalxu53fexjf5x52rl2niqtm

CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy

Hirokazu Kimura, Hideki Yamamoto, Takeshi Harada, Katsumi Fumoto, Yoshihito Osugi, Ryota Sada, Natsumi Maehara, Hayato Hikita, Soichiro Mori, Hidetoshi Eguchi, Masahito Ikawa, Tetsuo Takehara (+1 others)
2019 Clinical Cancer Research  
Takehara Study supervision: H. Kimura, A.  ... 
doi:10.1158/1078-0432.ccr-18-2124 pmid:30610103 fatcat:32lf2bik3vfbflcojc6mlesrjy

A Reference Value of Higher Brain Function for Resumption of Driving in Patients with Brain Injury
脳損傷者の自動車運転再開に必要な高次脳機能評価値の検討

Itaru Takehara, Masahito Hitosugi, Shu Watanabe, Yasufumi Hayashi, Kyozo Yonemoto, Masahiro Abo
2016 The Japanese Journal of Rehabilitation Medicine  
Objective:An actual-condition survey was conducted to verify the validity of reference values of higher brain function necessary for patients with brain injury to resume automobile driving. Subjects:Of the 74 patients admitted to the Tokyo Metropolitan Rehabilitation Hospital between November 1, 2008 and November 30, 2012, who underwent evaluation using the hospital's automobile driving resumption system at the time of discharge, 71 patients with brain injury who were judged capable of resuming
more » ... driving were included in this study. Methods:Questionnaires were sent at least 1 year after discharge, to determine whether the subjects had actually resumed automobile driving. Subjects were classified by admission date into two groups:1)A provisional reference group that included patients admitted between November 2008 and November 2011 who had resumed driving;and 2) verification group that included patients who had been admitted between December 2011 and November 2012 and had resumed driving. The relationship between results on the higher brain function test for the verification group and provisional reference values was investigated. Results:The provisional reference value group included 29 patients, and the verification group included 13 patients. In the verification group, the results of 9 patients with brain injury on the higher brain function test were within provisional reference values. Conclusion:The results of the paper-based test are a reliable predictor of whether a patient is capable of resuming driving, but do not represent an absolute standard. Therefore, the safety of resuming driving should be 脳損傷者の自動車運転再開に必要な 高次脳機能評価値の検討
doi:10.2490/jjrmc.53.247 fatcat:hlcxd3w5fje7dgywo5dw5d2onq

A nationwide survey on non-B, non-C hepatocellular carcinoma in Japan: 2011–2015 update

Ryosuke Tateishi, Koji Uchino, Naoto Fujiwara, Tetsuo Takehara, Takeshi Okanoue, Masataka Seike, Hitoshi Yoshiji, Hiroshi Yatsuhashi, Masahito Shimizu, Takuji Torimura, Mitsuhiko Moriyama, Isao Sakaida (+10 others)
2018 Journal of gastroenterology  
We previously reported that the incidence of hepatocellular carcinoma (HCC) with non-viral etiologies increased rapidly between 1991 and 2010 in Japan. Methods To update this investigation, we enrolled patients who were initially diagnosed as having non-B, non-C HCC at participating hospitals between 2011 and 2015. In addition to the patient characteristics investigated in the previous report, we also investigated the duration of alcohol consumption. The overall survival rate was analyzed using
more » ... the Kaplan-Meier method, and the hazard function against the body mass index (BMI) was plotted using cubic splines. Results A total of 2087 patients were enrolled. The proportion of patients with non-viral etiologies has continued to increase from 10.0% in 1991 to 32.5% in 2015. Patients were also older (median ages, 70-73 years) and more obese (median BMIs, 23.9-24.2 kg/m 2 ), and the proportions of patients with diabetes mellitus (46.1% to 51.6%), hypertension (42.7% to 58.6%), dyslipidemia (14.6% to 22.9%), and fatty liver (24.0% to 28.8%) had all increased Electronic supplementary material The online version of this article (https://doi.
doi:10.1007/s00535-018-1532-5 pmid:30498904 fatcat:fjorthi7cvekzgq7ipqwk4crzm

運転者の体調変化による事故に関する効果的予防対策の提言
Proposal of comprehensive preventive measures for the vehicle collisions due to drivers' health problems

Masahito HITOSUGI, Nobuo ARAKI, Mihoko MATSUMURA, Tetsuya SAKAMOTO, Mineko BABA, Itaru TAKEHARA, Shu WATANABE, Yousuke SANBAYASHI, Shoichi WASHINO, Hiroaki MATSUOKA, Takao OKUBO
2016 Journal of the Japanese Council of Traffic Science  
(5) Itaru TAKEHARA (6) Shu WATANABE (7) Yousuke SANBAYASHI (8) Shoichi WASHINO (9) Hiroaki MATSUOKA (10) Takao OKUBO (11) ( 場 美 年 子, 一 杉 正 仁, 相 磯 貞 和: 睡 眠 時 無 呼 吸 症 候 群  ...  Proposal of comprehensive preventive measures for the vehicle collisions due to drivers' health problems Masahito HITOSUGI (1) Nobuo ARAKI (2) Mihoko MATSUMURA (3) Tetsuya SAKAMOTO (4) Mineko BABA  ... 
doi:10.24597/jcts.15.3_58 fatcat:cb5cko2lujappmp4x5hkqyyumi

論文誌目次

2021 Transactions of Japan Society of Kansei Engineering  
TAKEHARA, Narihisa MATSUMOTO, and Ryohei P.  ...  ························· 141 Analysis of Annual Changes and Trends in Contents of Consultations at a Cancer Counseling and Support Center Miwa MITOMA, Masumi AZUMA, Kyoko ISHIGAKI, Miyuki FUKUSHIMA, Masahito  ... 
doi:10.5057/kansei.19.2_95 fatcat:eqkypxrlqfcllo75szb74skvru

Role of the Frontal Cortex throughout the Learning
新規学習における前頭葉の役割

Shu Watanabe, Hironobu Kuruma, Tadamitsu Matsuda, Yoshiyuki Murakami, Rui Watanabe, Atsushi Senoo, Kyouzou Yonemoto, Nori Hiratsuka, Itaru Takehara, Yasuo Hayashi, Masahito Hitosugi, Kanji Akahori (+2 others)
Rigaku ryohogaku  
Tokyo Metrope] i †all IlniverslLy GrとLd し Late Schooi ot Hea1Lh Scicpces 2〕 東京都 リ ハ ビ リ テ ー シ ョ ン 病 院 Itnru Takehara , MD , Yasuo Ilayashi .  ... 
doi:10.15063/rigaku.kj00005931414 fatcat:2joxsanvhjemflegqcrmlcbgwa

AUTHOR INDEX

2014 Circulation Journal  
Takata, Kohei 2955 Takatoh, Mikio 1144 Takatsu, Yoshiki 2719 Takaya, Tomofumi 1882 Takaya, Yoichi 71, 377 Takayama, Morimasa 708, 929, 1684, 2926 Takayama, Narimasa 2284 Takeda, Yasuharu 322 Takehara  ...  Takiguchi, Mai 890 Takiuchi, Shin 2565 Tamaki, Hideaki 1950 Tamaki, Shunsuke 322 Tamaki, Toshiaki 1176 Tamakoshi, Akiko 649 Tamakoshi, Koji 1379 Tamaru, Hiroto 1451 Tamura, Kentaro 2876 Tamura, Masahito  ... 
doi:10.1253/circj.cj-78-12-index_2 fatcat:iwwh7ocrbbhnhjayys4l473rii

AUTHOR INDEX

2013 Circulation Journal  
Narimasa 1474 Takayama, Tadateru 1180 Takayama, Toshio 1996 Takechi, Shigeru 926 Takeda, Morihiko 447 Takeda, Shinhiro 1920 Takeda, Yasuharu 359, 886 Takeda, Yukiji 2766 Takeda, Yutaka 2619 Takehara  ...  Ogasawara, Kozue 786 Ogasawara, Kuniaki 1315 Ogata, Kazunori 490 Ogata, Yasuhiro 1267 Ogawa, Akira 1315 Ogawa, Hisao 934, 1267, 1337, 2341, 2479, 2807, 2841, 2844, 3023 Ogawa, Junko 749 Ogawa, Masahito  ... 
doi:10.1253/circj.cj-77-12-index_2 fatcat:5j2ywraopnfjbc2uh2xedkfb3y

Higher Brain Dysfunction and Driving
脳障害者の自動車運転

2013 The Japanese Journal of Rehabilitation Medicine  
Philos Trans R Soc Lond B Biol Sci 1996 ; : 1405.1411 11 , , , , : . 2001 ; : 465.470 Resumption of Driving after Stroke Itaru TAKEHARA, Yasufumi HAYASHI, Masahito HITOSUGI, Shu WATANABE,  ...  J Stroke Cerebrovasc Dis 2012 ; Hitosugi M, Takehara I, Watanabe S, Hayashi Y, Tokudome S. Support for stroke patients in resumption of driving : patient survey and driving simulator trial.  ... 
doi:10.2490/jjrmc.50.87 fatcat:nj2avohcwzcdjoaynr3f6zxjwy
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