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Applications of multi-nuclear magnetic resonance spectroscopy at 7T

Mary C Stephenson
2011 World Journal of Radiology  
Applications of multi-nuclear MRS at 7T Stephenson MC et al . Applications of multi-nuclear MRS at 7T  ...  Stephenson MC et al . Applications of multi-nuclear MRS at 7T tion, the Cramer-Rao lower bounds (CRLB), from LC-Model analysis are shown in Table 1 .  ... 
doi:10.4329/wjr.v3.i4.105 pmid:21532871 pmcid:PMC3084434 fatcat:yked3mbkdrafzco7j3uuetfv7i

Higher risk of hospitalization among females with cystic fibrosis

Anne Stephenson, Janet Hux, Elizabeth Tullis, Peter C. Austin, Mary Corey, Joel Ray
2011 Journal of Cystic Fibrosis  
Stephenson had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.  ...  Stephenson has no conflicts of interest to disclose. Dr. Hux has no conflicts of interest to disclose. Dr. Tullis has no conflicts of interest to disclose. Dr.  ... 
doi:10.1016/j.jcf.2010.10.005 pmid:21131240 fatcat:5yafepknnvbfxjfvd6gly2w4wm

Increased GABA Contributes to Enhanced Control over Motor Excitability in Tourette Syndrome

Amelia Draper, Mary C. Stephenson, Georgina M. Jackson, Sophia Pépés, Paul S. Morgan, Peter G. Morris, Stephen R. Jackson
2014 Current Biology  
(C) Scatterplot showing the negative association (r = 20.63, p < 0.01) between individual GABA/ NAA ratios in the SMA voxel and fMRI BOLD signal change values within that same voxel.  ...  (C) Scatterplot showing the significant positive association (r = 0.75, p < 0.05) between individual FA values within corpus callosum ROI and GABA concentration values within the SMA voxel.  ... 
doi:10.1016/j.cub.2014.08.038 pmid:25264251 pmcid:PMC4188813 fatcat:4icnc64ezja4xj5zmx7moceemy

Protein kinases A and C regulate receptor-mediated increases in cAMP in rabbit erythrocytes

Shaquria P. Adderley, Meera Sridharan, Elizabeth A. Bowles, Alan H. Stephenson, Mary L. Ellsworth, Randy S. Sprague
2010 American Journal of Physiology. Heart and Circulatory Physiology  
Adderley SP, Sridharan M, Bowles EA, Stephenson AH, Ellsworth ML, Sprague RS. Protein kinases A and C regulate receptormediated increases in cAMP in rabbit erythrocytes.  ...  In contrast, in the presence of the PDE3 inhibitor, cilostazol (10 M), pretreatment of erythrocytes with either H89 (1 M) or two chemically dissimilar inhibitors of PKC, calphostin C (1 M) or GFX109203X  ...  The erythrocyte-ethanol mixture was centrifuged at 14,000 g for 10 min at 4°C, to remove precipitated proteins. The supernatant was removed and stored overnight at Ϫ20°C.  ... 
doi:10.1152/ajpheart.00975.2009 pmid:20008267 pmcid:PMC2822589 fatcat:zjvaa3bptfdlnfglxdlfjpc734

Synergistic effects of C-peptide and insulin on low O2-induced ATP release from human erythrocytes

Jennifer P. Richards, Alan H. Stephenson, Mary L. Ellsworth, Randy S. Sprague
2013 American Journal of Physiology. Regulatory Integrative and Comparative Physiology  
However, in vivo, insulin is coreleased with connecting peptide (C-peptide) at equimolar concentrations, but because of the shorter insulin half-life, the peptides circulate at ratios of C-peptide to insulin  ...  Here, we investigate the hypothesis that C-peptide and insulin work synergistically to maintain low O 2-induced ATP release from human erythrocytes.  ...  Effect of C-peptide on low O2-induced ATP release from erythrocytes.  ... 
doi:10.1152/ajpregu.00341.2013 pmid:24089376 pmcid:PMC3882563 fatcat:iwxekjdwtjcvjikob3pbrhq7ry

Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition

Carine Z. J. Lim, Yan Zhang, Yu Chen, Haitao Zhao, Mary C. Stephenson, Nicholas R. Y. Ho, Yuan Chen, Jaehoon Chung, Anthonin Reilhac, Tze Ping Loh, Christopher L. H. Chen, Huilin Shao
2019 Nature Communications  
The photoresist was spin-coated onto a Si wafer at 2000 rpm for 30 s, and baked at 65°C and 95°C for 2 min and 5 min, respectively.  ...  The source data underlying Fig. 2a , b, d, e; 3e and 4b and Supplementary Figs 6a, 8b, 12b, c, 13a, c and 14a , b are provided as a Source Data file.  ... 
doi:10.1038/s41467-019-09030-2 pmid:30850633 pmcid:PMC6408581 fatcat:b3gclo77anabfdkfqswl5mbala

Quantitative 18F-fluorocholine positron emission tomography for prostate cancer: correlation between kinetic parameters and Gleason scoring

Joshua D. Schaefferkoetter, Ziting Wang, Mary C. Stephenson, Sharmili Roy, Maurizio Conti, Lars Eriksson, David W. Townsend, Thomas Thamboo, Edmund Chiong
2017 EJNMMI Research  
Improvements in tumor uptake have been reported for other tracers including 11 C-and 18 F-choline [3, [5] [6] [7] , 11 C-acetate [8] [9] [10] , 11 Cmethionine [11, 12] , and 18 F-fluorodihydrotestosterone  ...  applications, since scan time should be kept to a minimum for patient convenience and scanner throughput considerations and also to avoid bladder filling issues (which is not a consideration for the 11 C-labeled  ... 
doi:10.1186/s13550-017-0269-0 pmid:28324340 pmcid:PMC5360745 fatcat:ijuihcoxinhlvosewo3wzs3e3u

Comparison of Metrics for the Evaluation of Medical Segmentations using Prostate MRI Dataset

Ying-Hwey Nai, Bernice W. Teo, Nadya L. Tan, Sophie O'Doherty, Mary C. Stephenson, Yee Liang Thian, Edmund Chiong, Anthonin Reilhac
2021 Computers in Biology and Medicine  
Mary C. Stephenson: Writing -Review & Editing, Funding acquisition. Yee Liang Thian: Validation, Writing -Review & Editing, Funding acquisition.  ...  (b) > (c) and (d).  ... 
doi:10.1016/j.compbiomed.2021.104497 pmid:34022486 fatcat:hmqcmzh7hvg3pm4tlz7xold2ee

tDCS-induced alterations in GABA concentration within primary motor cortex predict motor learning and motor memory: A 7T magnetic resonance spectroscopy study

Soyoung Kim, Mary C. Stephenson, Peter G. Morris, Stephen R. Jackson
2014 NeuroImage  
The whiskers indicate the range of the data within 1.5 times of the box width. b & c.  ...  Note that, whereas force trials decrease in error with practice, errors during catch trials increase. c.  ... 
doi:10.1016/j.neuroimage.2014.05.070 pmid:24904994 pmcid:PMC4121086 fatcat:aftamdtu6vc6xmjspgbvj6j2jq

Timing of seasonal migration in mule deer: effects of climate, plant phenology, and life-history characteristics

Kevin L. Monteith, Vernon C. Bleich, Thomas R. Stephenson, Becky M. Pierce, Mary M. Conner, Robert W. Klaver, R. Terry Bowyer
2011 Ecosphere  
Landells Aviation was largely responsible for the helicopter capture and survey work, especially, S. deJesus, and C. Pickrell, who worked closely with CDFG capture specialists R. Teagle and T.  ...  For each model, we calculated Akaike's information criterion adjusted for small sample size (Akaike 1973; AIC c ), DAIC c , and Akaike weight (w i ; Burnham and Anderson 2002) .  ...  deer captures in March, we used an ultrasound with a 3-MHz linear transducer to determine pregnancy and fetal rates (number of fetuses per female) of females during the second one-third of gestation (Stephenson  ... 
doi:10.1890/es10-00096.1 fatcat:6z3asda6mnbmjfd5y6iu2eh2h4

Diagnostic Accuracy of Virtual Pathology vs Traditional Microscopy in a Large Dermatopathology Study

Michael N. Kent, Thomas G. Olsen, Theresa A. Feeser, Katherine C. Tesno, John C. Moad, Michael P. Conroy, Mary Jo Kendrick, Sean R. Stephenson, Michael R. Murchland, Ayesha U. Khan, Elizabeth A. Peacock, Alexa Brumfiel (+1 others)
2017 JAMA dermatology  
IMPORTANCE Digital pathology represents a transformative technology that impacts dermatologists and dermatopathologists from residency to academic and private practice. Two concerns are accuracy of interpretation from whole-slide images (WSI) and effect on workflow. Studies of considerably large series involving single-organ systems are lacking. OBJECTIVE To evaluate whether diagnosis from WSI on a digital microscope is inferior to diagnosis of glass slides from traditional microscopy (TM) in a
more » ... large cohort of dermatopathology cases with attention on image resolution, specifically eosinophils in inflammatory cases and mitotic figures in melanomas, and to measure the workflow efficiency of WSI compared with TM. DESIGN, SETTING, AND PARTICIPANTS Three dermatopathologists established interobserver ground truth consensus (GTC) diagnosis for 499 previously diagnosed cases proportionally representing the spectrum of diagnoses seen in the laboratory. Cases were distributed to 3 different dermatopathologists who diagnosed by WSI and TM with a minimum 30-day washout between methodologies. Intraobserver WSI/TM diagnoses were compared, followed by interobserver comparison with GTC. Concordance, major discrepancies, and minor discrepancies were calculated and analyzed by paired noninferiority testing. We also measured pathologists' read rates to evaluate workflow efficiency between WSI and TM. This retrospective study was caried out in an independent, national, university-affiliated dermatopathology laboratory. MAIN OUTCOMES AND MEASURES Intraobserver concordance of diagnoses between WSI and TM methods and interobserver variance from GTC, following College of American Pathology guidelines. RESULTS Mean intraobserver concordance between WSI and TM was 94%. Mean interobserver concordance was 94% for WSI and GTC and 94% for TM and GTC. Mean interobserver concordance between WSI, TM, and GTC was 91%. Diagnoses from WSI were noninferior to those from TM. Whole-slide image read rates were commensurate with WSI experience, achieving parity with TM by the most experienced user. CONCLUSIONS AND RELEVANCE Diagnosis from WSI was found equivalent to diagnosis from glass slides using TM in this statistically powerful study of 499 dermatopathology cases. This study supports the viability of WSI for primary diagnosis in the clinical setting.
doi:10.1001/jamadermatol.2017.3284 pmid:29049424 pmcid:PMC5817435 fatcat:2phhlh7pujeqtar4mmpumjqp5u

A neurochemical hypothesis for the origin of hominids

Mary Ann Raghanti, Melissa K. Edler, Alexa R. Stephenson, Emily L. Munger, Bob Jacobs, Patrick R. Hof, Chet C. Sherwood, Ralph L. Holloway, C. Owen Lovejoy
2018 Proceedings of the National Academy of Sciences of the United States of America  
C, caudate nucleus; cc, corpus callosum; ic, internal capsule; P, putamen; vS, ventral striatum.  ...  Fig. 2 . 2 The neurochemical profile of each species within the caudate nucleus [dorsal caudate nucleus (A) and medial caudate nucleus (B)] and putamen (C) of 9 | www.pnas.org/cgi/doi/10.1073/pnas  ... 
doi:10.1073/pnas.1719666115 pmid:29358369 pmcid:PMC5819450 fatcat:nrhjpgwpxjdxrg5lkg6efomhiy

Intimate Partner Violence is Associated with Increased CD4+ T-Cell Activation Among HIV-Negative High-Risk Women

Ameeta Shivdas Kalokhe, Chris C. Ibegbu, Surinder P. Kaur, Rama R. Amara, Mary E. Kelley, Carlos Del Rio, Rob Stephenson
2016 Pathogens and Immunity  
Four women were excluded for not meeting HIV risk criteria, 2 for being HIV-infected, 2 for being hepatitis C infected, and 2 because we were unable to obtain an adequate blood sample.  ...  (C) Representative flow diagrams depicting frequencies of regulatory (CD4 + FoxP3 + CD25 + ) T-cell phenotypes using CD45RA and HLA-DR markers in the PBMC of two donors with low versus high reporting of  ... 
doi:10.20411/pai.v1i1.120 pmid:27668294 pmcid:PMC5034930 fatcat:frmykpncyzgl7dx5cfivvqiese

Risk-sensitive allocation in seasonal dynamics of fat and protein reserves in a long-lived mammal

Kevin L. Monteith, Thomas R. Stephenson, Vernon C. Bleich, Mary M. Conner, Becky M. Pierce, R. Terry Bowyer, Ian Montgomery
2013 Journal of Animal Ecology  
Mohr and C.  ...  For each model, we calculated AIC c , DAIC c and Akaike weight (w i ; Burnham & Anderson 2002 ).  ...  We determined pregnancy and number of foetuses by ultrasonography with transabdominal scanning using a 3-MHz transducer (Stephenson et al. 1995) .  ... 
doi:10.1111/1365-2656.12016 pmid:23379674 fatcat:ifoqftxlhzab7ktp4ce4hdmsmm

Investigating the Metabolic Changes due to Visual Stimulation using Functional Proton Magnetic Resonance Spectroscopy at 7 T

Yan Lin, Mary C Stephenson, Lijing Xin, Antonio Napolitano, Peter G Morris
2012 Journal of Cerebral Blood Flow and Metabolism  
[2]Christine C et al. Eur Radiol. 15:47-52(2005) . [3] Lin AL, et al. Neuroimage. 44:16-22 (2009 ). [4]Mangia, S et al. JCBFM, 27,1055 -1063 (2007 .  ...  (D) as (C), but the spectrum acquired during stimulation was linebroadened by 0.5Hz to match the linewidth of the spectrum acquired at rest, in order to eliminate the linewidth changes.  ... 
doi:10.1038/jcbfm.2012.33 pmid:22434070 pmcid:PMC3421086 fatcat:w6iwq4wukbhirj2b2zswjnvb24
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