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Herpes Simplex Virus Type 1 at the Central Nervous System [chapter]

Carola Otth, Francisca Acuña-Hinrichsen, Luis Leyton, Carolina Martin, Margarita I. Concha
<span title="2016-09-07">2016</span> <i title="InTech"> Herpesviridae </i> &nbsp;
Herpes simplex virus type 1 (HSV-1) is a ubiquitous and neurotropic pathogen and is the most common cause of acute sporadic encephalitis in humans. This virus is characterized by establishing a persistent latent infection in neurons of its hosts for life. The pathogenic mechanisms of HSV-1 at the central nervous system (CNS) are not completely elucidated. Besides, evidences suggest that HSV-1 establish latency in the CNS in humans and that this condition would not be harmless, especially in
more &raquo; ... le whose immune system is declined. This trait has been strongly suggested as a risk factor for the development of neurodegenerative pathologies such as Alzheimer's disease. Currently, it is unclear whether a neuron, which undergoes viral reactivation and produces infectious particles, survives and resumes latency, loses functionality, or is killed. These data highlight the need for more studies at cellular and molecular levels to understand the strategies used by the virus and the host cells during both productive and latent infection. The present chapter discusses the current investigations about HSV-1 infection at the CNS and the potential risk of neuronal dysfunction and chronic neurological diseases.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5772/64130">doi:10.5772/64130</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/rklgtyyrorhcdhasaicywygsne">fatcat:rklgtyyrorhcdhasaicywygsne</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190503103837/https://cdn.intechopen.com/pdfs/51604.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7c/01/7c01996b96ef225043ae5e3347fdc2f7551cca41.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5772/64130"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

The Effect of Resveratrol on Cell Viability in the Burkitt's Lymphoma Cell Line Ramos

Paola Jara, Johana Spies, Constanza Cárcamo, Yennyfer Arancibia, Gabriela Vargas, Carolina Martin, Mónica Salas, Carola Otth, Angara Zambrano
<span title="2017-12-21">2017</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dstyyzbt45gknhqqjsh45p55h4" style="color: black;">Molecules</a> </i> &nbsp;
Resveratrol is a polyphenolic natural compound produced by a variety of crops. Currently, resveratrol is considered a multi-target anti-cancer agent with pleiotropic activity, including the ability to prevent the proliferation of malignant cells by inhibiting angiogenesis and curtailing invasive and metastatic factors in many cancer models. However, the molecular mechanisms mediating resveratrol-specific effects on lymphoma cells remain unknown. To begin tackling this question, we treated the
more &raquo; ... rkitt's lymphoma cell line Ramos with resveratrol and assessed cell survival and gene expression. Our results suggest that resveratrol shows a significant anti-proliferative and pro-apoptotic activity on Ramos cells, inducing the DNA damage response, DNA repairing, and modulating the expression of several genes that regulate the apoptotic process and their proliferative activity. Molecules 2018, 23, 0014 2 of 12 abundant data regarding the chemopreventive role of RSV in many cancers, relatively little information exists on the antiproliferative activity of RSV in human lymphoma cells [16] [17] [18] . Although RSV is a promising multi-target anticancer agent with pleiotropic activities, its specific mechanisms of action remain unclear [19] . In general, RSV targets a great number of intracellular molecules implicated in apoptosis induction. For example, RSV induces cell death by altering proteins of the Bcl-2 family. Specifically, it is able to upregulate the expression of pro-apoptotic proteins such as Bak, Bax, NOXA and PUMA, while lowering the expression of anti-apoptotic members such as Bcl-2, . Moreover, RSV increases cellular apoptosis by modulating the extrinsic pathway that relies on binding of ligands such as FASL or TRAIL [6, 23, 24] , whereas it also activates the intrinsic apoptotic pathway by inducing the mitochondrial release of cytochrome C, the generation of ROS, and the modulation of the p53 pathway [20, [25] [26] [27] . Interestingly, RSV binds and activates the serine protein kinase ataxia telangiectasia mutated (ATM), inducing autophosphorylation and substrate phosphorylation [28] . ATM activates signaling checkpoints upon genotoxic stress, especially DNA double strand breaks. Indeed, the loss of ATM activity has been observed in various tumor types. RSV is able to induce extensive DNA damage and more specifically DNA double strand breaks in human colon carcinoma cells [29, 30] . Also, RSV works on blocking topoisomerase (TOPO) activity. Indeed, RSV induced a delay in S-phase progression with the concomitant phosphorylation of the histone H2AX (H2A histone family, member X) [29, 31] . Specifically, in B-cell lymphocytes, DNA double-strand breaks (DSBs) are generated in all developing lymphocytes, a process that is essential for normal lymphocyte development [32] . DSB activates an ATM-dependent signaling pathway that leads to phosphorylation and inactivation of the transcriptional coactivator CRTC2 [33] . CRTC2, in turn, regulates many target genes, some of which are involved in processes that modulate GC B-cell proliferation, self-renewal and also inhibit plasma cell differentiation [34] . In the case of lymphomas, Jazirehi et al., reported that RSV downregulates two anti-apoptotic proteins, Bcl-XL and Mcl-1, whereas it upregulates the pro-apoptotic proteins Bax and Apaf-1 in the Burkitt's lymphoma cell line Ramos [35] . RSV also promotes cell growth inhibition in NALM-6 cells [36] and blunts PI-3K signaling and glucose metabolism in germinal center-like LY1 and LY18 human diffuse large B-cell lymphomas (DLBCLs) [17] . However, the molecular mechanisms of action of RSV in lymphoma cells remain largely unknown. In this study, we analyzed the effect of RSV on cell viability in the Burkitt's lymphoma cell line Ramos. We demonstrate that RSV has anti-proliferative and pro-apoptotic effects on these cells. We show that RSV induces the DNA damage response; activation of DNA repair; and modulates the expression of genes with key roles regulating the apoptotic process and the proliferative activity in this model cell line. Results RSV Induces Decrease in Cell Viability in Ramos Cells Even though many beneficial properties of RSV have been reported, including anti-proliferative and pro-apoptotic activity in different human cancer cell lines, its effects in human lymphoma cells are poorly described. To determine whether RSV has an antiproliferative effect on Ramos cells, we incubated this cell line with different concentrations of RSV for 24 h and 48 h, and determined viability using the MTT assay. Cell viability decreased in a concentration-dependent manner in response to RSV, by 25% with 50 µM RSV up to 60% using 150 µM RSV at 24 h, and by 30% with 20 µM RSV up to 60% using 150 µM RSV at 48 h ( Figure 1A ). Similar results were obtained independently using the Trypan Blue exclusion assay to determine cell survival, showing a maximum antiproliferative activity with 150 µM RSV at 24 h and 48 h of treatment ( Figure 1B) . These data demonstrate that RSV effectively reduces Molecules 2018, 23, 0014 3 of 12 cell proliferation and viability in Ramos cells. For subsequent experiments we chose concentrations between 50 µM and 100 µM, which decrease cell viability by 50% after 24 h of treatment. Molecules 2017, 22, 2247 3 of 12 concentrations between 50 µM and 100 µM, which decrease cell viability by 50% after 24 h of treatment.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/molecules23010014">doi:10.3390/molecules23010014</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29267250">pmid:29267250</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/qfa3up5yrbet5fzresh63zvkcq">fatcat:qfa3up5yrbet5fzresh63zvkcq</a> </span>
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Herpes Simplex Virus type 1 neuronal infection triggers disassembly of key structural components of dendritic spines [article]

Francisca Acuna-Hinrichsen, Adriana Covarrubias-Pinto, Yuta Ishizuka, Maria Francisca Stolzenbach, Carolina Martin, Paula Salazar, Maite A. Castro, Clive Bramham, Carola Otth
<span title="2020-05-31">2020</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Herpes simplex virus type 1 (HSV-1) is a widespread neurotropic virus. The primary infection in facial epithelium leads to retrograde axonal transport to the central nervous system (CNS) where it establishes latency. Under stressful conditions, the virus reactivates, and new progeny is transported anterogradely to the primary site of infection. In late stages of neuronal infection, axonal damage is known to occur. However, the impact of HSV-1 infection on morphology and functional integrity at
more &raquo; ... arlier stages of infection in neuronal dendrites is unknown. Previously, we demonstrated that acute HSV-1 infection in neuronal cell lines selectively enhances the expression of Arc protein - a major regulator of long-term synaptic plasticity and memory consolidation, known for being a protein-interaction hub in the postsynaptic dendritic compartment. Thus, HSV-1 induced Arc may alter the functionality of the infected neurons having an impact on dendritic spine dynamics. In this study we demonstrated that HSV-1 infection causes structural disassembly and functional deregulation in cultured cortical neurons, through protein homeostasis alteration with intracellular accumulation of Arc, and decreased expression of spine scaffolding-like proteins such as PSD-95, Drebrin and CaMKIIβ. Our findings reveal progressive deleterious effects of HSV-1 infection on excitatory neuronal synapse function and dendritic morphology, supporting the thesis of the infectious origin of neurodegenerative processes. Key words: HSV-1, neurotropic virus, Arc, PSD-95, Drebrin, CaMKIIβ, dendritic spines, neuronal infection, neurodegeneration.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.05.30.124958">doi:10.1101/2020.05.30.124958</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bk4fcrhtazcezayjllushrzwxu">fatcat:bk4fcrhtazcezayjllushrzwxu</a> </span>
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Herpes simplex virus tipo 1 como factor de riesgo asociado con la enfermedad de Alzheimer

Carolina Martin, Loretto Solís, Margarita I Concha, Carola Otth
<span title="">2011</span> <i title="SciELO Comision Nacional de Investigacion Cientifica Y Tecnologica (CONICYT)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/xqlqhmtoojcqppvjacq2aqomqu" style="color: black;">Revista médica de Chile (Impresa)</a> </i> &nbsp;
Martin et al Rev Med Chile 2011; 139: 779-786  ...  Martin et al cual es más evidente en los casos de enfermedades neurodegenerativas, en donde circuitos nerviosos responsables del mantenimiento de los procesos cerebrales cognitivos se ven afectados 19  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4067/s0034-98872011000600013">doi:10.4067/s0034-98872011000600013</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/iustbct3o5g2bchrs3x727pgfi">fatcat:iustbct3o5g2bchrs3x727pgfi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170817080249/http://www.scielo.cl/pdf/rmc/v139n6/art13.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e0/80/e0806a563e937ce3b36cc9df713f9ea7c28fe27b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4067/s0034-98872011000600013"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Herpes Simplex Virus Type 1 Enhances Expression of the Synaptic Protein Arc for Its Own Benefit

Francisca Acuña-Hinrichsen, Mariela Muñoz, Melissa Hott, Carolina Martin, Evelyn Mancilla, Paula Salazar, Luis Leyton, Angara Zambrano, Margarita I. Concha, Patricia V. Burgos, Carola Otth
<span title="2019-01-08">2019</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/n5oku2uutza7dou2nqqzxhetqy" style="color: black;">Frontiers in Cellular Neuroscience</a> </i> &nbsp;
2015; Otth et al., 2016).  ...  Shepherd, University of Utah, United States Copyright © 2019 Acuña-Hinrichsen, Muñoz, Hott, Martin, Mancilla, Salazar, Leyton, Zambrano, Concha, Burgos and Otth.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fncel.2018.00505">doi:10.3389/fncel.2018.00505</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30692913">pmid:30692913</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6340317/">pmcid:PMC6340317</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vwhjo32ktrhrviau7lquqaq4fu">fatcat:vwhjo32ktrhrviau7lquqaq4fu</a> </span>
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Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines

Francisca Acuña-Hinrichsen, Adriana Covarrubias-Pinto, Yuta Ishizuka, María Francisca Stolzenbach, Carolina Martin, Paula Salazar, Maite A. Castro, Clive R. Bramham, Carola Otth
<span title="2021-02-23">2021</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/n5oku2uutza7dou2nqqzxhetqy" style="color: black;">Frontiers in Cellular Neuroscience</a> </i> &nbsp;
After primary infection in buccal mucosa epithelium, viral progeny can be transported retrogradely through the axons of sensory neurons to the central nervous system (CNS) (Otth et al., 2016) .  ...  The infection and apoptosis rate in primary cultures infected with HSV-1 has a typical cytopathic effect during the late stages of infection (18-24 h post-infection hpi) (Leyton et al., 2015; Martin et  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fncel.2021.580717">doi:10.3389/fncel.2021.580717</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33708072">pmid:33708072</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7940845/">pmcid:PMC7940845</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/jyrx2bz3pvcbbcg6yq7jjd2x4u">fatcat:jyrx2bz3pvcbbcg6yq7jjd2x4u</a> </span>
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Immunocytochemical and Ultrastructural Evidence Supporting That Andes Hantavirus (ANDV) Is Transmitted Person-to-Person Through the Respiratory and/or Salivary Pathways

Enrique Pizarro, Maritza Navarrete, Carolina Mendez, Luis Zaror, Carlos Mansilla, Mauricio Tapia, Cristian Carrasco, Paula Salazar, Roberto Murua, Paula Padula, Carola Otth, Esteban Martin Rodríguez
<span title="2020-01-10">2020</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/67anf6qgandy5adz4rakospiuq" style="color: black;">Frontiers in Microbiology</a> </i> &nbsp;
In South America Andes hantavirus (ANDV) is hosted by the rodent Oligoryzomys longicaudatus (also known as pygmy rice rat). In humans, ANDV causes Hantavirus Pulmonary Syndrome (HPS), with a fatality rate of about 40%. Epidemiologic and molecular evidence has shown that ANDV can be transmitted from person to person. Sin Nombre hantavirus, occurring in North America, and ANDV are genetically related, and both cause HPS with similar clinical evolution and mortality rate. However, only ANDV is
more &raquo; ... smitted from person to person. A recent hantavirus outbreak in a small village in Southern Argentine, with 29 HPS cases and 11 deaths has brought to mind that person-to-person transmission continues to be a public health emergency. The present investigation was aimed to understand how does ANDV actually spread between persons. Tissue samples of lung and salivary glands from infected Oligoryzomys longicaudatus and lethal cases of human HPS were investigated by bright field immunocytochemistry, multichannel immunofluorescence, and transmission electron microscopy. The findings are consistent with ANDV infection and replication in the lung alveolar epithelium and macrophages, and in the secretory cells of the submandibular salivary glands. In the lung of infected Oligoryzomys longicaudatus and human cases HPS, the bulk of immunoreactive hantavirus antigens was localized in epithelial cells of the alveolar walls and macrophages. The ultrastructural study supports that in the lung of HPS patients the virus replicates in the alveolar epithelial cells with virus particles being discharged into the alveolar lumen. Virus-like particles were seen within vacuoles of the lung macrophages. Considering that these macrophages can reach the conductive segments of the airways, their expectoration becomes a deadly bullet for ANDV transmission. In the submandibular glands of infected rodents and HPS cases, ANDV antigens were in capillary endothelium, the secretory cells and filling the lumen of the excretory pathway. It is proposed that in patients with HPS caused by ANDV the alveolar epithelium and macrophages would be the gate for the airway spreading of the virus, while the salivary glands are a target for virus replication and an exit pathway through saliva.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fmicb.2019.02992">doi:10.3389/fmicb.2019.02992</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31998273">pmid:31998273</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6965362/">pmcid:PMC6965362</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/fzts47whczcuvbt64k6stbgrqe">fatcat:fzts47whczcuvbt64k6stbgrqe</a> </span>
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Herpes Simplex Virus Type 1 Neuronal Infection Perturbs Golgi Apparatus Integrity through Activation of Src Tyrosine Kinase and Dyn-2 GTPase

Carolina Martin, Luis Leyton, Melissa Hott, Yennyfer Arancibia, Carlos Spichiger, Mark A. McNiven, Felipe A. Court, Margarita I. Concha, Patricia V. Burgos, Carola Otth
<span title="2017-08-22">2017</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/6thgqfebmngxzdcx4yjgtkznqa" style="color: black;">Frontiers in Cellular and Infection Microbiology</a> </i> &nbsp;
Primary cortical neuronal culture was established with 17 days old mice embryos (E17) (Otth et al., 2007) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fcimb.2017.00371">doi:10.3389/fcimb.2017.00371</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28879169">pmid:28879169</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5572415/">pmcid:PMC5572415</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bqtkn2e675cqdkpbbizjpfkmq4">fatcat:bqtkn2e675cqdkpbbizjpfkmq4</a> </span>
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Patterns of phytoecdysteroids distribution in the plants of the section Otites Otth genus Silene L.: chemotaxonomic approach
Закономерности распространения экдистероидов в растениях секции Otites Otth рода Silene L.: хемотаксономический подход

Anna A. Seliverstova, Larisa N. Zibareva, Valentina I. Eremina
<span title="2014-09-01">2014</span> <i title="Tomsk State University"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3dnveylb5zesljygegzkysfcye" style="color: black;">Vestnik Tomskogo gosudarstvennogo universiteta Biologiya</a> </i> &nbsp;
Томск, Россия Закономерности распространения экдистероидов в растениях секции Otites Otth рода Silene L.: хемотаксономический подход Проведено сравнение различных систематик секции Otites Otth, описанных  ...  Otth) O. wolgensis (Hornem.) Grossh. (Viscago wolgensis Hornem., Cucubalus wolgensis Willd., S. wolgensis (Hornem.) Otth., S. effuse Otth, S. otites subsp. wolgensis (Hornem.) Schmalh.)  ...  Семена растений получены из ботанического сада Галле (Botanischer Garten der Martin-Luther-Universitat Halle-Wittenberg, Germany). Культивируются в Сибирском ботаническом саду ТГУ (г.  ... 
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Page 392 of Plant Disease Vol. , Issue SUPPLEMENT 73 [page]

<span title="1929-12-30">1929</span> <i title="American Phytopathological Society"> <a target="_blank" rel="noopener" href="https://archive.org/details/pub_plant-disease" style="color: black;">Plant Disease </a> </i> &nbsp;
Reported from Pennsylvania +Florida, Mississippi, Texas, +*Hyaloceras depezeoides (Otth,) Berner.. Kansas — (Martin) Leptospheeria coniothyrium (Fckl.) Sacc., cane blight.  ...  (Martin) Sphaerotheca pannosa (Wallr.) Lev., powdery: mildew.  ... 
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Page 261 of The Biological Bulletin Vol. 104, Issue 2 [page]

<span title="">1953</span> <i title="University of Chicago Press"> <a target="_blank" rel="noopener" href="https://archive.org/details/pub_biological-bulletin" style="color: black;">The Biological Bulletin </a> </i> &nbsp;
Martine, 1944. Mode of action of thiourea on the thyroid gland of rabbits. Endocrinology, 34: 44-49. Biaxstap, T. W., 1949.  ...  Action du thiourcil sur la metamorphose de Discoglussus pictus Otth. C. R. Soc. Biol., Paris, 142: 458-460. Gascue, P., Ann J. Druey, 1946.  ... 
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Page 102 of Plant Disease Vol. , Issue SUPPLEMENT 169 [page]

<span title="1947-06-15">1947</span> <i title="American Phytopathological Society"> <a target="_blank" rel="noopener" href="https://archive.org/details/pub_plant-disease" style="color: black;">Plant Disease </a> </i> &nbsp;
. & Martin, Leaf Spot. Yazoo, PLAT ANUS. . ie a . P. OCCIDENTALIS L., Sycamore. — 2 Diatrypella prominens Howe.. Marshall. _ . Eutypolla platani (Schw.) Sacc.  ...  Clay. x eae ad Exosporium platani Otth., Leaf Spot.. Oktibbeha. = Gloeosporium nerviseguum (Fckl.) Sacc., Léaf Spot. ‘Oktibbeha. Gnomonia veneta (Sacc. & Speg.) Kleb., Anthracnose.  ... 
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Page 645 of National Union Catalog Vol. 1, Issue [page]

<span title="">1963</span> <i title="J W Edwards Publisher In"> <a target="_blank" rel="noopener" href="https://archive.org/details/pub_national-union-catalog" style="color: black;">National Union Catalog </a> </i> &nbsp;
Aland, Kurt see Luther, Martin, 1483-1546, Die Briefe, Stuttgart, E. Klotz Verlag, 1959, Aland, Kurt, ed. see Luther, Martin, 1483-1546. Martin Luthers 95 Thesen.  ...  IL Title: Genes for resistance to Puccinia hordei Otth. in the barley varieties Sudan and Reka 1 as determined by means of translocation stocks.  ... 
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Page 94 of American Chiropractic Association. The ACA Journal of Chiropractic Vol. 29, Issue 6 [page]

<span title="">1992</span> <i title="The Journal of the American Chiropractic"> <a target="_blank" rel="noopener" href="https://archive.org/details/pub_american-chiropractic-association-the-aca-journal" style="color: black;">American Chiropractic Association. The ACA Journal of Chiropractic</a> </i> &nbsp;
B\ lowering the abdominal support section oTthe table las show n abo\el _\ou retain normal lumbar lordosis.  ...  Peter Martin, D.C. Dr.  ... 
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A New Kolsky Bar Dynamic Spall Technique for Brittle Materials

A. W. Dean, W. F. Heard, C. M. Loeffler, B. E. Martin, X. Nie
<span title="2016-03-28">2016</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zkizmmqrbrhxxmlaxryltohy3i" style="color: black;">Journal of Dynamic Behavior of Materials</a> </i> &nbsp;
The strain rates at x 0 þ Dx and x 0 À Dx are: oe x 0 þ Dx; t ð Þ =ot ¼ ðog x 0 þ Dx; t ð Þ =ot þ of x 0 þ Dx; t ð Þ =otÞ=E ð5Þ oe x 0 À Dx; t ð Þ =ot ¼ ðog x 0 À Dx; t ð Þ =ot þ of x 0 À Dx; t ð Þ =otÞ  ...  Therefore the following relation has to hold: oe x 0 ; t þ Dt ð Þ =ot ¼ ðog x 0 þ Dx; t ð Þ =ot þ of x 0 À Dx; t ð Þ =otÞ=E ð9Þ oe x 0 ; t À Dt ð Þ =ot ¼ ðog x 0 À Dx; t ð Þ =ot þ of x 0 þ Dx; t ð Þ =otÞ  ... 
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