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Cortical Hierarchy and The Dual Counterstream Architecture [article]

Julien Vezoli, Loïc Magrou, Xiao-Jing Wang, Kenneth Knoblauch, Martin Vinck, Henry Kennedy
2020 bioRxiv   pre-print
Annu Rev Neurosci 38, 269-289. 921 Barone, P., Batardiere, A., Knoblauch, K., Kennedy, H., 2000.  ...  Neuron 80, 442-457. 974 Binzegger, T., Douglas, R.J., Martin, K.A., 2004. A quantitative map of the circuit of cat 975 primary visual cortex.  ... 
doi:10.1101/2020.04.08.032706 fatcat:tnqm7czodzbi7et5fxshhyotlq

Comprehensive Optical Investigations of Charge Order in Organic Chain Compounds (TMTTF)2X

Martin Dressel, Michael Dumm, Tobias Knoblauch, Matteo Masino
2012 Crystals  
Charge ordering in the (TMTTF) 2 X salts with centrosymmetric anions (X = PF − 6 , AsF − 6 , SbF − 6 ) leads to a ferroelectric state around 100 K. For the first time and in great completeness, the intra-and intermolecular vibrational modes of (TMTTF) 2 X have been investigated by infrared and Raman spectroscopy as a function of temperature and pressure for different polarizations. In this original paper, we explore the development and amount of charge disproportionation and the coupling of the
more » ... electronic degrees of freedom to the counterions and the underlying lattice. The methyl groups undergo changes with temperature that are crucial for the anion cage formed by them. We find that the coupling of the TMTTF molecules to the hexafluorine anions changes upon cooling and especially at the charge-order transition, indicating a distortion of the anion. Additional features are identified that are caused by the anharmonic potential. The spin-Peierls transition entails additional modifications in the charge distribution. To complete the discussion, we also add the vibrational frequencies and eigenvectors based on ab-initio quantum-chemical calculations.
doi:10.3390/cryst2020528 fatcat:q6jrfyqaxzbrfbypfdmj2ijnte

Surface controlled reduction kinetics of nominally undoped polycrystalline CeO2

Nicole Knoblauch, Lars Dörrer, Peter Fielitz, Martin Schmücker, Günter Borchardt
2015 Physical Chemistry, Chemical Physics - PCCP  
The oxygen loss of nominally undoped dense polycrystalline ceria is monitored by thermogravimetric analyses. It is shown that the kinetics of oxygen release is surface controlled.
doi:10.1039/c4cp05742b pmid:25630597 fatcat:kqcubmi2sff3nf3t7dg55xr47e

Ceria: Recent Results on Dopant-Induced Surface Phenomena

Nicole Knoblauch, Heike Simon, Lars Dörrer, Daniel Uxa, Stefan Beschnitt, Peter Fielitz, Jens Wendelstorf, Karl-Heinz Spitzer, Martin Schmücker, Günter Borchardt
2017 Inorganics  
line scans; Peter Fielitz: kinetics data evaluation and interpretation, text assembling; Jens Wendelstorf: thermodynamic calculations; Karl-Heinz Spitzer: computer simulations of kinetic parameters; Martin  ...  D is the tracer diffusion coefficient of oxygen, respectively, follows with the correlation factor Souza's conclusion [56] :K * O /D * O > K O / D O (c) Armstrong et al. [29, 69] (for K * O ) and Knoblauch  ... 
doi:10.3390/inorganics5040076 fatcat:s7byrtko7rgqfa5tavzecupgde

Global integration of local color differences in transparency perception: An fMRI study

2006 Visual Neuroscience  
., 1998) , color knowledge (Martin et al., 1995) or the perception of naturally colored objects (Zeki & Marini, 1998) .  ... 
doi:10.1017/s0952523806233200 pmid:16961967 pmcid:PMC2064862 fatcat:x63oy3tmdfbapnljwmtpu5c6wy

Hydrogen storage in amine boranes: Ionic liquid supported thermal dehydrogenation of ethylene diamine bisborane

Sebastian Sahler, Hannelore Konnerth, Nicole Knoblauch, Martin H.G. Prechtl
2013 International journal of hydrogen energy  
Ethylene diamine bisborane Ammonia borane Ionic liquids Dehydrogenation Polarity a b s t r a c t A variety of ionic liquids has been tested for its catalytic effect on the dehydrogenation of ethylene diamine bisborane (EDB). The catalytic activity of ionic liquids, such as 1-butyl-2,3-dimethylimidazolium chloride ([BMMIM]Cl), 1-butyl-2,3-dimethylimidazolium acetate ([BMMIM][OAc]), 1-butyl-3-methylimidazolium acetate ([BMIM][OAc]) and 1-butyl-3methylimidazolium methylsulfonate ([BMIM][OMs]) is
more » ... mpared and the mixture [BMMIM]Cl/EDB was investigated. This system is able to deliver about 6.5 wt% of hydrogen at 140 C competing with conventional hydrogen storage pressure tanks. The correlation between polarity of the ILs and hydrogen yield was investigated and the suitability for hydrogen storage systems is evaluated and discussed.
doi:10.1016/j.ijhydene.2012.12.150 fatcat:qwdwzqmlnjhvpej73qaacdqlge

SCS122 Miura - New Rice Cultivar

Rubens Marschalek, Jose Alberto Noldin, Ester Wickert, Klaus Konrad Scheuermann, Moacir Antonio Schiocchet, Domingos Savio Eberhardt, Ronaldir Knoblauch, Eduardo Hickel, Gabriela Neves Martins, Juliana Vieira Raimondi, Alexander de Andrade
2017 Crop Breeding and Applied Biotechnology  
The rice cultivar SCS122 Miura has modern architecture, lodging resistance, late maturity cycle, moderate resistance to blast, high yield potential, long grains and adequate cooking quality. Industrial tests have demonstrated that the grains are suitable for parboiled rice. SCS122 Miura is recommended for all rice-producer regions of the state of Santa Catarina, Brazil.
doi:10.1590/1984-70332017v17n3c44 fatcat:pllf52mu5rchno5lfsfmx3xmbu

Under salt stress guard cells rewire ion transport and abscisic acid (ABA) signaling

Sohail M. Karimi, Matthias Freund, Brittney M. Wager, Michael Knoblauch, Jörg Fromm, Heike Müller, Peter Ache, Markus Krischke, Martin J. Mueller, Tobias Müller, Marcus Dittrich, Christoph‐Martin Geilfus (+3 others)
2021 New Phytologist  
The supernatant and pellet were frozen at À80°C followed by freeze-drying (Alpha 1-2 LDplus; Martin Christ).  ...  The frozen leaves were freezedried using a lyophilizer (Alpha 1-2 LDplus; Martin Christ, Osterode am Harz, Germany) for 48 h at À48°C and 1.4 Pa atmospheric pressure.  ... 
doi:10.1111/nph.17376 pmid:33774818 fatcat:vo6m2zmaezf3tftqfcecqcn2qa

SCS121 CL: Rice cultivar resistant to herbicides of imidazolinone chemical group

Moacir Antonio Schiocchet, Jose Alberto Noldin, Rubens Marschalek, Ester Wickert, Gabriela Neves Martins, Domingos Savio Eberhardt, Eduardo Hickel, Ronaldir Knoblauch, Klaus Konrad Scheuermann, Juliana Vieira Raimondi, Alexander de Andrade
2015 Crop Breeding and Applied Biotechnology  
SCS121 CL is a second-generation Clearfield® rice cultivar with resistance to herbicides of the imidazolinone group. The cultivar has modern plant type, lodging resistance, late maturity cycle, high yield potential, long grains and good cooking quality. The cultivar is recommended to all rice-producer regions of Santa Catarina, Brazil. Crop Breeding and Applied Biotechnology 15: 282-284, 2015 Brazilian Society of Plant Breeding. Printed in Brazil CULTIVAR RELEASE http://dx.
doi:10.1590/1984-70332015v15n4c47 fatcat:544swbauinbgbjcpfdtveyicyu

SCS118 Marques - New rice cultivar obtained through induced mutation

Moacir Antonio Schiocchet, Jose Alberto Noldin, Juliana Vieira Raimondi, Augusto Tulmann Neto, Rubens Marschalek, Ester Wickert, Gabriela Neves Martins, Eduardo Hickel, Ronaldir Knoblauch, Klaus Konrad Scheuermann, Domingos Savio Eberhardt, Alexander De Andrade
2014 Crop Breeding and Applied Biotechnology  
The new rice cultivar, SCS118 Marques, was obtained through gamma irradiation of SCSBRS Tio Taka cultivar. SCS118 Marques presents modern architecture, lodging resistance, late maturity cycle, moderate resistance to blast, high yield potential, long grains and very high cooking quality. Industrial tests performed with SCS118 Marques showed that grains are suitable for parboiling and white rice, and it is recommended to all rice-producing regions of Santa Catarina.
doi:10.1590/s1984-70332014000100012 fatcat:kutkt7vvofebrpjh7kahh55deq

Infrared spectra of the one-dimensional quarter-filled Wigner lattice compoundsδ-(EDT-TTF-CONMe2)2X(X=AsF6, Br): Domain-wall excitations

Ágnes Antal, Tobias Knoblauch, Martin Dressel, Patrick Batail, Natalia Drichko
2013 Physical Review B  
doi:10.1103/physrevb.87.075118 fatcat:szxeqsulezaplganljpxz74mxm

Rice straw incorporated just before soil flooding increases acetic acid formation and decreases available nitrogen

Ronaldir Knoblauch, Paulo Roberto Ernani, Francisco Carlos Deschamps, Luciano Colpo Gatiboni, Timothy Wayne Walker, Késia Silva Lourenço, Acácio Agostinho Martins, Angélica Pegoraro
2014 Revista Brasileira de Ciência do Solo  
The amount of straw produced by semi-dwarf rice cultivars is, on average, similar to the amount of grain (Costa, 2000; Knoblauch & Schiocchet, 2001) .  ... 
doi:10.1590/s0100-06832014000100017 fatcat:2g7u5rfhyvgrrog5bca64myouy

Exploring Variability: New Brazilian Varieties SCS119 Rubi and SCS120 Onix for the Specialty Rices Market

Ester Wickert, Moacir Antonio Schiocchet, José Alberto Noldin, Juliana Vieira Raimondi, Alexander de Andrade, Klaus Konrad Scheuermann, Rubens Marschalek, Gabriela Neves Martins, Eduardo Hickel, Domingos Savio Eberhardt, Ronaldir Knoblauch
2014 Open Journal of Genetics  
Specialty rices" is a common name for varieties that present uncommon grains with distinctive features as pericarp color, grain shape and size or aroma. Most of these rices are related to cultural traditions and ceremonies, but some have higher nutritionally value than white rice. Considering that today people are searching for foods that could help to improve and maintain health, specialty rices would also be considered in some way as functional food. As a specific market, the economic values
more » ... f these grains are also higher than those of white rice. So, the new red rice variety SCS119 Rubi and the new black rice variety SCS120 Onix were developed in order to attend the specific and economically important specialty rices market, and should be consumed as a whole rice grain. Experimental tests performed with these varieties showed that they could be recommended to all rice-producing regions of Santa Catarina State, Brazil.
doi:10.4236/ojgen.2014.42016 fatcat:l7n2nzietbcfdfexncbvtznz5i

A Phase I First-in-Human Pharmacokinetic and Pharmacodynamic Study of Serdemetan in Patients with Advanced Solid Tumors

J. Tabernero, L. Dirix, P. Schoffski, A. Cervantes, J. A. Lopez-Martin, J. Capdevila, L. van Beijsterveldt, S. Platero, B. Hall, Z. Yuan, R. Knoblauch, S. H. Zhuang
2011 Clinical Cancer Research  
Purpose: Originally isolated on the basis of its ability to induce p53, serdemetan showed potent activity in various preclinical models, inducing S-phase arrest and apoptosis in TP53 wild-type and mutant tumors. This study evaluated the safety and tolerability of serdemetan, determined the pharmacokinetic and pharmacodynamic profiles, and identified a recommended phase II dose. Patients and Methods: Patients (71) with refractory solid tumors were allocated to dose-escalating cohorts (3þ3
more » ... s each) and received oral serdemetan once daily in 21-day cycles to determine the maximum tolerated dose (MTD) and dose-limiting toxicities (DLT). Plasma was collected for pharmacokinetic analyses. Paired baseline and on-treatment skin and tumor biopsies were done; blood samples were collected for pharmacodynamic analyses, including p53 and macrophage inhibitory cytokine-1 induction. Results: The MTD of serdemetan was determined to be 350 mg once daily. During this study, grade 3 QTc prolongation was the most common DLT and nausea (66.2%) was the most frequent treatment-emergent adverse event. Serdemetan was rapidly absorbed after oral administration and exhibited dose-proportional pharmacokinetics. At steady state, mean maximum plasma concentration (C max ) was 2,330 ng/mL and mean area under plasma concentration curve (AUC 0-24h ) was 43.0 mg.h/mL, with serdemetan 300 mg/d. There was a dose-and exposure-dependent p53 induction. One patient with breast cancer showed a partial response; 22 (38.6%) patients had stable disease. Conclusions: Serdemetan treatment was associated with p53 induction in both tumor and surrogate tissue pharmacodynamic studies and modest clinical activity. Although serdemetan was well tolerated with dose-proportional pharmacokinetics, exposure-related QTc liability was observed.
doi:10.1158/1078-0432.ccr-11-1101 pmid:21831953 fatcat:3lcbugyf7fguzpgad3u5gl4mne

A chemical chaperone improves muscle function in mice with a RyR1 mutation

Chang Seok Lee, Amy D. Hanna, Hui Wang, Adan Dagnino-Acosta, Aditya D. Joshi, Mark Knoblauch, Yan Xia, Dimitra K. Georgiou, Jianjun Xu, Cheng Long, Hisayuki Amano, Corey Reynolds (+7 others)
2017 Nature Communications  
Mutations in the RYR1 gene cause severe myopathies. Mice with an I4895T mutation in the type 1 ryanodine receptor/Ca 2þ release channel (RyR1) display muscle weakness and atrophy, but the underlying mechanisms are unclear. Here we show that the I4895T mutation in RyR1 decreases the amplitude of the sarcoplasmic reticulum (SR) Ca 2þ transient, resting cytosolic Ca 2þ levels, muscle triadin content and calsequestrin (CSQ) localization to the junctional SR, and increases endoplasmic reticulum (ER)
more » ... stress/unfolded protein response (UPR) and mitochondrial ROS production. Treatment of mice carrying the I4895T mutation with a chemical chaperone, sodium 4-phenylbutyrate (4PBA), reduces ER stress/UPR and improves muscle function, but does not restore SR Ca 2þ transients in I4895T fibres to wild type levels, suggesting that decreased SR Ca 2þ release is not the major driver of the myopathy. These findings suggest that 4PBA, an FDA-approved drug, has potential as a therapeutic intervention for RyR1 myopathies that are associated with ER stress.
doi:10.1038/ncomms14659 pmid:28337975 pmcid:PMC5376670 fatcat:t2ailtemg5cyblbxe42lfas2cq
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