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The Doppler Wind And Temperature Sounder

Martin McHugh, Dave Fritts, Larry Gordley
<span title="2014-07-31">2014</span> <i title="Zenodo"> Zenodo </i> &nbsp;
The Doppler Wind and Temperature Sounder (DWTS) is novel sensor concept for measuring global winds and temperatures from cloud-top to the thermosphere. This will significantly improve medium- and long-range weather forecasts and enable more advanced tracking of severe storms. The approach uses the inherent high spectral resolution from gas filter correlation radiometry to simultaneously measure the Doppler shift and linewidth of limb emission spectra as viewed from low-Earth orbit. DWTS images
more &raquo; ... he limb through low-pressure gas cells containing CO2, NO and NO2. We describe here how very accurate vector winds and kinetic temperatures can be inferred from these observations. Profiles of temperature and wind can be measured day and night continuously from 15 to over 250 km at intervals of 10 km along-track with less than 2% uncertainty. A constellation of 6-12 DWTS instruments on small satellites would provide unprecedented observations of global atmospheric dynamics from the lower stratosphere into the middle thermosphere, greatly improving weather and storm forecasting. We present the current status and plans to realize this important mission.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5281/zenodo.11111">doi:10.5281/zenodo.11111</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/znlhtcpvazdmhhpq44kbc7zf34">fatcat:znlhtcpvazdmhhpq44kbc7zf34</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170813192058/https://zenodo.org/record/11111/files/I_9_McHugh_-_DWTS.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4a/a7/4aa71855abdae5c0d3bd4e909f59223051bc2fe6.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5281/zenodo.11111"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> zenodo.org </button> </a>

Nanoinformatics and DNA-Based Computing: Catalyzing Nanomedicine

Victor Maojo, Fernando Martin-Sanchez, Casimir Kulikowski, Alfonso Rodriguez-Paton, Martin Fritts
<span title="">2010</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/whvfa7dwcjdv3htgapecctdu2q" style="color: black;">Pediatric Research</a> </i> &nbsp;
These and other foundational initiatives have emerged to support Nanoinformatics as a discipline designed to catalyze and accelerate research and developments in nanomedicine (Baker NA, Fritts M, Guccione  ...  elucidating a molecular phenotype or fingerprint of a patient's cancer, delivering molecular targeted therapies, monitoring the efficacy of treatment, and informing future treatment decisions (R Cachau and M Fritts  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1203/pdr.0b013e3181d6245e">doi:10.1203/pdr.0b013e3181d6245e</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20118825">pmid:20118825</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wcrx72ih5nd3bfabxpgujd6ade">fatcat:wcrx72ih5nd3bfabxpgujd6ade</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200315101337/https://www.nature.com/articles/pr201088.pdf?error=cookies_not_supported&amp;code=ddd038d8-147a-4071-8199-a1b9514ca098" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/91/7b/917b56a711ebb869f743d081f7824e8e67c42839.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1203/pdr.0b013e3181d6245e"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Enhanced nutrient uptake is sufficient to drive emergent cross-feeding between bacteria [article]

Ryan K Fritts, Jordan T Bird, Megan G Behringer, Anna Lipzen, Joel Martin, Michael Lynch, James B McKinlay
<span title="2019-09-16">2019</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
AbstractInteractive microbial communities are ubiquitous on Earth. Within microbial communities, nutrient exchange, also called cross-feeding, is widespread. Cross-feeding is thought to arise from the need to satisfy nutrient requirements of recipient microbes, in many cases with producer microbes excreting costly, communally valuable metabolites such as vitamins, amino acids, or ammonium. However, we possess an incomplete understanding of the genetic basis and molecular mechanisms by which
more &raquo; ... s-feeding of communally valuable metabolites evolves. Previously we engineered a mutualistic cross-feeding relationship between N2-fixing Rhodopseudomonas palustris and fermentative Escherichia coli. In this synthetic mutualism, genetically engineered R. palustris excretes essential nitrogen in the form of ammonium to E. coli, while E. coli excretes essential carbon in the form of fermentation products to R. palustris. Here, we used the same species, but with a wildtype strain of R. palustris not known to excrete ammonium, to enrich for a nascent cross-feeding relationship. We found that emergent ammonium cross-feeding relies not on a mutation in the producer R. palustris but rather a single missense mutation in the recipient E. coli. This mutation in E. coli NtrC, the master regulator of nitrogen scavenging, results in constitutive activation of an ammonium transporter and likely allows E. coli to subsist on the small amount of ammonium that leaks from WT R. palustris and reciprocate through the excretion of organic acids. Overall, our results indicate that enhanced nutrient uptake by recipients, rather than increased excretion by producers, is a plausible and possibly prevalent mechanism by which cross-feeding interactions emerge.SignificanceMicrobial communities orchestrate biogeochemical cycles and can cause or prevent polymicrobial infections. Interactions between microbes, including nutrient cross-feeding, can determine which species successfully colonize and thrive in a given niche. Here, we demonstrate that within a cross-feeding relationship, recipients, rather than producers, can drive the evolutionary emergence of nutrient exchange. In this case, the recipient bacterium drives emergent ammonium cross-feeding by enhancing nutrient uptake via upregulation of nitrogen acquisition genes. Our findings show that microbial species can rapidly adapt to coexist by exchanging nutrients and that the recipient species play an underappreciated role in driving the emergence of cross-feeding interactions.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/770727">doi:10.1101/770727</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5wpzba7vhjdqdjmuqaohc7sepu">fatcat:5wpzba7vhjdqdjmuqaohc7sepu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201108232437/https://www.biorxiv.org/content/biorxiv/early/2020/04/04/770727.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/51/e0/51e0040389fb84831a06006e9345698c0d814e88.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/770727"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

In-Silico Nanobio-Design. A New Frontier in Computational Biology

Raul Cachau, Fernando Gonzalez-Nilo, Oscar Ventura, Martin Fritts
<span title="2007-08-01">2007</span> <i title="Bentham Science Publishers Ltd."> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/k222f4mitzcuhmu2nnbcda5dqa" style="color: black;">Current Topics in Medicinal Chemistry</a> </i> &nbsp;
Nanobiology is a fast-emerging discipline that brings the tools of nanotechnology to the biological sciences. The introduction of new techniques may accelerate the development of highly specific biomedical treatments, increase their efficiency, and minimize their side effects. Introducing foreign bodies into the complex machinery of the human body is, however, a great and humbling challenge, as past experience has shown. In order for nanobiology to reach its full potential, we must devise a
more &raquo; ... s to alter the properties of nanoparticles, as expressed in the human body, in a predictable manner. Computer-aided methods are the natural option to speed up the development of these technologies. Yet, the procedures for annotation and simulation of nanoparticle properties must be developed and their limitations understood before computational methods can be fully exploited. In this review we will compare the state of development of nanoscale simulations in the biological sciences to that of the computer-aided drug design efforts in the past, tracing a historical parallel between both disciplines. From this comparison, lessons can be learned and bottlenecks identified, helping to speed up the development of computer-aided nanobiodevice design tools.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2174/156802607782194680">doi:10.2174/156802607782194680</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17897041">pmid:17897041</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/fk5dllxm6vabredzcg2xmalhmq">fatcat:fk5dllxm6vabredzcg2xmalhmq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20161228074255/https://isp.ncifcrf.gov/library/publications/pdf/16.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/97/1d/971d26d6ec15510cb4783b007a2818d2a12b80a9.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2174/156802607782194680"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Development of a model for the representation of nanotechnology-specific terminology

LeeAnn O Bailey, Christopher H Kennedy, Martin J Fritts, Francis W Hartel
<span title="">2006</span> <i title="American Medical Informatics Association"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/g6q27b56yzeupjryv6lby2r2pa" style="color: black;">AMIA Annual Symposium Proceedings</a> </i> &nbsp;
Nanotechnology is an important, rapidly-evolving, multidisciplinary field. The tremendous growth in this area necessitates the establishment of a common, open-source terminology to support the diverse biomedical applications of nanotechnology. Currently, the consensus process to define and categorize conceptual entities pertaining to nanotechnology is in a rudimentary stage. We have constructed a nanotechnology-specific conceptual hierarchy that can be utilized by end users to retrieve
more &raquo; ... controlled terminology regarding emerging nanotechnology and corresponding clinical applications.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/17238469">pmid:17238469</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC1839578/">pmcid:PMC1839578</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/2rrsmsmdz5eaxk5hvkp4f26nsi">fatcat:2rrsmsmdz5eaxk5hvkp4f26nsi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200209225721/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC1839578&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/98/eb/98ebdd44547bab6e4754e471eab4942bd03a126e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839578" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

High altitude thermal sounding using doppler modulated gas correlation

Larry L. Gordley, Benjamin T. Marshall, Martin J. McHugh, Dave Fritts, Chad Fish
<span title="">2010</span> <i title="IEEE"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/6i67v2zuujhfvocqaapmnsoifm" style="color: black;">2010 IEEE International Geoscience and Remote Sensing Symposium</a> </i> &nbsp;
INTRODUCTION This paper describes an important new measurement technique for high altitude thermal sounding (HATS), based on the Doppler modulated gas correlation (DMGC) approach. HATS measurements can potentially provide global temperature fields from cloud-top to 95 km at unprecedented spatial resolution. When assimilated into numerical weather models, these measurements can dramatically enhance forecast accuracy. HATS will enable prediction of the structure and effects of gravity waves on
more &raquo; ... lower and upper atmosphere, including their transport of energy and momentum, generation of turbulence, and their influence on plasma instabilities in the ionosphere. Gravity waves play a major role in determining the circulation, thermal structure, and temporal and spatial variability of stratosphere and mesosphere, and their effects extend well into the thermosphere[1]. The studies presented here confirm the measurement proof-of-concept and identify the technique's potential in next-generation sensors for atmospheric dynamics forecasting. CURRENT STATE OF TECHNOLOGY Atmospheric thermal sounding is routinely accomplished by observing emission in multiple spectral intervals of varying absorption strengths. Radiation received by a down-looking spacecraft emanates from various depths in the atmosphere. To infer the temperature at a specific altitude, the instrument must measure and distinguish emission that predominantly emanates from that altitude. However, spectral absorption lines from gases at high altitude are very narrow due to their lack of pressure broadening. For example, the CO 2 emission lines near 15 m require a resolution of 0.002 cm -1 or better. Thermal microwave and infrared sounding using current technology (AIRS[2], GOES[3], AMSU[4]) has proven successful, but only with moderate spatial resolution and not above the mid-stratosphere, as illustrated in Figure 1 .
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/igarss.2010.5651438">doi:10.1109/igarss.2010.5651438</a> <a target="_blank" rel="external noopener" href="https://dblp.org/rec/conf/igarss/GordleyMMFF10.html">dblp:conf/igarss/GordleyMMFF10</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/uatgwkbvvzct3nlgg43aapvrxa">fatcat:uatgwkbvvzct3nlgg43aapvrxa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170811182318/http://vigir.missouri.edu/~gdesouza/Research/Conference_CDs/IGARSS_2010/pdfs/4125.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/0e/de/0ede6e152c5e8af55b248dd02f2f71d112c8ed69.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/igarss.2010.5651438"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a>

Importance of the slick thickness for effective in-situ burning of crude oil

Laurens van Gelderen, Nicholas L. Brogaard, Martin X. Sørensen, Janne Fritt-Rasmussen, Ali S. Rangwala, Grunde Jomaas
<span title="">2015</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/6jhpimlyhrh7xlspzxo5ile76a" style="color: black;">Fire safety journal</a> </i> &nbsp;
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.firesaf.2015.07.005">doi:10.1016/j.firesaf.2015.07.005</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ix3j4tl25rfnxntlmmlfc6oxem">fatcat:ix3j4tl25rfnxntlmmlfc6oxem</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180722061326/http://orbit.dtu.dk/files/130081545/DTU_ORBIT_Importance_of_the_slick_thickness_for_effective_in_situ_burning_of_crude_oil_Van_Gelderen_et_al._2015.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c6/42/c64249e952f8cba185999369a536c64eaf59da7d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.firesaf.2015.07.005"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Effects of oil and oil burn residues on seabird feathers

Janne Fritt-Rasmussen, Jannie Fries Linnebjerg, Martin X. Sørensen, Nicholas L. Brogaard, Frank F. Rigét, Paneeraq Kristensen, Grunde Jomaas, David M. Boertmann, Susse Wegeberg, Kim Gustavson
<span title="">2016</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ud7h2fmzczbshoux3s2pzgtf2q" style="color: black;">Marine Pollution Bulletin</a> </i> &nbsp;
IFO30 was provided by Trumf Bunker in Aabenraa, Denmark (Fritt-Rasmussen 2010).  ...  After flame extinction a highly viscous and sticky burn residue that might sink is left behind (Fritt-Rasmussen et al. 2015) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.marpolbul.2016.05.029">doi:10.1016/j.marpolbul.2016.05.029</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27234369">pmid:27234369</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/zw62hwrtxjea7nkbwnewvrscwm">fatcat:zw62hwrtxjea7nkbwnewvrscwm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180723034924/http://orbit.dtu.dk/ws/files/137681979/Manuscript_revised_Final.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d1/fe/d1fedfb3cdc40e6062ad821b7b1012ccbd755bda.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.marpolbul.2016.05.029"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a>

Informatics and standards for nanomedicine technology

Dennis G. Thomas, Fred Klaessig, Stacey L. Harper, Martin Fritts, Mark D. Hoover, Sharon Gaheen, Todd H. Stokes, Rebecca Reznik-Zellen, Elaine T. Freund, Juli D. Klemm, David S. Paik, Nathan A. Baker
<span title="2011-06-30">2011</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/izm4gdiinzh3bgyqlczpuccc6q" style="color: black;">Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology</a> </i> &nbsp;
There are several issues to be addressed concerning the management and effective use of information (or data), generated from nanotechnology studies in biomedical research and medicine. These data are large in volume, diverse in content, and are beset with gaps and ambiguities in the description and characterization of nanomaterials. In this work, we have reviewed three areas of nanomedicine informatics: information resources; taxonomies, controlled vocabularies, and ontologies; and information
more &raquo; ... standards. Informatics methods and standards in each of these areas are critical for enabling collaboration, data sharing, unambiguous representation and interpretation of data, semantic (meaningful) search and integration of data; and for ensuring data quality, reliability, and reproducibility. In particular, we have considered four types of information standards in this review, which are standard characterization protocols, common terminology standards, minimum information standards, and standard data communication (exchange) formats. Currently, due to gaps and ambiguities in the data, it is also difficult to apply computational methods and machine learning techniques to analyze, interpret and recognize patterns in data that are high dimensional in nature, and also to relate variations in nanomaterial properties to variations in their chemical composition, synthesis, characterization
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/wnan.152">doi:10.1002/wnan.152</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/21721140">pmid:21721140</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3189420/">pmcid:PMC3189420</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/x4nlyhsdxrgxtcq7ihabv3pwsy">fatcat:x4nlyhsdxrgxtcq7ihabv3pwsy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200710235701/https://ir.library.oregonstate.edu/downloads/cn69m484h" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/8f/e2/8fe23262bed9419fbc121bc70603639c75ca7ee4.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/wnan.152"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> wiley.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189420" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Olfactory Function and Associated Clinical Correlates in Former National Football League Players

Michael L. Alosco, Johnny Jarnagin, Yorghos Tripodis, Michael Platt, Brett Martin, Christine E. Chaisson, Christine M. Baugh, Nathan G. Fritts, Robert C. Cantu, Robert A. Stern
<span title="2017-02-15">2017</span> <i title="Mary Ann Liebert Inc"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/q7nbyt3lebgnvk7kwtt3v7qhme" style="color: black;">Journal of Neurotrauma</a> </i> &nbsp;
Professional American football players incur thousands of repetitive head impacts (RHIs) throughout their lifetime. The long-term consequences of RHI are not well characterized, but may include olfactory dysfunction. RHI has been associated with changes to brain regions involved in olfaction, and olfactory impairment is common after traumatic brain injury. Olfactory dysfunction is a frequent early sequelae of neurodegenerative diseases (e.g., Alzheimer's disease), and RHI is associated with the
more &raquo; ... neurodegenerative disease, chronic traumatic encephalopathy (CTE). We examined olfaction, and its association with clinical measures, in former National Football League (NFL) players. Ninety-five former NFL players (ages 40-69) and 28 same-age controls completed a neuropsychological and neuropsychiatric evaluation as part of a National Institutes of Health-funded study. The Brief Smell Identification Test (B-SIT) assessed olfaction. Principal component analysis generated a four-factor structure of the clinical measures: behavioral/mood, psychomotor speed/executive function, and verbal and visual memory. Former NFL players had worse B-SIT scores relative to controls ( p = 0.0096). A B-SIT cutoff of 11 had the greatest accuracy (c-statistic = 0.61) and specificity (79%) for discriminating former NFL players from controls. In the former NFL players, lower B-SIT scores correlated with greater behavioral/mood impairment ( p = 0.0254) and worse psychomotor speed/executive functioning ( p = 0.0464) after controlling for age and education. Former NFL players exhibited lower olfactory test scores relative to controls, and poorer olfactory test performance was associated with worse neuropsychological and neuropsychiatric functioning. Future work that uses more-comprehensive tests of olfaction and structural and functioning neuroimaging may improve understanding on the association between RHI and olfaction.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1089/neu.2016.4536">doi:10.1089/neu.2016.4536</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27430424">pmid:27430424</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5314992/">pmcid:PMC5314992</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7xjxbui5qrec5f6olgjngbe2cq">fatcat:7xjxbui5qrec5f6olgjngbe2cq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200506035048/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5314992&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1c/4d/1c4dac75d671558fedf6902275942f75607de08f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1089/neu.2016.4536"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314992" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

ISA-TAB-Nano: A Specification for Sharing Nanomaterial Research Data in Spreadsheet-based Format

Dennis G Thomas, Sharon Gaheen, Stacey L Harper, Martin Fritts, Fred Klaessig, Elizabeth Hahn-Dantona, David Paik, Sue Pan, Grace A Stafford, Elaine T Freund, Juli D Klemm, Nathan A Baker
<span title="">2013</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/rxfgte5g2bcizdvltz5dfdp7zi" style="color: black;">BMC Biotechnology</a> </i> &nbsp;
and motivation: The high-throughput genomics communities have been successfully using standardized spreadsheet-based formats to capture and share data within labs and among public repositories. The nanomedicine community has yet to adopt similar standards to share the diverse and multi-dimensional types of data (including metadata) pertaining to the description and characterization of nanomaterials. Owing to the lack of standardization in representing and sharing nanomaterial data, most of the
more &raquo; ... ata currently shared via publications and data resources are incomplete, poorly-integrated, and not suitable for meaningful interpretation and re-use of the data. Specifically, in its current state, data cannot be effectively utilized for the development of predictive models that will inform the rational design of nanomaterials. Results: We have developed a specification called ISA-TAB-Nano, which comprises four spreadsheet-based file formats for representing and integrating various types of nanomaterial data. Three file formats (Investigation, Study, and Assay files) have been adapted from the established ISA-TAB specification; while the Material file format was developed de novo to more readily describe the complexity of nanomaterials and associated small molecules. In this paper, we have discussed the main features of each file format and how to use them for sharing nanomaterial descriptions and assay metadata. Conclusion: The ISA-TAB-Nano file formats provide a general and flexible framework to record and integrate nanomaterial descriptions, assay data (metadata and endpoint measurements) and protocol information. Like ISA-TAB, ISA-TAB-Nano supports the use of ontology terms to promote standardized descriptions and to facilitate search and integration of the data. The ISA-TAB-Nano specification has been submitted as an ASTM work item to obtain community feedback and to provide a nanotechnology data-sharing standard for public development and adoption.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1472-6750-13-2">doi:10.1186/1472-6750-13-2</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23311978">pmid:23311978</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3598649/">pmcid:PMC3598649</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4dwaat3df5eqhlxslrsi6rrdoi">fatcat:4dwaat3df5eqhlxslrsi6rrdoi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170818011643/http://ir.library.oregonstate.edu/xmlui/bitstream/handle/1957/37919/HarperStaceyLEnvironmentalMolecularToxicologyISATABNanoSpecificationSharing.pdf?sequence=1" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e6/ec/e6eceaf5f414f913cbe0713da808db6aa7607c97.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1472-6750-13-2"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598649" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Age of first exposure to football and later-life cognitive impairment in former NFL players

J. M. Stamm, A. P. Bourlas, C. M. Baugh, N. G. Fritts, D. H. Daneshvar, B. M. Martin, M. D. McClean, Y. Tripodis, R. A. Stern
<span title="2015-01-28">2015</span> <i title="Ovid Technologies (Wolters Kluwer Health)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dogs2nidlzdtxigbzvv6d2bbc4" style="color: black;">Neurology</a> </i> &nbsp;
Fritts participated in drafting the manuscript and acquisition of data. Mr. Daneshvar participated in revising the manuscript and study design. Mr.  ...  Martin participated in data management and analysis for this study. Dr. McClean participated in revising the manuscript and interpreting the data. Dr.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1212/wnl.0000000000001358">doi:10.1212/wnl.0000000000001358</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25632088">pmid:25632088</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4371403/">pmcid:PMC4371403</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/d7lc7yb5ynhdfiuxs55kr3lgfy">fatcat:d7lc7yb5ynhdfiuxs55kr3lgfy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170810154937/http://www.espn.com/pdf/2015/0128/otlBUfootballstudy.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/82/1d/821deb4d6f4b6c358eefdb506c6d5914aaa90bf9.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1212/wnl.0000000000001358"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371403" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy

Robert A. Stern, Yorghos Tripodis, Christine M. Baugh, Nathan G. Fritts, Brett M. Martin, Christine Chaisson, Robert C. Cantu, James A. Joyce, Sahil Shah, Tsuneya Ikezu, Jing Zhang, Cicek Gercel-Taylor (+2 others)
<span title="2016-04-12">2016</span> <i title="IOS Press"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/uux5o5kf5zaednhl4637xcmbte" style="color: black;">Journal of Alzheimer&#39;s Disease</a> </i> &nbsp;
Chronic traumatic encephalopathy (CTE) is a tauopathy associated with prior exposure to repetitive head impacts, such as those incurred through American football and other collision sports. Diagnosis is made through neuropathological examination. Many of the clinical features of CTE are common in the general population, with and without a history of head impact exposure, making clinical diagnosis difficult. As is now common in the diagnosis of other neurodegenerative disorders, such as
more &raquo; ... 's disease, there is a need for methods to diagnose CTE during life through objective biomarkers. Objective: The aim of this study was to examine tau-positive exosomes in plasma as a potential CTE biomarker. Methods: Subjects were 78 former National Football League (NFL) players and 16 controls. Extracellular vesicles were isolated from plasma. Fluorescent nanoparticle tracking analysis was used to determine the number of vesicles staining positive for tau. Results: The NFL group had higher exosomal tau than the control group (p < 0.0001). Exosomal tau discriminated between the groups, with 82% sensitivity, 100% specificity, 100% positive predictive value, and 53% negative predictive value. Within the NFL group, higher exosomal tau was associated with worse performance on tests of memory (p = 0.0126) and psychomotor speed (p = 0.0093). Conclusion: These preliminary findings suggest that exosomal tau in plasma may be an accurate, noninvasive CTE biomarker.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3233/jad-151028">doi:10.3233/jad-151028</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26890775">pmid:26890775</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4833534/">pmcid:PMC4833534</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/p7kscrs4qfbw3obobcofz5o42y">fatcat:p7kscrs4qfbw3obobcofz5o42y</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191112150940/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4833534&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7b/f6/7bf6a82eac12686f35ea1b01c0d5762040a3ca9f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3233/jad-151028"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833534" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Integration among databases and data sets to support productive nanotechnology: Challenges and recommendations

Sandra Karcher, Egon L. Willighagen, John Rumble, Friederike Ehrhart, Chris T. Evelo, Martin Fritts, Sharon Gaheen, Stacey L. Harper, Mark D. Hoover, Nina Jeliazkova, Nastassja Lewinski, Richard L. Marchese Robinson (+5 others)
<span title="">2018</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/lhyggvurrjd3ze6xoy3apkg2ny" style="color: black;">NanoImpact</a> </i> &nbsp;
A B S T R A C T Many groups within the broad field of nanoinformatics are already developing data repositories and analytical tools driven by their individual organizational goals. Integrating these data resources across disciplines and with non-nanotechnology resources can support multiple objectives by enabling the reuse of the same information. Integration can also serve as the impetus for novel scientific discoveries by providing the framework to support deeper data analyses. This article
more &raquo; ... scusses current data integration practices in nanoinformatics and in comparable mature fields, and nanotechnology-specific challenges impacting data integration. Based on results from a nanoinformatics-community-wide survey, recommendations for achieving integration of existing operational nanotechnology resources are presented. Nanotechnology-specific data integration challenges, if effectively resolved, can foster the application and validation of nanotechnology within and across disciplines. This paper is one of a series of articles by the Nanomaterial Data Curation Initiative that address data issues such as data curation workflows, data completeness and quality, curator responsibilities, and metadata.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.impact.2017.11.002">doi:10.1016/j.impact.2017.11.002</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30246165">pmid:30246165</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6145474/">pmcid:PMC6145474</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ipdbnr2n3rhzti7v6opjx2vkv4">fatcat:ipdbnr2n3rhzti7v6opjx2vkv4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190430051946/http://eprints.whiterose.ac.uk/124176/8/1-s2.0-S2452074817301398-main.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/5b/70/5b7091ed2f1ee2e1dd17bdc2c55bb97535ff7376.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.impact.2017.11.002"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145474" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Nanoinformatics: developing new computing applications for nanomedicine

Victor Maojo, Martin Fritts, Fernando Martin-Sanchez, Diana De la Iglesia, Raul E. Cachau, Miguel Garcia-Remesal, Jose Crespo, Joyce A. Mitchell, Alberto Anguita, Nathan Baker, Jose Maria Barreiro, Sonia E. Benitez (+23 others)
<span title="2012-03-07">2012</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dusph3ot3rfilc55znthn7tkmu" style="color: black;">Computing</a> </i> &nbsp;
García-Remesal M, García-Ruiz A, Pérez-Rey D, de la Iglesia D, Fritts M, Cachau R, Kulikowski CA, Maojo V (2011) Automatically extracting nanotoxicology-related entities from the literature (in preparation  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00607-012-0191-2">doi:10.1007/s00607-012-0191-2</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22942787">pmid:22942787</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3430140/">pmcid:PMC3430140</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ttef5foh5bgfbom2kllejh62fa">fatcat:ttef5foh5bgfbom2kllejh62fa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170922000620/http://dspace.utalca.cl/bitstream/1950/9116/1/Texto%20Completo.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/3c/d5/3cd578aa3a36dd3bd4659c23f31a9305db7b1c4b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00607-012-0191-2"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3430140" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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