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Dekonstruktion von Wertschöpfungsketten

Bernhard Swoboda, Martin Jager, Markus Meierer
2008 WiSt - Wirtschaftswissenschaftliches Studium  
Swoboda/Jager/Meierer, Dekonstruktion von Wertschöpfungsketten externe Transaktions-Management-Aktivitäten (zwischen Unternehmen stattfindende Kauf-und Verkaufsaktivitä- ten) und die Konsumaktivitäten  ...  Während auf Branchenebene nicht jede Veränderung der Wertschöpfungskette eines Unternehmens auch zu veränderter Branchenwertschöpfung führt, verän-Swoboda/Jager/Meierer, Dekonstruktion von Wertschöpfungsketten  ... 
doi:10.15358/0340-1650-2008-10-532 fatcat:vyt6nzqv4ffsfh5rqd5wjkaipa

Muskeldysmorphie

Robin Halioua, Markus Deutschmann, Stefan Vetter, Matthias Jäger, Erich Seifritz, Malte Christian Claussen
2019 Swiss Medical Forum = Schweizerisches Medizin-Forum  
doi:10.4414/smf.2019.08039 fatcat:t4b43gcmdvf2dhowi4w7ogucy4

Dysmorphie musculaire

Robin Halioua, Markus Deutschmann, Stefan Vetter, Matthias Jäger, Erich Seifritz, Malte Christian Claussen
2019 Swiss Medical Forum = Forum Médical Suisse  
L'idéal de beauté musculaire pour l'homme a évolué au cours des dernières décennies. Une image corporelle négative, autrement dit la crainte de ne pas être suffisamment musclé, amène à s'astreindre à un programme d'entraînement et à des régimes alimentaires stricts. S'il en résulte des perturbations de la vie quotidienne ou une souffrance, on parle de dysmorphie musculaire.
doi:10.4414/fms.2019.08039 fatcat:5dmtegff2ncgbp57n3mosq6eyu

In vitro measurement of temperature changes during implantation of cemented glenoid components

Patric Raiss, Guido Pape, Sebastian Jäger, Markus Loew, Rudi Bitsch, Markus Rickert
2010 Acta Orthopaedica  
and purpose It is unclear whether the increase in temperature during cement curing may cause osteonecrosis, leading to loosening of the glenoid component in shoulder arthroplasty. We therefore analyzed the temperature during implantation of cemented glenoid implants. Methods 8 keeled and 8 pegged glenoids were implanted in standardized fashion in 8 pairs of scapulas. Temperature and pressure sensors were implanted at the bone-cement interface in the glenoid. Real-time measurements were made of
more » ... emperature and pressure within the glenoid vault. Results In no case was the temperature reached high enough to endanger the surrounding bone. The mean increase in temperature was 5° (0.5-6.9) in the keeled group and 2.7° (1.7-3.6) in the pegged group. The mean maximum pressure in the keeled group was 50 kPa (20-100) and in the pegged group it was 113 kPa (60-181). Both differences were statistically significant. Interpretation The temperatures that occur during implantation of cemented components are low and probably not high enough to cause osteonecrosis in the surrounding bone.
doi:10.3109/17453671003717823 pmid:20367412 pmcid:PMC2895340 fatcat:2cmq5gytvjbqdluqfinarmla7y

A hyponatraemia ritka oka: McKittrick–Wheelock-szindróma

Rita Nagy, Csaba Márkus, László Jáger, Csaba Tóth, Zoltán Lőcsei
2017 Orvosi Hetilap  
A szerzők a heveny veseelégtelenség és hyponatraemia ritka okát, a szecernáló tubulovillosus vastagbél-adenoma okozta McKittrick-Wheelock-szindrómát mutatják be saját esetük ismertetése kapcsán. Híg, vizes hasmenés, súlyos dehidráció, az elektrolit-háztartás zavara, akut veseelégtelenség miatt öt hónap alatt több alkalommal szorult belgyógyászati osztályon kezelésre a 75 éves nőbeteg, amíg a diagnózisra, ezáltal a szükséges terápiára fény derült. Esetüket a szindróma ritkasága és
more » ... gnosztikai nehézsége miatt tartották bemutatásra érdemesnek. Orv Hetil. 2017; 158 (18) : 711-714. A rare cause of hyponatraemia: McKittrick-Wheelock syndrome Case report Authors present a case of acute renal failure and hyponatraemia caused by a secretory tubulovillous adenoma of the colon, the rare so called McKittrick-Wheelock syndrome. A 75 year old woman was in need of treatment many times on medical wards because of watery diarrhoea, severe dehydration, hydroelectrolyte disturbance. The authors keep their case to be worthy to present, owing to the syndrome's rarity and difficulties of differential diagnosis.
doi:10.1556/650.2017.30753 pmid:28468538 fatcat:cnc3sn2msrb3tkvujpviebpdnm

Derivation of Stokes-Plate-Equations modeling fluid flow interaction with thin porous elastic layers [article]

Markus Gahn, Maria Neuss-Radu, Willi Jäger
2021 arXiv   pre-print
In this paper we investigate the interaction of fluid flow with a thin porous elastic layer. We consider two fluid-filled bulk domains which are separated by a thin periodically perforated layer consisting of a fluid and an elastic solid part. Thickness and periodicity of the layer are of order ϵ, where ϵ is small compared to the size of the bulk domains. The fluid flow is described by an instationary Stokes equation and the solid via linear elasticity. The main contribution of this paper is
more » ... rigorous homogenization of the porous structure in the layer and the reduction of the layer to an interface Σ in the limit ϵ→ 0 using two-scale convergence. The effective model consists of the Stokes equation coupled to a time dependent plate equation on the interface Σ including homogenized elasticity coefficients carrying information about the micro structure of the layer. In the zeroth order approximation we obtain continuity of the velocities at the interface, where only a vertical movement occurs and the tangential components vanish. The tangential movement in the solid is of order ϵ and given as a Kirchhoff-Love displacement. Additionally, we derive higher order correctors for the fluid in the thin layer.
arXiv:2112.03583v1 fatcat:tigcumplmzg5ncpcoz6kwyqgna

Heterogenität schizophrener Psychosen im Langzeitverlauf – eine Herausforderung für klinische Praxis und Forschung

Markus Jäger
2014 Psychiatrische Praxis  
Dieser Ansatz ist jedoch mit der Gefahr verbunden, dass die verschiedenen im Krankheitsverlauf auftretenden Symptome unverbunden nebeneinander aufgelistet werden, ohne den Jäger M.  ... 
doi:10.1055/s-0034-1370096 pmid:25180587 fatcat:u46j4eka55bd7ohy32fkz7etpi

Improvement of surgical results for pancreatic cancer

Werner Hartwig, Jens Werner, Dirk Jäger, Jürgen Debus, Markus W Büchler
2013 The Lancet Oncology  
Surgery is the only potential hope of cure for patients with pancreatic cancer. Advantageous tumour characteristics and complete tumour resection are the factors most relevant for a positive prognosis, so detection of premalignant or early invasive lesions, combined with safe and oncologically adequate surgery, is an important goal. The experience and volume of both the individual surgeon and hospital are of paramount importance to achieve low morbidity and adequate management of complications.
more » ... Most pancreatic cancers are locally advanced or metastatic when diagnosed and need multimodal therapy. With increasing evidence on surgical and perioperative aspects of pancreatic cancer therapy, short-term and long-term outcomes of resectable and borderline resectable pancreatic cancer are improving.
doi:10.1016/s1470-2045(13)70172-4 pmid:24079875 fatcat:24fyuzmjezdi3hzb4xq542r5hu

Mutagenic Analysis of the HIV Restriction Factor Shiftless

Niklas Jäger, Shreya Ahana Ayyub, Natalia Korniy, Frank Peske, Markus Hoffmann, Marina V. Rodnina, Stefan Pöhlmann
2022 Viruses  
The interferon-induced host cell protein shiftless (SFL) was reported to inhibit human immunodeficiency virus (HIV) infection by blocking the –1 programmed ribosomal frameshifting (–1PRF) required for expression of the Gag-Pol polyprotein. However, it is not clear how SFL inhibits –1PRF. To address this question, we focused on a 36 amino acids comprising region (termed required for antiviral activity (RAA)) that is essential for suppression of –1PRF and HIV infection and is missing from SFL
more » ... t (SFLS), a splice variant of SFL with unknown function. Here, we confirm that SFL, but not SFLS, inhibits HIV –1PRF and show that inhibition is cell-type-independent. Mutagenic and biochemical analyses demonstrated that the RAA region is required for SFL self-interactions and confirmed that it is necessary for ribosome association and binding to the HIV RNA. Analysis of SFL mutants with six consecutive amino-acids-comprising deletions in the RAA region suggests effects on binding to the HIV RNA, complete inhibition of –1PRF, inhibition of Gag-Pol expression, and antiviral activity. In contrast, these amino acids did not affect SFL expression and were partially dispensable for SFL self-interactions and binding to the ribosome. Collectively, our results support the notion that SFL binds to the ribosome and the HIV RNA in order to block –1PRF and HIV infection, and suggest that the multimerization of SFL may be functionally important.
doi:10.3390/v14071454 pmid:35891432 pmcid:PMC9324250 fatcat:k6mbkotqq5bebkha6ejh7cmvlm

Identification of a naturally processed NY-ESO-1 peptide recognized by CD8+ T cells in the context of HLA-B51

Elke Jäger, Julia Karbach, Sacha Gnjatic, Dirk Jäger, Markus Maeurer, Akin Atmaca, Michael Arand, Jonathan Skipper, Elisabeth Stockert, Yao-Tseng Chen, Lloyd J Old, Alexander Knuth
2002 Cancer Immunity  
NY-ESO-1 is one of the most immunogenic cancer antigens known to date, inducing humoral and cellular immune responses in a high proportion of patients with advanced NY-ESO-1-expressing cancers. The assessment of spontaneous and vaccine-induced CD8+ T cell responses has been limited to a small number of known NY-ESO-1 epitopes presented by MHC class I alleles. Recently, a new method to monitor NY-ESO-1-specific CD8+ T cell responses was introduced that does not depend on the individual MHC class
more » ... I status and on predefined peptide epitopes. Antigen-presenting cells transduced with recombinant adenoviral vectors encoding NY-ESO-1 were used to stimulate CD8+ selected NY-ESO-1-specific T cells. Effector cells were tested for recognition of autologous B cell targets transfected with NY-ESO-1 using a recombinant vaccinia virus construct. Using a modified approach we identified the NY-ESO-1 p94-102 peptide as being recognized by CD8+ T cells in the context of HLA- B51. NY-ESO-1 p94-102 specific CD8+ T cells recognized naturally processed NY-ESO-1 presented by HLA-B51+ monocyte-derived dendritic and tumor cells. Transfection of target cells with NY-ESO-1 combined with different HLA class I alleles confirmed that the NY-ESO-1 peptide was naturally processed and recognized by HLA-B51-restricted CD8+ T cell lines and clones. Therefore, NY-ESO-1 p94-102 is a new candidate peptide antigen for cancer immunotherapy and for the monitoring of spontaneous and vaccine-induced NY-ESO-1-specific T cell responses in HLA- B51+ patients with NY-ESO-1 expressing malignancies.
pmid:12747757 fatcat:bbhdhnpz5ne3hmmxd5wh3gw6xy

Prolonged Exposure to Oxaliplatin during HIPEC Improves Effectiveness in a Preclinical Micrometastasis Model

Nick Seyfried, Can Yurttas, Markus Burkard, Benedikt Oswald, Alexander Tolios, Franziska Herster, Joseph Kauer, Tarkan Jäger, Ingmar Königsrainer, Karolin Thiel, Markus Quante, Hans-Georg Rammensee (+5 others)
2022 Cancers  
Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) was considered a promising treatment for patients with peritoneal metastasis from colorectal cancer. However, the recently published randomized controlled PRODIGE 7 trial failed to demonstrate survival benefits through the addition of short-term oxaliplatin-based HIPEC. Constituting a complex multifactorial treatment, we investigated HIPEC in a preclinical model concerning the elimination of minimal tumor
more » ... ues, thereby aiming to better understand the size of effects and respective clinical trial results. Patient samples of peritoneal perfusates obtained during HIPEC treatments and oxaliplatin-containing solutions at clinically relevant dosages, conforming with established HIPEC protocols, were assessed regarding their ability to eliminate modelled ~100 µm thickness cancer cell layers. Impedance-based real-time cell analysis and classical end-point assays were used. Flow cytometry was employed to determine the effect of different HIPEC drug solvents on tumor cell properties. Effectiveness of peritoneal perfusate patient samples and defined oxaliplatin-containing solutions proved limited but reproducible. HIPEC simulations for 30 min reduced the normalized cell index below 50% with peritoneal perfusates from merely 3 out of 9 patients within 72 h, indicating full-thickness cytotoxic effects. Instead, prolonging HIPEC to 1 h enhanced these effects and comprised 7 patients' samples, while continuous drug exposure invariably resulted in complete cell death. Further, frequently used drug diluents caused approximately 25% cell size reduction within 30 min. Prolonging oxaliplatin exposure improved effectiveness of HIPEC to eliminate micrometastases in our preclinical model. Accordingly, insufficient penetration depth, short exposure time, and the physicochemical impact of drug solvents may constitute critical factors.
doi:10.3390/cancers14051158 pmid:35267468 pmcid:PMC8909393 fatcat:iog6djhzcfhfthm57362ldyrgm

Einleitung: Alternative gesellschaftliche Entwicklungen in Lateinamerika heute – Konzeptionelle Aspekte

Markus Auinger, Johannes Jäger, Bettina Köhler, Bernhard Leubold, Barbara Nothegger
2005 Journal für Entwicklungspolitik  
Jäger/Melinz/ Zimmermann 2001) als unausweichliche Folgen der "Globalisierung" dargestellt.  ...  Jäger 2005 Franziska Herdin untersucht die alternativen gesellschaftlichen Transformationsprozesse in Venezuela.  ...  Markus Auinger, Johannes Jäger, Bettina Köhler, Bernhard Leubolt, Barbara Nothegger  ... 
doi:10.20446/jep-2414-3197-21-2-4 fatcat:4pfwu2wxnbhpbngsutdb62r64q

Supplemental material for Migration, Identity, and Threatened Mental Health: Examples from Contemporary Fiction

Moritz E. Wigand, Hauke F. Wiegand, Ertan Altintas, Markus Jäger, Thomas Becker
2018 Figshare  
Wiegand, Ertan Altintas, Markus Jäger and Thomas Becker in Transcultural Psychiatry  ... 
doi:10.25384/sage.6954791 fatcat:6aphi5tj6vagdcwg6cm6b4y72u

Early neurone loss in Alzheimer's disease: cortical or subcortical?

Thomas Arendt, Martina K Brückner, Markus Morawski, Carsten Jäger, Hermann-Josef Gertz
2015 Acta Neuropathologica Communications  
Alzheimer's disease (AD) is a degenerative disorder where the distribution of pathology throughout the brain is not random but follows a predictive pattern used for pathological staging. While the involvement of defined functional systems is fairly well established for more advanced stages, the initial sites of degeneration are still ill defined. The prevailing concept suggests an origin within the transentorhinal and entorhinal cortex (EC) from where pathology spreads to other areas. Still,
more » ... s concept has been challenged recently suggesting a potential origin of degeneration in nonthalamic subcortical nuclei giving rise to cortical innervation such as locus coeruleus (LC) and nucleus basalis of Meynert (NbM). To contribute to the identification of the early site of degeneration, here, we address the question whether cortical or subcortical degeneration occurs more early and develops more quickly during progression of AD. To this end, we stereologically assessed neurone counts in the NbM, LC and EC layer-II in the same AD patients ranging from preclinical stages to severe dementia. In all three areas, neurone loss becomes detectable already at preclinical stages and is clearly manifest at prodromal AD/MCI. At more advanced AD, cell loss is most pronounced in the NbM > LC > layer-II EC. During early AD, however, the extent of cell loss is fairly balanced between all three areas without clear indications for a preference of one area. We can thus not rule out that there is more than one way of spreading from its site of origin or that degeneration even occurs independently at several sites in parallel.
doi:10.1186/s40478-015-0187-1 pmid:25853173 pmcid:PMC4359478 fatcat:5d43pgxr4zhwpn2zdlwulx2nza

Nanoparticles of the poly([N-(2-hydroxypropyl)]methacrylamide)-b-poly[2-(diisopropylamino)ethyl methacrylate] diblock copolymer for pH-triggered release of paclitaxel

Alessandro Jäger, Eliézer Jäger, František Surman, Anita Höcherl, Borislav Angelov, Karel Ulbrich, Markus Drechsler, Vasil M. Garamus, Cesar Rodriguez-Emmenegger, Frédéric Nallet, Petr Štěpánek
2015 Polymer Chemistry  
The potential of self-assembled nanoparticles for in vitro cytostatic activity has been explored on cancer cells.
doi:10.1039/c5py00567a fatcat:v7wigdd5i5ej7pe5h2ibsdi744
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