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Effektiv trainieren

Markus Gruber, Stefanie Gruber, Andreas Kramer
2015 neuroreha  
Unter Therapeuten gilt in der Gruber M, Gruber S B H, Kramer A.  ... 
doi:10.1055/s-0041-104793 fatcat:sb6zil4ugfemvmdjgnllsvdube

Critical force in active microrheology [article]

Markus Gruber, Antonio Manuel Puertas, Matthias Fuchs
2019 arXiv   pre-print
Soft solids like colloidal glasses exhibit a yield stress, above which the system starts to flow. The microscopic analogon in microrheology is the delocalization of a tracer particle subject to an external force exceeding a threshold value, in a glassy host. We characterize this delocalization transition based on a bifurcation analysis of the corresponding mode-coupling theory equations. A schematic model is presented first, that allows analytical progress, and the full physical model is
more » ... numerically next. This analysis yields a continuous type A transition with a critical power law decay of the probe correlation functions with exponent -1/2. In order to compare with simulations with a limited duration, a finite time analysis is performed, which yields reasonable results for not-too-small wave vectors. The theoretically predicted findings are verified by Langevin dynamics simulations. For small wave vectors we find anomalous behavior for the probe position correlation function, which can be traced back to a wave vector divergence of the critical amplitude. In addition we propose and test three methods to extract the critical force from experimental data, which provide the same value of the critical force when applied to the finite-time theory or simulations.
arXiv:1910.10198v1 fatcat:pngouzageffmbny2zgxxu7tjhu

Structure-Based Characterization of Multiprotein Complexes

Markus Wiederstein, Markus Gruber, Karl Frank, Francisco Melo, Manfred J. Sippl
2014 Structure  
doi:10.1016/j.str.2014.05.005 pmid:24954616 pmcid:PMC4087271 fatcat:wzxfexjvu5fxjcfeifebcuphj4

Telomeres and Age-Related Diseases

Hans-Jürgen Gruber, Maria Donatella Semeraro, Wilfried Renner, Markus Herrmann
2021 Biomedicines  
.; Gruber, H.J.; Herrmann, M. Physical activity, a modulator of aging through effects on telomere biology. Aging 2020, 12, 13803-13823. [CrossRef] 52.  ... 
doi:10.3390/biomedicines9101335 pmid:34680452 fatcat:ugtvnn5vujcglcyfyyi2zc34ua

The Structure of α-Helical Coiled Coils [chapter]

Andrei N. Lupas, Markus Gruber
2005 Advances in Protein Chemistry  
Hendecads and pentadecads are part of a larger picture (Gruber and Lupas, 2003) .  ... 
doi:10.1016/s0065-3233(05)70003-6 pmid:15837513 fatcat:swxmhuyi5fa6rcvc4fskqcr7x4

Orbitale Blutung während eines Tauchgangs

Markus Gruber, Thomas Reinhard, Philip Maier
2020 Der Ophthalmologe  
Therapie und Verlauf Diskussion » Diagnose: Implosion einer hohlwandigen Glasprothese aufgrund des Wasserdrucks Korrespondenzadresse Markus Gruber Klinik für Augenheilkunde, Universitätsklinikum  ...  Gruber, T. Reinhard und P. Maier geben an, dass kein Interessenkonflikt besteht. Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt.  ... 
doi:10.1007/s00347-020-01144-z pmid:32572553 fatcat:o5bdkbpzwjbx7oxwmz7c7dj4be

The size of Higman–Haines sets

Hermann Gruber, Markus Holzer, Martin Kutrib
2007 Theoretical Computer Science  
We show that for the family of Church-Rosser languages the Higman-Haines sets, which are the sets of all scattered subwords of a given language and the sets of all words that contain some word of a given language as a scattered subword, cannot be effectively constructed, although both these sets are regular for any language. This nicely contrasts the result on the effectiveness of the Higman-Haines sets for the family of context-free languages. The non-effectiveness is based on a non-recursive
more » ... radeoff result between the language description mechanism of Church-Rosser languages and the corresponding Higman-Haines sets, which in turn is also valid for all supersets of the language family under consideration, and in particular for the family of recursively enumerable languages. Finally for the family of regular languages we prove an upper and a matching lower bound on the size of the Higman-Haines sets in terms of nondeterministic finite automata.
doi:10.1016/j.tcs.2007.07.036 fatcat:pj5zmp5dfvhuvjridivq7l4zia

EmpiReS: Differential Analysis of Gene Expression and Alternative Splicing [article]

Gergely Csaba, Evi Berchtold, Armin Hadziahmetovic, Markus Gruber, Constantin Ammar, Ralf Zimmer
2020 bioRxiv   pre-print
While absolute quantification is challenging in high-throughput measurements, changes of features between conditions can often be determined with high precision. Therefore, analysis of fold changes is the standard method, but often, a doubly differential analysis of "changes of changes" is required. Differential alternative splicing is an example of a doubly differential analysis, i.e. fold changes between conditions for different isoforms of a gene. EmpiRe is a quantitative approach for
more » ... kinds of omics data based on fold changes for appropriate features of biological objects. Empirical error distributions for these fold changes are estimated from Replicate measurements and used to quantify feature fold changes and their directions. We assess the performance of EmpiRe to detect differentially expressed genes applied to RNA-Seq using simulated data. It achieved higher precision than established tools at nearly the same recall level. Furthermore, we assess the detection of alternatively Spliced genes via changes of isoform fold changes (EmpiReS) on distribution-free simulations and experimentally validated splicing events. EmpiReS achieves the best precision-recall values for simulations based on different biological datasets. We propose EmpiRe(S) as a general, quantitative and fast approach with high reliability and an excellent trade-off between sensitivity and precision in (doubly) differential analyses.
doi:10.1101/2020.08.23.234237 fatcat:ibi2eug5bzc5pft4ijchbqim6i

The performance of balance exercises during daily tooth brushing is not sufficient to improve balance and muscle strength in healthy older adults

Urs Granacher, Thomas Muehlbauer, Gerd Göstemeyer, Stefanie Gruber, Markus Gruber
2021 BMC Geriatrics  
Background High prevalence rates have been reported for physical inactivity, mobility limitations, and falls in older adults. Home-based exercise might be an adequate means to increase physical activity by improving health- (i.e., muscle strength) and skill-related components of physical fitness (i.e., balance), particularly in times of restricted physical activity due to pandemics. Objective The objective of this study was to examine the effects of home-based balance exercises conducted during
more » ... daily tooth brushing on measures of balance and muscle strength in healthy older adults. Methods Fifty-one older adults were randomly assigned to a balance exercise group (n = 27; age: 65.1 ± 1.1 years) or a passive control group (n = 24; age: 66.2 ± 3.3 years). The intervention group conducted balance exercises over a period of eight weeks twice daily for three minutes each during their daily tooth brushing routine. Pre- and post-intervention, tests were included for the assessment of static steady-state balance (i.e., Romberg test), dynamic steady-state balance (i.e., 10-m single and dual-task walk test using a cognitive and motor interference task), proactive balance (i.e., Timed-Up-and-Go Test [TUG], Functional-Reach-Test [FRT]), and muscle strength (i.e., Chair-Rise-Test [CRT]). Results Irrespective of group, the statistical analysis revealed significant main effects for time (pre vs. post) for dual-task gait speed (p < .001, 1.12 ≤ d ≤ 2.65), TUG (p < .001, d = 1.17), FRT (p = .002, d = 0.92), and CRT (p = .002, d = 0.94) but not for single-task gait speed and for the Romberg-Test. No significant group × time interactions were found for any of the investigated variables. Conclusions The applied lifestyle balance training program conducted twice daily during tooth brushing routines appears not to be sufficient in terms of exercise dosage and difficulty level to enhance balance and muscle strength in healthy adults aged 60–72 years. Consequently, structured balance training programs using higher exercise dosages and/or more difficult balance tasks are recommended for older adults to improve balance and muscle strength.
doi:10.1186/s12877-021-02206-w pmid:33865308 fatcat:dvmvku3475fuhkhrumwmexzt5a

Language operations with regular expressions of polynomial size

Hermann Gruber, Markus Holzer
2009 Theoretical Computer Science  
This work deals with questions regarding to what extent regularity-preserving language operations affect the descriptional complexity of regular expressions. Some language operations are identified which are feasible for regular expressions in the sense that the result of the operation can be represented as a regular expression of size polynomial in that of the operands. We prove that taking language quotients, in particular the prefix and suffix closures, of a regular set can incur at most a
more » ... adratic blow-up on the required expression size. The circular shift operation can cause only a cubic increase in size and an at least quadratic bloat can be necessary in the worst case.
doi:10.1016/j.tcs.2009.04.009 fatcat:xu4jvacrjbci3ks7g2jklheahu

Convergence Proof for Actor-Critic Methods Applied to PPO and RUDDER [article]

Markus Holzleitner, Lukas Gruber, José Arjona-Medina, Johannes Brandstetter, Sepp Hochreiter
2020 arXiv   pre-print
We prove under commonly used assumptions the convergence of actor-critic reinforcement learning algorithms, which simultaneously learn a policy function, the actor, and a value function, the critic. Both functions can be deep neural networks of arbitrary complexity. Our framework allows showing convergence of the well known Proximal Policy Optimization (PPO) and of the recently introduced RUDDER. For the convergence proof we employ recently introduced techniques from the two time-scale
more » ... c approximation theory. Our results are valid for actor-critic methods that use episodic samples and that have a policy that becomes more greedy during learning. Previous convergence proofs assume linear function approximation, cannot treat episodic examples, or do not consider that policies become greedy. The latter is relevant since optimal policies are typically deterministic.
arXiv:2012.01399v1 fatcat:xtrzqeoucnbsvfvcflhqwjueoq

Short Regular Expressions from Finite Automata: Empirical Results [chapter]

Hermann Gruber, Markus Holzer, Michael Tautschnig
2009 Lecture Notes in Computer Science  
Gruber, M. Holzer: Provably shorter regular expressions from deterministic finite automata (extended abstract). In Proc.  ... 
doi:10.1007/978-3-642-02979-0_22 fatcat:46b7oliwrjcinekkxnv3rvftce

More on Deterministic and Nondeterministic Finite Cover Automata [chapter]

Hermann Gruber, Markus Holzer, Sebastian Jakobi
2015 Lecture Notes in Computer Science  
Finite languages are an important sub-regular language family, which were intensively studied during the last two decades in particular from a descriptional complexity perspective. An important contribution to the theory of finite languages are the deterministic and the recently introduced nondeterministic finite cover automata (DFCAs and NFCAs, respectively) as an alternative representation of finite languages by ordinary finite automata. We compare these two types of cover automata from a
more » ... riptional complexity point of view, showing that these devices have a lot in common with ordinary finite automata. In particular, we study how to adapt lower bound techniques for nondeterministic finite automata to NFCAs such as, e.g., the biclique edge cover technique, solving an open problem from the literature. Moreover, the tradeoff of conversions between DFCAs and NFCAs as well as between finite cover automata and ordinary finite automata are investigated. Finally, we present some results on the average size of finite cover automata.
doi:10.1007/978-3-319-22360-5_10 fatcat:xezi36ob3bcirfm3ssikhhtyuq

Die Herzschulbewegung

Jakob Gruber, Markus Weinbacher, Andreas Fried
2017 Schweizerische Zeitschrift für Ganzheitsmedizin / Swiss Journal of Integrative Medicine  
www.herzschule-muenchen.de Jakob Gruber a Markus Weinbacher b Andreas Fried c Aus der Praxis für die Praxis Schweiz Z Ganzheitsmed 2017;29:94-96 95 tienten und Therapeuten erstreckt sich über  ...  Jakob Gruber Leitender Oberarzt Innere Medizin und Leitender Arzt Kardiologie Gemeinschaftskrankenhaus Herdecke gemeinnützige GmbH Gerhard-Kienle-Weg 4, 58313 Herdecke, Deutschland innere @ gemeinschaftskrankenhaus.de  ... 
doi:10.1159/000464383 fatcat:k24y67fpond7zms4tqjflceeja

Tight Bounds on the Descriptional Complexity of Regular Expressions [chapter]

Hermann Gruber, Markus Holzer
2009 Lecture Notes in Computer Science  
We improve on some recent results on lower bounds for conversion problems for regular expressions. In particular we consider the conversion of planar deterministic finite automata to regular expressions, study the effect of the complementation operation on the descriptional complexity of regular expressions, and the conversion of regular expressions extended by adding intersection or interleaving to ordinary regular expressions. Almost all obtained lower bounds are optimal, and the presented
more » ... mples are over a binary alphabet, which is best possible. Conversion known results this paper with |Σ| = 2 planar DFA to RE 2 Θ( √ n) for |Σ| = 4 [10] 2 Θ( √ n) [Thm. 4]
doi:10.1007/978-3-642-02737-6_22 fatcat:zo6ay47qazekvixb2m5flrwlku
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