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KMap: Providing Orientation for Practitioners When Introducing Knowledge Management [chapter]

Stefanie Lindstaedt, Markus Strohmaier, Herwig Rollett, Janez Hrastnik, Karin Bruhnsen, Georg Droschl, Markus Gerold
2002 Lecture Notes in Computer Science  
Bruhnsen, Georg Droschl, Markus Gerold Stefanie Lindstaedt, Markus Strohmaier, Herwig Rollett, Janez Hrastnik, Karin Bruhnsen, Stefanie Lindstaedt, Markus Strohmaier, Herwig Rollett, Janez Hrastnik  ...  Thus, KMap can be tailored to specific 8 Stefanie Lindstaedt, Markus Strohmaier, Herwig Rollett, Janez Hrastnik, Karin Bruhnsen, Georg Droschl, Markus Gerold needs of a variety of potential users and ensures  ... 
doi:10.1007/3-540-36277-0_2 fatcat:drybaixlonbwtjrych5uhhlzw4

Human Borrelia miyamotoi Infection, Austria

Selma Tobudic, Heinz Burgmann, Gerold Stanek, Stefan Winkler, Anna-Margarita Schötta, Markus Obermüller, Mateusz Markowicz, Heimo Lagler
2020 Emerging Infectious Diseases  
Selma Tobudic, Heinz Burgmann , Gerold Stanek, Stefan Winkler, Anna-Margarita Schötta, Markus Obermüller, Mateusz Markowicz, Heimo Lagler Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 26, No. 9  ... 
doi:10.3201/eid2609.191501 pmid:32818401 fatcat:of5b5a3eejhlnmux54c54np7be

Frequency-selective induction of excitation waves near sub- and supercritical Hopf bifurcation

Gerold Baier, Markus Müller
2004 Physics Letters A  
We study diffusively coupled excitable systems where local perturbations induces propagation waves only within finite frequency bands. Resonance-associated complex wave trains are found for parameters fixed near the subcritical Hopf bifurcation, and crisis-associated regular spiking near a supercritical Hopf bifurcation. Whereas in the subcritical case the qualitative excitation pattern of the coupled system is similar to that of an individual element, in the supercritical case the coupling
more » ... s as a narrow band-pass filter for the external perturbation.
doi:10.1016/j.physleta.2004.07.057 fatcat:eucnvqwrbnhkhdmt2rjxqljw7e

Understanding human functioning using graphical models

Markus Kalisch, Bernd AG Fellinghauer, Eva Grill, Marloes H Maathuis, Ulrich Mansmann, Peter Bühlmann, Gerold Stucki
2010 BMC Medical Research Methodology  
Functioning and disability are universal human experiences. However, our current understanding of functioning from a comprehensive perspective is limited. The development of the International Classification of Functioning, Disability and Health (ICF) on the one hand and recent developments in graphical modeling on the other hand might be combined and open the door to a more comprehensive understanding of human functioning. The objective of our paper therefore is to explore how graphical models
more » ... an be used in the study of ICF data for a range of applications. Methods: We show the applicability of graphical models on ICF data for different tasks: Visualization of the dependence structure of the data set, dimension reduction and comparison of subpopulations. Moreover, we further developed and applied recent findings in causal inference using graphical models to estimate bounds on intervention effects in an observational study with many variables and without knowing the underlying causal structure. Results: In each field, graphical models could be applied giving results of high face-validity. In particular, graphical models could be used for visualization of functioning in patients with spinal cord injury. The resulting graph consisted of several connected components which can be used for dimension reduction. Moreover, we
doi:10.1186/1471-2288-10-14 pmid:20149230 pmcid:PMC2831907 fatcat:vrypuvbty5hydigylwhfcwku4m

Production of Lycopene in the Non-Carotenoid-Producing Yeast Yarrowia lipolytica

Falk Matthäus, Markus Ketelhot, Michael Gatter, Gerold Barth
2013 Applied and Environmental Microbiology  
ABSTRACTThe codon-optimized genescrtBandcrtIofPantoea ananatiswere expressed inYarrowia lipolyticaunder the control of theTEF1promoter ofY. lipolytica. Additionally, the rate-limiting genes for isoprenoid biosynthesis inY. lipolytica,GGS1andHMG1, were overexpressed to increase the production of lycopene. All of the genes were also expressed in aY. lipolyticastrain withPOX1toPOX6andGUT2deleted, which led to an increase in the size of lipid bodies and a further increase in lycopene production.
more » ... opene is located mainly within lipid bodies, and increased lipid body formation leads to an increase in the lycopene storage capacity ofY. lipolytica. Growth-limiting conditions increase the specific lycopene content. Finally, a yield of 16 mg g−1(dry cell weight) was reached in fed-batch cultures, which is the highest value reported so far for a eukaryotic host.
doi:10.1128/aem.03167-13 pmid:24375130 pmcid:PMC3957620 fatcat:hyeuxufkjza33gea7chidtormm

Characterizing correlation changes of complex pattern transitions: The case of epileptic activity

Gerold Baier, Markus Müller, Ulrich Stephani, Hiltrud Muhle
2007 Physics Letters A  
We analyze the time-dependent spectrum of eigenvalues of the correlation matrix for multivariate EEG data at the transition to epileptic seizures. By a mechanism of level repulsion between states at both edges of the spectrum of the correlation matrix, relevant information about quantitative correlation changes is reflected in the largest and smallest eigenvalues and corresponding eigenvectors. By the application of measures from random matrix theory we provide evidence that statistically
more » ... nt information can be obtained both at the upper and the lower end of the spectrum. In addition, information about spatial characteristics of correlation changes can be extracted.
doi:10.1016/j.physleta.2006.11.003 fatcat:aej7u5fawzchpprmrmlhluywsm

Evolution of Genuine Cross-Correlation Strength of Focal Onset Seizures

Markus F. Müller, Gerold Baier, Yurytzy López Jiménez, Arlex O. Marín García, Christian Rummel, Kaspar Schindler
2011 Journal of clinical neurophysiology  
To quantify the evolution of genuine zero-lag cross-correlations of focal onset seizures, we apply a recently introduced multivariate measure to broad band and to narrow-band EEG data. For frequency components below 12.5 Hz, the strength of genuine cross-correlations decreases significantly during the seizure and the immediate postseizure period, while higher frequency bands show a tendency of elevated cross-correlations during the same period. We conclude that in terms of genuine zero-lag
more » ... -correlations, the electrical brain activity as assessed by scalp electrodes shows a significant spatial fragmentation, which might promote seizure offset.
doi:10.1097/wnp.0b013e318231c894 pmid:21946370 fatcat:sd6b47swxfc3lerh7xgzonidvi

Detection and characterization of changes of the correlation structure in multivariate time series

Markus Müller, Gerold Baier, Andreas Galka, Ulrich Stephani, Hiltrud Muhle
2005 Physical Review E  
We propose a method based on the equal-time correlation matrix as a sensitive detector for phase-shape correlations in multivariate data sets. The key point of the method is that changes of the degree of synchronization between time series provoke level repulsions between eigenstates at both edges of the spectrum of the correlation matrix. Consequently, detailed information about the correlation structure of the multivariate data set is imprinted into the dynamics of the eigenvalues and into
more » ... structure of the corresponding eigenvectors. The performance of the technique is demonstrated by application to N f -tori, autoregressive models, and coupled chaotic systems. The high sensitivity, the comparatively small computational effort, and the excellent time resolution of the method recommend it for application to the analysis of complex, spatially extended, nonstationary systems.
doi:10.1103/physreve.71.046116 pmid:15903735 fatcat:4nkvj7hcmjc53hhujll7hw4jnq

Neutron diffraction study of (KxNa1−x)NbO3-based ceramics from low to high temperatures

Henry Mgbemere, Gerold Schneider, Markus Hoelzel, Manuel Hinterstein
2016 Journal of Applied Crystallography  
A neutron diffraction study of (KxNa1−x)NbO3-based ceramics has been carried out from 5 K to high temperatures well above the Curie temperature. The diffraction data were analysed using Rietveld refinement. For pure KNN samples, especially at the Na-rich side of the phase diagram, the low-temperature structure of simple rhombohedral symmetry changes to a highly complex monoclinic structure at a higher temperature. Chemical analysis on the samples showed good agreement of the expected and actual
more » ... compositions. Trigonal, monoclinic, orthorhombic, tetragonal and cubic phase models as well as two-phase mixtures are observed depending on the temperature of measurement. Space groupsR3c,P1m1,P11m,Amm2,P4mm, Pm\overline 3m and their combinations are used to refine the trigonal, monoclinic, orthorhombic, tetragonal, cubic and mixed phases, respectively. For the (K0.48Na0.48Li0.04)(Nb0.86Ta0.1Sb0.04)O3sample at temperatures between 5 and 300 K, the monoclinicP11mspace group gives the best refinement fit. For the (K0.17Na0.83)NbO3sample, a two-phase refinement using the trigonalR3cand monoclinicPmspace groups gave the best fit at 300 K, while at 5–150 K the trigonalR3cspace group gives the best fit. The understanding of the structure of these lead-free ceramics will help in the optimization of their piezoelectric properties.
doi:10.1107/s1600576716005197 fatcat:thaiwwk5pzevxkja6e5j7ideky

Antihypertensive Treatment in Kidney Transplant Recipients-A Current Single Center Experience

Ulrich Jehn, Katharina Schütte-Nütgen, Markus Strauss, Jan Kunert, Hermann Pavenstädt, Gerold Thölking, Barbara Suwelack, Stefan Reuter
2020 Journal of Clinical Medicine  
Arterial hypertension affects the survival of the kidney graft and the cardiovascular morbidity and mortality of the recipient after kidney transplantation (KTx). Thus, antihypertensive treatment is necessary for a vast majority of these patients. Long-term data on antihypertensive drugs and their effects on allograft function after KTx is still limited, and further investigation is required. We retrospectively analyzed a cohort of 854 recipients who received a kidney transplant at our
more » ... t center between 2007 and 2015 with regard to antihypertensive treatment and its influence on graft function and survival. 1-y after KTx, 95.3% patients were treated with antihypertensive therapy. Of these, 38.6% received mono- or dual-drug therapy, 38.0% received three to four drugs and 8.1% were on a regimen of ≥5 drugs. Beta-blockers were the most frequently used antihypertensive agents (68.1%). Neither the use of angiotensin-converting enzyme inhibitor/angiotensin receptor blockers (51.9%) and calcium channel blockers (51.5%), nor the use the use of loop diuretics (38.7%) affected allograft survival. Arterial hypertension and the number of antihypertensive agents were associated with unfavorable allograft outcomes (each p < 0.001). In addition to the well-known risk factors of cold ischemic time and acute rejection episodes, the number of antihypertensive drugs after one year, which reflects the severity of hypertension, is a strong predictor of unfavorable allograft survival.
doi:10.3390/jcm9123969 pmid:33297518 pmcid:PMC7762385 fatcat:l3uewkra4rcijgv7zk3sdcvmpu

Age and gender related neuromuscular changes in trunk flexion-extension

Thomas Kienbacher, Birgit Paul, Richard Habenicht, Christian Starek, Markus Wolf, Josef Kollmitzer, Patrick Mair, Gerold Ebenbichler
2015 Journal of NeuroEngineering and Rehabilitation  
The root mean square surface electromyographic activity of lumbar extensor muscles during dynamic trunk flexion and extension from a standing position and task specific spine ranges of motion objectively assess muscle function in healthy young and middle age individuals. However, literature on neuromuscular activation and associated spine and hip kinematics in older individuals is sparse. This cross sectional study sought to examine the sex and age (<40 versus >60 years) related differences in
more » ... he neuromuscular activation profiles of the lumbar extensors and the related spine and hip kinematics from healthy individuals during a standardized trunk flexion-extension task. Methods: Twenty five older (13 females, 60-90 years) and 24 younger (12 females, 18-40 years) healthy individuals performed trunk flexion-extension testing by holding static positions at half-flexion way and full range of motion between standing and maximum trunk flexion. The associated lumbar extensor muscle activity was derived from measurements at standing, half, and maximum flexion positions. The range of motion at the hip and lumbar spine was recorded using 3d accelerometers attached to the skin overlying the multifidus and semispinalis thoracis muscles lateral to the L5 and T4 spinous processes, respectively. Statistical calculations were performed using a permutation ANOVA with bootstrap confidence intervals. Results: The muscle activity in the half related to the maximum flexion position (half flexion relaxation ratio) was significantly smaller in older males when compared with younger males. Moreover, measurements revealed smaller activity changes from standing to the half and from half to the maximum flexion position in older compared to younger individuals. Older males displayed smaller gross trunk range of motion from standing to maximum flexion than any other group. Conclusions: Gender and normal aging significantly affect both the activation patterns of the lumbar extensor muscles and the kinematics of the trunk during a standardized trunk flexion-extension task. Measurement results from healthy young and middle age individuals should not be used for the assessment of individuals older than 60 years of age.
doi:10.1186/1743-0003-12-3 pmid:25566847 pmcid:PMC4326518 fatcat:ii7xtjvl6jhs3orvwu6htnvteu

Two new proteases in the MHC class I processing pathway

Lars Stoltze, Markus Schirle, Gerold Schwarz, Christian Schröter, Michael W. Thompson, Louis B. Hersh, Hubert Kalbacher, Stefan Stevanovic, Hans-Georg Rammensee, Hansjörg Schild
2000 Nature Immunology  
The proteasome generates exact major histocompatibility complex (MHC) class I ligands as well as NH 2 -terminal-extended precursor peptides. The proteases responsible for the final NH 2 -terminal trimming of the precursor peptides had, until now, not been determined. By using specific selective criteria we purified two cytosolic proteolytic activities, puromycin-sensitive aminopeptidase and bleomycin hydrolase. These proteases could remove NH 2 -terminal amino acids from the vesicular
more » ... virus nucleoprotein cytotoxic T cell epitope 52-59 (RGYVYQGL) resulting, in combination with proteasomes, in the generation of the correct epitope. Our data provide evidence for the existence of redundant systems acting downstream of the proteasome in the antigen-processing pathway for MHC class I molecules.
doi:10.1038/80852 pmid:11062501 fatcat:fwiyvgj5lnew3h7gnphnx3rpku

Pharmacokinetics of cathinone, cathine and norephedrine after the chewing of khat leaves

Stefan W. Toennes, Sebastian Harder, Markus Schramm, Constanze Niess, Gerold F. Kauert
2003 British Journal of Clinical Pharmacology  
Aim The stimulating herbal drug khat is habitually used in East Africa and the Arabian peninsula but is also imported into other countries. The aim was to study the pharmacokinetics of its alkaloids cathinone, cathine and norephedrine. Methods Four volunteers chewed khat leaves in an amount equivalent to onequarter of that used in a typical khat session. Blood samples were collected up to 80 h and the alkaloids were assayed using gas chromatography-mass spectrometry. The data were evaluated
more » ... g computerized pharmacokinetic compartmental analysis. Results The plasma concentration-time data for the alkaloids could be described using a two-compartment model with two-segment absorption. The mucosa of the oral cavity is considered to be the first absorption segment, where the major proportion of the alkaloids is absorbed (mean ± SD 59 ± 21% for cathinone and 84 ± 6% for cathine). The extraction of the alkaloids from the leaves by chewing was very effective with only 9.1 ± 4.2% remaining as a residue. Cathinone was eliminated from the central compartment with a mean half-life of 1.5 ± 0.8 h. The half-life of cathine was 5.2 ± 3.4 h. The metabolism of cathinone to norephedrine had a substantial influence on its plasma concentration profile. Psychophysical functions were essentially unaffected by the chewing of khat. Conclusions The pharmacokinetics of khat alkaloids in humans explain why chewing is the preferred form of khat ingestion. Subjects absorbed a mean dose of 45 mg of cathinone, and did not suffer any severe adverse reactions.
doi:10.1046/j.1365-2125.2003.01834.x pmid:12848785 pmcid:PMC1884326 fatcat:7mqkauyjqfdmdpt6v4gcsfxmsi

Nonlinear dynamic conversion of analog signals into excitation patterns

Gerold Baier, Markus Müller
2004 Physical Review E  
Local periodic perturbations induce frequency-dependent propagation waves in an excitable spatio-temporally chaotic system. We show how segments of noise-contaminated and chaotic perturbations induce characteristic sequences of excitations in the model system. Using a set of tuned excitable systems, it is possible to characterize signals by their spectral composition of excitation pattern. As an example we analyze an epileptic spike-and-wave time series.
doi:10.1103/physreve.70.037201 pmid:15524677 fatcat:ytznbwp7jrdbpl7pacuyvrkpvm

Expanding the Host Range of Hepatitis C Virus through Viral Adaptation

Markus von Schaewen, Marcus Dorner, Kathrin Hueging, Lander Foquet, Sherif Gerges, Gabriela Hrebikova, Brigitte Heller, Julia Bitzegeio, Juliane Doerrbecker, Joshua A. Horwitz, Gisa Gerold, Sebastian Suerbaum (+4 others)
2016 mBio  
This work, including the efforts of Markus von Schaewen, was funded by Deutsche Forschungsgemeinschaft (DFG).  ... 
doi:10.1128/mbio.01915-16 pmid:27834208 pmcid:PMC5101358 fatcat:4pde53i5ujcynap6y254n2zzy4
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