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Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

Cristina Cudalbu, Pierre Bady, Marta Lai, Lijing Xin, Olga Gusyatiner, Marie-France Hamou, Mario Lepore, Jean-Philippe Brouland, Roy T. Daniel, Andreas F. Hottinger, Monika E. Hegi
2021 Acta Neuropathologica Communications  
PDOX) in the mouse and the corresponding patients' tumors.  ...  MRS analyses sampled across different areas of the patients' tumors.  ...  Acknowledgements We thank the patients and their families for their support and participation. Information about TCGA can be found at "http:// cance rgeno me. nih. gov".  ... 
doi:10.1186/s40478-021-01232-4 fatcat:vufxxwz7jffehlk4eyrt2435ay

Minichromosome Maintenance (MCM) Family as potential diagnostic and prognostic tumor markers for human gliomas

Cong Hua, Gang Zhao, Yunqian Li, Li Bie
2014 BMC Cancer  
Conclusions: High expression of MCM 2, MCM3 and MCM7 mRNA correlated with poor outcome and may be clinically useful molecular prognostic markers in glioma.  ...  Furthermore, we report that MCM7 is strongly correlated with patient outcome in patients with WHO grade II-IV tumor.  ...  Here we report that MCM family genes are almost upregulated in 59 human glioma tumor samples compared to six normal brain controls by qRT-PCR.  ... 
doi:10.1186/1471-2407-14-526 pmid:25046975 pmcid:PMC4223428 fatcat:3mgupawzsbdgze6u5atqs3hq2i

Pathologic Correlates of Primary Central Nervous System Lymphoma Defined in an Orthotopic Xenograft Model

C. Kadoch, E. B. Dinca, R. Voicu, L. Chen, D. Nguyen, S. Parikh, J. Karrim, M. A. Shuman, C. A. Lowell, P. A. Treseler, C. D. James, J. L. Rubenstein
2009 Clinical Cancer Research  
We also show for the first time the feasibility and accuracy of tumor bioluminescence in the monitoring of a highly infiltrative brain tumor.  ...  Purpose: The prospect for advances in the treatment of patients with primary central nervous system lymphoma (PCNSL) is likely dependent on the systematic evaluation of its pathobiology.  ...  A recent analysis of the cerebrospinal fluid proteome in brain tumor patients showed that tryptic peptides derived from CD14, a marker of activated macrophages, are significantly up-regulated in patients  ... 
doi:10.1158/1078-0432.ccr-08-2054 pmid:19276270 pmcid:PMC4372389 fatcat:vytk4jq63fge3ki3qb4ypir2ay


Roberta P. Glick, Terry Lichtor
2001 Neuro-Oncology  
The goals of this meeting were 3-fold: to present and evaluate current laboratory and clinical research in the field of brain tumor immunotherapy in order to coordinate and disseminate current information  ...  gene, was injected into 9L gliosarcoma brain tumors in Fischer rats.  ... 
doi:10.1093/neuonc/3.4.258 pmid:11584896 pmcid:PMC1920623 fatcat:rco3v4sob5e7jo2bhwzaqz5vnu

Diagnostic value of PRND gene expression profiles in astrocytomas: Relationship to tumor grades of malignancy

S. Comincini, V. Ferrara, A. Arias, A. Malovini, A. Azzalin, L. Ferretti, E. Benericetti, M. Cardarelli, M. Gerosa, M. Passarin, S. Turazzi, R. Bellazzi
2007 Oncology Reports  
Extensive differences in PRND gene expression were also found within each grade of malignancy, suggesting that PRND mRNA quantitation might be useful to distinguish astrocytoma subtypes, and important  ...  Recently, ectopic expression of doppel was found in two different tumor types, specifically in glial and haematological cancers.  ...  RNA normalisation was performed using GAPDH as a housekeeping gene, after a selection of appropriate reference genes (GAPDH, ACTB, ß-tubulin, HPRT).  ... 
doi:10.3892/or.17.5.989 fatcat:o357gawb3zafjkmbcqiy4z6rpi

Promoter hypermethylation profiling of distant breast cancer metastases

Willemijne A. M. E. Schrijver, Laura S. Jiwa, Paul J. van Diest, Cathy B. Moelans
2015 Breast Cancer Research and Treatment  
These promising findings warrant further validation in larger patient cohorts and more tumor suppressor genes.  ...  Methylation status of 40 tumor suppressor genes was compared between 53 primary breast tumors and their corresponding metastases to brain, lung, liver, or skin.  ...  tumor suppressor genes show high patient specificity.  ... 
doi:10.1007/s10549-015-3362-y pmid:25841351 pmcid:PMC4408366 fatcat:hujc3lhwknbz7ipjytzpoerdte

Inhibition of N-Myc down regulated gene 1 inin vitrocultured human glioblastoma cells

Harun M Said
2012 World Journal of Clinical Oncology  
and contributed to the development of the experimental strategy; Anacker J designed the primers used for reverse transcription polymerase chain reaction and participated in the study design and evaluation  ...  in the study design; Polat B, Stein S, Guckenberger M and Hagemann C co-authored the manuscript and participated in the study design; Said HM, Stein S, Hagemann C and Vordermark D coordinated the group  ...  CONCLUSION: NDRG1 represents an additional diagnostic marker for brain tumor detection, due to the role of hypoxia in regulating this gene, and it can Said HM et al .  ... 
doi:10.5306/wjco.v3.i7.104 pmid:22787578 pmcid:PMC3394081 fatcat:gvc4vsw5yrdrfduph2sqoxe2da

Translational Application of Circulating DNA in Oncology: Review of the Last Decades Achievements

Tuaeva, Falzone, Porozov, Nosyrev, Trukhan, Kovatsi, Spandidos, Drakoulis, Kalogeraki, Mamoulakis, Tzanakakis, Libra (+1 others)
2019 Cells  
In particular, special attention was paid to the early diagnosis of primary cancer, to the diagnosis of tumors with an unknown primary location, and finally to the prognosis of cancer patients.  ...  In recent years, the introduction of new molecular techniques in experimental and clinical settings has allowed researchers and clinicians to propose circulating-tumor DNA (ctDNA) analysis and liquid biopsy  ...  Alternatively, it might be useful to perform a massively parallel sequencing as done by Leary and coworkers in order to select specific targets to be analyzed in ctDNA [57] .  ... 
doi:10.3390/cells8101251 pmid:31615102 pmcid:PMC6829588 fatcat:g4pb6n4o5jfzrbg7wonixpgnaq

Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas

Michael E. Berens, Anup Sood, Jill S. Barnholtz-Sloan, John F. Graf, Sanghee Cho, Seungchan Kim, Jeffrey Kiefer, Sara A. Byron, Rebecca F. Halperin, Sara Nasser, Jonathan Adkins, Lori Cuyugan (+17 others)
2019 PLoS ONE  
Multiplexed immunofluorescence (MxIF) was used to generate single cell data for 43 protein markers representing all cancer hallmarks, Genomic sequencing (exome and RNA (normal and tumor) and magnetic resonance  ...  Protein expression by hallmark was generally lower in the IDHmt vs wt patients.  ...  In parallel, marker staining is evaluated by reviewing AF removed images and markers that failed to stain or images with large artefacts are removed from analysis.  ... 
doi:10.1371/journal.pone.0219724 pmid:31881020 pmcid:PMC6934292 fatcat:3yl5u3ugyzbezgkczzroqnxzaq

MicroRNA Signatures as Biomarkers and Therapeutic Target for CNS Embryonal Tumors: The Pros and the Cons

Tarek Shalaby, Giulio Fiaschetti, Martin Baumgartner, Michael Grotzer
2014 International Journal of Molecular Sciences  
However the successful use of microRNAs as reliable biomarkers for the detection and management of pediatric brain tumors represents a substantial challenge.  ...  Recent neurobiological studies have uncovered the key role of microRNAs (miRNAs) in embryonal tumors biology and their potential use as biomarkers is increasingly being recognized and investigated.  ...  miRNAs is used as marker.  ... 
doi:10.3390/ijms151121554 pmid:25421247 pmcid:PMC4264241 fatcat:qntcsfcgdze55hzcfdt2hvexqu

ISG20 promotes local tumor immunity and contributes to poor survival in human glioma

Mengqi Gao, Yi Lin, Xing Liu, Yiming Li, Chuanbao Zhang, Zheng Wang, Zhiliang Wang, Yulin Wang, Zongze Guo
2018 Oncoimmunology  
Only one gene, interferon-stimulated exonuclease gene 20 (ISG20), with reduced expression in IDH mutant tumors, demonstrated significant prognostic value.  ...  We conclude that ISG20 is a useful biomarker to identify IDH-mediated immune processes in glioma and may serve as a potential therapeutic target.  ...  Brain Tumor Center.  ... 
doi:10.1080/2162402x.2018.1534038 pmid:30713788 pmcid:PMC6343791 fatcat:fsv2or5a2zc7hol2sdd5lj2tjy

High-Resolution Cartography of the Transcriptome and Methylome Landscapes of Diffuse Gliomas

Edith Willscher, Lydia Hopp, Markus Kreuz, Maria Schmidt, Siras Hakobyan, Arsen Arakelyan, Bettina Hentschel, David T. W. Jones, Stefan M. Pfister, Markus Loeffler, Henry Loeffler-Wirth, Hans Binder
2021 Cancers  
Thereby, molecular cartography provides a graphical coordinate system that links gene-level information with glioma subtypes, their phenotypes, and clinical context.  ...  We analyzed details of coregulation between gene expression and DNA methylation and of the immunogenic micro-environment presumably driving tumor development and treatment resistance.  ...  Epitranscriptome-related genes are activated in gliomas compared with brain-like NL tumors.  ... 
doi:10.3390/cancers13133198 pmid:34206856 pmcid:PMC8268631 fatcat:kmtuj7tm3jfmth5spbipu6bxce

Keratin 13 expression reprograms bone and brain metastases of human prostate cancer cells

Qinlong Li, Lijuan Yin, Lawrence W. Jones, Gina C-Y Chu, Jason B-Y. Wu, Jen-Ming Huang, Quanlin Li, Sungyong You, Jayoung Kim, Yi-Tsung Lu, Stefan Mrdenovic, Ruoxiang Wang (+5 others)
2016 OncoTarget  
When KRT13 expression was determined at a single cell level in primary tumor tissues of 44 prostate cancer cases, KRT13 level predicted bone metastasis and the overall survival of prostate cancer patients  ...  KRT13 expression was elevated in bone, brain, and soft tissue metastatic prostate cancer cell lines and in primary and metastatic clinical prostate, lung, and breast cancer specimens.  ...  GRANT SUPPORT This study was supported in part by NCI-P01-CA098912. DOD CDMRP WX81XWH-14-1-0273.  ... 
doi:10.18632/oncotarget.13175 pmid:27835867 pmcid:PMC5356688 fatcat:h44x3bpde5gupmer3gpdz2xlgu

The Human Cell Surfaceome of Breast Tumors

Júlia Pinheiro Chagas da Cunha, Pedro Alexandre Favoretto Galante, Jorge Estefano Santana de Souza, Martin Pieprzyk, Dirce Maria Carraro, Lloyd J. Old, Anamaria Aranha Camargo, Sandro José de Souza
2013 BioMed Research International  
We used a high-throuput qPCR system for the analysis of 573 cell surface protein-coding genes in 12 primary breast tumors, 8 breast cell lines, and 21 normal human tissues including breast.  ...  To better understand the role of these genes in breast tumors, we used a series of bioinformatics strategies to integrates different type, of the datasets, such as KEGG, protein-protein interaction databases  ...  In that report, we further selected 573 cell surface genes as the most promising candidates for cancer diagnostics and therapy based on their expression profiling through the use of Massively Parallel  ... 
doi:10.1155/2013/976816 pmid:24195083 pmcid:PMC3781997 fatcat:mrffn2dkpzdmtbeoznkrfe3hwm

Cancer stem cells in glioblastoma

Justin D. Lathia, Stephen C. Mack, Erin E. Mulkearns-Hubert, Claudia L.L. Valentim, Jeremy N. Rich
2015 Genes & Development  
ICT-107, a patient-derived DC vaccine developed against six antigens highly expressed in glioma CSCs (Phuphanich et al. 2013) , is currently under clinical evaluation for use in patients.  ...  Informed by techniques used to enrich and characterize NSPCs, several groups in parallel demonstrated that gliomas and other primary brain tumors contain self-renewing, tumorigenic cells (Ignatova et  ... 
doi:10.1101/gad.261982.115 pmid:26109046 pmcid:PMC4495393 fatcat:d34yqwzgnvgynpp5sji562zl2i
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