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The microspheres were expected to accumulate at the surface of the gel and enter any location with an opening size larger than 200 nm, thus marking any potential leak paths. ...  We followed the approach of Johnson and Tarbell  , who developed a onedimensional biphasic model that is confined in the directions perpendicular to a flow (Q) of viscosity µ. ...pmid:18401073 pmcid:PMC2562030 fatcat:a56uclkqmfgspic2mj2bpbmzry
For patients with persistent systemic or suprasystemic right ventricular pressure, marked asymmetry in pulmonary blood flow, or symptoms, balloon dilation angioplasty has been used to improve arterial ...doi:10.1172/jci35309 pmid:18452001 pmcid:PMC2358987 fatcat:p5cvp2wdyrajtniirx4wevrkma
Bell, William H. Johnson, Mark Godman, and Edna Cotner, The English We Need, Book I. Philadelphia: John C. Winston Co., 1944. Pp. 405. 228 conversations.” ...doi:10.2307/807703 fatcat:v7th45rcavdhbp5p3qb46iauxe
Bell; William H. Johnson; Mark Goodman; and Edna Colner, The English We Need, Book II. Philadelphia: John C. Winston Co., 1945. Pp. 435. ...doi:10.2307/807945 fatcat:ohhpscyrmbcntmblhkfuqzu4my
These social behaviours then generate further epigenetic marks. ... Epigenetics concerns cellular processes of interaction between DNA and epigenetic 'marks', where an organism's patterns of behaviour leave marks in the form of proteins and chemicals in the environment ...doi:10.1007/s42438-020-00190-9 fatcat:ujbvokctfbdzbbktc6utubf7tq
The following sections review the irregular Z-buffer algorithm introduced by Johnson et al.  and Aila and ... Johnson et al. (a) Conventional Z-buffer. (b) Irregular Z-buffer. (c) Conventional shadow mapping. (d) Irregular shadow mapping. ... Fig. 5 : 5 Conventional and irregular shadow mapping compared.Steps marked "*" are repeated per light source. ...doi:10.1145/1095878.1095889 fatcat:r2na225rm5gmpgjdgz74y5plai
William Johnson developed the initial topic outline and identified some review material. Zia Bukhari and Mark W. LeChevallier edited the initial draft and identified additional literature sources. ...doi:10.3390/pathogens4030470 pmid:26140674 pmcid:PMC4584268 fatcat:o7akwv6bwvhcxn7pm2i5mfckcm
We investigated the reported differences in the modulating effect of sodium on renal a2-adrenoceptor binding between inbred Dahl Salt-Sensitive (S/JR) and Salt-Resistant (R/JR) Rats. Saturation binding of [3H]rauwolscine to renal a2-adrenoceptors and its displacement by epinephrine were performed in the absence and presence of NaCI, GppNHp, or MgC12 in S/JR and R/JR rats. We omitted sucrose in our buffers which preserves endogenous catecholamines in renal membranes. MgC12 but not NaCI or GppNHpdoi:10.1291/hypres.17.179 fatcat:pzt63abhgvfz7dx3hmi4ve7y6y
more »... decreased the apparent density and affinity of renal a2-adrenoceptors for [3H]rauwolscine in both strains. NaCI and GppNHp reduced and MgC12 increased the affinity of renal a2-adrenoceptors for epinephrine in both strains. There were no differences in the modulating effects of sodium on renal a2-adrenoceptor binding between the two strains except for the higher receptor density in S/JR than in R/JR rats. These data suggest that the difference in renal a2-adrenoceptors between S/JR and R/JR is not due to alterations which affect receptor protein structure or interaction with G proteins. Thus, future investigations should be directed at the regulation of the receptor gene expression. (Hypertens Res 1994;17: 179-185)
A strategy for the dereplication of a complete and a partial structure using 1H NMR, 1H–13C HSQC and 1H–1H COSY spectral data, a molecular formula composition range and structural fragments against a massive database of about 22 million compounds is considered.doi:10.1039/c5ob01713k pmid:26381222 fatcat:ebpk3mffbrgnxhtanenda3uvza
Melanomas are characterized by activating "driver" mutations in BRAF, NRAS, KIT, GNAQ, and GNA11. Resultant mitogen-activated protein kinase (MAPK) pathway signaling makes some melanomas susceptible to BRAF (BRAF V600 mutations), MEK1/2 (BRAF V600, L597, fusions; NRAS mutations), or other kinase inhibitors (KIT), respectively. Among driver-negative ("pan-negative") patients, an unexplained heterogeneity of response to MEK1/2 inhibitors has been observed. Analysis of 16 pan-negative melanomadoi:10.18632/oncotarget.4255 pmid:26084293 pmcid:PMC4673168 fatcat:ozpsedf6enagpkfzdvik475dhe
more »... lines revealed that 8 (50%; termed Class I) are sensitive to the MEK1/2 inhibitor, trametinib, similar to BRAF V600E melanomas. A second set (termed Class II) display reduced trametinib sensitivity, paradoxical activation of MEK1/2 and basal activation of ERBBs 1, 2, and 3 (4 lines, 25%). In 3 of these lines, PI3K/AKT and MAPK pathway signaling is abrogated using the ERBB inhibitor, afatinib, and proliferation is even further reduced upon the addition of trametinib. A potential mechanism of ERBB activation in Class II melanomas is minimal expression of the ERK1/2 phosphatase, DUSP4, as ectopic restoration of DUSP4 attenuated ERBB signaling through potential modulation of the ERBB ligand, amphiregulin (AREG). Consistent with these data, immunohistochemical analysis of patient melanomas revealed a trend towards lower overall DUSP4 expression in pannegative versus BRAF-and NRAS-mutant tumors. This study is the first to demonstrate that differential ERBB activity in pan-negative melanoma may modulate sensitivity to clinically-available MEK1/2 inhibitors and provides rationale for the use of ERBB inhibitors, potentially in combination with MEK1/2 inhibitors, in subsets of this disease.
Retinal imaging spectroscopy can provide functional maps using chromophore spectra. For example, oxygen saturation maps show ischemic areas from diabetes and venous occlusions. Obtaining retinal spatial-spectral data has been difficult due to saccades and long data acquisition times ͑Ͼ5 s͒. We present a snapshot imaging spectrometer with far-reaching applicability that acquires a complete spatial-spectral image cube in ϳ3 ms from 450 to 700 nm with 50 bands, eliminating motion artifacts anddoi:10.1117/1.2434950 pmid:17343511 fatcat:f6z5nzwb2zgdhaq2y5qm2dw3x4
more »... l misregistration. Current retinal spectral imaging approaches are incapable of true snapshot operation over a wide spectral range with a large number of spectral bands. Coupled to a fundus camera, the instrument returns true color retinal images for comparison to standard fundus images and for image validation while the patient is still dilated. Oxygen saturation maps were obtained with a three-wavelength algorithm: for healthy subjects arteries were ϳ95% and veins 30 to 35% less. The instrument is now undergoing clinical trials. © 2007 Society of Photo-Optical Instrumentation Engineers.
The nature of the spatial representations that underlie simple visually guided actions early in life was investigated in toddlers with Williams syndrome (WS), Down syndrome (DS), and healthy chronological ... Johnson et al. ... Williams syndrome is caused by a sub-microscopic deletion on chromosome 7q.11.23, and occurs in approximately 1 in 20,000 live births. ...doi:10.1016/s0028-3932(02)00299-3 pmid:12667539 fatcat:s7x4mdfrejekxiqatdx7v62pvq
Further research is necessary to understand the processes underlying change. and environmental triggers Johnson et al. ... Given the severity of psychosocial problems in the aftermath of bipolar episodes, such treatment effects are particularly encouraging. approaches to the treatment of bipolar disorder Johnson et al. 71 ...doi:10.1097/00001504-200001000-00012 fatcat:a34jdjwah5a2zfwqluykx6ojl4
The gray blocks mark 2004 (for which we had no data). ... The red vertical line in (a) shows the 08/15/07 when there was a marked increase in unwinding of the carry trade. (b) Carry trade index Υ. ...arXiv:0905.4912v2 fatcat:lhyuu67unjcl5iy647ufp2p37i
(c) Occipital electrode sites used for ERP and phase locked ã burst analysis are marked as black ®lled circles. ... The groups with autism and Williams Syndrome showed no stimulus-dependent differences in coherence across conditions. ...doi:10.1097/00001756-200108280-00021 pmid:11522950 fatcat:m22eanoeqbcxxfy22tbupvneqm
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