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Understanding and preventing type 1 diabetes through the unique working model of TrialNet

Manuela Battaglia, Mark S. Anderson, Jane H. Buckner, Susan M. Geyer, Peter A. Gottlieb, Thomas W. H. Kay, Åke Lernmark, Sarah Muller, Alberto Pugliese, Bart O. Roep, Carla J. Greenbaum, Mark Peakman
2017 Diabetologia  
This analysis involves quantitative PCR amplification of INS DNA, with epigenetic marks that identify the DNA source as cells that actively transcribe insulin.  ...  International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s)  ... 
doi:10.1007/s00125-017-4384-2 pmid:28770323 pmcid:PMC5838353 fatcat:g7jip5rgg5dfrlenz3uso3gpyq

Application of implicit–explicit high order Runge–Kutta methods to discontinuous-Galerkin schemes

Alex Kanevsky, Mark H. Carpenter, David Gottlieb, Jan S. Hesthaven
2007 Journal of Computational Physics  
We use Sutherland's law to relate the dynamic viscosity to the temperature µ(T ) µ s = T T s 3 2 T s + S T + S , (11) where µ s = 1.716 × 10 −5 kg/m sec, T s = 273 o K, S = 111 o K and the Prandtl number  ...  d has a stiffness S ≈ 96.4, and N ozzle e has a stiffness S ≈ 928.6.  ... 
doi:10.1016/j.jcp.2007.02.021 fatcat:lsv7rfnmhbf3rdweegpzwguyzu

Almost There: Transmission Routes of Bacterial Symbionts between Trophic Levels

Elad Chiel, Einat Zchori-Fein, Moshe Inbar, Yuval Gottlieb, Tetsuya Adachi-Hagimori, Suzanne E. Kelly, Mark K. Asplen, Martha S. Hunter, Jason E. Stajich
2009 PLoS ONE  
PCR conditions were: 95uC for 2 min followed by 35 cycles of 92uC, 30 s; 60uC, 30 s; 72uC, 30 s, and final incubation at 72uC for 5 min.  ... 
doi:10.1371/journal.pone.0004767 pmid:19274091 pmcid:PMC2651630 fatcat:2ex5bvw4mbhevphs2azfkheedq

Pediatric Psoriasis Comorbidity Screening Guidelines

Emily Osier, Audrey S. Wang, Megha M. Tollefson, Kelly M. Cordoro, Stephen R. Daniels, Andrew Eichenfield, Joel M. Gelfand, Alice B. Gottlieb, Alexa B. Kimball, Mark Lebwohl, Nehal N. Mehta, Amy S. Paller (+5 others)
2017 JAMA dermatology  
Psoriasis is a complex inflammatory skin condition associated with serious medical comorbidities in adults, including obesity, hypertension, dyslipidemia, type 2 diabetes mellitus, psoriatic arthritis, nonalcoholic fatty liver disease, depression, anxiety, and decreased quality of life. Because psoriasis begins in childhood in almost one-third of patients, early identification of risk may be critical to minimizing effects on future health.
doi:10.1001/jamadermatol.2017.0499 pmid:28514463 pmcid:PMC5748031 fatcat:pzaf72howvdirgfwxlda54gana

Psoriasis in the elderly: From the Medical Board of the National Psoriasis Foundation

Ivan S. Grozdev, Abby S. Van Voorhees, Alice B. Gottlieb, Sylvia Hsu, Mark G. Lebwohl, Bruce F. Bebo, Neil J. Korman
2011 Journal of American Academy of Dermatology  
Collins P, Rogers S. The efficacy of methotrexate in psoriasisea review of 40 cases.  ...  Gottlieb 5. No studies have been performed evaluating the role of acitretin in the elderly.  ... 
doi:10.1016/j.jaad.2010.05.014 pmid:21496950 fatcat:6gqsc6gikndedn4xi44vuahgdi

Comparison of Chevron Osteotomy and Modified McBride Bunionectomy for Correction of Mild to Moderate Hallux Valgus Deformity

Jeffrey E. Johnson, Thomas O. Clanton, Donald E. Baxter, Mark S. Gottlieb
1991 Foot & Ankle  
This • s similar to the average passive range of motion of the remaining Chevron patients that did not have a capsular release and adductor tenotomy ( Table 2) .  ...  All 10 patients returned for an interview, phy s . ical examination and had pre-and postoperative x. rays. All patients were females with an average age of 35.4 years (range, 23-50 years).  ... 
doi:10.1177/107110079101200201 pmid:1773996 fatcat:qjq5utk5bbfpxpedpqduv6gndu

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

Mark D. Pescovitz, Carla J. Greenbaum, Heidi Krause-Steinrauf, Dorothy J. Becker, Stephen E. Gitelman, Robin Goland, Peter A. Gottlieb, Jennifer B. Marks, Paula F. McGee, Antoinette M. Moran, Philip Raskin, Henry Rodriguez (+5 others)
2009 New England Journal of Medicine  
Gottlieb, receiving grant support from Bayhill Therapeutics, MacroGenics, and Tolerx; Dr.  ...  Marks, serving on advisory boards for Genentech, Roche, and Biogen Idec and receiving grant support from Eli Lilly; Dr.  ... 
doi:10.1056/nejmoa0904452 pmid:19940299 pmcid:PMC6410357 fatcat:hozvvffbjjbstj6nwnqevy2quu

B-Lymphocyte Depletion With Rituximab and -Cell Function: Two-Year Results

M. D. Pescovitz, C. J. Greenbaum, B. Bundy, D. J. Becker, S. E. Gitelman, R. Goland, P. A. Gottlieb, J. B. Marks, A. Moran, P. Raskin, H. Rodriguez, D. A. Schatz (+4 others)
2013 Diabetes Care  
We previously reported that selective depletion of B-lymphocytes with rituximab, an anti-CD20 monoclonal antibody, slowed decline of β-cell function in recent-onset type 1 diabetes mellitus (T1DM) at 1 year. Subjects were followed further to determine whether there was persistence of effect. Eighty-seven subjects (aged 8-40 years) were randomly assigned to, and 81 received, infusions of rituximab or placebo on days 1, 8, 15, and 22. The primary outcome-baseline-adjusted mean 2-h area under the
more » ... urve (AUC) serum C-peptide during a mixed-meal tolerance test (MMTT) at 1 year-showed higher C-peptide AUC with rituximab versus placebo. Subjects were further followed with additional MMTTs every 6 months. The rate of decline of C-peptide was parallel between groups but shifted by 8.2 months in rituximab-treated subjects. Over 30 months, AUC, insulin dose, and HbA1c were similar for rituximab and placebo. However, in evaluating change in C-peptide over the entire follow-up period, the rituximab group means were significantly larger as compared within assessment times with the placebo group means using a global test (P = 0.03). Odds ratio for loss of C-peptide to <0.2 nmol/L following rituximab was 0.565 (P = 0.064). B-lymphocytes recovered to baseline values by 18 months. Serum IgG levels were maintained in the normal range but IgM levels were depressed. Like several other immunotherapeutic approaches tested, in recent-onset T1DM, rituximab delays the fall in C-peptide but does not appear to fundamentally alter the underlying pathophysiology of the disease.
doi:10.2337/dc13-0626 pmid:24026563 pmcid:PMC3898764 fatcat:dqtzpfc245ao5h6mvx7v5lzucm

Sleep-Disordered Breathing and Mortality: A Prospective Cohort Study

Naresh M. Punjabi, Brian S. Caffo, James L. Goodwin, Daniel J. Gottlieb, Anne B. Newman, George T. O'Connor, David M. Rapoport, Susan Redline, Helaine E. Resnick, John A. Robbins, Eyal Shahar, Mark L. Unruh (+2 others)
2009 PLoS Medicine  
Apneas were identified if airflow was absent or nearly absent for at least 10 s.  ...  Hypopneas were identified when there was at least 30% reduction in airflow or thoracoabdominal movement for at least 10 s.  ... 
doi:10.1371/journal.pmed.1000132 pmid:19688045 pmcid:PMC2722083 fatcat:zupwb2bqmffcribns7c4xzls4y

Cytomegalovirus-specific CD4+ and CD8+ T-cells follow a similar reconstitution pattern after allogeneic stem cell transplantation

Aaron E Foster, David J Gottlieb, Mary Sartor, Mark S Hertzberg, Kenneth F Bradstock
2002 Biology of Blood and Marrow Transplantation  
Several recipients (patients 16 through 20) who were analyzed for both CD4 + and CD8 + T-cells concurrently showed marked increases in CMVspecific CD8 + frequency and corresponding CD4 + expansion after  ... 
doi:10.1053/bbmt.2002.v8.pm12374455 pmid:12374455 fatcat:sfgeecsfj5fmjd5lvi5fczqeeq

Comparison of Conflict of Interest Policies and Reported Practices in Academic Medical Centers in the United States

MICHAELA A. DINAN, KEVIN P. WEINFURT, JOËLLE Y. FRIEDMAN, JENNIFER S. ALLSBROOK, JULIE GOTTLIEB, KEVIN A. SCHULMAN, MARK A. HALL, JATINDER K. DHILLON, JEREMY SUGARMAN
2006 Accountability in Research  
Purpose-To assess the level of consistency between academic medical centers' conflict of interest policies and reported practices. Method-The authors reviewed the written conflict of interest policies of 9 academic medical centers in the United States and interviewed members of the institutional review boards (IRBs) and conflict of interest committees (COICs) at those institutions. Topics of interest included communication between IRBs and COICs, processes for reporting and managing conflicts
more » ... interest, and disclosure of conflicts of interest to potential research participants. Results-Reported relationships between IRBs and COICs varied, but only 2 institutions had written policies governing these relationships. Many institutions used processes for reporting and managing conflicts of interest that were more decentralized than the processes described in their formal policies. Policies and practices regarding disclosure of conflicts of interest also varied. At most institutions, no clear and comprehensive policy existed to guide investigators regarding disclosure of financial conflicts of interest to potential research participants. Correspondence to Kevin P. Weinfurt, PhD Conclusions-This study confirms the need to ensure that institutions' practices match their policies. Considerable differences in understanding of conflict of interest policies were observed between IRB and COIC officials, suggesting that clear, comprehensive, and well-disseminated policies may lead to more consistent practice within institutions.
doi:10.1080/08989620601003414 pmid:17849643 pmcid:PMC2474571 fatcat:tst3losam5gvrko5n5k5odv4ze

Research gaps in psoriasis: Opportunities for future studies

Caitriona Ryan, Neil J. Korman, Joel M. Gelfand, Henry W. Lim, Craig A. Elmets, Steven R. Feldman, Alice B. Gottlieb, John Y.M. Koo, Mark Lebwohl, Craig L. Leonardi, Abby S. Van Voorhees, Reva Bhushan (+1 others)
2014 Journal of American Academy of Dermatology  
Over the past 2 decades, considerable progress has been made to further elucidate the complex pathogenesis of psoriasis, facilitating the development of a new armamentarium of more effective, targeted therapies. Despite these important advances, substantial deficits remain in our understanding of psoriasis and its treatment, necessitating further research in many areas. In the sixth section of the American Academy of Dermatology Psoriasis Guidelines of Care, gaps in research and care were
more » ... fied. We discuss the most important gaps in research that currently exist and make suggestions for studies that should be performed to address these deficits. These encompass both basic science and clinical research studies, including large, prospective epidemiologic studies to determine the true prevalence and natural history of psoriasis; further molecular studies in patients with psoriatic and psoriatic arthritis to understand the function of psoriasis susceptibility genes and to identify novel therapeutic targets; studies to examine the role of environmental factors in the development of psoriasis; further investigation of the relationship between psoriasis and cardiometabolic disease; studies that examine the role of adjunctive therapies such as psychological interventions in appropriate patient groups; and finally, studies to identify biomarkers of disease severity and treatment response to optimize patient therapy. ( J Am Acad Dermatol 2014;70:146-67.)
doi:10.1016/j.jaad.2013.08.042 pmid:24126079 fatcat:bzofidjdcbc77p6vtr5gdp5oxe

Costimulation Modulation With Abatacept in Patients With Recent-Onset Type 1 Diabetes: Follow-up 1 Year After Cessation of Treatment

Tihamer Orban, Brian Bundy, Dorothy J. Becker, Linda A. DiMeglio, Stephen E. Gitelman, Robin Goland, Peter A. Gottlieb, Carla J. Greenbaum, Jennifer B. Marks, Roshanak Monzavi, Antoinette Moran, Mark Peakman (+7 others)
2013 Diabetes Care  
Gottlieb, 7 Carla J. Greenbaum, 8 Jennifer B. Marks, 9 Roshanak Monzavi, 10 Antoinette Moran, 11 Mark Peakman, 12 Philip Raskin, 13  ... 
doi:10.2337/dc13-0604 pmid:24296850 pmcid:PMC3964491 fatcat:ax7ceninnvhmfntmfrwrpxkuz4

Comparison of initial detection and redetection of ventricular fibrillation in a transvenous defibrillator system with automatic gain control

Charles I. Berul, David J. Callans, David S. Schwartzman, Mark W. Preminger, Charles D. Gottlieb, Francis E. Marchlinski
1995 Journal of the American College of Cardiology  
Tbe mean f SD initial time to detection of ventricular fibrillation was 5.5 + 1.7 s (range 2.4 to 10.8); the time to iedetection ranged from 1.5 to 18.5 s (mean 4.5 -t 2.8, p = NS vs. detection time).  ...  Abnormal redetection episodes, defined as a redetection time >10.2 s (i.e., >2 SD above the mean redetection time), were observed in 4 (18%) of 22 patients. C~t&.Gons.  ...  In all abnormal redetection episodes, there was marked variability in the amplitude af the signals recorded from the integrated bipolar sensing system.  ... 
doi:10.1016/0735-1097(94)00418-p pmid:7829798 fatcat:4pb3xtjyabag3potomsrqywwhm

Guidelines of care for the management of psoriasis and psoriatic arthritis

Alice Gottlieb, Neil J. Korman, Kenneth B. Gordon, Steven R. Feldman, Mark Lebwohl, John Y.M. Koo, Abby S. Van Voorhees, Craig A. Elmets, Craig L. Leonardi, Karl R. Beutner, Reva Bhushan, Alan Menter
2008 Journal of American Academy of Dermatology  
VITAMIN D ANALOGUES Calcipotriol (calcipotriene), a synthetic vitamin D analogue, was first introduced in the early 1990's in Europe to treat psoriasis and is now available in the United States.  ...  II Efficacy of different classes of topical corticosteroids for the treatment of psoriasis 1 (superpotent) 58%-92% Bernhard et al 13 (1991) Lebwohl et al 14 (2002) Gottlieb, Ford, and Spellman 15  ... 
doi:10.1016/j.jaad.2008.02.040 pmid:18423261 fatcat:qyic273po5eh3dqjymmghqnmhq
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