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Staphylococcus aureusbiofilms

Nathan K. Archer, Mark J. Mazaitis, J. William Costerton, Jeff G. Leid, Mary Elizabeth Powers, Mark E. Shirtliff
2011 Virulence  
The sequencing of the whole genome of multiple S. aureus strains, 123 followed by those of methicillin-resistant 124, 125 and vancomycin-intermediate 126 and epidemic 127 strains undoubtedly marked  ... 
doi:10.4161/viru.2.5.17724 pmid:21921685 pmcid:PMC3322633 fatcat:f57gtxzmmrherl7ynbtqrqi3ki

S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking

Taylor S. Cohen, Michelle L. Boland, Brandon B. Boland, Virginia Takahashi, Andrey Tovchigrechko, Young Lee, Aimee D. Wilde, Mark J. Mazaitis, Omari Jones-Nelson, Christine Tkaczyk, Rajiv Raja, C. Kendall Stover (+1 others)
2018 Cell Reports  
Clinical severity of Staphylococcus aureus respiratory infection correlates with alpha toxin (AT) expression. AT activates the NLRP3 inflammasome; deletion of Nlrp3, or AT neutralization, protects mice from lethal S. aureus pneumonia. We tested the hypothesis that this protection is not due to a reduction in inflammasome-dependent cytokines (IL-1β/IL-18) but increased bactericidal function of macrophages. In vivo, neutralization of AT or NLRP3 improved bacterial clearance and survival, while
more » ... cking IL-1β/IL-18 did not. Primary human monocytes were used in vitro to determine the mechanism through which NLRP3 alters bacterial killing. In cells treated with small interfering RNA (siRNA) targeting NLRP3 or infected with AT-null S. aureus, mitochondria co-localize with bacterial-containing phagosomes. Mitochondrial engagement activates caspase-1, a process dependent on complex II of the electron transport chain, near the phagosome, promoting its acidification. These data demonstrate a mechanism utilized by S. aureus to sequester itself from antimicrobial processes within the cell.
doi:10.1016/j.celrep.2018.02.027 pmid:29490278 pmcid:PMC7160668 fatcat:kas2cwuovfax7m7zaotupzrgxa

A data analysis and coordination center for the human microbiome project

Jennifer Wortman, Michelle Giglio, Heather Creasy, Amy Chen, Konstantinos Liolios, Ken Chu, Noam Davidovics, Mark Mazaitis, Todd DeSantis, Navjeet Singh, Joshua Orvis, Jonathan Crabtree (+8 others)
2010 Genome Biology  
doi:10.1186/gb-2010-11-s1-o13 fatcat:wmovaheggfcr5eu24b64o2sp6m

EcoRI cleavage sites in the argECBH region of the Escherichia coli chromosome

E A Devine, M C Moran, P J Jederlinic, A J Mazaitis, H J Vogel
1977 Journal of Bacteriology  
The suplO2 deletion marks the position of the argECBH cluster. The bar represents 1 kilobase (1,000 base pairs).  ...  The droplet technique of Lang and Mitani (5), as modified by Mazaitis et al. (6), was used. Samples of sucrose gradient fractions were used without prior dialysis.  ... 
doi:10.1128/jb.129.2.1072-1077.1977 fatcat:p64zjxlzxzbsrmz4shpndjalfq

Turn-on of inactive genes by promoter recruitment in Escherichia coli: inverted repeats resulting in artificial divergent operons

D Charlier, Y Severne, M Zafarullah, N Glansdorff
1983 Genetics  
ELSEVIERS et d. (1972) idtin MAZAITIS et al. (1976) GLANSDORFF (1 965) R. WEISBERG MAZAITIS et al. (1976) idmi R. THOMAS R.  ...  In Xl3/hAAl heteroduplexes (CHARLIER et al. 1979, Figures 2 and 7) , the base of the stem formed by the second and third copies was found some 300-400 bp to the right of the loop marking the sup102 deletion  ... 
pmid:6227522 pmcid:PMC1202169 fatcat:l3knjcrgdna7naq7hao7qkwzf4

Electron microscopy of simian virus 40 DNA configuration under denaturation conditions

F Mayer, A J Mazaitis, A Pühler
1975 Journal of Virology  
MAYER, MAZAITIS, AND POHLER sites, or circular and linear single strands (24, 28) .  ...  Isolated low-multiplicity SV40 DNA was kindly provided by Mark Rush, New York University, School of Medicine, New York, N.Y.  ... 
doi:10.1128/jvi.15.3.585-598.1975 fatcat:2u3g7jrmkze25crwqcadh6bdqq

Cloning and expression of the gene for the vitamin B12 receptor protein in the outer membrane of Escherichia coli

K Heller, B J Mann, R J Kadner
1985 Journal of Bacteriology  
The BtuB+ plasmids L23D (pBJM003 with a TnlOOO insertion outside btuB), pKH3-3, pKH3-8, and pBJM003 (data not shown) caused marked elevation in production of an outer membrane polypeptide with a molecular  ...  The btuB region was cloned from the specialized transducing phage, A dargECBHJ3, which has been isolated by Mazaitis et al. (21) and carries the chromosomal genes ppc, argECBH, and btuB.  ... 
doi:10.1128/jb.161.3.896-903.1985 fatcat:whflnhyvpvcsjash2d2nu7nfrm

Cloning and expression of the gene for the vitamin B12 receptor protein in the outer membrane of Escherichia coli

K Heller, B J Mann, R J Kadner
1985 Journal of Bacteriology  
The BtuB+ plasmids L23D (pBJM003 with a TnlOOO insertion outside btuB), pKH3-3, pKH3-8, and pBJM003 (data not shown) caused marked elevation in production of an outer membrane polypeptide with a molecular  ...  The btuB region was cloned from the specialized transducing phage, A dargECBHJ3, which has been isolated by Mazaitis et al. (21) and carries the chromosomal genes ppc, argECBH, and btuB.  ... 
pmid:2982793 pmcid:PMC214981 fatcat:vzbk6xmi6ngtdikduh4txhiwpm

Quasar: Datasets for Question Answering by Search and Reading [article]

Bhuwan Dhingra, Kathryn Mazaitis, William W. Cohen
2017 arXiv   pre-print
Each sentence was marked with a thread identifier, a post identifier, and the tags for the thread.  ...  For QUASAR-T we collected annotations for a total of 144 questions, out of which 12 we marked as ambiguous.  ... 
arXiv:1707.03904v2 fatcat:5tf263qt7vfchmcmgbbge35weq

Dependency Parsing for Weibo: An Efficient Probabilistic Logic Programming Approach

William Yang Wang, Lingpeng Kong, Kathryn Mazaitis, William W Cohen
2014 Proceedings of the 2014 Conference on Empirical Methods in Natural Language Processing (EMNLP)  
This allows us to observe some interesting phenomena that mark the differences of the two languages. For example: • Function words are more frequently used in English than in Chinese.  ... 
doi:10.3115/v1/d14-1122 dblp:conf/emnlp/WangKMC14 fatcat:zqvwuwp6irgcfnyoq6x4u4bqfi

Electron microscopy of simian virus 40 DNA configuration under denaturation conditions

F Mayer, A J Mazaitis, A Pühler
1975 Journal of Virology  
Isolated low-multiplicity SV40 DNA was kindly provided by Mark Rush, New York University, School of Medicine, New York, N.Y.  ...  Complex forms of SV40 DNA (i.e., DNA molecules with multiple MAYER, MAZAITIS, AND PUHLER viral contour length; 21) were not observed in the sample.  ... 
pmid:234540 pmcid:PMC354495 fatcat:w5jhbytkpzf3vp2m2u4fequ5dq

Dark matter RNA illuminates the puzzle of genome-wide association studies

Georges St. Laurent, Yuri Vyatkin, Philipp Kapranov
2014 BMC Medicine  
Acknowledgments We would like to thank Dmitry Shtokalo, Maxim Ri, Denis Antonets, Olga Saik, Tim McCaffrey and Mark Mazaitis for their helpful discussions and help with figure generation.  ... 
doi:10.1186/1741-7015-12-97 pmid:24924000 pmcid:PMC4054906 fatcat:e7j7r6y3ojgo5foqgrds6wdy6m

Learning to Define Terms in the Software Domain

Vidhisha Balachandran, Dheeraj Rajagopal, Rose Catherine Kanjirathinkal, William Cohen
2018 Proceedings of the 2018 EMNLP Workshop W-NUT: The 4th Workshop on Noisy User-generated Text  
Additionally, the authors would like to thank Kathryn Mazaitis for her help with data collection and analysis.  ...  From each thread, we used all text that is not marked as code and segmented them into sentences.  ... 
doi:10.18653/v1/w18-6122 dblp:conf/aclnut/BalachandranRKC18 fatcat:rzukyorg3zfcfnjddxvbpt2opq

TensorLog: Deep Learning Meets Probabilistic DBs [article]

William W. Cohen, Fan Yang, Kathryn Rivard Mazaitis
2017 arXiv   pre-print
Currently this is implemented by marking learned functions g with the predicate q, a mode, and a depth argument d, and ensuring that function calls inside g p io,d to q always call the next-deeper version  ...  Their system includes representation-learning as a component, as well as a template-instantiation approach (similar to (Wang, Mazaitis, & Cohen, 2014) ), allowing structure learning as well.  ... 
arXiv:1707.05390v1 fatcat:prust3afrfeippdyz5enfx5jse

Structural Requirements of N- and C-Terminal Orai Strands to allow Maximal Store-Operated Ca2+ Current Activation by STIM1

Isabella Derler, Marc Fahrner, Peter Plenk, Christoph Romanin
2013 Biophysical Journal  
Duman 2 , Mark W. Moody 1 , Liangyi Chen 3 , Bertil Hille 1 . 1 Univeristy of Washington, Seattle, WA, USA, 2 Baylor College of Medicine, Houston, TX, USA, 3 Peking University, Beijing, China.  ...  Khairallah RJ, Shi G, Sbrana F, Prosser BL, Borroto C, Mazaitis MJ, Hoffman EP, Mahurkar A, Sachs F, Sun Y, Chen YW, Raiteri R, Lederer WJ, Dorsey SG, Ward CW (2012) Microtubules underlie dysfunction in  ... 
doi:10.1016/j.bpj.2012.11.3408 fatcat:e7w6tp7t2vg25gsfq5t3ul6rim
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